SMYD5 (SMYD family member 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10322
• Gene name: SMYD family member 5
• Gene symbol: SMYD5
• Synonyms (NCBI Gene): NN8-4AG, RAI15, RRG1, ZMYND23
• Chromosome: 2
• Chromosome location: 2p13.2

miRNA Show/Hide all (291)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045908	hsa-miR-125b-5p	CLASH	23622248
MIRT1374695	hsa-miR-103a	CLIP-seq
MIRT1374696	hsa-miR-107	CLIP-seq
MIRT1374697	hsa-miR-148a	CLIP-seq
MIRT1374698	hsa-miR-148b	CLIP-seq
MIRT1374699	hsa-miR-152	CLIP-seq
MIRT1374700	hsa-miR-15a	CLIP-seq
MIRT1374701	hsa-miR-15b	CLIP-seq
MIRT1374702	hsa-miR-16	CLIP-seq
MIRT1374703	hsa-miR-1825	CLIP-seq
MIRT1374704	hsa-miR-195	CLIP-seq
MIRT1374705	hsa-miR-198	CLIP-seq
MIRT1374706	hsa-miR-214	CLIP-seq
MIRT1374707	hsa-miR-2467-3p	CLIP-seq
MIRT1374708	hsa-miR-3155	CLIP-seq
MIRT1374709	hsa-miR-3155b	CLIP-seq
MIRT1374710	hsa-miR-3192	CLIP-seq
MIRT1374711	hsa-miR-3545-5p	CLIP-seq
MIRT1374712	hsa-miR-3619-5p	CLIP-seq
MIRT1374713	hsa-miR-3678-3p	CLIP-seq
MIRT1374714	hsa-miR-424	CLIP-seq
MIRT1374715	hsa-miR-4253	CLIP-seq
MIRT1374716	hsa-miR-4260	CLIP-seq
MIRT1374717	hsa-miR-4268	CLIP-seq
MIRT1374718	hsa-miR-4291	CLIP-seq
MIRT1374719	hsa-miR-4299	CLIP-seq
MIRT1374720	hsa-miR-4303	CLIP-seq
MIRT1374721	hsa-miR-4314	CLIP-seq
MIRT1374722	hsa-miR-4327	CLIP-seq
MIRT1374723	hsa-miR-4447	CLIP-seq
MIRT1374724	hsa-miR-4456	CLIP-seq
MIRT1374725	hsa-miR-4472	CLIP-seq
MIRT1374726	hsa-miR-4492	CLIP-seq
MIRT1374727	hsa-miR-4498	CLIP-seq
MIRT1374728	hsa-miR-4505	CLIP-seq
MIRT1374729	hsa-miR-450b-3p	CLIP-seq
MIRT1374730	hsa-miR-4519	CLIP-seq
MIRT1374731	hsa-miR-4640-5p	CLIP-seq
MIRT1374732	hsa-miR-4646-5p	CLIP-seq
MIRT1374733	hsa-miR-4685-5p	CLIP-seq
MIRT1374734	hsa-miR-4690-5p	CLIP-seq
MIRT1374735	hsa-miR-4691-5p	CLIP-seq
MIRT1374736	hsa-miR-4713-3p	CLIP-seq
MIRT1374737	hsa-miR-4722-5p	CLIP-seq
MIRT1374738	hsa-miR-4726-5p	CLIP-seq
MIRT1374739	hsa-miR-4731-5p	CLIP-seq
MIRT1374740	hsa-miR-4761-3p	CLIP-seq
MIRT1374741	hsa-miR-4768-3p	CLIP-seq
MIRT1374742	hsa-miR-484	CLIP-seq
MIRT1374743	hsa-miR-497	CLIP-seq
MIRT1374744	hsa-miR-512-3p	CLIP-seq
MIRT1374745	hsa-miR-512-5p	CLIP-seq
MIRT1374746	hsa-miR-541	CLIP-seq
MIRT1374747	hsa-miR-548q	CLIP-seq
MIRT1374748	hsa-miR-628-5p	CLIP-seq
MIRT1374749	hsa-miR-638	CLIP-seq
MIRT1374750	hsa-miR-654-5p	CLIP-seq
MIRT1374751	hsa-miR-665	CLIP-seq
MIRT1374752	hsa-miR-761	CLIP-seq
MIRT1374753	hsa-miR-762	CLIP-seq
MIRT1374754	hsa-miR-769-3p	CLIP-seq
MIRT1374755	hsa-miR-922	CLIP-seq
MIRT2111509	hsa-miR-1182	CLIP-seq
MIRT2111510	hsa-miR-1200	CLIP-seq
MIRT2111511	hsa-miR-1207-5p	CLIP-seq
MIRT2111512	hsa-miR-1224-5p	CLIP-seq
MIRT2111513	hsa-miR-1225-3p	CLIP-seq
MIRT2111514	hsa-miR-124	CLIP-seq
MIRT2111515	hsa-miR-1275	CLIP-seq
MIRT2111516	hsa-miR-1293	CLIP-seq
MIRT1374700	hsa-miR-15a	CLIP-seq
MIRT1374701	hsa-miR-15b	CLIP-seq
MIRT1374702	hsa-miR-16	CLIP-seq
MIRT1374704	hsa-miR-195	CLIP-seq
MIRT2111517	hsa-miR-197	CLIP-seq
MIRT1374706	hsa-miR-214	CLIP-seq
MIRT2111518	hsa-miR-24	CLIP-seq
MIRT2111519	hsa-miR-3128	CLIP-seq
MIRT1374708	hsa-miR-3155	CLIP-seq
MIRT1374709	hsa-miR-3155b	CLIP-seq
MIRT2111520	hsa-miR-326	CLIP-seq
MIRT2111521	hsa-miR-330-5p	CLIP-seq
MIRT2111522	hsa-miR-3611	CLIP-seq
MIRT1374712	hsa-miR-3619-5p	CLIP-seq
MIRT2111523	hsa-miR-3622a-5p	CLIP-seq
MIRT2111524	hsa-miR-3689d	CLIP-seq
MIRT2111525	hsa-miR-3943	CLIP-seq
MIRT2111526	hsa-miR-3977	CLIP-seq
MIRT1374714	hsa-miR-424	CLIP-seq
MIRT1374718	hsa-miR-4291	CLIP-seq
MIRT1374720	hsa-miR-4303	CLIP-seq
MIRT2111527	hsa-miR-4313	CLIP-seq
MIRT2111528	hsa-miR-4324	CLIP-seq
MIRT1374723	hsa-miR-4447	CLIP-seq
MIRT1374725	hsa-miR-4472	CLIP-seq
MIRT2111529	hsa-miR-4483	CLIP-seq
MIRT1374730	hsa-miR-4519	CLIP-seq
MIRT2111530	hsa-miR-4525	CLIP-seq
MIRT2111531	hsa-miR-4645-5p	CLIP-seq
MIRT2111532	hsa-miR-4665-5p	CLIP-seq
MIRT2111533	hsa-miR-4667-5p	CLIP-seq
MIRT2111534	hsa-miR-4673	CLIP-seq
MIRT2111535	hsa-miR-4680-5p	CLIP-seq
MIRT2111536	hsa-miR-4691-3p	CLIP-seq
MIRT2111537	hsa-miR-4700-5p	CLIP-seq
MIRT2111538	hsa-miR-4708-3p	CLIP-seq
MIRT2111539	hsa-miR-4710	CLIP-seq
MIRT2111540	hsa-miR-4720-5p	CLIP-seq
MIRT2111541	hsa-miR-4723-5p	CLIP-seq
MIRT2111542	hsa-miR-4736	CLIP-seq
MIRT2111543	hsa-miR-4747-5p	CLIP-seq
MIRT2111544	hsa-miR-4751	CLIP-seq
MIRT2111545	hsa-miR-4755-3p	CLIP-seq
MIRT1374740	hsa-miR-4761-3p	CLIP-seq
MIRT2111546	hsa-miR-4763-3p	CLIP-seq
MIRT2111547	hsa-miR-4799-3p	CLIP-seq
MIRT1374742	hsa-miR-484	CLIP-seq
MIRT1374743	hsa-miR-497	CLIP-seq
MIRT2111548	hsa-miR-506	CLIP-seq
MIRT1374745	hsa-miR-512-5p	CLIP-seq
MIRT1374746	hsa-miR-541	CLIP-seq
MIRT2111549	hsa-miR-544b	CLIP-seq
MIRT2111550	hsa-miR-601	CLIP-seq
MIRT2111551	hsa-miR-625	CLIP-seq
MIRT2111552	hsa-miR-634	CLIP-seq
MIRT2111553	hsa-miR-637	CLIP-seq
MIRT2111554	hsa-miR-642a	CLIP-seq
MIRT1374750	hsa-miR-654-5p	CLIP-seq
MIRT1374752	hsa-miR-761	CLIP-seq
MIRT1374755	hsa-miR-922	CLIP-seq
MIRT2111555	hsa-miR-942	CLIP-seq
MIRT2111515	hsa-miR-1275	CLIP-seq
MIRT1374700	hsa-miR-15a	CLIP-seq
MIRT1374701	hsa-miR-15b	CLIP-seq
MIRT1374702	hsa-miR-16	CLIP-seq
MIRT1374704	hsa-miR-195	CLIP-seq
MIRT1374705	hsa-miR-198	CLIP-seq
MIRT1374706	hsa-miR-214	CLIP-seq
MIRT2334625	hsa-miR-3175	CLIP-seq
MIRT2111520	hsa-miR-326	CLIP-seq
MIRT2111521	hsa-miR-330-5p	CLIP-seq
MIRT1374712	hsa-miR-3619-5p	CLIP-seq
MIRT2334626	hsa-miR-3934	CLIP-seq
MIRT1374714	hsa-miR-424	CLIP-seq
MIRT1374715	hsa-miR-4253	CLIP-seq
MIRT1374718	hsa-miR-4291	CLIP-seq
MIRT1374719	hsa-miR-4299	CLIP-seq
MIRT1374720	hsa-miR-4303	CLIP-seq
MIRT2334627	hsa-miR-4434	CLIP-seq
MIRT1374723	hsa-miR-4447	CLIP-seq
MIRT1374724	hsa-miR-4456	CLIP-seq
MIRT1374725	hsa-miR-4472	CLIP-seq
MIRT2334628	hsa-miR-4516	CLIP-seq
MIRT1374730	hsa-miR-4519	CLIP-seq
MIRT2111530	hsa-miR-4525	CLIP-seq
MIRT2111532	hsa-miR-4665-5p	CLIP-seq
MIRT2111533	hsa-miR-4667-5p	CLIP-seq
MIRT1374733	hsa-miR-4685-5p	CLIP-seq
MIRT2111537	hsa-miR-4700-5p	CLIP-seq
MIRT2111541	hsa-miR-4723-5p	CLIP-seq
MIRT1374740	hsa-miR-4761-3p	CLIP-seq
MIRT1374743	hsa-miR-497	CLIP-seq
MIRT1374745	hsa-miR-512-5p	CLIP-seq
MIRT1374746	hsa-miR-541	CLIP-seq
MIRT1374747	hsa-miR-548q	CLIP-seq
