SP2 (Sp2 transcription factor)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 6668
• Gene name: Sp2 transcription factor
• Gene symbol: SP2
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q21.32
• Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This p

miRNA Show/Hide all (218)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049983	hsa-miR-29a-3p	CLASH	23622248
MIRT053760	hsa-miR-638	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24623314
MIRT666151	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT666152	hsa-miR-24-1-5p	HITS-CLIP	23824327
MIRT666150	hsa-miR-24-2-5p	HITS-CLIP	23824327
MIRT666149	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT666148	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT666147	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT467365	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT467366	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT467364	hsa-miR-1321	PAR-CLIP	23592263
MIRT467363	hsa-miR-4739	PAR-CLIP	23592263
MIRT467362	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT467361	hsa-miR-6782-5p	PAR-CLIP	23592263
MIRT467360	hsa-miR-7112-5p	PAR-CLIP	23592263
MIRT467359	hsa-miR-7515	PAR-CLIP	23592263
MIRT467357	hsa-miR-3179	PAR-CLIP	23592263
MIRT467358	hsa-miR-4419a	PAR-CLIP	23592263
MIRT467356	hsa-miR-4510	PAR-CLIP	23592263
MIRT467355	hsa-miR-6127	PAR-CLIP	23592263
MIRT467354	hsa-miR-6129	PAR-CLIP	23592263
MIRT467353	hsa-miR-6130	PAR-CLIP	23592263
MIRT467352	hsa-miR-6133	PAR-CLIP	23592263
MIRT467351	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT467350	hsa-miR-6134	PAR-CLIP	23592263
MIRT467349	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT467348	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT467347	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT467346	hsa-miR-765	PAR-CLIP	23592263
MIRT467345	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT467344	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT467343	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT467341	hsa-miR-8085	PAR-CLIP	23592263
MIRT467342	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT467340	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT467339	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT467338	hsa-miR-4710	PAR-CLIP	23592263
MIRT467337	hsa-miR-1294	PAR-CLIP	23592263
MIRT467336	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT467335	hsa-miR-6724-5p	PAR-CLIP	23592263
MIRT467334	hsa-miR-6773-5p	PAR-CLIP	23592263
MIRT666151	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT666152	hsa-miR-24-1-5p	HITS-CLIP	23824327
MIRT666150	hsa-miR-24-2-5p	HITS-CLIP	23824327
MIRT666149	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT666148	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT666147	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT467365	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT467366	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT467364	hsa-miR-1321	PAR-CLIP	23592263
MIRT467363	hsa-miR-4739	PAR-CLIP	23592263
MIRT467362	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT467361	hsa-miR-6782-5p	PAR-CLIP	23592263
MIRT467360	hsa-miR-7112-5p	PAR-CLIP	23592263
MIRT467359	hsa-miR-7515	PAR-CLIP	23592263
MIRT467357	hsa-miR-3179	PAR-CLIP	23592263
MIRT467358	hsa-miR-4419a	PAR-CLIP	23592263
MIRT467356	hsa-miR-4510	PAR-CLIP	23592263
MIRT467355	hsa-miR-6127	PAR-CLIP	23592263
MIRT467354	hsa-miR-6129	PAR-CLIP	23592263
MIRT467353	hsa-miR-6130	PAR-CLIP	23592263
MIRT467352	hsa-miR-6133	PAR-CLIP	23592263
MIRT467351	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT467350	hsa-miR-6134	PAR-CLIP	23592263
