SPICE1 (spindle and centriole associated protein 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 152185
• Gene name: Spindle and centriole associated protein 1
• Gene symbol: SPICE1
• Synonyms (NCBI Gene): CCDC52, SPICE
• Chromosome: 3
• Chromosome location: 3q13.2

miRNA Show/Hide all (261)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028713	hsa-miR-27a-3p	Sequencing	20371350
MIRT1383963	hsa-let-7a	CLIP-seq
MIRT1383964	hsa-let-7b	CLIP-seq
MIRT1383965	hsa-let-7c	CLIP-seq
MIRT1383966	hsa-let-7d	CLIP-seq
MIRT1383967	hsa-let-7e	CLIP-seq
MIRT1383968	hsa-let-7f	CLIP-seq
MIRT1383969	hsa-let-7g	CLIP-seq
MIRT1383970	hsa-let-7i	CLIP-seq
MIRT1383971	hsa-miR-1228	CLIP-seq
MIRT1383972	hsa-miR-1251	CLIP-seq
MIRT1383973	hsa-miR-1273e	CLIP-seq
MIRT1383974	hsa-miR-1304	CLIP-seq
MIRT1383975	hsa-miR-18a	CLIP-seq
MIRT1383976	hsa-miR-18b	CLIP-seq
MIRT1383977	hsa-miR-202	CLIP-seq
MIRT1383978	hsa-miR-216b	CLIP-seq
MIRT1383979	hsa-miR-23a	CLIP-seq
MIRT1383980	hsa-miR-23b	CLIP-seq
MIRT1383981	hsa-miR-23c	CLIP-seq
MIRT1383982	hsa-miR-3120-3p	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383984	hsa-miR-3125	CLIP-seq
MIRT1383985	hsa-miR-3152-5p	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT1383987	hsa-miR-3163	CLIP-seq
MIRT1383988	hsa-miR-3200-5p	CLIP-seq
MIRT1383989	hsa-miR-338-3p	CLIP-seq
MIRT1383990	hsa-miR-34b	CLIP-seq
MIRT1383991	hsa-miR-3613-3p	CLIP-seq
MIRT1383992	hsa-miR-3647-3p	CLIP-seq
MIRT1383993	hsa-miR-3675-3p	CLIP-seq
MIRT1383994	hsa-miR-3692	CLIP-seq
MIRT1383995	hsa-miR-377	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT1383997	hsa-miR-3916	CLIP-seq
MIRT1383998	hsa-miR-3926	CLIP-seq
MIRT1383999	hsa-miR-3941	CLIP-seq
MIRT1384000	hsa-miR-4270	CLIP-seq
MIRT1384001	hsa-miR-4307	CLIP-seq
MIRT1384002	hsa-miR-4433	CLIP-seq
MIRT1384003	hsa-miR-4441	CLIP-seq
MIRT1384004	hsa-miR-4457	CLIP-seq
MIRT1384005	hsa-miR-4458	CLIP-seq
MIRT1384006	hsa-miR-4459	CLIP-seq
MIRT1384007	hsa-miR-4468	CLIP-seq
MIRT1384008	hsa-miR-4500	CLIP-seq
MIRT1384009	hsa-miR-466	CLIP-seq
MIRT1384010	hsa-miR-4668-5p	CLIP-seq
MIRT1384011	hsa-miR-4672	CLIP-seq
MIRT1384012	hsa-miR-4684-5p	CLIP-seq
MIRT1384013	hsa-miR-4724-5p	CLIP-seq
MIRT1384014	hsa-miR-4731-3p	CLIP-seq
MIRT1384015	hsa-miR-4733-5p	CLIP-seq
MIRT1384016	hsa-miR-4735-3p	CLIP-seq
MIRT1384017	hsa-miR-4756-3p	CLIP-seq
MIRT1384018	hsa-miR-4766-5p	CLIP-seq
MIRT1384019	hsa-miR-4768-3p	CLIP-seq
MIRT1384020	hsa-miR-4801	CLIP-seq
MIRT1384021	hsa-miR-500a	CLIP-seq
MIRT1384022	hsa-miR-5096	CLIP-seq
