SLC13A1 (solute carrier family 13 member 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6561
• Gene name: Solute carrier family 13 member 1
• Gene symbol: SLC13A1
• Synonyms (NCBI Gene): NAS1, NaSi-1
• Chromosome: 7
• Chromosome location: 7q31.32
• Summary: The protein encoded by this gene is an apical membrane Na(+)-sulfate cotransporter involved in sulfate homeostasis in the kidney. Defects in this gene lead to many pathophysiologic problems. [provided by RefSeq, May 2016]

miRNA Show/Hide all (161)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1352416	hsa-miR-1273	CLIP-seq
MIRT1352417	hsa-miR-1279	CLIP-seq
MIRT1352418	hsa-miR-15a	CLIP-seq
MIRT1352419	hsa-miR-15b	CLIP-seq
MIRT1352420	hsa-miR-16	CLIP-seq
MIRT1352421	hsa-miR-1827	CLIP-seq
MIRT1352422	hsa-miR-195	CLIP-seq
MIRT1352423	hsa-miR-216a	CLIP-seq
MIRT1352424	hsa-miR-300	CLIP-seq
MIRT1352425	hsa-miR-3180-5p	CLIP-seq
MIRT1352426	hsa-miR-3192	CLIP-seq
MIRT1352427	hsa-miR-330-3p	CLIP-seq
MIRT1352428	hsa-miR-3673	CLIP-seq
MIRT1352429	hsa-miR-3689a-3p	CLIP-seq
MIRT1352430	hsa-miR-3689c	CLIP-seq
MIRT1352431	hsa-miR-374a	CLIP-seq
MIRT1352432	hsa-miR-374b	CLIP-seq
MIRT1352433	hsa-miR-381	CLIP-seq
MIRT1352434	hsa-miR-3942-5p	CLIP-seq
MIRT1352435	hsa-miR-3977	CLIP-seq
MIRT1352436	hsa-miR-424	CLIP-seq
MIRT1352437	hsa-miR-4252	CLIP-seq
MIRT1352438	hsa-miR-4258	CLIP-seq
MIRT1352439	hsa-miR-4327	CLIP-seq
MIRT1352440	hsa-miR-4464	CLIP-seq
MIRT1352441	hsa-miR-4473	CLIP-seq
MIRT1352442	hsa-miR-4486	CLIP-seq
MIRT1352443	hsa-miR-4537	CLIP-seq
MIRT1352444	hsa-miR-4649-3p	CLIP-seq
MIRT1352445	hsa-miR-4649-5p	CLIP-seq
MIRT1352446	hsa-miR-4666-3p	CLIP-seq
MIRT1352447	hsa-miR-4671-3p	CLIP-seq
MIRT1352448	hsa-miR-4703-5p	CLIP-seq
MIRT1352449	hsa-miR-4722-5p	CLIP-seq
MIRT1352450	hsa-miR-4728-5p	CLIP-seq
MIRT1352451	hsa-miR-4733-5p	CLIP-seq
MIRT1352452	hsa-miR-4748	CLIP-seq
MIRT1352453	hsa-miR-4768-3p	CLIP-seq
MIRT1352454	hsa-miR-4789-5p	CLIP-seq
MIRT1352455	hsa-miR-4793-3p	CLIP-seq
MIRT1352456	hsa-miR-490-3p	CLIP-seq
MIRT1352457	hsa-miR-497	CLIP-seq
MIRT1352458	hsa-miR-508-5p	CLIP-seq
MIRT1352459	hsa-miR-512-3p	CLIP-seq
MIRT1352460	hsa-miR-520a-5p	CLIP-seq
MIRT1352461	hsa-miR-520d-5p	CLIP-seq
MIRT1352462	hsa-miR-520f	CLIP-seq
MIRT1352463	hsa-miR-524-5p	CLIP-seq
MIRT1352464	hsa-miR-525-5p	CLIP-seq
MIRT1352465	hsa-miR-592	CLIP-seq
MIRT1352466	hsa-miR-597	CLIP-seq
MIRT1352467	hsa-miR-616	CLIP-seq
MIRT1352468	hsa-miR-647	CLIP-seq
MIRT1352469	hsa-miR-656	CLIP-seq
MIRT1352470	hsa-miR-661	CLIP-seq
MIRT1352471	hsa-miR-766	CLIP-seq
MIRT1352472	hsa-miR-940	CLIP-seq
MIRT1352426	hsa-miR-3192	CLIP-seq
MIRT1352429	hsa-miR-3689a-3p	CLIP-seq
MIRT1352430	hsa-miR-3689c	CLIP-seq
MIRT1352439	hsa-miR-4327	CLIP-seq
MIRT1352443	hsa-miR-4537	CLIP-seq
MIRT1352450	hsa-miR-4728-5p	CLIP-seq
MIRT1352456	hsa-miR-490-3p	CLIP-seq
MIRT1352421	hsa-miR-1827	CLIP-seq
MIRT2104362	hsa-miR-3153	CLIP-seq
MIRT1352426	hsa-miR-3192	CLIP-seq
MIRT1352429	hsa-miR-3689a-3p	CLIP-seq
MIRT1352430	hsa-miR-3689c	CLIP-seq
MIRT1352439	hsa-miR-4327	CLIP-seq
MIRT1352443	hsa-miR-4537	CLIP-seq
MIRT1352444	hsa-miR-4649-3p	CLIP-seq
MIRT1352449	hsa-miR-4722-5p	CLIP-seq
MIRT1352450	hsa-miR-4728-5p	CLIP-seq
MIRT1352453	hsa-miR-4768-3p	CLIP-seq
MIRT1352456	hsa-miR-490-3p	CLIP-seq
MIRT1352472	hsa-miR-940	CLIP-seq
MIRT1352416	hsa-miR-1273	CLIP-seq
MIRT1352421	hsa-miR-1827	CLIP-seq
MIRT2328791	hsa-miR-214	CLIP-seq
MIRT2328792	hsa-miR-27a	CLIP-seq
MIRT2328793	hsa-miR-27b	CLIP-seq
MIRT1352426	hsa-miR-3192	CLIP-seq
MIRT2328794	hsa-miR-3619-5p	CLIP-seq
MIRT1352429	hsa-miR-3689a-3p	CLIP-seq
