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Gene Gene information from NCBI Gene database.
Entrez ID 6693
Gene name Sialophorin
Gene symbol SPN
Synonyms (NCBI Gene)
CD43GALGPGPL115LEU-22LSN
Chromosome 16
Chromosome location 16p11.2
Summary This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular
miRNA miRNA information provided by mirtarbase database.
1071 Show/Hide all (1071)
miRTarBase ID miRNA Experiments Reference
MIRT052328 hsa-let-7b-5p CLASH 23622248
MIRT051630 hsa-let-7e-5p CLASH 23622248
MIRT710297 hsa-miR-590-3p HITS-CLIP 19536157
MIRT710296 hsa-miR-6765-3p HITS-CLIP 19536157
MIRT710295 hsa-miR-1279 HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SP1 Activation 8055899
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
59 Show/Hide all (59)
GO ID Ontology Definition Evidence Reference
GO:0001562 Process Response to protozoan IEA
GO:0001808 Process Negative regulation of type IV hypersensitivity IEA
GO:0001931 Component Uropod IEA
GO:0001931 Component Uropod ISS
GO:0002296 Process T-helper 1 cell lineage commitment IDA 18036228
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182160 11249 ENSG00000197471
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P16150
Protein name Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]
Protein function Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its
Family and domains
Tissue specificity TISSUE SPECIFICITY: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Sequence
MATLLLLLGVLVVSPDALGSTTAVQTPTSGEPLVSTSEPLSSKMYTTSITSDPKADSTGD
QTSALPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPI
TANSLGSHTVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSK
GTSGPPVTMATDSLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTMMSPTTSTNA
STVPFRNPDENSRGMLPVAVLVALLAVIVLVALLLLWRRRQKRRTGALVLSRGGKRNGVV
DAWAGPAQVPEEGAVTVTVGGSGGDKGSGFPDGEGSSRRPTLTTFFGRRKSRQGSLAMEE
LKSGSGPSLKGEEEPLVASEDGAVDAPAPDEPEGGDGAAP
Sequence length 400
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Cell adhesion molecules Cell surface interactions at the vascular wall
  Basigin interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
CALCINOSIS — CTD 21335463
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEART VALVE DISEASE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEART VALVE DISEASES — CTD 21335463
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEART VALVE PROLAPSE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SPN-related disorder Benign; Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations