SLC25A39 (solute carrier family 25 member 39)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 51629
• Gene name: Solute carrier family 25 member 39
• Gene symbol: SLC25A39
• Synonyms (NCBI Gene): CGI-69, CGI69
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wid

miRNA Show/Hide all (212)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022636	hsa-miR-124-3p	Microarray	18668037
MIRT025628	hsa-miR-7-5p	Microarray	19073608
MIRT025628	hsa-miR-7-5p	Sequencing	20371350
MIRT027062	hsa-miR-103a-3p	Sequencing	20371350
MIRT031718	hsa-miR-16-5p	Sequencing	20371350
MIRT042872	hsa-miR-324-3p	CLASH	23622248
MIRT036523	hsa-miR-1226-3p	CLASH	23622248
MIRT1356678	hsa-miR-124	CLIP-seq
MIRT1356679	hsa-miR-1343	CLIP-seq
MIRT1356680	hsa-miR-146b-3p	CLIP-seq
MIRT1356681	hsa-miR-148a	CLIP-seq
MIRT1356682	hsa-miR-148b	CLIP-seq
MIRT1356683	hsa-miR-152	CLIP-seq
MIRT1356684	hsa-miR-3120-3p	CLIP-seq
MIRT1356685	hsa-miR-3173-5p	CLIP-seq
MIRT1356686	hsa-miR-3179	CLIP-seq
MIRT1356687	hsa-miR-3202	CLIP-seq
MIRT1356688	hsa-miR-3655	CLIP-seq
MIRT1356689	hsa-miR-3690	CLIP-seq
MIRT1356690	hsa-miR-3915	CLIP-seq
MIRT1356691	hsa-miR-3928	CLIP-seq
MIRT1356692	hsa-miR-3943	CLIP-seq
MIRT1356693	hsa-miR-4254	CLIP-seq
MIRT1356694	hsa-miR-4261	CLIP-seq
MIRT1356695	hsa-miR-4308	CLIP-seq
MIRT1356696	hsa-miR-4313	CLIP-seq
MIRT1356697	hsa-miR-4469	CLIP-seq
MIRT1356698	hsa-miR-4633-3p	CLIP-seq
MIRT1356699	hsa-miR-4663	CLIP-seq
MIRT1356700	hsa-miR-4728-5p	CLIP-seq
MIRT1356701	hsa-miR-4747-5p	CLIP-seq
MIRT1356702	hsa-miR-486-3p	CLIP-seq
MIRT1356703	hsa-miR-506	CLIP-seq
MIRT1356704	hsa-miR-512-3p	CLIP-seq
MIRT1356705	hsa-miR-545	CLIP-seq
MIRT1356706	hsa-miR-548an	CLIP-seq
MIRT1356707	hsa-miR-548v	CLIP-seq
MIRT1356708	hsa-miR-659	CLIP-seq
MIRT1356709	hsa-miR-874	CLIP-seq
MIRT1356710	hsa-miR-1207-3p	CLIP-seq
MIRT1356678	hsa-miR-124	CLIP-seq
MIRT1356711	hsa-miR-1275	CLIP-seq
MIRT1356712	hsa-miR-133a	CLIP-seq
MIRT1356713	hsa-miR-133b	CLIP-seq
MIRT1356679	hsa-miR-1343	CLIP-seq
MIRT1356680	hsa-miR-146b-3p	CLIP-seq
MIRT1356681	hsa-miR-148a	CLIP-seq
MIRT1356682	hsa-miR-148b	CLIP-seq
MIRT1356714	hsa-miR-151-3p	CLIP-seq
MIRT1356683	hsa-miR-152	CLIP-seq
MIRT1356715	hsa-miR-15a	CLIP-seq
MIRT1356716	hsa-miR-15b	CLIP-seq
MIRT1356717	hsa-miR-16	CLIP-seq
MIRT1356718	hsa-miR-193a-5p	CLIP-seq
MIRT1356719	hsa-miR-195	CLIP-seq
MIRT1356720	hsa-miR-1976	CLIP-seq
MIRT1356721	hsa-miR-214	CLIP-seq
MIRT1356722	hsa-miR-302a	CLIP-seq
MIRT1356723	hsa-miR-302b	CLIP-seq
MIRT1356724	hsa-miR-302c	CLIP-seq
MIRT1356725	hsa-miR-302d	CLIP-seq
MIRT1356726	hsa-miR-302e	CLIP-seq