MIRT1384023	hsa-miR-513b	CLIP-seq
MIRT1384024	hsa-miR-548ac	CLIP-seq
MIRT1384025	hsa-miR-548ae	CLIP-seq
MIRT1384026	hsa-miR-548aj	CLIP-seq
MIRT1384027	hsa-miR-548am	CLIP-seq
MIRT1384028	hsa-miR-548d-3p	CLIP-seq
MIRT1384029	hsa-miR-548s	CLIP-seq
MIRT1384030	hsa-miR-548x	CLIP-seq
MIRT1384031	hsa-miR-548z	CLIP-seq
MIRT1384032	hsa-miR-570	CLIP-seq
MIRT1384033	hsa-miR-579	CLIP-seq
MIRT1384034	hsa-miR-590-3p	CLIP-seq
MIRT1384035	hsa-miR-633	CLIP-seq
MIRT1384036	hsa-miR-665	CLIP-seq
MIRT1384037	hsa-miR-7	CLIP-seq
MIRT1384038	hsa-miR-98	CLIP-seq
MIRT1383963	hsa-let-7a	CLIP-seq
MIRT1383964	hsa-let-7b	CLIP-seq
MIRT1383965	hsa-let-7c	CLIP-seq
MIRT1383966	hsa-let-7d	CLIP-seq
MIRT1383967	hsa-let-7e	CLIP-seq
MIRT1383968	hsa-let-7f	CLIP-seq
MIRT1383969	hsa-let-7g	CLIP-seq
MIRT1383970	hsa-let-7i	CLIP-seq
MIRT1383977	hsa-miR-202	CLIP-seq
MIRT1554095	hsa-miR-3929	CLIP-seq
MIRT1554096	hsa-miR-4419b	CLIP-seq
MIRT1384005	hsa-miR-4458	CLIP-seq
MIRT1554097	hsa-miR-4478	CLIP-seq
MIRT1384008	hsa-miR-4500	CLIP-seq
MIRT1384038	hsa-miR-98	CLIP-seq
MIRT1383971	hsa-miR-1228	CLIP-seq
MIRT2114911	hsa-miR-140-3p	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT1383998	hsa-miR-3926	CLIP-seq
MIRT2114912	hsa-miR-4720-3p	CLIP-seq
MIRT2114913	hsa-miR-4804-3p	CLIP-seq
MIRT2114914	hsa-miR-513a-5p	CLIP-seq
MIRT1384024	hsa-miR-548ac	CLIP-seq
MIRT1384028	hsa-miR-548d-3p	CLIP-seq
MIRT1384029	hsa-miR-548s	CLIP-seq
MIRT1384031	hsa-miR-548z	CLIP-seq
MIRT1383963	hsa-let-7a	CLIP-seq
MIRT1383964	hsa-let-7b	CLIP-seq
MIRT1383965	hsa-let-7c	CLIP-seq
MIRT1383966	hsa-let-7d	CLIP-seq
MIRT1383967	hsa-let-7e	CLIP-seq
MIRT1383968	hsa-let-7f	CLIP-seq
MIRT1383969	hsa-let-7g	CLIP-seq
MIRT1383970	hsa-let-7i	CLIP-seq
MIRT1383971	hsa-miR-1228	CLIP-seq
MIRT2337620	hsa-miR-1238	CLIP-seq
MIRT2337621	hsa-miR-1278	CLIP-seq
MIRT1383974	hsa-miR-1304	CLIP-seq
MIRT1383977	hsa-miR-202	CLIP-seq
MIRT2337622	hsa-miR-2276	CLIP-seq
MIRT2337623	hsa-miR-24	CLIP-seq
MIRT2337624	hsa-miR-27a	CLIP-seq
MIRT2337625	hsa-miR-27b	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT1383988	hsa-miR-3200-5p	CLIP-seq
MIRT2337626	hsa-miR-342-3p	CLIP-seq
MIRT1383990	hsa-miR-34b	CLIP-seq
MIRT2337627	hsa-miR-3662	CLIP-seq
MIRT2337628	hsa-miR-3664-3p	CLIP-seq
MIRT2337629	hsa-miR-3674	CLIP-seq
MIRT1383995	hsa-miR-377	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT1383998	hsa-miR-3926	CLIP-seq
MIRT1554095	hsa-miR-3929	CLIP-seq
MIRT2337630	hsa-miR-4284	CLIP-seq
MIRT2337631	hsa-miR-4328	CLIP-seq
MIRT1554096	hsa-miR-4419b	CLIP-seq
MIRT1384002	hsa-miR-4433	CLIP-seq