MIRT2111551	hsa-miR-625	CLIP-seq
MIRT2111553	hsa-miR-637	CLIP-seq
MIRT1374750	hsa-miR-654-5p	CLIP-seq
MIRT1374752	hsa-miR-761	CLIP-seq
MIRT1374755	hsa-miR-922	CLIP-seq
MIRT2111555	hsa-miR-942	CLIP-seq
MIRT1374700	hsa-miR-15a	CLIP-seq
MIRT1374701	hsa-miR-15b	CLIP-seq
MIRT1374702	hsa-miR-16	CLIP-seq
MIRT1374704	hsa-miR-195	CLIP-seq
MIRT1374705	hsa-miR-198	CLIP-seq
MIRT1374706	hsa-miR-214	CLIP-seq
MIRT1374707	hsa-miR-2467-3p	CLIP-seq
MIRT1374712	hsa-miR-3619-5p	CLIP-seq
MIRT2394902	hsa-miR-3714	CLIP-seq
MIRT2394903	hsa-miR-3915	CLIP-seq
MIRT2394904	hsa-miR-3928	CLIP-seq
MIRT1374714	hsa-miR-424	CLIP-seq
MIRT1374715	hsa-miR-4253	CLIP-seq
MIRT1374718	hsa-miR-4291	CLIP-seq
MIRT1374719	hsa-miR-4299	CLIP-seq
MIRT1374723	hsa-miR-4447	CLIP-seq
MIRT1374724	hsa-miR-4456	CLIP-seq
MIRT1374725	hsa-miR-4472	CLIP-seq
MIRT2394905	hsa-miR-4476	CLIP-seq
MIRT1374730	hsa-miR-4519	CLIP-seq
MIRT1374733	hsa-miR-4685-5p	CLIP-seq
MIRT1374740	hsa-miR-4761-3p	CLIP-seq
MIRT1374743	hsa-miR-497	CLIP-seq
MIRT1374745	hsa-miR-512-5p	CLIP-seq
MIRT1374746	hsa-miR-541	CLIP-seq
MIRT1374747	hsa-miR-548q	CLIP-seq
MIRT1374750	hsa-miR-654-5p	CLIP-seq
MIRT1374752	hsa-miR-761	CLIP-seq
MIRT1374755	hsa-miR-922	CLIP-seq
MIRT2111510	hsa-miR-1200	CLIP-seq
MIRT2460066	hsa-miR-1245b-5p	CLIP-seq
MIRT2460067	hsa-miR-1470	CLIP-seq
MIRT1374707	hsa-miR-2467-3p	CLIP-seq
MIRT2460068	hsa-miR-3142	CLIP-seq
MIRT2394902	hsa-miR-3714	CLIP-seq
MIRT2394903	hsa-miR-3915	CLIP-seq
MIRT2394904	hsa-miR-3928	CLIP-seq
MIRT2111528	hsa-miR-4324	CLIP-seq
MIRT2394905	hsa-miR-4476	CLIP-seq
MIRT2460069	hsa-miR-4667-3p	CLIP-seq
MIRT2111549	hsa-miR-544b	CLIP-seq
MIRT2111510	hsa-miR-1200	CLIP-seq
MIRT2460066	hsa-miR-1245b-5p	CLIP-seq
MIRT2460067	hsa-miR-1470	CLIP-seq
MIRT1374707	hsa-miR-2467-3p	CLIP-seq
MIRT2460068	hsa-miR-3142	CLIP-seq
MIRT2394902	hsa-miR-3714	CLIP-seq
MIRT2394903	hsa-miR-3915	CLIP-seq
MIRT2394904	hsa-miR-3928	CLIP-seq
MIRT2111528	hsa-miR-4324	CLIP-seq
MIRT2394905	hsa-miR-4476	CLIP-seq
MIRT2460069	hsa-miR-4667-3p	CLIP-seq
MIRT2111549	hsa-miR-544b	CLIP-seq
MIRT2111510	hsa-miR-1200	CLIP-seq
MIRT2111511	hsa-miR-1207-5p	CLIP-seq
MIRT2460066	hsa-miR-1245b-5p	CLIP-seq
MIRT2628626	hsa-miR-1252	CLIP-seq
MIRT2628627	hsa-miR-146a	CLIP-seq
MIRT2628628	hsa-miR-146b-5p	CLIP-seq
MIRT2460067	hsa-miR-1470	CLIP-seq
MIRT2628629	hsa-miR-1909	CLIP-seq
MIRT2628630	hsa-miR-193a-3p	CLIP-seq
MIRT2628631	hsa-miR-193b	CLIP-seq
MIRT2628632	hsa-miR-23a	CLIP-seq
MIRT2628633	hsa-miR-23b	CLIP-seq
MIRT2628634	hsa-miR-23c	CLIP-seq
MIRT1374707	hsa-miR-2467-3p	CLIP-seq
MIRT2460068	hsa-miR-3142	CLIP-seq
MIRT2628635	hsa-miR-3157-5p	CLIP-seq
MIRT2628636	hsa-miR-3173-3p	CLIP-seq
MIRT1374710	hsa-miR-3192	CLIP-seq
MIRT2111522	hsa-miR-3611	CLIP-seq
MIRT2628637	hsa-miR-3665	CLIP-seq
MIRT2394902	hsa-miR-3714	CLIP-seq
MIRT2394903	hsa-miR-3915	CLIP-seq
MIRT2394904	hsa-miR-3928	CLIP-seq
MIRT2334626	hsa-miR-3934	CLIP-seq
MIRT2628638	hsa-miR-4323	CLIP-seq
MIRT2111528	hsa-miR-4324	CLIP-seq
MIRT2628639	hsa-miR-4428	CLIP-seq
MIRT2628640	hsa-miR-4461	CLIP-seq
MIRT2394905	hsa-miR-4476	CLIP-seq
