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Gene Gene information from NCBI Gene database.
Entrez ID 79085
Gene name Solute carrier family 25 member 23
Gene symbol SLC25A23
Synonyms (NCBI Gene)
APC2MCSC2SCAMC3SCaMC-3
Chromosome 19
Chromosome location 19p13.3
miRNA miRNA information provided by mirtarbase database.
450 Show/Hide all (450)
miRTarBase ID miRNA Experiments Reference
MIRT017835 hsa-miR-335-5p Microarray 18185580
MIRT002545 hsa-miR-373-3p Microarray 15685193
MIRT029435 hsa-miR-26b-5p Microarray 19088304
MIRT038719 hsa-miR-93-3p CLASH 23622248
MIRT1355700 hsa-miR-1204 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31 Show/Hide all (31)
GO ID Ontology Definition Evidence Reference
GO:0000295 Function Adenine nucleotide transmembrane transporter activity IDA 15123600
GO:0002082 Process Regulation of oxidative phosphorylation IEA
GO:0003014 Process Renal system process IEA
GO:0005347 Function ATP transmembrane transporter activity IBA
GO:0005509 Function Calcium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608746 19375 ENSG00000125648
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BV35
Protein name Mitochondrial adenyl nucleotide antiporter SLC25A23 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Short calcium-binding mitochondrial carrier protein 3) (SCaMC-3) (Solute carrier family 25 member 23)
Protein function Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotid
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00153 Mito_carr 275 → 367 Mitochondrial carrier protein Family
PF00153 Mito_carr 182 → 274 Mitochondrial carrier protein Family
PF00153 Mito_carr 372 → 466 Mitochondrial carrier protein Family
PF13202 EF-hand_5 16 → 39 EF hand Domain
PF13499 EF-hand_7 79 → 142 EF-hand domain pair Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at low levels in most tissues examined, with highest expression in brain, skeletal muscle and pancreas. {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:15716113}.
Sequence
Sequence length 468
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Ovarian serous cystadenocarcinoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1 Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Uveal melanoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (96)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Accessory kidney Accessory Kidney HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 12036940, 14647414, 30779081
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 10021369, 10551328, 11691822, 22513088, 23840886, 24931405, 25208568, 25960217, 27694902, 29533772, 29617376, 30019417, 30510602, 31109967, 31206208
View all (2 more)
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome LHGDN 18157572
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 26035058 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease, Late Onset Alzheimer disease BEFREE 26035058
★★★★★
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 10551328, 29617376
★★★★★
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain neoplasms Pubtator 10551328 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma CTD_human_DG 18507500
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 27694902, 30880222
★★★★★
★☆☆☆☆
Found in Text Mining only