SNX21 (sorting nexin family member 21)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 90203
• Gene name: Sorting nexin family member 21
• Gene symbol: SNX21
• Synonyms (NCBI Gene): C20orf161, PP3993, SNX-L, SNXL, dJ337O18.4
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like

miRNA Show/Hide all (223)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1377322	hsa-miR-125a-5p	CLIP-seq
MIRT1377323	hsa-miR-125b	CLIP-seq
MIRT1377324	hsa-miR-146a	CLIP-seq
MIRT1377325	hsa-miR-146b-5p	CLIP-seq
MIRT1377326	hsa-miR-3620	CLIP-seq
MIRT1377327	hsa-miR-412	CLIP-seq
MIRT1377328	hsa-miR-421	CLIP-seq
MIRT1377329	hsa-miR-4318	CLIP-seq
MIRT1377330	hsa-miR-4319	CLIP-seq
MIRT1377331	hsa-miR-4677-3p	CLIP-seq
MIRT1377332	hsa-miR-4693-5p	CLIP-seq
MIRT1377333	hsa-miR-4709-5p	CLIP-seq
MIRT1377334	hsa-miR-579	CLIP-seq
MIRT1377335	hsa-miR-589	CLIP-seq
MIRT1377336	hsa-miR-892a	CLIP-seq
MIRT1377337	hsa-miR-1200	CLIP-seq
MIRT1377338	hsa-miR-147	CLIP-seq
MIRT1377339	hsa-miR-148a	CLIP-seq
MIRT1377340	hsa-miR-148b	CLIP-seq
MIRT1377341	hsa-miR-152	CLIP-seq
MIRT1377342	hsa-miR-2681	CLIP-seq
MIRT1377343	hsa-miR-3128	CLIP-seq
MIRT1377344	hsa-miR-3145-3p	CLIP-seq
MIRT1377345	hsa-miR-3150a-3p	CLIP-seq
MIRT1377346	hsa-miR-3151	CLIP-seq
MIRT1377347	hsa-miR-3175	CLIP-seq
MIRT1377348	hsa-miR-3179	CLIP-seq
MIRT1377349	hsa-miR-3197	CLIP-seq
MIRT1377350	hsa-miR-323-5p	CLIP-seq
MIRT1377351	hsa-miR-3664-3p	CLIP-seq
MIRT1377352	hsa-miR-3672	CLIP-seq
MIRT1377353	hsa-miR-3675-5p	CLIP-seq
MIRT1377354	hsa-miR-3911	CLIP-seq
MIRT1377355	hsa-miR-3926	CLIP-seq
MIRT1377356	hsa-miR-3929	CLIP-seq
MIRT1377357	hsa-miR-3942-3p	CLIP-seq
MIRT1377358	hsa-miR-4419b	CLIP-seq
MIRT1377359	hsa-miR-4433	CLIP-seq
MIRT1377360	hsa-miR-4447	CLIP-seq
MIRT1377361	hsa-miR-4450	CLIP-seq
MIRT1377362	hsa-miR-4459	CLIP-seq
MIRT1377363	hsa-miR-4472	CLIP-seq
MIRT1377364	hsa-miR-4478	CLIP-seq
MIRT1377365	hsa-miR-4536	CLIP-seq
MIRT1377366	hsa-miR-4649-3p	CLIP-seq
MIRT1377367	hsa-miR-4688	CLIP-seq
MIRT1377368	hsa-miR-4691-3p	CLIP-seq
MIRT1377369	hsa-miR-4695-5p	CLIP-seq
MIRT1377370	hsa-miR-4725-5p	CLIP-seq
MIRT1377371	hsa-miR-4727-3p	CLIP-seq
MIRT1377372	hsa-miR-4728-5p	CLIP-seq
MIRT1377373	hsa-miR-4757-5p	CLIP-seq
MIRT1377374	hsa-miR-4768-3p	CLIP-seq
MIRT1377375	hsa-miR-4786-5p	CLIP-seq
MIRT1377376	hsa-miR-485-5p	CLIP-seq
MIRT1377377	hsa-miR-486-3p	CLIP-seq
MIRT1377378	hsa-miR-491-5p	CLIP-seq
MIRT1377379	hsa-miR-504	CLIP-seq
MIRT1377380	hsa-miR-581	CLIP-seq
MIRT1377381	hsa-miR-644	CLIP-seq
MIRT1377382	hsa-miR-767-3p	CLIP-seq
MIRT1377383	hsa-miR-769-5p	CLIP-seq
MIRT1377384	hsa-miR-876-3p	CLIP-seq
MIRT1377385	hsa-miR-939	CLIP-seq
MIRT2112319	hsa-miR-4292	CLIP-seq
MIRT2112320	hsa-miR-4640-5p	CLIP-seq
MIRT2112321	hsa-miR-4726-5p	CLIP-seq
MIRT2112322	hsa-miR-3667-3p	CLIP-seq
MIRT2335535	hsa-miR-3194-3p	CLIP-seq
MIRT1377349	hsa-miR-3197	CLIP-seq
MIRT1377351	hsa-miR-3664-3p	CLIP-seq
MIRT2335536	hsa-miR-3670	CLIP-seq
MIRT1377356	hsa-miR-3929	CLIP-seq
MIRT1377358	hsa-miR-4419b	CLIP-seq
MIRT1377359	hsa-miR-4433	CLIP-seq
MIRT1377362	hsa-miR-4459	CLIP-seq
MIRT2335537	hsa-miR-4475	CLIP-seq
MIRT1377364	hsa-miR-4478	CLIP-seq
MIRT1377366	hsa-miR-4649-3p	CLIP-seq
MIRT1377369	hsa-miR-4695-5p	CLIP-seq
MIRT1377374	hsa-miR-4768-3p	CLIP-seq
MIRT1377376	hsa-miR-485-5p	CLIP-seq
MIRT1377382	hsa-miR-767-3p	CLIP-seq
MIRT2335538	hsa-miR-933	CLIP-seq
MIRT2460167	hsa-miR-1276	CLIP-seq
MIRT2460168	hsa-miR-1291	CLIP-seq
MIRT2460169	hsa-miR-1299	CLIP-seq
MIRT2460170	hsa-miR-188-5p	CLIP-seq
MIRT2460171	hsa-miR-204	CLIP-seq
MIRT2460172	hsa-miR-211	CLIP-seq
MIRT2460173	hsa-miR-2114	CLIP-seq
MIRT2460174	hsa-miR-3148	CLIP-seq
MIRT1377349	hsa-miR-3197	CLIP-seq
MIRT2460175	hsa-miR-323b-3p	CLIP-seq
MIRT2460176	hsa-miR-328	CLIP-seq
MIRT2460177	hsa-miR-3654	CLIP-seq
MIRT2460178	hsa-miR-3663-5p	CLIP-seq
MIRT1377356	hsa-miR-3929	CLIP-seq
MIRT2460179	hsa-miR-3977	CLIP-seq
MIRT2460180	hsa-miR-4311	CLIP-seq
MIRT1377358	hsa-miR-4419b	CLIP-seq
MIRT1377359	hsa-miR-4433	CLIP-seq
MIRT1377362	hsa-miR-4459	CLIP-seq
MIRT1377364	hsa-miR-4478	CLIP-seq
MIRT2460181	hsa-miR-4499	CLIP-seq
MIRT2460182	hsa-miR-4527	CLIP-seq
MIRT2460183	hsa-miR-4638-3p	CLIP-seq
MIRT1377366	hsa-miR-4649-3p	CLIP-seq
MIRT2460184	hsa-miR-4653-3p	CLIP-seq
MIRT2460185	hsa-miR-4661-3p	CLIP-seq
MIRT1377369	hsa-miR-4695-5p	CLIP-seq
MIRT1377374	hsa-miR-4768-3p	CLIP-seq
MIRT2460186	hsa-miR-4780	CLIP-seq
MIRT2460187	hsa-miR-4789-3p	CLIP-seq
MIRT1377376	hsa-miR-485-5p	CLIP-seq
MIRT2460188	hsa-miR-548a-3p	CLIP-seq
MIRT2460189	hsa-miR-548e	CLIP-seq
MIRT2460190	hsa-miR-548f	CLIP-seq
MIRT1377334	hsa-miR-579	CLIP-seq
MIRT2460191	hsa-miR-582-5p	CLIP-seq
MIRT2460192	hsa-miR-583	CLIP-seq
MIRT2460193	hsa-miR-623	CLIP-seq
MIRT2460194	hsa-miR-875-3p	CLIP-seq
MIRT2629549	hsa-miR-1290	CLIP-seq
MIRT2460169	hsa-miR-1299	CLIP-seq
MIRT2629550	hsa-miR-1910	CLIP-seq
MIRT2460174	hsa-miR-3148	CLIP-seq
MIRT2629551	hsa-miR-3167	CLIP-seq
MIRT2629552	hsa-miR-3183	CLIP-seq
MIRT1377349	hsa-miR-3197	CLIP-seq
MIRT2629553	hsa-miR-326	CLIP-seq
MIRT2629554	hsa-miR-330-5p	CLIP-seq
MIRT2460177	hsa-miR-3654	CLIP-seq
MIRT2460178	hsa-miR-3663-5p	CLIP-seq
MIRT1377351	hsa-miR-3664-3p	CLIP-seq
MIRT1377356	hsa-miR-3929	CLIP-seq
MIRT2460179	hsa-miR-3977	CLIP-seq
MIRT1377329	hsa-miR-4318	CLIP-seq
MIRT1377358	hsa-miR-4419b	CLIP-seq
MIRT1377359	hsa-miR-4433	CLIP-seq
MIRT1377362	hsa-miR-4459	CLIP-seq
MIRT1377364	hsa-miR-4478	CLIP-seq
MIRT2460182	hsa-miR-4527	CLIP-seq
MIRT2629555	hsa-miR-455-3p	CLIP-seq
MIRT2460183	hsa-miR-4638-3p	CLIP-seq
MIRT1377366	hsa-miR-4649-3p	CLIP-seq
MIRT2460185	hsa-miR-4661-3p	CLIP-seq
MIRT1377331	hsa-miR-4677-3p	CLIP-seq
MIRT1377332	hsa-miR-4693-5p	CLIP-seq
MIRT1377369	hsa-miR-4695-5p	CLIP-seq
MIRT2629556	hsa-miR-4723-3p	CLIP-seq
MIRT1377370	hsa-miR-4725-5p	CLIP-seq
MIRT1377374	hsa-miR-4768-3p	CLIP-seq
MIRT2629557	hsa-miR-4782-5p	CLIP-seq
MIRT2460187	hsa-miR-4789-3p	CLIP-seq
MIRT1377376	hsa-miR-485-5p	CLIP-seq
MIRT1377379	hsa-miR-504	CLIP-seq
MIRT2460188	hsa-miR-548a-3p	CLIP-seq
MIRT2460189	hsa-miR-548e	CLIP-seq
MIRT2460190	hsa-miR-548f	CLIP-seq
MIRT1377334	hsa-miR-579	CLIP-seq
MIRT1377382	hsa-miR-767-3p	CLIP-seq
MIRT2460194	hsa-miR-875-3p	CLIP-seq
MIRT2629558	hsa-miR-876-5p	CLIP-seq
MIRT1377336	hsa-miR-892a	CLIP-seq
MIRT2335538	hsa-miR-933	CLIP-seq
MIRT2629549	hsa-miR-1290	CLIP-seq
MIRT2460169	hsa-miR-1299	CLIP-seq
MIRT1377324	hsa-miR-146a	CLIP-seq
MIRT1377325	hsa-miR-146b-5p	CLIP-seq
MIRT2629550	hsa-miR-1910	CLIP-seq
MIRT2691703	hsa-miR-1914	CLIP-seq
MIRT2460174	hsa-miR-3148	CLIP-seq
MIRT2629551	hsa-miR-3167	CLIP-seq
MIRT2691704	hsa-miR-3170	CLIP-seq
MIRT2629552	hsa-miR-3183	CLIP-seq
MIRT1377349	hsa-miR-3197	CLIP-seq
MIRT2629553	hsa-miR-326	CLIP-seq
MIRT2629554	hsa-miR-330-5p	CLIP-seq
MIRT2460177	hsa-miR-3654	CLIP-seq
MIRT2460178	hsa-miR-3663-5p	CLIP-seq
MIRT1377351	hsa-miR-3664-3p	CLIP-seq
MIRT2691705	hsa-miR-3689a-3p	CLIP-seq
MIRT2691706	hsa-miR-3689c	CLIP-seq
MIRT1377356	hsa-miR-3929	CLIP-seq
MIRT2460179	hsa-miR-3977	CLIP-seq
MIRT1377329	hsa-miR-4318	CLIP-seq
MIRT1377358	hsa-miR-4419b	CLIP-seq
MIRT1377359	hsa-miR-4433	CLIP-seq
MIRT1377362	hsa-miR-4459	CLIP-seq
MIRT1377364	hsa-miR-4478	CLIP-seq
MIRT2460182	hsa-miR-4527	CLIP-seq
MIRT2629555	hsa-miR-455-3p	CLIP-seq
MIRT2460183	hsa-miR-4638-3p	CLIP-seq
MIRT2691707	hsa-miR-4648	CLIP-seq
MIRT1377366	hsa-miR-4649-3p	CLIP-seq
MIRT2460184	hsa-miR-4653-3p	CLIP-seq
MIRT2691708	hsa-miR-4654	CLIP-seq
MIRT2460185	hsa-miR-4661-3p	CLIP-seq
MIRT1377331	hsa-miR-4677-3p	CLIP-seq
MIRT1377332	hsa-miR-4693-5p	CLIP-seq
MIRT1377369	hsa-miR-4695-5p	CLIP-seq
MIRT2629556	hsa-miR-4723-3p	CLIP-seq
MIRT1377370	hsa-miR-4725-5p	CLIP-seq
MIRT1377372	hsa-miR-4728-5p	CLIP-seq
MIRT1377374	hsa-miR-4768-3p	CLIP-seq
MIRT2691709	hsa-miR-4769-5p	CLIP-seq
MIRT2629557	hsa-miR-4782-5p	CLIP-seq
MIRT2460187	hsa-miR-4789-3p	CLIP-seq
MIRT1377376	hsa-miR-485-5p	CLIP-seq
MIRT1377379	hsa-miR-504	CLIP-seq
MIRT2691710	hsa-miR-505	CLIP-seq
MIRT2460188	hsa-miR-548a-3p	CLIP-seq
MIRT2460189	hsa-miR-548e	CLIP-seq
MIRT2460190	hsa-miR-548f	CLIP-seq
MIRT1377334	hsa-miR-579	CLIP-seq
MIRT1377335	hsa-miR-589	CLIP-seq
MIRT2691711	hsa-miR-765	CLIP-seq
MIRT1377382	hsa-miR-767-3p	CLIP-seq
MIRT2460194	hsa-miR-875-3p	CLIP-seq
MIRT2629558	hsa-miR-876-5p	CLIP-seq
MIRT1377336	hsa-miR-892a	CLIP-seq
MIRT2335538	hsa-miR-933	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IEA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	ISS
GO:0005768	Component	Endosome	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031901	Component	Early endosome membrane	IBA
GO:0031901	Component	Early endosome membrane	IEA
GO:0031901	Component	Early endosome membrane	ISS
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IEA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	ISS
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:1901981	Function	Phosphatidylinositol phosphate binding	IBA

Other IDs

• MIM: 619200
• HGNC: 16154
• e!Ensembl: ENSG00000124104

Protein

• UniProt ID: Q969T3
• Protein name: Sorting nexin-21 (Sorting nexin L) (SNX-L)
• Protein function: Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00787	PX	160 → 241	PX domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in fetus liver, but only weakly expressed in brain, skeleton muscle, smooth muscle, and cardiac muscle, kidney, and adrenal gland. {ECO:0000269|PubMed:12459172}.
• Sequence:

  MHRGTQEGAMASRLLHRLRHALAGDGPGEAAASPEAEQFPESSELEDDDAEGLSSRLSGT
  LSFTSAEDDEDDEDEDDEEAGPDQLPLGDGTSGEDAERSPPPDGQWGSQLLARQLQDFWK
  KSRNTLAPQRLLFEVTSANVVKDPPSKYVLYTLAVIGPGPPDCQPAQISRRYSDFERLHR
  NLQRQFRGPMAAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRHAPDLQDFFV
  LPELRRAQSLTCTGLYREALALWANAWQLQAQLGTPSGPDRPLLTLAGLAVCHQELEDPG
  EARACCEKALQLLGDKSLHPLLAPFLEAHVRLSWRLGLDKRQSEARLQALQEAGLTPTPP
  PSLKELLIKEVLD

• Sequence length: 373

Related Genes

No strongly related genes found yet for SNX21.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SNX21.