SIT1 (signaling threshold regulating transmembrane adaptor 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 27240
• Gene name: Signaling threshold regulating transmembrane adaptor 1
• Gene symbol: SIT1
• Synonyms (NCBI Gene): SIT, SIT-R
• Chromosome: 9
• Chromosome location: 9p13.3

miRNA Show/Hide all (163)

miRTarBase ID	miRNA	Experiments	Reference
MIRT724562	hsa-miR-3145-5p	HITS-CLIP	19536157
MIRT724561	hsa-miR-7113-5p	HITS-CLIP	19536157
MIRT724560	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT724559	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT649943	hsa-miR-5193	HITS-CLIP	19536157
MIRT724558	hsa-miR-1281	HITS-CLIP	19536157
MIRT724557	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT724556	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT724555	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724553	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT699572	hsa-miR-759	HITS-CLIP	23313552
MIRT699571	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT699570	hsa-miR-4481	HITS-CLIP	23313552
MIRT699569	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT699568	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT699567	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT699566	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT699565	hsa-miR-4284	HITS-CLIP	23313552
MIRT699564	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT699563	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT699562	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT699561	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT699560	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT699559	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT699558	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT699557	hsa-miR-1233-5p	HITS-CLIP	23313552
MIRT699556	hsa-miR-6778-5p	HITS-CLIP	23313552
MIRT699555	hsa-miR-7977	HITS-CLIP	23313552
MIRT699554	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT699553	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT699552	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT699551	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT699550	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT699549	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT699548	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT699547	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT699546	hsa-miR-3689c	HITS-CLIP	23313552
MIRT699545	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT699544	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT699543	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT699542	hsa-miR-3122	HITS-CLIP	23313552
MIRT699541	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT699540	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT699539	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT664830	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT664829	hsa-miR-5186	HITS-CLIP	23824327
MIRT664828	hsa-miR-1202	HITS-CLIP	23824327
MIRT664827	hsa-miR-3972	HITS-CLIP	23824327
MIRT664826	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT649946	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT649944	hsa-miR-1470	HITS-CLIP	23824327
MIRT649945	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649943	hsa-miR-5193	HITS-CLIP	23824327
MIRT649942	hsa-miR-4469	HITS-CLIP	23824327
MIRT649941	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT664828	hsa-miR-1202	PAR-CLIP	27292025
MIRT664827	hsa-miR-3972	PAR-CLIP	27292025
MIRT664826	hsa-miR-5006-5p	PAR-CLIP	27292025
MIRT664829	hsa-miR-5186	PAR-CLIP	27292025
MIRT664828	hsa-miR-1202	HITS-CLIP	27418678
MIRT664828	hsa-miR-1202	HITS-CLIP	27418678
MIRT664828	hsa-miR-1202	HITS-CLIP	27418678
MIRT664827	hsa-miR-3972	HITS-CLIP	27418678
MIRT664827	hsa-miR-3972	HITS-CLIP	27418678
MIRT664827	hsa-miR-3972	HITS-CLIP	27418678
MIRT664826	hsa-miR-5006-5p	HITS-CLIP	27418678
MIRT664826	hsa-miR-5006-5p	HITS-CLIP	27418678
MIRT664826	hsa-miR-5006-5p	HITS-CLIP	27418678
MIRT664829	hsa-miR-5186	HITS-CLIP	27418678
MIRT664829	hsa-miR-5186	HITS-CLIP	27418678
MIRT664829	hsa-miR-5186	HITS-CLIP	27418678
MIRT724562	hsa-miR-3145-5p	HITS-CLIP	19536157
MIRT724561	hsa-miR-7113-5p	HITS-CLIP	19536157
MIRT724560	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT724559	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT649943	hsa-miR-5193	HITS-CLIP	19536157
MIRT724558	hsa-miR-1281	HITS-CLIP	19536157
MIRT724557	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT724556	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT724555	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724553	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT699572	hsa-miR-759	HITS-CLIP	23313552
MIRT699571	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT699570	hsa-miR-4481	HITS-CLIP	23313552
MIRT699569	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT699568	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT699567	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT699566	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT699565	hsa-miR-4284	HITS-CLIP	23313552
