Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 348235
Gene name Spindle and kinetochore associated complex subunit 2
Gene symbol SKA2
Synonyms (NCBI Gene)
FAM33A
Chromosome 17
Chromosome location 17q22
miRNA miRNA information provided by mirtarbase database.
700 Show/Hide all (700)
miRTarBase ID miRNA Experiments Reference
MIRT019891 hsa-miR-375 Microarray 20215506
MIRT051441 hsa-let-7e-5p CLASH 23622248
MIRT715770 hsa-miR-548a-3p HITS-CLIP 19536157
MIRT715769 hsa-miR-548ar-3p HITS-CLIP 19536157
MIRT715768 hsa-miR-548az-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33 Show/Hide all (33)
GO ID Ontology Definition Evidence Reference
GO:0000070 Process Mitotic sister chromatid segregation IMP 17093495, 19289083
GO:0000278 Process Mitotic cell cycle IBA
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000776 Component Kinetochore IEA
GO:0000776 Component Kinetochore IPI 21633384
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616674 28006 ENSG00000182628
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WVK7
Protein name Spindle and kinetochore-associated protein 2 (Protein FAM33A)
Protein function Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis,
PDB 4AJ5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16740 SKA2 2 → 115 Spindle and kinetochore-associated protein 2 Domain
Sequence
Sequence length 121
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation