SNX33 (sorting nexin 33)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 257364
• Gene name: Sorting nexin 33
• Gene symbol: SNX33
• Synonyms (NCBI Gene): SH3PX3, SH3PXD3C, SNX30
• Chromosome: 15
• Chromosome location: 15q24.2
• Summary: The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcri

miRNA Show/Hide all (253)

miRTarBase ID	miRNA	Experiments	Reference
MIRT534127	hsa-miR-339-5p	PAR-CLIP	22012620
MIRT534126	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT534125	hsa-miR-329-5p	PAR-CLIP	22012620
MIRT534124	hsa-miR-4281	PAR-CLIP	22012620
MIRT534123	hsa-miR-2113	PAR-CLIP	22012620
MIRT534122	hsa-miR-5010-3p	PAR-CLIP	22012620
MIRT534121	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT534127	hsa-miR-339-5p	PAR-CLIP	22012620
MIRT534126	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT534125	hsa-miR-329-5p	PAR-CLIP	22012620
MIRT534124	hsa-miR-4281	PAR-CLIP	22012620
MIRT534123	hsa-miR-2113	PAR-CLIP	22012620
MIRT534122	hsa-miR-5010-3p	PAR-CLIP	22012620
MIRT534121	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT1378154	hsa-miR-1224-5p	CLIP-seq
MIRT1378155	hsa-miR-125a-5p	CLIP-seq
MIRT1378156	hsa-miR-125b	CLIP-seq
MIRT1378157	hsa-miR-1289	CLIP-seq
MIRT1378158	hsa-miR-1915	CLIP-seq
MIRT1378159	hsa-miR-2110	CLIP-seq
MIRT1378160	hsa-miR-2115	CLIP-seq
MIRT1378161	hsa-miR-2278	CLIP-seq
MIRT1378162	hsa-miR-30a	CLIP-seq
MIRT1378163	hsa-miR-30b	CLIP-seq
MIRT1378164	hsa-miR-30c	CLIP-seq
MIRT1378165	hsa-miR-30d	CLIP-seq
MIRT1378166	hsa-miR-30e	CLIP-seq
MIRT1378167	hsa-miR-3140-5p	CLIP-seq
MIRT1378168	hsa-miR-3180-5p	CLIP-seq
MIRT1378169	hsa-miR-3198	CLIP-seq
MIRT1378170	hsa-miR-3671	CLIP-seq
MIRT1378171	hsa-miR-4271	CLIP-seq
MIRT1378172	hsa-miR-4294	CLIP-seq
MIRT1378173	hsa-miR-4309	CLIP-seq
MIRT1378174	hsa-miR-4319	CLIP-seq
MIRT1378175	hsa-miR-4420	CLIP-seq
MIRT1378176	hsa-miR-4495	CLIP-seq
MIRT1378177	hsa-miR-4688	CLIP-seq
MIRT1378178	hsa-miR-4690-5p	CLIP-seq
MIRT1378179	hsa-miR-4693-3p	CLIP-seq
MIRT1378180	hsa-miR-4704-3p	CLIP-seq
MIRT1378181	hsa-miR-4709-3p	CLIP-seq
MIRT1378182	hsa-miR-4725-3p	CLIP-seq
MIRT1378183	hsa-miR-4726-3p	CLIP-seq
MIRT1378184	hsa-miR-4732-3p	CLIP-seq
MIRT1378185	hsa-miR-4751	CLIP-seq
MIRT1378186	hsa-miR-4802-5p	CLIP-seq
MIRT1378187	hsa-miR-520a-5p	CLIP-seq
MIRT1378188	hsa-miR-525-5p	CLIP-seq
MIRT1378189	hsa-miR-542-5p	CLIP-seq
MIRT1378190	hsa-miR-556-5p	CLIP-seq
MIRT1378191	hsa-miR-605	CLIP-seq
MIRT1378192	hsa-miR-670	CLIP-seq
MIRT1378193	hsa-miR-924	CLIP-seq
MIRT2112743	hsa-miR-103a	CLIP-seq
MIRT2112744	hsa-miR-107	CLIP-seq
MIRT1378154	hsa-miR-1224-5p	CLIP-seq
MIRT2112745	hsa-miR-1226	CLIP-seq
MIRT2112746	hsa-miR-1237	CLIP-seq
MIRT2112747	hsa-miR-1248	CLIP-seq
MIRT2112748	hsa-miR-1827	CLIP-seq
MIRT1378158	hsa-miR-1915	CLIP-seq
MIRT2112749	hsa-miR-214	CLIP-seq
MIRT1378161	hsa-miR-2278	CLIP-seq
MIRT1378162	hsa-miR-30a	CLIP-seq
MIRT1378163	hsa-miR-30b	CLIP-seq
MIRT1378164	hsa-miR-30c	CLIP-seq
MIRT1378165	hsa-miR-30d	CLIP-seq
MIRT1378166	hsa-miR-30e	CLIP-seq
MIRT1378167	hsa-miR-3140-5p	CLIP-seq
MIRT2112750	hsa-miR-3158-3p	CLIP-seq
MIRT2112751	hsa-miR-3183	CLIP-seq
MIRT2112752	hsa-miR-331-3p	CLIP-seq
MIRT2112753	hsa-miR-338-3p	CLIP-seq
MIRT2112754	hsa-miR-3612	CLIP-seq
MIRT2112755	hsa-miR-361-3p	CLIP-seq
MIRT2112756	hsa-miR-3619-5p	CLIP-seq
MIRT2112757	hsa-miR-3925-3p	CLIP-seq
MIRT2112758	hsa-miR-3944-5p	CLIP-seq
MIRT2112759	hsa-miR-4292	CLIP-seq
MIRT2112760	hsa-miR-4326	CLIP-seq
MIRT1378175	hsa-miR-4420	CLIP-seq
MIRT2112761	hsa-miR-4476	CLIP-seq
MIRT1378176	hsa-miR-4495	CLIP-seq
MIRT2112762	hsa-miR-4643	CLIP-seq
MIRT2112763	hsa-miR-4667-5p	CLIP-seq
MIRT2112764	hsa-miR-4685-5p	CLIP-seq
MIRT1378178	hsa-miR-4690-5p	CLIP-seq
MIRT1378179	hsa-miR-4693-3p	CLIP-seq
MIRT2112765	hsa-miR-4700-5p	CLIP-seq
MIRT1378180	hsa-miR-4704-3p	CLIP-seq
MIRT1378181	hsa-miR-4709-3p	CLIP-seq
MIRT2112766	hsa-miR-4713-5p	CLIP-seq
MIRT2112767	hsa-miR-4723-3p	CLIP-seq
MIRT2112768	hsa-miR-4733-3p	CLIP-seq
MIRT1378185	hsa-miR-4751	CLIP-seq
MIRT2112769	hsa-miR-4766-5p	CLIP-seq
MIRT2112770	hsa-miR-4796-3p	CLIP-seq
MIRT2112771	hsa-miR-515-5p	CLIP-seq
MIRT1378189	hsa-miR-542-5p	CLIP-seq
MIRT2112772	hsa-miR-551a	CLIP-seq
MIRT2112773	hsa-miR-551b	CLIP-seq
MIRT2112774	hsa-miR-597	CLIP-seq
MIRT2112775	hsa-miR-616	CLIP-seq
MIRT2112776	hsa-miR-637	CLIP-seq
MIRT2112777	hsa-miR-642b	CLIP-seq
MIRT2112778	hsa-miR-650	CLIP-seq
MIRT2112779	hsa-miR-665	CLIP-seq
MIRT2112780	hsa-miR-761	CLIP-seq
MIRT2112781	hsa-miR-766	CLIP-seq
MIRT1378193	hsa-miR-924	CLIP-seq
MIRT2112782	hsa-miR-942	CLIP-seq
MIRT1378154	hsa-miR-1224-5p	CLIP-seq
MIRT2335710	hsa-miR-1293	CLIP-seq
MIRT2112748	hsa-miR-1827	CLIP-seq
MIRT1378161	hsa-miR-2278	CLIP-seq
MIRT1378167	hsa-miR-3140-5p	CLIP-seq
MIRT2335711	hsa-miR-3150a-3p	CLIP-seq
MIRT2335712	hsa-miR-3175	CLIP-seq
MIRT2112754	hsa-miR-3612	CLIP-seq
MIRT2335713	hsa-miR-3661	CLIP-seq
MIRT1378175	hsa-miR-4420	CLIP-seq
MIRT2335714	hsa-miR-4483	CLIP-seq
MIRT1378178	hsa-miR-4690-5p	CLIP-seq
MIRT2335715	hsa-miR-4695-5p	CLIP-seq
MIRT1378181	hsa-miR-4709-3p	CLIP-seq
MIRT1378185	hsa-miR-4751	CLIP-seq
MIRT2335716	hsa-miR-491-5p	CLIP-seq
MIRT2335717	hsa-miR-631	CLIP-seq