MIRT1356684	hsa-miR-3120-3p	CLIP-seq
MIRT1356727	hsa-miR-3126-5p	CLIP-seq
MIRT1356728	hsa-miR-3158-3p	CLIP-seq
MIRT1356685	hsa-miR-3173-5p	CLIP-seq
MIRT1356686	hsa-miR-3179	CLIP-seq
MIRT1356729	hsa-miR-3185	CLIP-seq
MIRT1356687	hsa-miR-3202	CLIP-seq
MIRT1356730	hsa-miR-3545-3p	CLIP-seq
MIRT1356731	hsa-miR-3614-5p	CLIP-seq
MIRT1356732	hsa-miR-3616-3p	CLIP-seq
MIRT1356733	hsa-miR-3619-5p	CLIP-seq
MIRT1356734	hsa-miR-3652	CLIP-seq
MIRT1356688	hsa-miR-3655	CLIP-seq
MIRT1356735	hsa-miR-3682-3p	CLIP-seq
MIRT1356689	hsa-miR-3690	CLIP-seq
MIRT1356736	hsa-miR-372	CLIP-seq
MIRT1356737	hsa-miR-373	CLIP-seq
MIRT1356738	hsa-miR-382	CLIP-seq
MIRT1356690	hsa-miR-3915	CLIP-seq
MIRT1356691	hsa-miR-3928	CLIP-seq
MIRT1356739	hsa-miR-3929	CLIP-seq
MIRT1356692	hsa-miR-3943	CLIP-seq
MIRT1356740	hsa-miR-424	CLIP-seq
MIRT1356693	hsa-miR-4254	CLIP-seq
MIRT1356694	hsa-miR-4261	CLIP-seq
MIRT1356741	hsa-miR-4270	CLIP-seq
MIRT1356742	hsa-miR-4279	CLIP-seq
MIRT1356743	hsa-miR-4286	CLIP-seq
MIRT1356744	hsa-miR-4290	CLIP-seq
MIRT1356695	hsa-miR-4308	CLIP-seq
MIRT1356696	hsa-miR-4313	CLIP-seq
MIRT1356745	hsa-miR-4419b	CLIP-seq
MIRT1356746	hsa-miR-4430	CLIP-seq
MIRT1356747	hsa-miR-4441	CLIP-seq
MIRT1356697	hsa-miR-4469	CLIP-seq
MIRT1356748	hsa-miR-4477b	CLIP-seq
MIRT1356749	hsa-miR-4478	CLIP-seq
MIRT1356750	hsa-miR-4505	CLIP-seq
MIRT1356751	hsa-miR-4632	CLIP-seq
MIRT1356698	hsa-miR-4633-3p	CLIP-seq
MIRT1356752	hsa-miR-4635	CLIP-seq
MIRT1356753	hsa-miR-4649-3p	CLIP-seq
MIRT1356754	hsa-miR-4651	CLIP-seq
MIRT1356699	hsa-miR-4663	CLIP-seq
MIRT1356755	hsa-miR-4665-5p	CLIP-seq
MIRT1356756	hsa-miR-4699-5p	CLIP-seq
MIRT1356757	hsa-miR-4711-3p	CLIP-seq
MIRT1356758	hsa-miR-4721	CLIP-seq
MIRT1356759	hsa-miR-4722-3p	CLIP-seq
MIRT1356700	hsa-miR-4728-5p	CLIP-seq
MIRT1356760	hsa-miR-4731-5p	CLIP-seq
MIRT1356761	hsa-miR-4733-3p	CLIP-seq
MIRT1356701	hsa-miR-4747-5p	CLIP-seq
MIRT1356702	hsa-miR-486-3p	CLIP-seq
MIRT1356762	hsa-miR-497	CLIP-seq
MIRT1356703	hsa-miR-506	CLIP-seq
MIRT1356704	hsa-miR-512-3p	CLIP-seq
MIRT1356763	hsa-miR-520a-3p	CLIP-seq
MIRT1356764	hsa-miR-520b	CLIP-seq
MIRT1356765	hsa-miR-520c-3p	CLIP-seq
MIRT1356766	hsa-miR-520d-3p	CLIP-seq
MIRT1356767	hsa-miR-520e	CLIP-seq
MIRT1356705	hsa-miR-545	CLIP-seq
MIRT1356706	hsa-miR-548an	CLIP-seq
MIRT1356707	hsa-miR-548v	CLIP-seq
MIRT1356768	hsa-miR-555	CLIP-seq
MIRT1356769	hsa-miR-592	CLIP-seq
MIRT1356770	hsa-miR-599	CLIP-seq
MIRT1356771	hsa-miR-608	CLIP-seq
MIRT1356772	hsa-miR-647	CLIP-seq
MIRT1356708	hsa-miR-659	CLIP-seq
MIRT1356773	hsa-miR-7	CLIP-seq
MIRT1356774	hsa-miR-761	CLIP-seq
MIRT1356709	hsa-miR-874	CLIP-seq