MIRT1384005	hsa-miR-4458	CLIP-seq
MIRT1384006	hsa-miR-4459	CLIP-seq
MIRT2337632	hsa-miR-4464	CLIP-seq
MIRT1554097	hsa-miR-4478	CLIP-seq
MIRT1384008	hsa-miR-4500	CLIP-seq
MIRT2337633	hsa-miR-4503	CLIP-seq
MIRT1384010	hsa-miR-4668-5p	CLIP-seq
MIRT2337634	hsa-miR-4695-5p	CLIP-seq
MIRT2337635	hsa-miR-4696	CLIP-seq
MIRT2337636	hsa-miR-4698	CLIP-seq
MIRT2114912	hsa-miR-4720-3p	CLIP-seq
MIRT2337637	hsa-miR-4748	CLIP-seq
MIRT2337638	hsa-miR-4760-3p	CLIP-seq
MIRT1384019	hsa-miR-4768-3p	CLIP-seq
MIRT2337639	hsa-miR-4772-3p	CLIP-seq
MIRT2114913	hsa-miR-4804-3p	CLIP-seq
MIRT2337640	hsa-miR-485-5p	CLIP-seq
MIRT1384021	hsa-miR-500a	CLIP-seq
MIRT2337641	hsa-miR-510	CLIP-seq
MIRT2337642	hsa-miR-512-5p	CLIP-seq
MIRT2114914	hsa-miR-513a-5p	CLIP-seq
MIRT2337643	hsa-miR-539	CLIP-seq
MIRT1384029	hsa-miR-548s	CLIP-seq
MIRT1384033	hsa-miR-579	CLIP-seq
MIRT1384038	hsa-miR-98	CLIP-seq
MIRT1383974	hsa-miR-1304	CLIP-seq
MIRT2395021	hsa-miR-19a	CLIP-seq
MIRT2395022	hsa-miR-19b	CLIP-seq
MIRT2395023	hsa-miR-2053	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT2395024	hsa-miR-3165	CLIP-seq
MIRT1383988	hsa-miR-3200-5p	CLIP-seq
MIRT2395025	hsa-miR-3714	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT1383998	hsa-miR-3926	CLIP-seq
MIRT2395026	hsa-miR-4251	CLIP-seq
MIRT2395027	hsa-miR-4329	CLIP-seq
MIRT1384002	hsa-miR-4433	CLIP-seq
MIRT1384006	hsa-miR-4459	CLIP-seq
MIRT1384010	hsa-miR-4668-5p	CLIP-seq
MIRT1384019	hsa-miR-4768-3p	CLIP-seq
MIRT1384029	hsa-miR-548s	CLIP-seq
MIRT2395028	hsa-miR-569	CLIP-seq
MIRT2395029	hsa-miR-892a	CLIP-seq
MIRT2395030	hsa-miR-940	CLIP-seq
MIRT1383971	hsa-miR-1228	CLIP-seq
MIRT2460410	hsa-miR-3120-5p	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT1383991	hsa-miR-3613-3p	CLIP-seq
MIRT2460411	hsa-miR-3664-5p	CLIP-seq
MIRT2460412	hsa-miR-371-5p	CLIP-seq
MIRT2460413	hsa-miR-371b-5p	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT2460414	hsa-miR-4311	CLIP-seq
MIRT2460415	hsa-miR-4432	CLIP-seq
MIRT2460416	hsa-miR-4522	CLIP-seq
MIRT1384010	hsa-miR-4668-5p	CLIP-seq
MIRT2337643	hsa-miR-539	CLIP-seq
MIRT1383971	hsa-miR-1228	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT1383992	hsa-miR-3647-3p	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT1384010	hsa-miR-4668-5p	CLIP-seq
MIRT1384012	hsa-miR-4684-5p	CLIP-seq
MIRT1384013	hsa-miR-4724-5p	CLIP-seq
MIRT1384014	hsa-miR-4731-3p	CLIP-seq
MIRT1384020	hsa-miR-4801	CLIP-seq
MIRT1383971	hsa-miR-1228	CLIP-seq
MIRT1383974	hsa-miR-1304	CLIP-seq
