STYK1 (serine/threonine/tyrosine kinase 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55359
• Gene name: Serine/threonine/tyrosine kinase 1
• Gene symbol: STYK1
• Synonyms (NCBI Gene): NOK, SuRTK106
• Chromosome: 12
• Chromosome location: 12p13.2
• Summary: Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]

miRNA Show/Hide all (303)

miRTarBase ID	miRNA	Experiments	Reference
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT532798	hsa-miR-548u	PAR-CLIP	22012620
MIRT532797	hsa-miR-7161-5p	PAR-CLIP	22012620
MIRT532796	hsa-miR-7109-3p	PAR-CLIP	22012620
MIRT532795	hsa-miR-4499	PAR-CLIP	22012620
MIRT532794	hsa-miR-3614-3p	PAR-CLIP	22012620
MIRT532793	hsa-miR-1248	PAR-CLIP	22012620
MIRT532792	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT532791	hsa-miR-610	PAR-CLIP	22012620
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT532798	hsa-miR-548u	PAR-CLIP	22012620
MIRT532797	hsa-miR-7161-5p	PAR-CLIP	22012620
MIRT532796	hsa-miR-7109-3p	PAR-CLIP	22012620
MIRT532795	hsa-miR-4499	PAR-CLIP	22012620
MIRT532794	hsa-miR-3614-3p	PAR-CLIP	22012620
MIRT532793	hsa-miR-1248	PAR-CLIP	22012620
MIRT532792	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT532791	hsa-miR-610	PAR-CLIP	22012620
MIRT1401826	hsa-miR-128	CLIP-seq
MIRT1401827	hsa-miR-144	CLIP-seq
MIRT1401828	hsa-miR-27a	CLIP-seq
MIRT1401829	hsa-miR-27b	CLIP-seq
MIRT1401830	hsa-miR-3074-3p	CLIP-seq
MIRT1401831	hsa-miR-338-3p	CLIP-seq
MIRT1401832	hsa-miR-3942-3p	CLIP-seq
MIRT1401833	hsa-miR-421	CLIP-seq
MIRT1401834	hsa-miR-4422	CLIP-seq
MIRT1401835	hsa-miR-4530	CLIP-seq
MIRT1401836	hsa-miR-4709-5p	CLIP-seq
MIRT1401837	hsa-miR-4716-5p	CLIP-seq
MIRT1401838	hsa-miR-4740-3p	CLIP-seq
MIRT1401839	hsa-miR-513a-5p	CLIP-seq
MIRT1401840	hsa-miR-587	CLIP-seq
MIRT2342594	hsa-miR-1245b-3p	CLIP-seq
MIRT1401830	hsa-miR-3074-3p	CLIP-seq
MIRT2342595	hsa-miR-340	CLIP-seq
MIRT2342596	hsa-miR-362-5p	CLIP-seq
MIRT2342597	hsa-miR-3667-3p	CLIP-seq
MIRT2342598	hsa-miR-500b	CLIP-seq
MIRT2342599	hsa-miR-501-5p	CLIP-seq
MIRT1401840	hsa-miR-587	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 23010592, 32707033, 35384245
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA

Other IDs

• MIM: 611433
• HGNC: 18889
• e!Ensembl: ENSG00000060140

Protein

• UniProt ID: Q6J9G0
• Protein name: Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
• Protein function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase an
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07714	PK_Tyr_Ser-Thr	114 → 380	Protein tyrosine and serine/threonine kinase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in o
• Sequence:

  MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG
  PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI
  CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL
  EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE
  FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL
  RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK
  SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS
  ML

• Sequence length: 422

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Hepatocellular carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (41)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	19409952, 25190507		★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	26398136	Associate	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	22688887	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	17415682		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39684488	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	17298854, 31542233		★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	24894011	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Hemorrhage	Cerebral hemorrhage	Pubtator	28487959	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	28487959	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25169509, 25884558		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25169509, 25884558	Associate	★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	19409952	Associate	★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	29413947		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	22688887	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	27983928		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	28487959		★☆☆☆☆ Found in Text Mining only
Intrahepatic Cholangiocarcinoma	Intrahepatic Cholangiocarcinoma	BEFREE	27542675		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	19409952	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	19409952	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27628214		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	17298854		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24894011	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	25884558	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic Metastasis	BEFREE	31819514		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17415682		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	17298854, 31542233		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	29340057		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	19664042		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30584361		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17298854, 25884558, 27542675, 27628214, 27983928, 28410146, 29413947, 31819514		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17415682		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	28720063	Associate	★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	28720063		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15150103, 25169509, 25884558, 27628214, 29413947, 30584361, 31164631		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24894011, 31164631, 31542233, 31819514		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29340057		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	19664042		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19664042	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32572882	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30584361		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for STYK1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to STYK1.