Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9121
Gene name	Solute carrier family 16 member 5
Gene symbol	SLC16A5
Synonyms (NCBI Gene)	MCT5MCT6
Chromosome	17
Chromosome location	17q25.1
Summary	This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT720454	hsa-miR-3183	HITS-CLIP	19536157
MIRT720453	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT720452	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT720451	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT720450	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT720449	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT720448	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT720446	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT720447	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT720445	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT720444	hsa-miR-145-5p	HITS-CLIP	19536157
MIRT720443	hsa-miR-5195-3p	HITS-CLIP	19536157
MIRT720442	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT720441	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT720440	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT617170	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT617169	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT617168	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT617167	hsa-miR-3119	HITS-CLIP	23824327
MIRT617166	hsa-miR-623	HITS-CLIP	23824327
MIRT617165	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT617164	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT617163	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617162	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT636761	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT636760	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT636759	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT636758	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT636757	hsa-miR-3135b	HITS-CLIP	23824327
MIRT636756	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT636755	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT636754	hsa-miR-3652	HITS-CLIP	23824327
MIRT636753	hsa-miR-4430	HITS-CLIP	23824327
MIRT636752	hsa-miR-3650	HITS-CLIP	23824327
MIRT636751	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT636750	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT636749	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT636748	hsa-miR-5698	HITS-CLIP	23824327
MIRT617170	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT617169	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT617168	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT617167	hsa-miR-3119	HITS-CLIP	23824327
MIRT617166	hsa-miR-623	HITS-CLIP	23824327
MIRT617165	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT617164	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT617163	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617162	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT720454	hsa-miR-3183	HITS-CLIP	19536157
MIRT720453	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT720452	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT720451	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT720450	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT720449	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT720448	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT720446	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT720447	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT720445	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT720444	hsa-miR-145-5p	HITS-CLIP	19536157
MIRT720443	hsa-miR-5195-3p	HITS-CLIP	19536157
MIRT720442	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT720441	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT720440	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT617170	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT617169	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT617168	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT617167	hsa-miR-3119	HITS-CLIP	23824327
MIRT617166	hsa-miR-623	HITS-CLIP	23824327
MIRT617165	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT617164	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT617163	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617162	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT636761	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT636760	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT636759	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT636758	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT636757	hsa-miR-3135b	HITS-CLIP	23824327
MIRT636756	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT636755	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT636754	hsa-miR-3652	HITS-CLIP	23824327
MIRT636753	hsa-miR-4430	HITS-CLIP	23824327
MIRT636752	hsa-miR-3650	HITS-CLIP	23824327
MIRT636751	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT636750	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT636749	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT636748	hsa-miR-5698	HITS-CLIP	23824327
MIRT617170	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT617169	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT617168	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT617167	hsa-miR-3119	HITS-CLIP	23824327
MIRT617166	hsa-miR-623	HITS-CLIP	23824327
MIRT617165	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT617164	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT617163	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617162	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1353096	hsa-miR-24	CLIP-seq
MIRT1353097	hsa-miR-3065-5p	CLIP-seq
MIRT1353098	hsa-miR-323-5p	CLIP-seq
MIRT1353099	hsa-miR-3922-5p	CLIP-seq
MIRT1353100	hsa-miR-4257	CLIP-seq
MIRT1353101	hsa-miR-498	CLIP-seq
MIRT1353102	hsa-miR-505	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9425115
GO:0008028	Function	Monocarboxylic acid transmembrane transporter activity	IBA
GO:0008028	Function	Monocarboxylic acid transmembrane transporter activity	IEA
GO:0008028	Function	Monocarboxylic acid transmembrane transporter activity	TAS	9425115
GO:0015293	Function	Symporter activity	IEA
GO:0015718	Process	Monocarboxylic acid transport	IEA
GO:0015718	Process	Monocarboxylic acid transport	TAS	9425115
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9425115
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA

MIM	HGNC	e!Ensembl
603879	10926	ENSG00000170190

O15375

Protein name

Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5)

Protein function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07690	MFS_1	12 → 297	Major Facilitator Superfamily	Family
PF07690	MFS_1	236 → 489	Major Facilitator Superfamily	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in kidney.

Sequence

MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILT
AVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCF
SFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFL
HCCICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCV
YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAF
ASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMD
QFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQ
KKEQGKQAVAADALERDLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWGCPASSRT
SHEWLLWPKAVLQAKQTALGWNSPT

Sequence length

505

Interactions

View interactions

Related Genes Genes most often co-reported with SLC16A5 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for SLC16A5.

Diseases Linked via Similar Genes Diseases curated for genes most similar to SLC16A5 (see Related Genes above), that are NOT already directly curated for SLC16A5 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to SLC16A5.

SLC16A5 (solute carrier family 16 member 5)

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