SULT1C4 (sulfotransferase family 1C member 4)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 27233
• Gene name: Sulfotransferase family 1C member 4
• Gene symbol: SULT1C4
• Synonyms (NCBI Gene): SULT1C, SULT1C2
• Chromosome: 2
• Chromosome location: 2q12.3
• Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and

miRNA Show/Hide all (49)

miRTarBase ID	miRNA	Experiments	Reference
MIRT621212	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT621210	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT621211	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT621209	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT621208	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT637916	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT637915	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT637914	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT621207	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT621206	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT621212	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT621210	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT621211	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT621209	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT621208	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT621207	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT621206	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT621212	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT621210	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT621211	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT621209	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT621208	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT637916	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT637915	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT637914	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT621207	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT621206	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT621212	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT621210	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT621211	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT621209	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT621208	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT621207	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT621206	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT2636658	hsa-miR-197	CLIP-seq
MIRT2636659	hsa-miR-3152-5p	CLIP-seq
MIRT2636660	hsa-miR-3200-3p	CLIP-seq
MIRT2636661	hsa-miR-411	CLIP-seq
MIRT2636662	hsa-miR-4762-3p	CLIP-seq
MIRT2636663	hsa-miR-4775	CLIP-seq
MIRT2636664	hsa-miR-4778-5p	CLIP-seq
MIRT2636665	hsa-miR-590-3p	CLIP-seq
MIRT2636666	hsa-miR-766	CLIP-seq
MIRT2636658	hsa-miR-197	CLIP-seq
MIRT2636659	hsa-miR-3152-5p	CLIP-seq
MIRT2636660	hsa-miR-3200-3p	CLIP-seq
MIRT2636663	hsa-miR-4775	CLIP-seq
MIRT2636665	hsa-miR-590-3p	CLIP-seq
MIRT2636666	hsa-miR-766	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004062	Function	Aryl sulfotransferase activity	IBA
GO:0004062	Function	Aryl sulfotransferase activity	IDA	17425406, 23207770
GO:0004062	Function	Aryl sulfotransferase activity	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	28222028
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006068	Process	Ethanol catabolic process	IDA	23207770
GO:0006805	Process	Xenobiotic metabolic process	IDA	20056724, 26948952
GO:0008146	Function	Sulfotransferase activity	IDA	20056724, 26948952, 28222028
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008146	Function	Sulfotransferase activity	NAS	9852044
GO:0009812	Process	Flavonoid metabolic process	IDA	28222028
GO:0016740	Function	Transferase activity	IEA
GO:0044598	Process	Doxorubicin metabolic process	IDA	26948952
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA	23207770, 28222028
GO:0051923	Process	Sulfation	IBA
GO:0051923	Process	Sulfation	IDA	20056724, 23207770

Other IDs

• MIM: 608357
• HGNC: 11457
• e!Ensembl: ENSG00000198075

Protein

• UniProt ID: O75897
• Protein name: Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
• Protein function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and envir
• PDB: 2AD1 , 2GWH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00685	Sulfotransfer_1	45 → 295	Sulfotransferase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal cord. {ECO:0000269|PubMed:9852044}.
• Sequence:

  MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTW
  TQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHL
  LPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWH
  EHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMK
  QNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHF
  QF

• Sequence length: 302

Pathways

Reactome Pathway:

Cytosolic sulfonation of small molecules

Related Genes

No strongly related genes found yet for SULT1C4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SULT1C4.