Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	445329
Gene name	Sulfotransferase family 1A member 4
Gene symbol	SULT1A4
Synonyms (NCBI Gene)	HAST3M-PSTST1A3ST1A3/ST1A4ST1A4STMTL-PST
Chromosome	16
Chromosome location	16p11.2
Summary	Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and

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miRTarBase ID	miRNA	Experiments
MIRT1402833	hsa-miR-1208	CLIP-seq
MIRT1402834	hsa-miR-1257	CLIP-seq
MIRT1402835	hsa-miR-1343	CLIP-seq
MIRT1402836	hsa-miR-142-3p	CLIP-seq
MIRT1402837	hsa-miR-143	CLIP-seq
MIRT1402838	hsa-miR-3166	CLIP-seq
MIRT1402839	hsa-miR-345	CLIP-seq
MIRT1402840	hsa-miR-3606	CLIP-seq
MIRT1402841	hsa-miR-3674	CLIP-seq
MIRT1402842	hsa-miR-3678-3p	CLIP-seq
MIRT1402843	hsa-miR-3680	CLIP-seq
MIRT1402844	hsa-miR-3713	CLIP-seq
MIRT1402845	hsa-miR-378g	CLIP-seq
MIRT1402846	hsa-miR-3945	CLIP-seq
MIRT1402847	hsa-miR-4252	CLIP-seq
MIRT1402848	hsa-miR-4253	CLIP-seq
MIRT1402849	hsa-miR-4645-5p	CLIP-seq
MIRT1402850	hsa-miR-4673	CLIP-seq
MIRT1402851	hsa-miR-4732-5p	CLIP-seq
MIRT1402852	hsa-miR-4770	CLIP-seq
MIRT1402853	hsa-miR-4771	CLIP-seq
MIRT1402854	hsa-miR-4790-3p	CLIP-seq
MIRT1402855	hsa-miR-550a	CLIP-seq
MIRT2342788	hsa-miR-1182	CLIP-seq
MIRT2342789	hsa-miR-1273e	CLIP-seq
MIRT1402836	hsa-miR-142-3p	CLIP-seq
MIRT2342790	hsa-miR-193a-5p	CLIP-seq
MIRT2342791	hsa-miR-2115	CLIP-seq
MIRT2342792	hsa-miR-3199	CLIP-seq
MIRT1402840	hsa-miR-3606	CLIP-seq
MIRT2342793	hsa-miR-431	CLIP-seq
MIRT1402849	hsa-miR-4645-5p	CLIP-seq
MIRT1402850	hsa-miR-4673	CLIP-seq
MIRT2342794	hsa-miR-516a-3p	CLIP-seq
MIRT2342795	hsa-miR-552	CLIP-seq
MIRT2342796	hsa-miR-562	CLIP-seq
MIRT2342788	hsa-miR-1182	CLIP-seq
MIRT2460807	hsa-miR-1321	CLIP-seq
MIRT2342790	hsa-miR-193a-5p	CLIP-seq
MIRT2460808	hsa-miR-4419a	CLIP-seq
MIRT2460809	hsa-miR-4443	CLIP-seq
MIRT2460810	hsa-miR-4510	CLIP-seq
MIRT2460811	hsa-miR-4728-5p	CLIP-seq
MIRT2460812	hsa-miR-4739	CLIP-seq
MIRT2460813	hsa-miR-4756-5p	CLIP-seq
MIRT2460814	hsa-miR-9	CLIP-seq
MIRT2636639	hsa-miR-1184	CLIP-seq
MIRT2636640	hsa-miR-1205	CLIP-seq
MIRT2636641	hsa-miR-1225-3p	CLIP-seq
MIRT2636642	hsa-miR-1233	CLIP-seq
MIRT2636643	hsa-miR-3132	CLIP-seq
MIRT2636644	hsa-miR-3158-5p	CLIP-seq
MIRT2636645	hsa-miR-3613-3p	CLIP-seq
MIRT2636646	hsa-miR-371b-5p	CLIP-seq
MIRT2636647	hsa-miR-4469	CLIP-seq
MIRT2636648	hsa-miR-487a	CLIP-seq
MIRT2636649	hsa-miR-508-5p	CLIP-seq
MIRT2636650	hsa-miR-526b	CLIP-seq
MIRT2636651	hsa-miR-548c-3p	CLIP-seq
MIRT2636652	hsa-miR-642a	CLIP-seq
MIRT2636653	hsa-miR-665	CLIP-seq
MIRT2636654	hsa-miR-888	CLIP-seq
MIRT2636641	hsa-miR-1225-3p	CLIP-seq
MIRT2636642	hsa-miR-1233	CLIP-seq
MIRT2636645	hsa-miR-3613-3p	CLIP-seq
MIRT2636646	hsa-miR-371b-5p	CLIP-seq
MIRT2636648	hsa-miR-487a	CLIP-seq
MIRT2636650	hsa-miR-526b	CLIP-seq
MIRT2636651	hsa-miR-548c-3p	CLIP-seq
MIRT2636654	hsa-miR-888	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004062	Function	Aryl sulfotransferase activity	IBA
GO:0004062	Function	Aryl sulfotransferase activity	IDA	8093002
GO:0004062	Function	Aryl sulfotransferase activity	IEA
GO:0004062	Function	Aryl sulfotransferase activity	IMP	9855620
GO:0005515	Function	Protein binding	IPI	25416956, 32152050
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006068	Process	Ethanol catabolic process	IDA	23207770
GO:0006584	Process	Catecholamine metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	20056724
GO:0008146	Function	Sulfotransferase activity	IDA	10199779, 20056724, 29524394
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008146	Function	Sulfotransferase activity	IMP	14622112
GO:0008202	Process	Steroid metabolic process	IEA
GO:0009812	Process	Flavonoid metabolic process	IDA	20056724
GO:0016740	Function	Transferase activity	IEA
GO:0042403	Process	Thyroid hormone metabolic process	IDA	10199779
GO:0042414	Process	Epinephrine metabolic process	IDA	29524394
GO:0042415	Process	Norepinephrine metabolic process	IDA	29524394
GO:0042417	Process	Dopamine metabolic process	IDA	29524394
GO:0042417	Process	Dopamine metabolic process	IMP	24136195
GO:0042420	Process	Dopamine catabolic process	IDA	8093002, 23207770
GO:0042420	Process	Dopamine catabolic process	IMP	14622112
GO:0042428	Process	Serotonin metabolic process	IDA	29524394
GO:0043199	Function	Sulfate binding	IDA	10543947
GO:0047685	Function	Amine sulfotransferase activity	IDA	23207770
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA	23207770
GO:0051923	Process	Sulfation	IBA
GO:0051923	Process	Sulfation	IDA	10199779, 20056724, 23207770, 29524394
GO:1903351	Process	Cellular response to dopamine	IMP	24136195

MIM	HGNC	e!Ensembl
615819	30004	ENSG00000213648

P0DMN0

Protein name

Sulfotransferase 1A4 (ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Sulfotransferase 1A3/1A4)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	38 → 288	Sulfotransferase domain	Domain

Sequence

MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDM
IYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLD
QKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNY
TTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

Sequence length

295

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Chemical carcinogenesis - DNA adducts	Cytosolic sulfonation of small molecules
	XBP1(S) activates chaperone genes

SULT1A4 (sulfotransferase family 1A member 4)

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