MIRT1356714	hsa-miR-151-3p	CLIP-seq
MIRT1920916	hsa-miR-298	CLIP-seq
MIRT1356714	hsa-miR-151-3p	CLIP-seq
MIRT1920916	hsa-miR-298	CLIP-seq
MIRT1356714	hsa-miR-151-3p	CLIP-seq
MIRT1920916	hsa-miR-298	CLIP-seq
MIRT1356710	hsa-miR-1207-3p	CLIP-seq
MIRT1356711	hsa-miR-1275	CLIP-seq
MIRT1356712	hsa-miR-133a	CLIP-seq
MIRT1356713	hsa-miR-133b	CLIP-seq
MIRT1356679	hsa-miR-1343	CLIP-seq
MIRT1356714	hsa-miR-151-3p	CLIP-seq
MIRT1920916	hsa-miR-298	CLIP-seq
MIRT1356684	hsa-miR-3120-3p	CLIP-seq
MIRT1356728	hsa-miR-3158-3p	CLIP-seq
MIRT1356686	hsa-miR-3179	CLIP-seq
MIRT1356730	hsa-miR-3545-3p	CLIP-seq
MIRT1356732	hsa-miR-3616-3p	CLIP-seq
MIRT1356735	hsa-miR-3682-3p	CLIP-seq
MIRT1356689	hsa-miR-3690	CLIP-seq
MIRT1356739	hsa-miR-3929	CLIP-seq
MIRT1356693	hsa-miR-4254	CLIP-seq
MIRT1356694	hsa-miR-4261	CLIP-seq
MIRT1356741	hsa-miR-4270	CLIP-seq
MIRT1356745	hsa-miR-4419b	CLIP-seq
MIRT1356747	hsa-miR-4441	CLIP-seq
MIRT1356748	hsa-miR-4477b	CLIP-seq
MIRT1356749	hsa-miR-4478	CLIP-seq
MIRT1356752	hsa-miR-4635	CLIP-seq
MIRT1356754	hsa-miR-4651	CLIP-seq
MIRT1356755	hsa-miR-4665-5p	CLIP-seq
MIRT1356756	hsa-miR-4699-5p	CLIP-seq
MIRT1356758	hsa-miR-4721	CLIP-seq
MIRT1356761	hsa-miR-4733-3p	CLIP-seq
MIRT1356702	hsa-miR-486-3p	CLIP-seq
MIRT1356705	hsa-miR-545	CLIP-seq
MIRT1356707	hsa-miR-548v	CLIP-seq
MIRT1356768	hsa-miR-555	CLIP-seq
MIRT1356771	hsa-miR-608	CLIP-seq
MIRT1356708	hsa-miR-659	CLIP-seq
MIRT1356773	hsa-miR-7	CLIP-seq
MIRT1356710	hsa-miR-1207-3p	CLIP-seq
MIRT1356711	hsa-miR-1275	CLIP-seq
MIRT1356712	hsa-miR-133a	CLIP-seq
MIRT1356713	hsa-miR-133b	CLIP-seq
MIRT1356684	hsa-miR-3120-3p	CLIP-seq
MIRT1356686	hsa-miR-3179	CLIP-seq
MIRT1356730	hsa-miR-3545-3p	CLIP-seq
MIRT1356735	hsa-miR-3682-3p	CLIP-seq
MIRT1356693	hsa-miR-4254	CLIP-seq
MIRT1356694	hsa-miR-4261	CLIP-seq
MIRT1356744	hsa-miR-4290	CLIP-seq
MIRT1356752	hsa-miR-4635	CLIP-seq
MIRT1356754	hsa-miR-4651	CLIP-seq
MIRT1356755	hsa-miR-4665-5p	CLIP-seq
MIRT1356756	hsa-miR-4699-5p	CLIP-seq
MIRT1356702	hsa-miR-486-3p	CLIP-seq
MIRT1356705	hsa-miR-545	CLIP-seq
MIRT1356707	hsa-miR-548v	CLIP-seq
MIRT1356768	hsa-miR-555	CLIP-seq
MIRT1356771	hsa-miR-608	CLIP-seq
MIRT1356773	hsa-miR-7	CLIP-seq
MIRT1356710	hsa-miR-1207-3p	CLIP-seq
MIRT1356712	hsa-miR-133a	CLIP-seq
MIRT1356713	hsa-miR-133b	CLIP-seq
MIRT1356752	hsa-miR-4635	CLIP-seq
MIRT1356756	hsa-miR-4699-5p	CLIP-seq
MIRT1356773	hsa-miR-7	CLIP-seq
MIRT1356715	hsa-miR-15a	CLIP-seq
MIRT1356716	hsa-miR-15b	CLIP-seq
MIRT1356717	hsa-miR-16	CLIP-seq
MIRT1356719	hsa-miR-195	CLIP-seq
MIRT1356735	hsa-miR-3682-3p	CLIP-seq
MIRT1356740	hsa-miR-424	CLIP-seq
