SRSF12 (serine and arginine rich splicing factor 12)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 135295
• Gene name: Serine and arginine rich splicing factor 12
• Gene symbol: SRSF12
• Synonyms (NCBI Gene): SFRS13B, SFRS19, SRrp35
• Chromosome: 6
• Chromosome location: 6q15

miRNA Show/Hide all (182)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019116	hsa-miR-335-5p	Microarray	18185580
MIRT716237	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT716236	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT716235	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT716234	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT716233	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716232	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT716231	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT716237	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT716236	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT716235	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT716234	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT716233	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716232	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT716231	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT1390242	hsa-miR-106a	CLIP-seq
MIRT1390243	hsa-miR-106b	CLIP-seq
MIRT1390244	hsa-miR-1245b-3p	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390246	hsa-miR-17	CLIP-seq
MIRT1390247	hsa-miR-186	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390249	hsa-miR-1976	CLIP-seq
MIRT1390250	hsa-miR-199a-3p	CLIP-seq
MIRT1390251	hsa-miR-199b-3p	CLIP-seq
MIRT1390252	hsa-miR-20a	CLIP-seq
MIRT1390253	hsa-miR-20b	CLIP-seq
MIRT1390254	hsa-miR-299-3p	CLIP-seq
MIRT1390255	hsa-miR-302a	CLIP-seq
MIRT1390256	hsa-miR-302b	CLIP-seq
MIRT1390257	hsa-miR-302c	CLIP-seq
MIRT1390258	hsa-miR-302d	CLIP-seq
MIRT1390259	hsa-miR-302e	CLIP-seq
MIRT1390260	hsa-miR-302f	CLIP-seq
MIRT1390261	hsa-miR-3129-3p	CLIP-seq
MIRT1390262	hsa-miR-3129-5p	CLIP-seq
MIRT1390263	hsa-miR-3133	CLIP-seq
MIRT1390264	hsa-miR-3159	CLIP-seq
MIRT1390265	hsa-miR-3176	CLIP-seq
MIRT1390266	hsa-miR-3183	CLIP-seq
MIRT1390267	hsa-miR-3190	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT1390269	hsa-miR-331-5p	CLIP-seq
MIRT1390270	hsa-miR-362-5p	CLIP-seq
MIRT1390271	hsa-miR-3675-3p	CLIP-seq
MIRT1390272	hsa-miR-371-5p	CLIP-seq
MIRT1390273	hsa-miR-371b-5p	CLIP-seq
MIRT1390274	hsa-miR-372	CLIP-seq
MIRT1390275	hsa-miR-373	CLIP-seq
MIRT1390276	hsa-miR-378g	CLIP-seq
MIRT1390277	hsa-miR-3922-3p	CLIP-seq
MIRT1390278	hsa-miR-3973	CLIP-seq
MIRT1390279	hsa-miR-4312	CLIP-seq
MIRT1390280	hsa-miR-4437	CLIP-seq
MIRT1390281	hsa-miR-4474-5p	CLIP-seq
MIRT1390282	hsa-miR-4491	CLIP-seq
MIRT1390283	hsa-miR-4517	CLIP-seq
MIRT1390284	hsa-miR-4657	CLIP-seq
MIRT1390285	hsa-miR-4666-5p	CLIP-seq
MIRT1390286	hsa-miR-4674	CLIP-seq
MIRT1390287	hsa-miR-4678	CLIP-seq
MIRT1390288	hsa-miR-4694-3p	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT1390290	hsa-miR-4722-3p	CLIP-seq
MIRT1390291	hsa-miR-4723-3p	CLIP-seq
MIRT1390292	hsa-miR-4733-3p	CLIP-seq
MIRT1390293	hsa-miR-4757-5p	CLIP-seq
MIRT1390294	hsa-miR-4760-5p	CLIP-seq
MIRT1390295	hsa-miR-4789-5p	CLIP-seq
MIRT1390296	hsa-miR-4795-3p	CLIP-seq
MIRT1390297	hsa-miR-500b	CLIP-seq
MIRT1390298	hsa-miR-501-5p	CLIP-seq
MIRT1390299	hsa-miR-519d	CLIP-seq
MIRT1390300	hsa-miR-520a-3p	CLIP-seq
MIRT1390301	hsa-miR-520b	CLIP-seq
MIRT1390302	hsa-miR-520c-3p	CLIP-seq
MIRT1390303	hsa-miR-520d-3p	CLIP-seq
MIRT1390304	hsa-miR-520e	CLIP-seq
MIRT1390305	hsa-miR-520f	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq
MIRT1390308	hsa-miR-522	CLIP-seq
MIRT1390309	hsa-miR-548a-5p	CLIP-seq
MIRT1390310	hsa-miR-548ab	CLIP-seq
MIRT1390311	hsa-miR-548ak	CLIP-seq
MIRT1390312	hsa-miR-548b-5p	CLIP-seq
MIRT1390313	hsa-miR-548c-5p	CLIP-seq
MIRT1390314	hsa-miR-548d-5p	CLIP-seq
MIRT1390315	hsa-miR-548h	CLIP-seq
MIRT1390316	hsa-miR-548i	CLIP-seq
MIRT1390317	hsa-miR-548j	CLIP-seq
MIRT1390318	hsa-miR-548l	CLIP-seq
MIRT1390319	hsa-miR-548n	CLIP-seq
MIRT1390320	hsa-miR-548w	CLIP-seq
MIRT1390321	hsa-miR-548y	CLIP-seq
MIRT1390322	hsa-miR-559	CLIP-seq
MIRT1390323	hsa-miR-889	CLIP-seq
MIRT1390324	hsa-miR-93	CLIP-seq
MIRT1390325	hsa-miR-936	CLIP-seq
MIRT1390242	hsa-miR-106a	CLIP-seq