MIRT2460410	hsa-miR-3120-5p	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT2395024	hsa-miR-3165	CLIP-seq
MIRT1383991	hsa-miR-3613-3p	CLIP-seq
MIRT1383992	hsa-miR-3647-3p	CLIP-seq
MIRT2460411	hsa-miR-3664-5p	CLIP-seq
MIRT2631216	hsa-miR-3665	CLIP-seq
MIRT2395025	hsa-miR-3714	CLIP-seq
MIRT2460412	hsa-miR-371-5p	CLIP-seq
MIRT2460413	hsa-miR-371b-5p	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT2460414	hsa-miR-4311	CLIP-seq
MIRT2460415	hsa-miR-4432	CLIP-seq
MIRT1384002	hsa-miR-4433	CLIP-seq
MIRT1384006	hsa-miR-4459	CLIP-seq
MIRT2460416	hsa-miR-4522	CLIP-seq
MIRT1384010	hsa-miR-4668-5p	CLIP-seq
MIRT1384012	hsa-miR-4684-5p	CLIP-seq
MIRT2631217	hsa-miR-4719	CLIP-seq
MIRT1384013	hsa-miR-4724-5p	CLIP-seq
MIRT1384014	hsa-miR-4731-3p	CLIP-seq
MIRT2631218	hsa-miR-4736	CLIP-seq
MIRT1384019	hsa-miR-4768-3p	CLIP-seq
MIRT1384020	hsa-miR-4801	CLIP-seq
MIRT2337643	hsa-miR-539	CLIP-seq
MIRT1384033	hsa-miR-579	CLIP-seq
MIRT2395030	hsa-miR-940	CLIP-seq
MIRT1383971	hsa-miR-1228	CLIP-seq
MIRT1383974	hsa-miR-1304	CLIP-seq
MIRT1383983	hsa-miR-3122	CLIP-seq
MIRT1383986	hsa-miR-3153	CLIP-seq
MIRT2395024	hsa-miR-3165	CLIP-seq
MIRT1383992	hsa-miR-3647-3p	CLIP-seq
MIRT2631216	hsa-miR-3665	CLIP-seq
MIRT2395025	hsa-miR-3714	CLIP-seq
MIRT1383996	hsa-miR-3913-5p	CLIP-seq
MIRT1383998	hsa-miR-3926	CLIP-seq
MIRT1384002	hsa-miR-4433	CLIP-seq
MIRT1384006	hsa-miR-4459	CLIP-seq
MIRT1384010	hsa-miR-4668-5p	CLIP-seq
MIRT1384012	hsa-miR-4684-5p	CLIP-seq
MIRT2631217	hsa-miR-4719	CLIP-seq
MIRT1384013	hsa-miR-4724-5p	CLIP-seq
MIRT1384014	hsa-miR-4731-3p	CLIP-seq
MIRT2631218	hsa-miR-4736	CLIP-seq
MIRT1384019	hsa-miR-4768-3p	CLIP-seq
MIRT1384020	hsa-miR-4801	CLIP-seq
MIRT1384029	hsa-miR-548s	CLIP-seq
MIRT1384033	hsa-miR-579	CLIP-seq
MIRT2395030	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23455924, 26638075, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	20736305
GO:0005814	Component	Centriole	IEA
GO:0005819	Component	Spindle	IBA
GO:0005819	Component	Spindle	IDA	20736305
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0036064	Component	Ciliary basal body	IDA
GO:0046599	Process	Regulation of centriole replication	IBA
GO:0046599	Process	Regulation of centriole replication	IMP	20736305
GO:0051301	Process	Cell division	IEA
GO:0051310	Process	Metaphase chromosome alignment	IBA
GO:0051310	Process	Metaphase chromosome alignment	IMP	20736305
GO:0090307	Process	Mitotic spindle assembly	IBA
GO:0090307	Process	Mitotic spindle assembly	IEA
GO:0090307	Process	Mitotic spindle assembly	IMP	20736305

