SLX1A (structure-specific endonuclease subunit SLX1A) | Gene Details, Disease Associations & Pathways | GeDiPNet

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Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	548593
Gene name	Structure-specific endonuclease subunit SLX1A
Gene symbol	SLX1A
Synonyms (NCBI Gene)	GIYD1
Chromosome	16
Chromosome location	16p11.2
Summary	This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and rec

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miRTarBase ID	miRNA	Experiments	Reference
MIRT2109942	hsa-miR-4494	CLIP-seq
MIRT2109943	hsa-miR-499a-5p	CLIP-seq
MIRT2109944	hsa-miR-888	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000724	Process	Double-strand break repair via homologous recombination	IMP	19595721
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	19595721, 19596235, 19596236
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	IMP	19595721, 19595722, 19596235, 19596236
GO:0006310	Process	DNA recombination	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008821	Function	Crossover junction DNA endonuclease activity	IBA
GO:0008821	Function	Crossover junction DNA endonuclease activity	IDA	19595721, 19596235, 19596236
GO:0008821	Function	Crossover junction DNA endonuclease activity	IEA
GO:0010792	Process	DNA double-strand break processing involved in repair via single-strand annealing	IMP	19595721
GO:0010833	Process	Telomere maintenance via telomere lengthening	IMP	24012755
GO:0016787	Function	Hydrolase activity	IEA
GO:0017108	Function	5'-flap endonuclease activity	IBA
GO:0017108	Function	5'-flap endonuclease activity	IDA	19596235, 19596236
GO:0017108	Function	5'-flap endonuclease activity	IEA
GO:0032204	Process	Regulation of telomere maintenance	IEA
GO:0033557	Component	Slx1-Slx4 complex	IBA
GO:0033557	Component	Slx1-Slx4 complex	IDA	19595721, 19596235, 19596236
GO:0033557	Component	Slx1-Slx4 complex	IEA
GO:0033557	Component	Slx1-Slx4 complex	TAS	24012755
GO:0046872	Function	Metal ion binding	IEA
GO:0061820	Process	Telomeric D-loop disassembly	IMP	24012755
GO:0090656	Process	T-circle formation	IEA
GO:0090656	Process	T-circle formation	IMP	24012755
GO:0090656	Process	T-circle formation	ISS
GO:1904357	Process	Negative regulation of telomere maintenance via telomere lengthening	IMP	24012755
GO:1904431	Process	Positive regulation of t-circle formation	ISS

MIM	HGNC	e!Ensembl
615822	20922	ENSG00000132207

Interactions View interactions

KEGG Pathway	Reactome Pathway
Fanconi anemia pathway	Resolution of D-loop Structures through Holliday Junction Intermediates
	Fanconi Anemia Pathway