MIRT1352430	hsa-miR-3689c	CLIP-seq
MIRT2328795	hsa-miR-369-3p	CLIP-seq
MIRT1352431	hsa-miR-374a	CLIP-seq
MIRT1352432	hsa-miR-374b	CLIP-seq
MIRT2328796	hsa-miR-410	CLIP-seq
MIRT1352437	hsa-miR-4252	CLIP-seq
MIRT1352438	hsa-miR-4258	CLIP-seq
MIRT1352439	hsa-miR-4327	CLIP-seq
MIRT1352442	hsa-miR-4486	CLIP-seq
MIRT1352443	hsa-miR-4537	CLIP-seq
MIRT1352444	hsa-miR-4649-3p	CLIP-seq
MIRT1352445	hsa-miR-4649-5p	CLIP-seq
MIRT1352449	hsa-miR-4722-5p	CLIP-seq
MIRT1352450	hsa-miR-4728-5p	CLIP-seq
MIRT1352453	hsa-miR-4768-3p	CLIP-seq
MIRT1352455	hsa-miR-4793-3p	CLIP-seq
MIRT1352456	hsa-miR-490-3p	CLIP-seq
MIRT1352458	hsa-miR-508-5p	CLIP-seq
MIRT2328797	hsa-miR-513a-5p	CLIP-seq
MIRT1352468	hsa-miR-647	CLIP-seq
MIRT2328798	hsa-miR-657	CLIP-seq
MIRT1352470	hsa-miR-661	CLIP-seq
MIRT2328799	hsa-miR-761	CLIP-seq
MIRT1352471	hsa-miR-766	CLIP-seq
MIRT1352472	hsa-miR-940	CLIP-seq
MIRT1352449	hsa-miR-4722-5p	CLIP-seq
MIRT1352453	hsa-miR-4768-3p	CLIP-seq
MIRT1352472	hsa-miR-940	CLIP-seq
MIRT2459472	hsa-miR-3613-3p	CLIP-seq
MIRT2459473	hsa-miR-371-5p	CLIP-seq
MIRT2459474	hsa-miR-371b-5p	CLIP-seq
MIRT1352416	hsa-miR-1273	CLIP-seq
MIRT1352421	hsa-miR-1827	CLIP-seq
MIRT1352426	hsa-miR-3192	CLIP-seq
MIRT2459472	hsa-miR-3613-3p	CLIP-seq
MIRT1352429	hsa-miR-3689a-3p	CLIP-seq
MIRT1352430	hsa-miR-3689c	CLIP-seq
MIRT2459473	hsa-miR-371-5p	CLIP-seq
MIRT2459474	hsa-miR-371b-5p	CLIP-seq
MIRT1352437	hsa-miR-4252	CLIP-seq
MIRT1352438	hsa-miR-4258	CLIP-seq
MIRT1352439	hsa-miR-4327	CLIP-seq
MIRT1352442	hsa-miR-4486	CLIP-seq
MIRT1352443	hsa-miR-4537	CLIP-seq
MIRT1352445	hsa-miR-4649-5p	CLIP-seq
MIRT1352449	hsa-miR-4722-5p	CLIP-seq
MIRT1352450	hsa-miR-4728-5p	CLIP-seq
MIRT1352453	hsa-miR-4768-3p	CLIP-seq
MIRT1352455	hsa-miR-4793-3p	CLIP-seq
MIRT1352456	hsa-miR-490-3p	CLIP-seq
MIRT1352458	hsa-miR-508-5p	CLIP-seq
MIRT1352470	hsa-miR-661	CLIP-seq
MIRT1352471	hsa-miR-766	CLIP-seq
MIRT1352472	hsa-miR-940	CLIP-seq
MIRT1352416	hsa-miR-1273	CLIP-seq
MIRT1352426	hsa-miR-3192	CLIP-seq
MIRT2690863	hsa-miR-3607-3p	CLIP-seq
MIRT2459472	hsa-miR-3613-3p	CLIP-seq
MIRT2690864	hsa-miR-3686	CLIP-seq
MIRT1352429	hsa-miR-3689a-3p	CLIP-seq
MIRT1352430	hsa-miR-3689c	CLIP-seq
MIRT2459473	hsa-miR-371-5p	CLIP-seq
MIRT2459474	hsa-miR-371b-5p	CLIP-seq
MIRT1352437	hsa-miR-4252	CLIP-seq
MIRT1352438	hsa-miR-4258	CLIP-seq
MIRT1352439	hsa-miR-4327	CLIP-seq
MIRT1352442	hsa-miR-4486	CLIP-seq
MIRT1352443	hsa-miR-4537	CLIP-seq
MIRT1352445	hsa-miR-4649-5p	CLIP-seq
MIRT2690865	hsa-miR-4652-3p	CLIP-seq
MIRT1352450	hsa-miR-4728-5p	CLIP-seq
MIRT1352455	hsa-miR-4793-3p	CLIP-seq
MIRT1352456	hsa-miR-490-3p	CLIP-seq
MIRT1352458	hsa-miR-508-5p	CLIP-seq
MIRT1352470	hsa-miR-661	CLIP-seq
MIRT1352471	hsa-miR-766	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IBA
GO:0006814	Process	Sodium ion transport	IEA
GO:0008271	Function	Secondary active sulfate transmembrane transporter activity	IEA
GO:0015293	Function	Symporter activity	IEA
GO:0015370	Function	Solute:sodium symporter activity	IEA
GO:0015373	Function	Monoatomic anion:sodium symporter activity	IEA
GO:0015382	Function	Sodium:sulfate symporter activity	IBA
GO:0015382	Function	Sodium:sulfate symporter activity	IDA	11161786
GO:0015382	Function	Sodium:sulfate symporter activity	IEA
GO:0015382	Function	Sodium:sulfate symporter activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0098656	Process	Monoatomic anion transmembrane transport	IEA
GO:1902358	Process	Sulfate transmembrane transport	IBA
GO:1902358	Process	Sulfate transmembrane transport	IEA
GO:1902358	Process	Sulfate transmembrane transport	IEA

