SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 56904
• Gene name: SH3 domain containing GRB2 like, endophilin B2
• Gene symbol: SH3GLB2
• Synonyms (NCBI Gene): PP6569, PP9455, RRIG1
• Chromosome: 9
• Chromosome location: 9q34.11

miRNA Show/Hide all (150)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006065	hsa-miR-542-5p	Microarray, qRT-PCR	21310526
MIRT006065	hsa-miR-542-5p	Microarray, qRT-PCR	21310526
MIRT006065	hsa-miR-542-5p	Microarray, qRT-PCR	21310526
MIRT050894	hsa-miR-17-5p	CLASH	23622248
MIRT1345283	hsa-miR-1185	CLIP-seq
MIRT1345284	hsa-miR-1207-5p	CLIP-seq
MIRT1345285	hsa-miR-1226	CLIP-seq
MIRT1345286	hsa-miR-1233	CLIP-seq
MIRT1345287	hsa-miR-1294	CLIP-seq
MIRT1345288	hsa-miR-146b-3p	CLIP-seq
MIRT1345289	hsa-miR-1909	CLIP-seq
MIRT1345290	hsa-miR-1915	CLIP-seq
MIRT1345291	hsa-miR-2355-5p	CLIP-seq
MIRT1345292	hsa-miR-29a	CLIP-seq
MIRT1345293	hsa-miR-29b	CLIP-seq
MIRT1345294	hsa-miR-29c	CLIP-seq
MIRT1345295	hsa-miR-3136-3p	CLIP-seq
MIRT1345296	hsa-miR-3155	CLIP-seq
MIRT1345297	hsa-miR-3155b	CLIP-seq
MIRT1345298	hsa-miR-3160-3p	CLIP-seq
MIRT1345299	hsa-miR-3184	CLIP-seq
MIRT1345300	hsa-miR-3591-3p	CLIP-seq
MIRT1345301	hsa-miR-3679-5p	CLIP-seq
MIRT1345302	hsa-miR-3689a-3p	CLIP-seq
MIRT1345303	hsa-miR-3689c	CLIP-seq
MIRT1345304	hsa-miR-3907	CLIP-seq
MIRT1345305	hsa-miR-423-3p	CLIP-seq
MIRT1345306	hsa-miR-423-5p	CLIP-seq
MIRT1345307	hsa-miR-4283	CLIP-seq
MIRT1345308	hsa-miR-4312	CLIP-seq
MIRT1345309	hsa-miR-4316	CLIP-seq
MIRT1345310	hsa-miR-4435	CLIP-seq
MIRT1345311	hsa-miR-4446-3p	CLIP-seq
MIRT1345312	hsa-miR-4487	CLIP-seq
MIRT1345313	hsa-miR-4492	CLIP-seq
MIRT1345314	hsa-miR-4498	CLIP-seq
MIRT1345315	hsa-miR-4514	CLIP-seq
MIRT1345316	hsa-miR-4651	CLIP-seq
MIRT1345317	hsa-miR-4677-3p	CLIP-seq
MIRT1345318	hsa-miR-4688	CLIP-seq
MIRT1345319	hsa-miR-4692	CLIP-seq
MIRT1345320	hsa-miR-4726-3p	CLIP-seq
MIRT1345321	hsa-miR-4728-5p	CLIP-seq
MIRT1345322	hsa-miR-4755-3p	CLIP-seq
MIRT1345323	hsa-miR-4763-3p	CLIP-seq
MIRT1345324	hsa-miR-484	CLIP-seq
MIRT1345325	hsa-miR-486-3p	CLIP-seq
MIRT1345326	hsa-miR-520a-5p	CLIP-seq
MIRT1345327	hsa-miR-525-5p	CLIP-seq
MIRT1345328	hsa-miR-550a	CLIP-seq
MIRT1345329	hsa-miR-558	CLIP-seq
MIRT1345330	hsa-miR-608	CLIP-seq
MIRT1345331	hsa-miR-762	CLIP-seq
MIRT1345332	hsa-miR-885-3p	CLIP-seq
MIRT1345333	hsa-miR-940	CLIP-seq
MIRT1345284	hsa-miR-1207-5p	CLIP-seq
MIRT1345287	hsa-miR-1294	CLIP-seq
MIRT2102104	hsa-miR-185	CLIP-seq
MIRT1345298	hsa-miR-3160-3p	CLIP-seq
MIRT1345299	hsa-miR-3184	CLIP-seq
MIRT2102105	hsa-miR-342-5p	CLIP-seq
MIRT2102106	hsa-miR-3659	CLIP-seq