MIRT467349	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT467348	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT467347	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT467346	hsa-miR-765	PAR-CLIP	23592263
MIRT467345	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT467344	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT467343	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT467341	hsa-miR-8085	PAR-CLIP	23592263
MIRT467342	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT467340	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT467339	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT467338	hsa-miR-4710	PAR-CLIP	23592263
MIRT467337	hsa-miR-1294	PAR-CLIP	23592263
MIRT467336	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT467335	hsa-miR-6724-5p	PAR-CLIP	23592263
MIRT467334	hsa-miR-6773-5p	PAR-CLIP	23592263
MIRT1381215	hsa-miR-1197	CLIP-seq
MIRT1381216	hsa-miR-1206	CLIP-seq
MIRT1381217	hsa-miR-122	CLIP-seq
MIRT1381218	hsa-miR-124	CLIP-seq
MIRT1381219	hsa-miR-1260	CLIP-seq
MIRT1381220	hsa-miR-1260b	CLIP-seq
MIRT1381221	hsa-miR-1265	CLIP-seq
MIRT1381222	hsa-miR-128	CLIP-seq
MIRT1381223	hsa-miR-1285	CLIP-seq
MIRT1381224	hsa-miR-1286	CLIP-seq
MIRT1381225	hsa-miR-188-3p	CLIP-seq
MIRT1381226	hsa-miR-1908	CLIP-seq
MIRT1381227	hsa-miR-1915	CLIP-seq
MIRT1381228	hsa-miR-203	CLIP-seq
MIRT1381229	hsa-miR-299-5p	CLIP-seq
MIRT1381230	hsa-miR-300	CLIP-seq
MIRT1381231	hsa-miR-3121-5p	CLIP-seq
MIRT1381232	hsa-miR-3147	CLIP-seq
MIRT1381233	hsa-miR-3150b-3p	CLIP-seq
MIRT1381234	hsa-miR-3154	CLIP-seq
MIRT1381235	hsa-miR-3156-3p	CLIP-seq
MIRT1381236	hsa-miR-3173-3p	CLIP-seq
MIRT1381237	hsa-miR-3185	CLIP-seq
MIRT1381238	hsa-miR-3187-5p	CLIP-seq
MIRT1381239	hsa-miR-3200-5p	CLIP-seq
MIRT1381240	hsa-miR-338-5p	CLIP-seq
MIRT1381241	hsa-miR-34a	CLIP-seq
MIRT1381242	hsa-miR-34c-5p	CLIP-seq
MIRT1381243	hsa-miR-3622b-5p	CLIP-seq
MIRT1381244	hsa-miR-3665	CLIP-seq
MIRT1381245	hsa-miR-3689a-3p	CLIP-seq
MIRT1381246	hsa-miR-3689c	CLIP-seq
MIRT1381247	hsa-miR-3714	CLIP-seq
MIRT1381248	hsa-miR-381	CLIP-seq
MIRT1381249	hsa-miR-3910	CLIP-seq
MIRT1381250	hsa-miR-3944-5p	CLIP-seq
MIRT1381251	hsa-miR-3978	CLIP-seq
MIRT1381252	hsa-miR-4253	CLIP-seq
MIRT1381253	hsa-miR-4255	CLIP-seq
MIRT1381254	hsa-miR-4268	CLIP-seq
MIRT1381255	hsa-miR-4270	CLIP-seq
MIRT1381256	hsa-miR-4300	CLIP-seq
MIRT1381257	hsa-miR-4307	CLIP-seq
MIRT1381258	hsa-miR-4425	CLIP-seq
MIRT1381259	hsa-miR-4441	CLIP-seq
MIRT1381260	hsa-miR-4448	CLIP-seq
MIRT1381261	hsa-miR-4474-3p	CLIP-seq
MIRT1381262	hsa-miR-4492	CLIP-seq
MIRT1381263	hsa-miR-4498	CLIP-seq
MIRT1381264	hsa-miR-449a	CLIP-seq
MIRT1381265	hsa-miR-449b	CLIP-seq
MIRT1381266	hsa-miR-4505	CLIP-seq
MIRT1381267	hsa-miR-4508	CLIP-seq
MIRT1381268	hsa-miR-4666-3p	CLIP-seq
MIRT1381269	hsa-miR-4672	CLIP-seq
MIRT1381270	hsa-miR-4706	CLIP-seq
MIRT1381271	hsa-miR-4717-3p	CLIP-seq
MIRT1381272	hsa-miR-4722-5p	CLIP-seq
MIRT1381273	hsa-miR-4731-3p	CLIP-seq
MIRT1381274	hsa-miR-4733-3p	CLIP-seq
MIRT1381275	hsa-miR-4749-5p	CLIP-seq
MIRT1381276	hsa-miR-4764-5p	CLIP-seq
MIRT1381277	hsa-miR-4781-5p	CLIP-seq
MIRT1381278	hsa-miR-4784	CLIP-seq
MIRT1381279	hsa-miR-4789-5p	CLIP-seq
MIRT1381280	hsa-miR-4796-5p	CLIP-seq
MIRT1381281	hsa-miR-4801	CLIP-seq
MIRT1381282	hsa-miR-4802-3p	CLIP-seq
MIRT1381283	hsa-miR-506	CLIP-seq
MIRT1381284	hsa-miR-542-5p	CLIP-seq
MIRT1381285	hsa-miR-612	CLIP-seq
MIRT1381286	hsa-miR-657	CLIP-seq
MIRT1381287	hsa-miR-662	CLIP-seq
MIRT1381288	hsa-miR-663	CLIP-seq
MIRT1381289	hsa-miR-744	CLIP-seq
MIRT1381290	hsa-miR-762	CLIP-seq
MIRT1381291	hsa-miR-764	CLIP-seq
MIRT1381292	hsa-miR-920	CLIP-seq
MIRT1381222	hsa-miR-128	CLIP-seq
