SH3D21 (SH3 domain containing 21)

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Gene Gene information from NCBI Gene database.
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Entrez ID 79729
Gene name SH3 domain containing 21
Gene symbol SH3D21
Synonyms (NCBI Gene)
C1orf113
Chromosome 1
Chromosome location 1p34.3
miRNA miRNA information provided by mirtarbase database.
6 Show/Hide all (6)
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miRTarBase ID miRNA Experiments Reference
MIRT017054 hsa-miR-335-5p Microarray 18185580
MIRT1345049 hsa-miR-3126-5p CLIP-seq
MIRT1345050 hsa-miR-361-3p CLIP-seq
MIRT1345051 hsa-miR-4670-5p CLIP-seq
MIRT1345052 hsa-miR-658 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
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GO ID Ontology Definition Evidence Reference
GO:0007015 Process Actin filament organization IBA
GO:0016477 Process Cell migration IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A4FU49
Protein name SH3 domain-containing protein 21
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07653 SH3_2 69 → 123 Variant SH3 domain Domain
Sequence 
MVQSELQLQPRAGGRAEAASWGDRGNDKGGLGNPDMPSVSPGPQRPPKLSSLAYDSPPDY
LQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNF
VLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRD
SQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMP
DKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTP
EKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLG
DEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAP
PPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSND
ERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQK
TRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLT
DIWEELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY
Sequence length 640
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
TYPE 2 DIABETES MELLITUS — GWAS catalog 32541925
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Malignant neoplasm of pancreas Pancreatic cancer BEFREE 31844142
★★★★★
★☆☆☆☆
Found in Text Mining only
Pancreatic carcinoma Pancreatic carcinoma BEFREE 31844142
★★★★★
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Pancreatic neoplasm Pubtator 31844142 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only

No strongly related genes found yet for SH3D21.

No additional diseases found yet through genes similar to SH3D21.