SEPHS2 (selenophosphate synthetase 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 22928
• Gene name: Selenophosphate synthetase 2
• Gene symbol: SEPHS2
• Synonyms (NCBI Gene): SPS2
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-fram

miRNA Show/Hide all (154)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041739	hsa-miR-484	CLASH	23622248
MIRT041273	hsa-miR-193b-3p	CLASH	23622248
MIRT039955	hsa-miR-615-3p	CLASH	23622248
MIRT036036	hsa-miR-1301-3p	CLASH	23622248
MIRT726630	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726629	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT1336247	hsa-miR-1271	CLIP-seq
MIRT1336248	hsa-miR-1323	CLIP-seq
MIRT1336249	hsa-miR-133a	CLIP-seq
MIRT1336250	hsa-miR-133b	CLIP-seq
MIRT1336251	hsa-miR-182	CLIP-seq
MIRT1336252	hsa-miR-186	CLIP-seq
MIRT1336253	hsa-miR-3065-5p	CLIP-seq
MIRT1336254	hsa-miR-31	CLIP-seq
MIRT1336255	hsa-miR-3133	CLIP-seq
MIRT1336256	hsa-miR-3156-5p	CLIP-seq
MIRT1336257	hsa-miR-338-5p	CLIP-seq
MIRT1336258	hsa-miR-33a	CLIP-seq
MIRT1336259	hsa-miR-33b	CLIP-seq
MIRT1336260	hsa-miR-3977	CLIP-seq
MIRT1336261	hsa-miR-4528	CLIP-seq
MIRT1336262	hsa-miR-4684-3p	CLIP-seq
MIRT1336263	hsa-miR-4714-3p	CLIP-seq
MIRT1336264	hsa-miR-4735-5p	CLIP-seq
MIRT1336265	hsa-miR-4760-5p	CLIP-seq
MIRT1336266	hsa-miR-490-3p	CLIP-seq
MIRT1336267	hsa-miR-548o	CLIP-seq
MIRT1336268	hsa-miR-550b	CLIP-seq
MIRT1336269	hsa-miR-576-5p	CLIP-seq
MIRT1336270	hsa-miR-579	CLIP-seq
MIRT1336271	hsa-miR-619	CLIP-seq
MIRT1336272	hsa-miR-96	CLIP-seq
MIRT1553324	hsa-miR-4705	CLIP-seq
MIRT2099468	hsa-miR-1248	CLIP-seq
MIRT1336251	hsa-miR-182	CLIP-seq
MIRT2099469	hsa-miR-202	CLIP-seq
MIRT1336254	hsa-miR-31	CLIP-seq
MIRT2099470	hsa-miR-3143	CLIP-seq
MIRT2099471	hsa-miR-3614-3p	CLIP-seq
MIRT2099472	hsa-miR-4257	CLIP-seq
MIRT2099473	hsa-miR-4436b-3p	CLIP-seq
MIRT2099474	hsa-miR-4514	CLIP-seq
MIRT2099475	hsa-miR-4678	CLIP-seq
MIRT2099476	hsa-miR-4692	CLIP-seq
MIRT1553324	hsa-miR-4705	CLIP-seq
MIRT2099477	hsa-miR-548u	CLIP-seq
MIRT2099478	hsa-miR-570	CLIP-seq
MIRT2099479	hsa-miR-760	CLIP-seq
MIRT2099480	hsa-miR-9	CLIP-seq
MIRT2324142	hsa-miR-142-5p	CLIP-seq
MIRT2324143	hsa-miR-1914	CLIP-seq
MIRT2324144	hsa-miR-1973	CLIP-seq
MIRT2324145	hsa-miR-198	CLIP-seq
MIRT2324146	hsa-miR-19a	CLIP-seq
MIRT2324147	hsa-miR-19b	CLIP-seq
MIRT2324148	hsa-miR-216a	CLIP-seq