MIRT699564	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT699563	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT699562	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT699561	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT699560	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT699559	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT699558	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT699557	hsa-miR-1233-5p	HITS-CLIP	23313552
MIRT699556	hsa-miR-6778-5p	HITS-CLIP	23313552
MIRT699555	hsa-miR-7977	HITS-CLIP	23313552
MIRT699554	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT699553	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT699552	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT699551	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT699550	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT699549	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT699548	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT699547	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT699546	hsa-miR-3689c	HITS-CLIP	23313552
MIRT699545	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT699544	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT699543	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT699542	hsa-miR-3122	HITS-CLIP	23313552
MIRT699541	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT699540	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT699539	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT664830	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT664829	hsa-miR-5186	HITS-CLIP	23824327
MIRT664828	hsa-miR-1202	HITS-CLIP	23824327
MIRT664827	hsa-miR-3972	HITS-CLIP	23824327
MIRT664826	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT649946	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT649944	hsa-miR-1470	HITS-CLIP	23824327
MIRT649945	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649943	hsa-miR-5193	HITS-CLIP	23824327
MIRT649942	hsa-miR-4469	HITS-CLIP	23824327
MIRT649941	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT1350358	hsa-miR-1280	CLIP-seq
MIRT1350359	hsa-miR-1914	CLIP-seq
MIRT1350360	hsa-miR-3150b-3p	CLIP-seq
MIRT1350361	hsa-miR-361-3p	CLIP-seq
MIRT1350362	hsa-miR-4689	CLIP-seq
MIRT1350363	hsa-miR-4784	CLIP-seq
MIRT1350364	hsa-miR-544b	CLIP-seq
MIRT1350365	hsa-miR-550a	CLIP-seq
MIRT1350366	hsa-miR-938	CLIP-seq
MIRT2103794	hsa-miR-127-5p	CLIP-seq
MIRT2103795	hsa-miR-4287	CLIP-seq
MIRT2103796	hsa-miR-4330	CLIP-seq
MIRT2103797	hsa-miR-4476	CLIP-seq
MIRT2103798	hsa-miR-4635	CLIP-seq
MIRT2103799	hsa-miR-4685-3p	CLIP-seq
MIRT2103800	hsa-miR-4780	CLIP-seq
MIRT2103801	hsa-miR-623	CLIP-seq
MIRT2103794	hsa-miR-127-5p	CLIP-seq
MIRT2327970	hsa-miR-3125	CLIP-seq
MIRT2327971	hsa-miR-3916	CLIP-seq
MIRT2327972	hsa-miR-3928	CLIP-seq
MIRT2103795	hsa-miR-4287	CLIP-seq
MIRT2103796	hsa-miR-4330	CLIP-seq
MIRT2103797	hsa-miR-4476	CLIP-seq
MIRT2327973	hsa-miR-4489	CLIP-seq
MIRT2103798	hsa-miR-4635	CLIP-seq
MIRT2103799	hsa-miR-4685-3p	CLIP-seq
MIRT2103800	hsa-miR-4780	CLIP-seq
MIRT2103801	hsa-miR-623	CLIP-seq
MIRT2103794	hsa-miR-127-5p	CLIP-seq
MIRT2103795	hsa-miR-4287	CLIP-seq
MIRT2103796	hsa-miR-4330	CLIP-seq
MIRT2103797	hsa-miR-4476	CLIP-seq
MIRT2103798	hsa-miR-4635	CLIP-seq
MIRT2103799	hsa-miR-4685-3p	CLIP-seq
MIRT2103800	hsa-miR-4780	CLIP-seq
MIRT2103801	hsa-miR-623	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	10209036, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	10209036, 11390434
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	11433379
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	10209036
GO:0016020	Component	Membrane	IEA
GO:0019900	Function	Kinase binding	IBA
GO:0019900	Function	Kinase binding	IPI	10209036
GO:0042169	Function	SH2 domain binding	TAS	11433379
GO:0043029	Process	T cell homeostasis	IEA
GO:0050863	Process	Regulation of T cell activation	IBA
GO:0050863	Process	Regulation of T cell activation	IDA	10209036
GO:0050863	Process	Regulation of T cell activation	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 604964
• HGNC: 17710
• e!Ensembl: ENSG00000137078

Protein

• UniProt ID: Q9Y3P8
• Protein name: Signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein) (Suppression-inducing transmembrane adapter 1) (gp30/40)
• Protein function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. {ECO:0000269|PubMed:10209036, ECO:0000269|PubMed:16160011}.
• Sequence:

  MNQADPRLRAVCLWTLTSAAMSRGDNCTDLLALGIPSITQAWGLWVLLGAVTLLFLISLA
  AHLSQWTRGRSRSHPGQGRSGESVEEVPLYGNLHYLQTGRLSQDPEPDQQDPTLGGPARA
  AEEVMCYTSLQLRPPQGRIPGPGTPVKYSEVVLDSEPKSQASGPEPELYASVCAQTRRAR
  ASFPDQAYANSQPAAS

• Sequence length: 196

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	35589863	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for SIT1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SIT1.