MIRT1356743	hsa-miR-4286	CLIP-seq
MIRT1356762	hsa-miR-497	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	11256614, 37917749
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006783	Process	Heme biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0034634	Function	Glutathione transmembrane transporter activity	IDA	34707288, 35513392, 37917749, 38157846
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IDA	37917749, 38157846
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IEA
GO:0071281	Process	Cellular response to iron ion	IDA	37917749, 38157846
GO:0072753	Process	Cellular response to glutathione	IDA	37917749, 38157846
GO:0160007	Process	Glutathione import into mitochondrion	IDA	34707288, 37917749, 38157846
GO:0160007	Process	Glutathione import into mitochondrion	IMP	35513392
GO:0170036	Process	Import into the mitochondrion	IBA
GO:1990542	Process	Mitochondrial transmembrane transport	IEA

Other IDs

• MIM: 610820
• HGNC: 24279
• e!Ensembl: ENSG00000013306

Protein

• UniProt ID: Q9BZJ4
• Protein name: Mitochondrial glutathione transporter SLC25A39 (Solute carrier family 25 member 39)
• Protein function: Mitochondrial transporter required for glutathione import into mitochondria (PubMed:34707288, PubMed:35513392, PubMed:37917749, PubMed:38157846). Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00153	Mito_carr	7 → 156	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	251 → 352	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	158 → 248	Mitochondrial carrier protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues (PubMed:11139402). Abundant in testis and kidney (PubMed:11139402). {ECO:0000269|PubMed:11139402}.
• Sequence:

  MADQDPAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLS
  YTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGT
  RTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVTVIS
  PLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFNYELV
  KSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHV
  DSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQDRLLGG

• Sequence length: 359

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	33691015	Associate	★☆☆☆☆ Found in Text Mining only
Glomerulonephritis	Glomerulonephritis	Pubtator	40186888	Inhibit	★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	40186888	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	34148545	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	33963205	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for SLC25A39.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SLC25A39.