MIRT1390243	hsa-miR-106b	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390246	hsa-miR-17	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390252	hsa-miR-20a	CLIP-seq
MIRT1390253	hsa-miR-20b	CLIP-seq
MIRT1390255	hsa-miR-302a	CLIP-seq
MIRT1390256	hsa-miR-302b	CLIP-seq
MIRT1390257	hsa-miR-302c	CLIP-seq
MIRT1390258	hsa-miR-302d	CLIP-seq
MIRT1390259	hsa-miR-302e	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT1390272	hsa-miR-371-5p	CLIP-seq
MIRT1390273	hsa-miR-371b-5p	CLIP-seq
MIRT1390274	hsa-miR-372	CLIP-seq
MIRT1390275	hsa-miR-373	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT1390299	hsa-miR-519d	CLIP-seq
MIRT1390300	hsa-miR-520a-3p	CLIP-seq
MIRT1390301	hsa-miR-520b	CLIP-seq
MIRT1390302	hsa-miR-520c-3p	CLIP-seq
MIRT1390303	hsa-miR-520d-3p	CLIP-seq
MIRT1390304	hsa-miR-520e	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq
MIRT2116878	hsa-miR-587	CLIP-seq
MIRT2116879	hsa-miR-607	CLIP-seq
MIRT1390324	hsa-miR-93	CLIP-seq
MIRT1390242	hsa-miR-106a	CLIP-seq
MIRT1390243	hsa-miR-106b	CLIP-seq
MIRT2339266	hsa-miR-1264	CLIP-seq
MIRT2339267	hsa-miR-1343	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390246	hsa-miR-17	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390249	hsa-miR-1976	CLIP-seq
MIRT1390252	hsa-miR-20a	CLIP-seq
MIRT1390253	hsa-miR-20b	CLIP-seq
MIRT1390255	hsa-miR-302a	CLIP-seq
MIRT1390256	hsa-miR-302b	CLIP-seq
MIRT1390257	hsa-miR-302c	CLIP-seq
MIRT1390258	hsa-miR-302d	CLIP-seq
MIRT1390259	hsa-miR-302e	CLIP-seq
MIRT1390264	hsa-miR-3159	CLIP-seq
MIRT2339268	hsa-miR-3179	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT2339269	hsa-miR-3646	CLIP-seq
MIRT1390272	hsa-miR-371-5p	CLIP-seq
MIRT1390273	hsa-miR-371b-5p	CLIP-seq
MIRT1390274	hsa-miR-372	CLIP-seq
MIRT1390275	hsa-miR-373	CLIP-seq
MIRT1390276	hsa-miR-378g	CLIP-seq
MIRT2339270	hsa-miR-4257	CLIP-seq
MIRT1390279	hsa-miR-4312	CLIP-seq
MIRT2339271	hsa-miR-4436b-3p	CLIP-seq
MIRT1390280	hsa-miR-4437	CLIP-seq
MIRT2339272	hsa-miR-4495	CLIP-seq
MIRT1390286	hsa-miR-4674	CLIP-seq
MIRT2339273	hsa-miR-4687-3p	CLIP-seq
MIRT2339274	hsa-miR-4700-3p	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT2339275	hsa-miR-4720-3p	CLIP-seq
MIRT1390290	hsa-miR-4722-3p	CLIP-seq
MIRT2339276	hsa-miR-4731-5p	CLIP-seq
MIRT2339277	hsa-miR-5095	CLIP-seq
MIRT2339278	hsa-miR-512-3p	CLIP-seq
MIRT1390299	hsa-miR-519d	CLIP-seq
MIRT1390300	hsa-miR-520a-3p	CLIP-seq
MIRT1390301	hsa-miR-520b	CLIP-seq
MIRT1390302	hsa-miR-520c-3p	CLIP-seq
MIRT1390303	hsa-miR-520d-3p	CLIP-seq
MIRT1390304	hsa-miR-520e	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq
MIRT2339279	hsa-miR-548k	CLIP-seq
MIRT1390324	hsa-miR-93	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000244	Process	Spliceosomal tri-snRNP complex assembly	NAS	11684676
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IBA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IDA	11684676
GO:0000395	Process	MRNA 5'-splice site recognition	IDA	11684676
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	11684676
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	23602568, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	ISS	11684676
GO:0005654	Component	Nucleoplasm	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IBA
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	ISS	11684676
GO:0050733	Function	RS domain binding	NAS	11684676
GO:0051082	Function	Unfolded protein binding	NAS	11684676

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8WXF0
• Protein name: Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
• Protein function: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	12 → 82	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:11684676}.
• Sequence:

  MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED
  VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKERHPCSPSDHRRSRSPSQRRT
  RSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRNFGSRGRS
  RSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTNSETKVQT
  AKHSHFRSHSRSRSYRHKNSW

• Sequence length: 261

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ARTHRITIS	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	29924316	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37359548	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	39463061	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for SRSF12.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SRSF12.