SORBS3 (sorbin and SH3 domain containing 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10174
• Gene name: Sorbin and SH3 domain containing 3
• Gene symbol: SORBS3
• Synonyms (NCBI Gene): SCAM-1, SCAM1, SH3D4
• Chromosome: 8
• Chromosome location: 8p21.3
• Summary: This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein`s ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gen

miRNA Show/Hide all (137)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037629	hsa-miR-744-5p	CLASH	23622248
MIRT037354	hsa-miR-877-5p	CLASH	23622248
MIRT036259	hsa-miR-1229-3p	CLASH	23622248
MIRT715114	hsa-miR-8485	HITS-CLIP	19536157
MIRT715113	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT715112	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT715111	hsa-miR-603	HITS-CLIP	19536157
MIRT715110	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT715109	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT715108	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT715107	hsa-miR-600	HITS-CLIP	19536157
MIRT715106	hsa-miR-4433a-5p	HITS-CLIP	19536157
MIRT715105	hsa-miR-3941	HITS-CLIP	19536157
MIRT715104	hsa-miR-4672	HITS-CLIP	19536157
MIRT715103	hsa-miR-466	HITS-CLIP	19536157
MIRT715102	hsa-miR-1260a	HITS-CLIP	19536157
MIRT715101	hsa-miR-1260b	HITS-CLIP	19536157
MIRT715100	hsa-miR-4433b-5p	HITS-CLIP	19536157
MIRT715114	hsa-miR-8485	HITS-CLIP	19536157
MIRT715113	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT715112	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT715111	hsa-miR-603	HITS-CLIP	19536157
MIRT715110	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT715109	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT715108	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT715107	hsa-miR-600	HITS-CLIP	19536157
MIRT715106	hsa-miR-4433a-5p	HITS-CLIP	19536157
MIRT715105	hsa-miR-3941	HITS-CLIP	19536157
MIRT715104	hsa-miR-4672	HITS-CLIP	19536157
MIRT715103	hsa-miR-466	HITS-CLIP	19536157
MIRT715102	hsa-miR-1260a	HITS-CLIP	19536157
MIRT715101	hsa-miR-1260b	HITS-CLIP	19536157
MIRT715100	hsa-miR-4433b-5p	HITS-CLIP	19536157
MIRT1379515	hsa-miR-1254	CLIP-seq
MIRT1379516	hsa-miR-3116	CLIP-seq
MIRT1379517	hsa-miR-330-3p	CLIP-seq
MIRT1379518	hsa-miR-3663-5p	CLIP-seq
MIRT1379519	hsa-miR-4742-3p	CLIP-seq
MIRT1379520	hsa-miR-4753-5p	CLIP-seq
MIRT1379521	hsa-miR-522	CLIP-seq
MIRT1379522	hsa-miR-875-3p	CLIP-seq
MIRT1553937	hsa-miR-4505	CLIP-seq
MIRT2113311	hsa-miR-1236	CLIP-seq
MIRT1379515	hsa-miR-1254	CLIP-seq
MIRT2113312	hsa-miR-1275	CLIP-seq
MIRT2113313	hsa-miR-181a	CLIP-seq
MIRT2113314	hsa-miR-181b	CLIP-seq
MIRT2113315	hsa-miR-181c	CLIP-seq
MIRT2113316	hsa-miR-181d	CLIP-seq
MIRT2113317	hsa-miR-18a	CLIP-seq
MIRT2113318	hsa-miR-18b	CLIP-seq
MIRT2113319	hsa-miR-190	CLIP-seq
MIRT2113320	hsa-miR-190b	CLIP-seq
MIRT2113321	hsa-miR-2110	CLIP-seq
MIRT2113322	hsa-miR-214	CLIP-seq
MIRT2113323	hsa-miR-2392	CLIP-seq
MIRT2113324	hsa-miR-299-3p	CLIP-seq
MIRT1379516	hsa-miR-3116	CLIP-seq
MIRT2113325	hsa-miR-3125	CLIP-seq
MIRT2113326	hsa-miR-3135b	CLIP-seq
MIRT2113327	hsa-miR-3150a-3p	CLIP-seq
MIRT2113328	hsa-miR-3151	CLIP-seq
MIRT2113329	hsa-miR-3170	CLIP-seq
MIRT2113330	hsa-miR-3175	CLIP-seq
MIRT2113331	hsa-miR-3180-5p	CLIP-seq
MIRT2113332	hsa-miR-342-5p	CLIP-seq
MIRT2113333	hsa-miR-3619-5p	CLIP-seq
MIRT2113334	hsa-miR-3916	CLIP-seq
MIRT2113335	hsa-miR-3937	CLIP-seq
MIRT2113336	hsa-miR-4260	CLIP-seq
MIRT2113337	hsa-miR-4262	CLIP-seq
MIRT2113338	hsa-miR-4283	CLIP-seq
MIRT2113339	hsa-miR-4292	CLIP-seq
MIRT2113340	hsa-miR-4447	CLIP-seq
MIRT2113341	hsa-miR-4472	CLIP-seq
MIRT2113342	hsa-miR-4481	CLIP-seq
MIRT2113343	hsa-miR-4489	CLIP-seq
MIRT2113344	hsa-miR-4492	CLIP-seq
MIRT2113345	hsa-miR-4496	CLIP-seq
MIRT2113346	hsa-miR-4498	CLIP-seq
MIRT1553937	hsa-miR-4505	CLIP-seq
MIRT2113347	hsa-miR-4514	CLIP-seq
MIRT2113348	hsa-miR-4525	CLIP-seq
MIRT2113349	hsa-miR-4530	CLIP-seq
MIRT2113350	hsa-miR-4640-5p	CLIP-seq
MIRT2113351	hsa-miR-4651	CLIP-seq
MIRT2113352	hsa-miR-4652-5p	CLIP-seq
MIRT2113353	hsa-miR-4664-5p	CLIP-seq
MIRT2113354	hsa-miR-4665-5p	CLIP-seq
MIRT2113355	hsa-miR-4677-3p	CLIP-seq
MIRT2113356	hsa-miR-4685-5p	CLIP-seq
MIRT2113357	hsa-miR-4690-5p	CLIP-seq
MIRT2113358	hsa-miR-4692	CLIP-seq
MIRT2113359	hsa-miR-4723-5p	CLIP-seq
MIRT2113360	hsa-miR-4726-5p	CLIP-seq
MIRT2113361	hsa-miR-4731-5p	CLIP-seq
MIRT2113362	hsa-miR-4735-3p	CLIP-seq
MIRT2113363	hsa-miR-4745-5p	CLIP-seq
MIRT2113364	hsa-miR-4753-3p	CLIP-seq
MIRT2113365	hsa-miR-4764-5p	CLIP-seq
MIRT2113366	hsa-miR-4785	CLIP-seq
MIRT2113367	hsa-miR-491-5p	CLIP-seq
MIRT2113368	hsa-miR-520a-5p	CLIP-seq
MIRT1379521	hsa-miR-522	CLIP-seq
MIRT2113369	hsa-miR-525-5p	CLIP-seq
MIRT2113370	hsa-miR-608	CLIP-seq
MIRT2113371	hsa-miR-615-5p	CLIP-seq
MIRT2113372	hsa-miR-625	CLIP-seq
MIRT2113373	hsa-miR-637	CLIP-seq
MIRT2113374	hsa-miR-761	CLIP-seq
MIRT2113375	hsa-miR-762	CLIP-seq
MIRT1379522	hsa-miR-875-3p	CLIP-seq
MIRT2113376	hsa-miR-877	CLIP-seq
MIRT2113377	hsa-miR-939	CLIP-seq
MIRT2113378	hsa-miR-940	CLIP-seq
MIRT2336413	hsa-miR-1207-3p	CLIP-seq
MIRT2336414	hsa-miR-1910	CLIP-seq
MIRT2113326	hsa-miR-3135b	CLIP-seq
MIRT2336415	hsa-miR-3612	CLIP-seq
MIRT2336416	hsa-miR-4443	CLIP-seq
MIRT2336417	hsa-miR-455-3p	CLIP-seq
MIRT2113356	hsa-miR-4685-5p	CLIP-seq
MIRT2113371	hsa-miR-615-5p	CLIP-seq
MIRT2336418	hsa-miR-650	CLIP-seq
MIRT2113325	hsa-miR-3125	CLIP-seq
MIRT2113334	hsa-miR-3916	CLIP-seq
MIRT2113376	hsa-miR-877	CLIP-seq
MIRT1379515	hsa-miR-1254	CLIP-seq
MIRT1379516	hsa-miR-3116	CLIP-seq
MIRT1379520	hsa-miR-4753-5p	CLIP-seq
MIRT1379521	hsa-miR-522	CLIP-seq
MIRT1379522	hsa-miR-875-3p	CLIP-seq
MIRT1379515	hsa-miR-1254	CLIP-seq
MIRT1379516	hsa-miR-3116	CLIP-seq
MIRT1379520	hsa-miR-4753-5p	CLIP-seq
MIRT1379521	hsa-miR-522	CLIP-seq
MIRT1379522	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000165	Process	MAPK cascade	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	9885244
GO:0005515	Function	Protein binding	IPI	12660241, 15734736, 16189514, 16302969, 16374509, 16483316, 16831423, 18662323, 19294487, 21516116, 25416956, 26871637, 29892012, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA	9885244
GO:0005925	Component	Focal adhesion	IEA
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	9885244
GO:0017166	Function	Vinculin binding	IPI	9885244
GO:0030055	Component	Cell-substrate junction	IBA
GO:0031589	Process	Cell-substrate adhesion	IBA
GO:0031589	Process	Cell-substrate adhesion	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	NAS	9885244
GO:0051496	Process	Positive regulation of stress fiber assembly	IDA	9885244
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 610795
• HGNC: 30907
• e!Ensembl: ENSG00000120896

Protein

• UniProt ID: O60504
• Protein name: Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
• Protein function: Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
• PDB: 2CT3 , 2DLM , 2NWM , 2YUP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00018	SH3_1	460 → 507	SH3 domain	Domain
  PF02208	Sorb	119 → 160	Sorbin homologous domain	Family
  PF14604	SH3_9	619 → 669	Variant SH3 domain	Domain
  PF14604	SH3_9	388 → 435	Variant SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
• Sequence:

  MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCN
  GGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVK
  YEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQ
  QRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEE
  SWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSP
  KSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS
  STRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG
  EHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEH
  ICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSA
  RHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPL
  DLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKF
  GTFPGNYVAPV

• Sequence length: 671

Pathways

Reactome Pathway:

Smooth Muscle Contraction

Related Genes

No strongly related genes found yet for SORBS3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SORBS3.