MIRT2324149	hsa-miR-216b	CLIP-seq
MIRT2324150	hsa-miR-2278	CLIP-seq
MIRT2324151	hsa-miR-298	CLIP-seq
MIRT2324152	hsa-miR-3176	CLIP-seq
MIRT2324153	hsa-miR-339-5p	CLIP-seq
MIRT2324154	hsa-miR-340	CLIP-seq
MIRT2324155	hsa-miR-3664-5p	CLIP-seq
MIRT2324156	hsa-miR-3669	CLIP-seq
MIRT2324157	hsa-miR-3922-3p	CLIP-seq
MIRT2324158	hsa-miR-3944-5p	CLIP-seq
MIRT2324159	hsa-miR-448	CLIP-seq
MIRT2324160	hsa-miR-4698	CLIP-seq
MIRT2324161	hsa-miR-4714-5p	CLIP-seq
MIRT2324162	hsa-miR-4757-5p	CLIP-seq
MIRT1336265	hsa-miR-4760-5p	CLIP-seq
MIRT2324163	hsa-miR-483-3p	CLIP-seq
MIRT2324164	hsa-miR-518a-5p	CLIP-seq
MIRT2324165	hsa-miR-520a-5p	CLIP-seq
MIRT2324166	hsa-miR-525-5p	CLIP-seq
MIRT2324167	hsa-miR-527	CLIP-seq
MIRT2099477	hsa-miR-548u	CLIP-seq
MIRT2099479	hsa-miR-760	CLIP-seq
MIRT2620002	hsa-miR-1178	CLIP-seq
MIRT2620003	hsa-miR-1245b-3p	CLIP-seq
MIRT2620004	hsa-miR-1276	CLIP-seq
MIRT2620005	hsa-miR-1324	CLIP-seq
MIRT2620006	hsa-miR-150	CLIP-seq
MIRT1336252	hsa-miR-186	CLIP-seq
MIRT2620007	hsa-miR-1910	CLIP-seq
MIRT2324145	hsa-miR-198	CLIP-seq
MIRT2324150	hsa-miR-2278	CLIP-seq
MIRT2620008	hsa-miR-2467-5p	CLIP-seq
MIRT1336255	hsa-miR-3133	CLIP-seq
MIRT2620009	hsa-miR-3188	CLIP-seq
MIRT2620010	hsa-miR-3194-3p	CLIP-seq
MIRT1336258	hsa-miR-33a	CLIP-seq
MIRT1336259	hsa-miR-33b	CLIP-seq
MIRT2620011	hsa-miR-3655	CLIP-seq
MIRT2620012	hsa-miR-3665	CLIP-seq
MIRT2620013	hsa-miR-3691-3p	CLIP-seq
MIRT2620014	hsa-miR-378g	CLIP-seq
MIRT2620015	hsa-miR-3921	CLIP-seq
MIRT2620016	hsa-miR-3975	CLIP-seq
MIRT2620017	hsa-miR-4282	CLIP-seq
MIRT2620018	hsa-miR-4437	CLIP-seq
MIRT2620019	hsa-miR-4506	CLIP-seq
MIRT2620020	hsa-miR-4649-3p	CLIP-seq
MIRT2620021	hsa-miR-4653-5p	CLIP-seq
MIRT2620022	hsa-miR-4674	CLIP-seq
MIRT2620023	hsa-miR-4676-5p	CLIP-seq
MIRT1336262	hsa-miR-4684-3p	CLIP-seq
MIRT2620024	hsa-miR-4712-5p	CLIP-seq
MIRT2620025	hsa-miR-4713-5p	CLIP-seq
MIRT2620026	hsa-miR-4786-5p	CLIP-seq
MIRT2620027	hsa-miR-485-5p	CLIP-seq
MIRT2324165	hsa-miR-520a-5p	CLIP-seq
MIRT2324166	hsa-miR-525-5p	CLIP-seq
MIRT2620028	hsa-miR-532-3p	CLIP-seq
MIRT2620029	hsa-miR-575	CLIP-seq
MIRT2620030	hsa-miR-578	CLIP-seq
MIRT2620031	hsa-miR-657	CLIP-seq
MIRT2620032	hsa-miR-661	CLIP-seq
MIRT2099479	hsa-miR-760	CLIP-seq
MIRT2620033	hsa-miR-770-5p	CLIP-seq
MIRT2620002	hsa-miR-1178	CLIP-seq
MIRT2620003	hsa-miR-1245b-3p	CLIP-seq