MIRT2112778	hsa-miR-650	CLIP-seq
MIRT2335718	hsa-miR-765	CLIP-seq
MIRT2335719	hsa-miR-939	CLIP-seq
MIRT2394938	hsa-miR-137	CLIP-seq
MIRT1378154	hsa-miR-1224-5p	CLIP-seq
MIRT2629860	hsa-miR-1229	CLIP-seq
MIRT2629861	hsa-miR-1245b-5p	CLIP-seq
MIRT2629862	hsa-miR-1287	CLIP-seq
MIRT2335710	hsa-miR-1293	CLIP-seq
MIRT2112748	hsa-miR-1827	CLIP-seq
MIRT1378161	hsa-miR-2278	CLIP-seq
MIRT2629863	hsa-miR-3065-3p	CLIP-seq
MIRT1378162	hsa-miR-30a	CLIP-seq
MIRT1378163	hsa-miR-30b	CLIP-seq
MIRT1378164	hsa-miR-30c	CLIP-seq
MIRT1378165	hsa-miR-30d	CLIP-seq
MIRT1378166	hsa-miR-30e	CLIP-seq
MIRT2629864	hsa-miR-3120-3p	CLIP-seq
MIRT2629865	hsa-miR-3135b	CLIP-seq
MIRT1378167	hsa-miR-3140-5p	CLIP-seq
MIRT2629866	hsa-miR-3142	CLIP-seq
MIRT2335711	hsa-miR-3150a-3p	CLIP-seq
MIRT2629867	hsa-miR-3173-3p	CLIP-seq
MIRT2335712	hsa-miR-3175	CLIP-seq
MIRT2629868	hsa-miR-3189-5p	CLIP-seq
MIRT2629869	hsa-miR-345	CLIP-seq
MIRT2112754	hsa-miR-3612	CLIP-seq
MIRT2629870	hsa-miR-3619-3p	CLIP-seq
MIRT2629871	hsa-miR-3620	CLIP-seq
MIRT2335713	hsa-miR-3661	CLIP-seq
MIRT2629872	hsa-miR-370	CLIP-seq
MIRT2629873	hsa-miR-3919	CLIP-seq
MIRT2629874	hsa-miR-4263	CLIP-seq
MIRT2629875	hsa-miR-4286	CLIP-seq
MIRT2112759	hsa-miR-4292	CLIP-seq
MIRT1378175	hsa-miR-4420	CLIP-seq
MIRT2629876	hsa-miR-4428	CLIP-seq
MIRT2629877	hsa-miR-4481	CLIP-seq
MIRT2335714	hsa-miR-4483	CLIP-seq
MIRT1378176	hsa-miR-4495	CLIP-seq
MIRT2629878	hsa-miR-4521	CLIP-seq
MIRT2629879	hsa-miR-4522	CLIP-seq
MIRT2112762	hsa-miR-4643	CLIP-seq
MIRT2629880	hsa-miR-4650-5p	CLIP-seq
MIRT2629881	hsa-miR-4690-3p	CLIP-seq
MIRT1378178	hsa-miR-4690-5p	CLIP-seq
MIRT2335715	hsa-miR-4695-5p	CLIP-seq
MIRT1378181	hsa-miR-4709-3p	CLIP-seq
MIRT2629882	hsa-miR-4721	CLIP-seq
MIRT1378184	hsa-miR-4732-3p	CLIP-seq
MIRT2629883	hsa-miR-4745-5p	CLIP-seq
MIRT1378185	hsa-miR-4751	CLIP-seq
MIRT2629884	hsa-miR-4756-3p	CLIP-seq
MIRT2629885	hsa-miR-4757-5p	CLIP-seq
MIRT2629886	hsa-miR-4758-3p	CLIP-seq
MIRT2629887	hsa-miR-4776-5p	CLIP-seq
MIRT2335716	hsa-miR-491-5p	CLIP-seq
MIRT1378189	hsa-miR-542-5p	CLIP-seq
MIRT2335717	hsa-miR-631	CLIP-seq
MIRT2112777	hsa-miR-642b	CLIP-seq
MIRT2112778	hsa-miR-650	CLIP-seq
MIRT2335718	hsa-miR-765	CLIP-seq
MIRT2335719	hsa-miR-939	CLIP-seq
MIRT1378154	hsa-miR-1224-5p	CLIP-seq
MIRT2629860	hsa-miR-1229	CLIP-seq
MIRT2629861	hsa-miR-1245b-5p	CLIP-seq
MIRT2629862	hsa-miR-1287	CLIP-seq
MIRT2335710	hsa-miR-1293	CLIP-seq
MIRT2112748	hsa-miR-1827	CLIP-seq
MIRT1378158	hsa-miR-1915	CLIP-seq
MIRT1378159	hsa-miR-2110	CLIP-seq
MIRT1378161	hsa-miR-2278	CLIP-seq
MIRT2629863	hsa-miR-3065-3p	CLIP-seq
