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Gene Gene information from NCBI Gene database.
Entrez ID 140890
Gene name Splicing regulatory glutamic acid and lysine rich protein 1
Gene symbol SREK1
Synonyms (NCBI Gene)
SFRS12SRrp508SRrp86
Chromosome 5
Chromosome location 5q12.3
Summary This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript
miRNA miRNA information provided by mirtarbase database.
829 Show/Hide all (829)
miRTarBase ID miRNA Experiments Reference
MIRT023706 hsa-miR-1-3p Proteomics 18668040
MIRT024232 hsa-miR-218-5p Sequencing 20371350
MIRT030834 hsa-miR-21-5p Microarray 18591254
MIRT032150 hsa-let-7d-5p Sequencing 20371350
MIRT723264 hsa-miR-6757-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10 Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 23602568, 25416956, 32296183, 32707033, 33961781
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609268 17882 ENSG00000153914
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WXA9
Protein name Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)
Protein function Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 68 → 136 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Sequence
MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK
IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP
RALAFNGVMFGDRPLK
INHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE
SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK
KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD
RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK
SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE
KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA
PRTEENKIQHNGNCQLNEENLSTKTEAV
Sequence length 508
Interactions View interactions