MIRT2102107	hsa-miR-3911	CLIP-seq
MIRT1345306	hsa-miR-423-5p	CLIP-seq
MIRT2102108	hsa-miR-4269	CLIP-seq
MIRT2102109	hsa-miR-4306	CLIP-seq
MIRT1345309	hsa-miR-4316	CLIP-seq
MIRT2102110	hsa-miR-4452	CLIP-seq
MIRT1345312	hsa-miR-4487	CLIP-seq
MIRT1345315	hsa-miR-4514	CLIP-seq
MIRT2102111	hsa-miR-4644	CLIP-seq
MIRT1345316	hsa-miR-4651	CLIP-seq
MIRT2102112	hsa-miR-4658	CLIP-seq
MIRT2102113	hsa-miR-4664-5p	CLIP-seq
MIRT1345317	hsa-miR-4677-3p	CLIP-seq
MIRT1345318	hsa-miR-4688	CLIP-seq
MIRT1345319	hsa-miR-4692	CLIP-seq
MIRT1345321	hsa-miR-4728-5p	CLIP-seq
MIRT2102114	hsa-miR-4742-5p	CLIP-seq
MIRT1345323	hsa-miR-4763-3p	CLIP-seq
MIRT1345325	hsa-miR-486-3p	CLIP-seq
MIRT1345329	hsa-miR-558	CLIP-seq
MIRT2102115	hsa-miR-574-5p	CLIP-seq
MIRT1345330	hsa-miR-608	CLIP-seq
MIRT1345283	hsa-miR-1185	CLIP-seq
MIRT1345284	hsa-miR-1207-5p	CLIP-seq
MIRT2326605	hsa-miR-1275	CLIP-seq
MIRT1345289	hsa-miR-1909	CLIP-seq
MIRT1345292	hsa-miR-29a	CLIP-seq
MIRT1345293	hsa-miR-29b	CLIP-seq
MIRT1345294	hsa-miR-29c	CLIP-seq
MIRT2326606	hsa-miR-3065-5p	CLIP-seq
MIRT2326607	hsa-miR-3135	CLIP-seq
MIRT1345295	hsa-miR-3136-3p	CLIP-seq
MIRT1345298	hsa-miR-3160-3p	CLIP-seq
MIRT1345300	hsa-miR-3591-3p	CLIP-seq
MIRT2326608	hsa-miR-3620	CLIP-seq
MIRT1345301	hsa-miR-3679-5p	CLIP-seq
MIRT1345302	hsa-miR-3689a-3p	CLIP-seq
MIRT1345303	hsa-miR-3689c	CLIP-seq
MIRT2326609	hsa-miR-3960	CLIP-seq
MIRT1345307	hsa-miR-4283	CLIP-seq
MIRT2326610	hsa-miR-4286	CLIP-seq
MIRT1345311	hsa-miR-4446-3p	CLIP-seq
MIRT2326611	hsa-miR-4457	CLIP-seq
MIRT1345312	hsa-miR-4487	CLIP-seq
MIRT1345313	hsa-miR-4492	CLIP-seq
MIRT1345314	hsa-miR-4498	CLIP-seq
MIRT2326612	hsa-miR-4505	CLIP-seq
MIRT1345315	hsa-miR-4514	CLIP-seq
MIRT2326613	hsa-miR-4525	CLIP-seq
MIRT2326614	hsa-miR-4539	CLIP-seq
MIRT1345316	hsa-miR-4651	CLIP-seq
MIRT2326615	hsa-miR-4665-5p	CLIP-seq
MIRT1345318	hsa-miR-4688	CLIP-seq
MIRT1345319	hsa-miR-4692	CLIP-seq
MIRT2326616	hsa-miR-4713-5p	CLIP-seq
MIRT2326617	hsa-miR-4714-5p	CLIP-seq
MIRT2326618	hsa-miR-4723-5p	CLIP-seq
MIRT1345321	hsa-miR-4728-5p	CLIP-seq
MIRT2326619	hsa-miR-4731-3p	CLIP-seq
MIRT2326620	hsa-miR-4731-5p	CLIP-seq
MIRT2326621	hsa-miR-4734	CLIP-seq
MIRT2326622	hsa-miR-4758-3p	CLIP-seq
MIRT1345323	hsa-miR-4763-3p	CLIP-seq
MIRT2326623	hsa-miR-4801	CLIP-seq
MIRT1345325	hsa-miR-486-3p	CLIP-seq
MIRT2326624	hsa-miR-495	CLIP-seq
MIRT1345326	hsa-miR-520a-5p	CLIP-seq
MIRT1345327	hsa-miR-525-5p	CLIP-seq
MIRT1345329	hsa-miR-558	CLIP-seq
MIRT2326625	hsa-miR-592	CLIP-seq
MIRT2326626	hsa-miR-597	CLIP-seq
MIRT1345330	hsa-miR-608	CLIP-seq
MIRT2326627	hsa-miR-625	CLIP-seq
MIRT2326628	hsa-miR-637	CLIP-seq
MIRT1345331	hsa-miR-762	CLIP-seq
MIRT2326629	hsa-miR-892a	CLIP-seq
MIRT1345333	hsa-miR-940	CLIP-seq
MIRT2102104	hsa-miR-185	CLIP-seq
MIRT2394375	hsa-miR-3174	CLIP-seq
MIRT2394376	hsa-miR-3609	CLIP-seq
MIRT2102106	hsa-miR-3659	CLIP-seq
MIRT2102107	hsa-miR-3911	CLIP-seq
MIRT2102109	hsa-miR-4306	CLIP-seq
MIRT2102111	hsa-miR-4644	CLIP-seq
MIRT2102112	hsa-miR-4658	CLIP-seq
MIRT2394377	hsa-miR-548ah	CLIP-seq
MIRT2394378	hsa-miR-548t	CLIP-seq
MIRT2102115	hsa-miR-574-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11161816, 16189514, 20562859, 23414517, 25416956, 25910212, 27107012, 32296183, 32814053, 33961781, 35271311
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	11161816, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0016020	Component	Membrane	IBA
GO:0042802	Function	Identical protein binding	IPI	20562859, 27107012
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0061024	Process	Membrane organization	IBA

Other IDs

• MIM: 609288
• HGNC: 10834
• e!Ensembl: ENSG00000148341

Protein

• UniProt ID: Q9NR46
• Protein name: Endophilin-B2 (SH3 domain-containing GRB2-like protein B2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03114	BAR	5 → 280	BAR domain	Domain
  PF14604	SH3_9	342 → 392	Variant SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland. {ECO:0000269|PubMed:11161816}.
• Sequence:

  MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQT
  EVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAE
  AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAK
  AAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLE
  GISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTS
  PTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADE
  LITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS

• Sequence length: 395

Pathways

KEGG Pathway:

Endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Familial cancer of breast	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	18303116		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21266059	Inhibit	★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	39924156	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	21266059	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	18303116		★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	26753958	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	18303116		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	18303116		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for SH3GLB2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SH3GLB2.