MIRT1378162	hsa-miR-30a	CLIP-seq
MIRT1378163	hsa-miR-30b	CLIP-seq
MIRT1378164	hsa-miR-30c	CLIP-seq
MIRT1378165	hsa-miR-30d	CLIP-seq
MIRT1378166	hsa-miR-30e	CLIP-seq
MIRT2629864	hsa-miR-3120-3p	CLIP-seq
MIRT2629865	hsa-miR-3135b	CLIP-seq
MIRT1378167	hsa-miR-3140-5p	CLIP-seq
MIRT2629866	hsa-miR-3142	CLIP-seq
MIRT2335711	hsa-miR-3150a-3p	CLIP-seq
MIRT2629867	hsa-miR-3173-3p	CLIP-seq
MIRT2335712	hsa-miR-3175	CLIP-seq
MIRT2629868	hsa-miR-3189-5p	CLIP-seq
MIRT2629869	hsa-miR-345	CLIP-seq
MIRT2112754	hsa-miR-3612	CLIP-seq
MIRT2629870	hsa-miR-3619-3p	CLIP-seq
MIRT2629871	hsa-miR-3620	CLIP-seq
MIRT2335713	hsa-miR-3661	CLIP-seq
MIRT2629872	hsa-miR-370	CLIP-seq
MIRT2629874	hsa-miR-4263	CLIP-seq
MIRT1378171	hsa-miR-4271	CLIP-seq
MIRT2629875	hsa-miR-4286	CLIP-seq
MIRT1378175	hsa-miR-4420	CLIP-seq
MIRT2629876	hsa-miR-4428	CLIP-seq
MIRT2629877	hsa-miR-4481	CLIP-seq
MIRT2335714	hsa-miR-4483	CLIP-seq
MIRT1378176	hsa-miR-4495	CLIP-seq
MIRT2629878	hsa-miR-4521	CLIP-seq
MIRT2629879	hsa-miR-4522	CLIP-seq
MIRT2112762	hsa-miR-4643	CLIP-seq
MIRT2629880	hsa-miR-4650-5p	CLIP-seq
MIRT2629881	hsa-miR-4690-3p	CLIP-seq
MIRT1378178	hsa-miR-4690-5p	CLIP-seq
MIRT2335715	hsa-miR-4695-5p	CLIP-seq
MIRT1378181	hsa-miR-4709-3p	CLIP-seq
MIRT2629882	hsa-miR-4721	CLIP-seq
MIRT1378182	hsa-miR-4725-3p	CLIP-seq
MIRT1378183	hsa-miR-4726-3p	CLIP-seq
MIRT1378184	hsa-miR-4732-3p	CLIP-seq
MIRT2629883	hsa-miR-4745-5p	CLIP-seq
MIRT1378185	hsa-miR-4751	CLIP-seq
MIRT2629885	hsa-miR-4757-5p	CLIP-seq
MIRT2629886	hsa-miR-4758-3p	CLIP-seq
MIRT2629887	hsa-miR-4776-5p	CLIP-seq
MIRT2335716	hsa-miR-491-5p	CLIP-seq
MIRT1378189	hsa-miR-542-5p	CLIP-seq
MIRT2335717	hsa-miR-631	CLIP-seq
MIRT2112777	hsa-miR-642b	CLIP-seq
MIRT2112778	hsa-miR-650	CLIP-seq
MIRT2335718	hsa-miR-765	CLIP-seq
MIRT2335719	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0000281	Process	Mitotic cytokinesis	IEA
GO:0000281	Process	Mitotic cytokinesis	IMP	22718350
GO:0005515	Function	Protein binding	IPI	16374509, 18353773, 19487689, 19807924, 23085988, 25825872, 26496610, 28514442, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18353773, 18419754
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0006897	Process	Endocytosis	IMP	22718350
GO:0007032	Process	Endosome organization	IMP	21048941
GO:0009896	Process	Positive regulation of catabolic process	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IDA	18353773
GO:0016020	Component	Membrane	IEA
GO:0016197	Process	Endosomal transport	IBA
GO:0016197	Process	Endosomal transport	IEA
GO:0016197	Process	Endosomal transport	IMP	22718350