MIRT1381223	hsa-miR-1285	CLIP-seq
MIRT2114102	hsa-miR-1909	CLIP-seq
MIRT1381231	hsa-miR-3121-5p	CLIP-seq
MIRT2114103	hsa-miR-3184	CLIP-seq
MIRT1381238	hsa-miR-3187-5p	CLIP-seq
MIRT2114104	hsa-miR-3202	CLIP-seq
MIRT1381247	hsa-miR-3714	CLIP-seq
MIRT2114105	hsa-miR-378g	CLIP-seq
MIRT1381251	hsa-miR-3978	CLIP-seq
MIRT2114106	hsa-miR-423-5p	CLIP-seq
MIRT2114107	hsa-miR-4271	CLIP-seq
MIRT1381256	hsa-miR-4300	CLIP-seq
MIRT1381257	hsa-miR-4307	CLIP-seq
MIRT2114108	hsa-miR-4453	CLIP-seq
MIRT2114109	hsa-miR-4486	CLIP-seq
MIRT2114110	hsa-miR-4538	CLIP-seq
MIRT2114111	hsa-miR-4725-3p	CLIP-seq
MIRT2114112	hsa-miR-4747-5p	CLIP-seq
MIRT2114113	hsa-miR-4760-3p	CLIP-seq
MIRT2114114	hsa-miR-4792	CLIP-seq
MIRT1381285	hsa-miR-612	CLIP-seq
MIRT2114115	hsa-miR-622	CLIP-seq
MIRT2114116	hsa-miR-635	CLIP-seq
MIRT1381292	hsa-miR-920	CLIP-seq
MIRT2337060	hsa-miR-101	CLIP-seq
MIRT1381222	hsa-miR-128	CLIP-seq
MIRT2114102	hsa-miR-1909	CLIP-seq
MIRT2337061	hsa-miR-3689d	CLIP-seq
MIRT1381255	hsa-miR-4270	CLIP-seq
MIRT2337062	hsa-miR-4283	CLIP-seq
MIRT2337063	hsa-miR-4284	CLIP-seq
MIRT2337064	hsa-miR-4422	CLIP-seq
MIRT2337065	hsa-miR-4427	CLIP-seq
MIRT2337066	hsa-miR-4437	CLIP-seq
MIRT1381259	hsa-miR-4441	CLIP-seq
MIRT2337067	hsa-miR-4447	CLIP-seq
MIRT2114108	hsa-miR-4453	CLIP-seq
MIRT2337068	hsa-miR-4472	CLIP-seq
MIRT2114110	hsa-miR-4538	CLIP-seq
MIRT2337069	hsa-miR-4651	CLIP-seq
MIRT2337070	hsa-miR-4680-3p	CLIP-seq
MIRT2337071	hsa-miR-4688	CLIP-seq
MIRT1381273	hsa-miR-4731-3p	CLIP-seq
MIRT2337072	hsa-miR-4732-5p	CLIP-seq
MIRT1381279	hsa-miR-4789-5p	CLIP-seq
MIRT1381281	hsa-miR-4801	CLIP-seq
MIRT2337073	hsa-miR-608	CLIP-seq
MIRT2114116	hsa-miR-635	CLIP-seq
MIRT2394995	hsa-miR-3692	CLIP-seq
MIRT1381260	hsa-miR-4448	CLIP-seq
MIRT1381274	hsa-miR-4733-3p	CLIP-seq
MIRT1381216	hsa-miR-1206	CLIP-seq
MIRT1381222	hsa-miR-128	CLIP-seq
MIRT1381253	hsa-miR-4255	CLIP-seq
MIRT1381269	hsa-miR-4672	CLIP-seq
MIRT1381216	hsa-miR-1206	CLIP-seq
MIRT1381222	hsa-miR-128	CLIP-seq
MIRT1381253	hsa-miR-4255	CLIP-seq
MIRT1381269	hsa-miR-4672	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	10744779
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10744779
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	10744779
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	1341900
GO:0006955	Process	Immune response	TAS	1341900
GO:0008270	Function	Zinc ion binding	IEA
GO:0042826	Function	Histone deacetylase binding	IPI	17827154
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 601801
• HGNC: 11207
• e!Ensembl: ENSG00000167182

Protein

• UniProt ID: Q02086
• Protein name: Transcription factor Sp2
• Protein function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	555 → 579	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	525 → 549	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	585 → 607	Zinc finger, C2H2 type	Domain

• Sequence:

  MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPP
  QPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMI
  NKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPIK
  PAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPL
  SKTNKKARKKSLPASQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQ
  VQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPS
  GEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGS
  IISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPT
  QIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTS
  LLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHL
  TKHYKTHLVTKNL

• Sequence length: 613

Related Genes

No strongly related genes found yet for SP2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SP2.