Other IDs

• MIM: 606193
• HGNC: 10916
• e!Ensembl: ENSG00000081800

Protein

• UniProt ID: Q9BZW2
• Protein name: Solute carrier family 13 member 1 (Renal sodium/sulfate cotransporter) (Na(+)/sulfate cotransporter) (hNaSi-1)
• Protein function: Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:11161786). Can also mediate the transport of selenate and thiosulfate (By similarity). {ECO:0000250|UniProtKB:Q07782, ECO:0000269|PubMed:111617
• PDB: 8W6H , 8W6N , 8W6O , 8W6T , 8Y5U , 8Y5W , 8Y5X , 8Y5Y , 8Y5Z
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00939	Na_sulph_symp	6 → 579	Sodium:sulfate symporter transmembrane region	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in kidney; not detectable in the other tissues tested. {ECO:0000269|PubMed:11161786}.
• Sequence:

  MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTAL
  LPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNP
  AWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVEATQMTYFNGSTNHG
  LEIDESVNGHEINERKEKTKPVPGYNNDTGKISSKVELEKNSGMRTKYRTKKGHVTRKLT
  CLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCRCLNFGSWFTFSFPAALIILLLSW
  IWLQWLFLGFNFKEMFKCGKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALL
  WFSRDPGFVPGWSALFSEYPGFATDSTVALLIGLLFFLIPAKTLTKTTPTGEIVAFDYSP
  LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLM
  VTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVF
  SYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWAPAMSNETMP

• Sequence length: 595

Pathways

Reactome Pathway:

Sodium-coupled sulphate, di- and tri-carboxylate transporters

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Abnormality of neuronal migration	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (12)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autistic Disorder	Autism	Pubtator	36175384	Associate	★☆☆☆☆ Found in Text Mining only
Bone Diseases	Bone Disease	BEFREE	31600309		★☆☆☆☆ Found in Text Mining only
Bone Diseases	Bone disease	Pubtator	36175384	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomegaly	Cardiomegaly	Pubtator	36175384	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Pain	Chronic pain	Pubtator	36943258, 37895311	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	38062804	Associate	★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	BEFREE	24193406		★☆☆☆☆ Found in Text Mining only
Intervertebral disc disease	Intervertebral disc disease	Pubtator	35110524	Associate	★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	23300579		★☆☆☆☆ Found in Text Mining only
Mucopolysaccharidosis IV	Mucopolysaccharidosis	BEFREE	23300579		★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	30500848		★☆☆☆☆ Found in Text Mining only
Osteochondrodysplasias	Osteochondrodysplasia	BEFREE	23300579		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for SLC13A1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SLC13A1.