Other IDs

• MIM: 613447
• HGNC: 25083
• e!Ensembl: ENSG00000163611

Protein

• UniProt ID: Q8N0Z3
• Protein name: Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein)
• Protein function: Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15678	SPICE	36 → 434	Centriole duplication and mitotic chromosome congression	Family

• Sequence:

  MSFVRVNRCGPRVGVRKTPKVKKKKTSVKQEWDNTVTDLTVHRATPEDLVRRHEIHKSKN
  RALVHWELQEKALKRKWRKQKPETLNLEKRRLSIMKEILSDQYQMQDVLEKSDHLIAAAK
  ELFPRRRTGFPNVTVAPDSSQGPIVVNQDPITQSIFNESVIEPQALNDVDGEEEGTVNSQ
  SGESENENELDNSLNSQSNTNTDRFLQQLTEENFELISKLWTDIQQKIATQSQITPPGTP
  SSALSSGEQRAALNATNAVKRLQTRLQPEESTETLDSSYVVGHVLNSRKQKQLLNKVKRK
  PNLHALSKPKKNISSGSTTSADLPNRTNSNLDVLKHMIHEVEHEMEEYERWTGREVKGLQ
  SSQGLTGFTLSLVSSLCRLVRYLKESEIQLRKEVETRQQLEQVLGDHRELIDALTAEILR
  LREENAATQARLQQYMVTTDEQLISLTHAIKNCPVINNRQEIQASESGATGRRVMDSPER
  PVVNANVSVPLMFREEVAEFPQEELPVKLSQVPDPPDNMNLAKNFPAHIFEPAVLLTPPR
  QKSNLKFSPLQDVLRRTVQTRPAPRLPPTVEIIEKEQNWEEKTLPIDTDIQNSSEENRLF
  TQRWRVSHMGEDLENKTQAPFVNLSQPLCNSHSNTQQSRSPTFSEELPVLGDGQQLRTNE
  SLIQRKDIMTRIADLTLQNSAIKAHMNNIIEPRGEQGDGLRELNKQESASDMTSTFPVAQ
  SLTPGSMEERIAELNRQSMEARGKLLQLIEQQKLVGLNLSPPMSPVQLPLRAWTEGAKRT
  IEVSIPGAEAPESSKCSTVSPVSGINTRRSSGATGNSCSPLNATSGSGRFTPLNPRAKIE
  KQNEEGWFALSTHVS

• Sequence length: 855

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Familial cancer of breast	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Sarcoidosis	Sarcoidosis	Pubtator	29510755	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for SPICE1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SPICE1.