MIRT1374726	hsa-miR-4492	CLIP-seq
MIRT1374727	hsa-miR-4498	CLIP-seq
MIRT1374728	hsa-miR-4505	CLIP-seq
MIRT2628641	hsa-miR-4511	CLIP-seq
MIRT2628642	hsa-miR-4521	CLIP-seq
MIRT2628643	hsa-miR-4650-5p	CLIP-seq
MIRT2628644	hsa-miR-4663	CLIP-seq
MIRT2460069	hsa-miR-4667-3p	CLIP-seq
MIRT2111536	hsa-miR-4691-3p	CLIP-seq
MIRT2628645	hsa-miR-4726-3p	CLIP-seq
MIRT2111543	hsa-miR-4747-5p	CLIP-seq
MIRT2111546	hsa-miR-4763-3p	CLIP-seq
MIRT2628646	hsa-miR-4773	CLIP-seq
MIRT1374744	hsa-miR-512-3p	CLIP-seq
MIRT2111549	hsa-miR-544b	CLIP-seq
MIRT2628647	hsa-miR-548b-3p	CLIP-seq
MIRT2628648	hsa-miR-580	CLIP-seq
MIRT2628649	hsa-miR-582-3p	CLIP-seq
MIRT2628650	hsa-miR-589	CLIP-seq
MIRT1374748	hsa-miR-628-5p	CLIP-seq
MIRT2628651	hsa-miR-660	CLIP-seq
MIRT1374753	hsa-miR-762	CLIP-seq
MIRT2628630	hsa-miR-193a-3p	CLIP-seq
MIRT2628631	hsa-miR-193b	CLIP-seq
MIRT2628635	hsa-miR-3157-5p	CLIP-seq
MIRT2628636	hsa-miR-3173-3p	CLIP-seq
MIRT2628637	hsa-miR-3665	CLIP-seq
MIRT2334626	hsa-miR-3934	CLIP-seq
MIRT2628638	hsa-miR-4323	CLIP-seq
MIRT2628639	hsa-miR-4428	CLIP-seq
MIRT2628642	hsa-miR-4521	CLIP-seq
MIRT2628643	hsa-miR-4650-5p	CLIP-seq
MIRT2628644	hsa-miR-4663	CLIP-seq
MIRT2111536	hsa-miR-4691-3p	CLIP-seq
MIRT2628645	hsa-miR-4726-3p	CLIP-seq
MIRT2111543	hsa-miR-4747-5p	CLIP-seq
MIRT2628649	hsa-miR-582-3p	CLIP-seq
MIRT2628651	hsa-miR-660	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IDA	39048817
GO:0005515	Function	Protein binding	IPI	32296183, 35643234
GO:0005737	Component	Cytoplasm	IDA	39048817, 39103523
GO:0005737	Component	Cytoplasm	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016279	Function	Protein-lysine N-methyltransferase activity	IDA	39048817, 39103523
GO:0016279	Function	Protein-lysine N-methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0042799	Function	Histone H4K20 methyltransferase activity	IBA
GO:0042799	Function	Histone H4K20 methyltransferase activity	IEA
GO:0042799	Function	Histone H4K20 methyltransferase activity	ISS
GO:0045814	Process	Negative regulation of gene expression, epigenetic	IBA
GO:0045814	Process	Negative regulation of gene expression, epigenetic	IEA
GO:0045814	Process	Negative regulation of gene expression, epigenetic	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0140943	Function	Histone H4K20 trimethyltransferase activity	IEA
GO:0140955	Function	Histone H3K36 trimethyltransferase activity	IEA
GO:0140955	Function	Histone H3K36 trimethyltransferase activity	ISS
GO:0141005	Process	Transposable element silencing by heterochromatin formation	IEA
GO:0141005	Process	Transposable element silencing by heterochromatin formation	IMP	28951459
GO:1900249	Process	Positive regulation of cytoplasmic translational elongation	IDA	39048817, 39103523
GO:2000035	Process	Regulation of stem cell division	IEA
GO:2000035	Process	Regulation of stem cell division	ISS
GO:2000736	Process	Regulation of stem cell differentiation	IEA
GO:2000736	Process	Regulation of stem cell differentiation	IMP	28951459
GO:2000736	Process	Regulation of stem cell differentiation	ISS

Other IDs

• MIM: 619114
• HGNC: 16258
• e!Ensembl: ENSG00000135632

Protein

• UniProt ID: Q6GMV2
• Protein name: Protein-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H3]-lysine20 N-trimethyltransferase SMYD5) (EC 2.1.1.372) ([histone H4]-lysine36 N-trimethyl
• Protein function: Protein-lysine N-trimethyltransferase that specifically catalyzes trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome, thereby promoting translation elongation and protein synthesis (PubMed:39048817, PubMed:39103523). May al
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00856	SET	33 → 352	SET domain	Family

• Sequence:

  MAASMCDVFSFCVGVAGRARVSVEVRFVSSAKGKGLFATQLIRKGETIFVERPLVAAQFL
  WNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLPHPELCTVRKDLHQNCPHCQVMYCS
  AECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSIHYPPETASIMLMARMVATVKQA
  KDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLELLRRLFTEALYEEAVSQWFTPD
  GFRSLFALVGTNGQGIGTSSLSQWVHACDTLELKPQDREQLDAFIDQLYKDIEAATGEFL
  NCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIKPGEEICISYLDCCQRERS
  RHSRHKILRENYLFVCSCPKCLAEADEPNVTSEEEEEEEEEEEGEPEDAELGDEMTDV

• Sequence length: 418

Related Genes

No strongly related genes found yet for SMYD5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SMYD5.