GO:0017038	Process	Protein import	IDA	18353773, 18419754
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IDA	22718350
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035091	Function	Phosphatidylinositol binding	IBA
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0036089	Process	Cleavage furrow formation	IBA
GO:0036089	Process	Cleavage furrow formation	IEA
GO:0036089	Process	Cleavage furrow formation	IMP	22718350
GO:0042802	Function	Identical protein binding	IPI	19487689, 23085988
GO:0044351	Process	Macropinocytosis	IMP	21048941
GO:0045806	Process	Negative regulation of endocytosis	IDA	18353773, 18419754
GO:0051044	Process	Positive regulation of membrane protein ectodomain proteolysis	IDA	18353773, 18419754
GO:0051301	Process	Cell division	IEA
GO:0097320	Process	Plasma membrane tubulation	IBA
GO:0097320	Process	Plasma membrane tubulation	IDA	20964629
GO:2000009	Process	Negative regulation of protein localization to cell surface	IDA	18419754
GO:2000010	Process	Positive regulation of protein localization to cell surface	IDA	18353773

Other IDs

• MIM: 619107
• HGNC: 28468
• e!Ensembl: ENSG00000173548

Protein

• UniProt ID: Q8WV41
• Protein name: Sorting nexin-33 (SH3 and PX domain-containing protein 3)
• Protein function: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for eff
• PDB: 4AKV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00787	PX	253 → 335	PX domain	Domain
  PF10456	BAR_3_WASP_bdg	337 → 572	WASP-binding domain of Sorting nexin protein	Domain
  PF14604	SH3_9	7 → 57	Variant SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in heart and pancreas. {ECO:0000269|PubMed:18353773}.
• Sequence:

  MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVR
  SGISTNHADYSSSPAGSPGAQVSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDW
  DDGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVG
  RNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQ
  TKFKGIKSYISYKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEE
  DFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLL
  TFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSA
  FQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLS
  NFPDIIHLQKGAFAKVKESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRREL
  DFKHMMQNYLRQQILFYQRVGQQLEKTLRMYDNL

• Sequence length: 574

Pathways

KEGG Pathway:

Salmonella infection

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Lung cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for SNX33.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SNX33.