MIRT2620004	hsa-miR-1276	CLIP-seq
MIRT2620005	hsa-miR-1324	CLIP-seq
MIRT1336252	hsa-miR-186	CLIP-seq
MIRT2324145	hsa-miR-198	CLIP-seq
MIRT2324150	hsa-miR-2278	CLIP-seq
MIRT2620008	hsa-miR-2467-5p	CLIP-seq
MIRT1336255	hsa-miR-3133	CLIP-seq
MIRT2620009	hsa-miR-3188	CLIP-seq
MIRT2620010	hsa-miR-3194-3p	CLIP-seq
MIRT2620011	hsa-miR-3655	CLIP-seq
MIRT2620012	hsa-miR-3665	CLIP-seq
MIRT2620013	hsa-miR-3691-3p	CLIP-seq
MIRT2620014	hsa-miR-378g	CLIP-seq
MIRT2620015	hsa-miR-3921	CLIP-seq
MIRT2620016	hsa-miR-3975	CLIP-seq
MIRT2620017	hsa-miR-4282	CLIP-seq
MIRT2620018	hsa-miR-4437	CLIP-seq
MIRT2620020	hsa-miR-4649-3p	CLIP-seq
MIRT2620021	hsa-miR-4653-5p	CLIP-seq
MIRT2620022	hsa-miR-4674	CLIP-seq
MIRT2620023	hsa-miR-4676-5p	CLIP-seq
MIRT2620024	hsa-miR-4712-5p	CLIP-seq
MIRT2620026	hsa-miR-4786-5p	CLIP-seq
MIRT2620027	hsa-miR-485-5p	CLIP-seq
MIRT2324165	hsa-miR-520a-5p	CLIP-seq
MIRT2324166	hsa-miR-525-5p	CLIP-seq
MIRT2620029	hsa-miR-575	CLIP-seq
MIRT2620030	hsa-miR-578	CLIP-seq
MIRT2620031	hsa-miR-657	CLIP-seq
MIRT2620032	hsa-miR-661	CLIP-seq
MIRT2099479	hsa-miR-760	CLIP-seq
MIRT2620033	hsa-miR-770-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001887	Process	Selenium compound metabolic process	IEA
GO:0004756	Function	Selenide, water dikinase activity	IBA
GO:0004756	Function	Selenide, water dikinase activity	IEA
GO:0004756	Function	Selenide, water dikinase activity	NAS	8986768
GO:0004756	Function	Selenide, water dikinase activity	TAS
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0016259	Process	Selenocysteine metabolic process	IEA
GO:0016259	Process	Selenocysteine metabolic process	TAS
GO:0016260	Process	Selenocysteine biosynthetic process	IBA
GO:0016260	Process	Selenocysteine biosynthetic process	IEA
GO:0016260	Process	Selenocysteine biosynthetic process	NAS	8986768
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 606218
• HGNC: 19686
• e!Ensembl: ENSG00000179918

Protein

• UniProt ID: Q99611
• Protein name: Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2)
• Protein function: Synthesizes selenophosphate from selenide and ATP.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00586	AIRS	98 → 231	AIR synthase related protein, N-terminal domain	Domain
  PF02769	AIRS_C	243 → 418	AIR synthase related protein, C-terminal domain	Domain

• Sequence:

  MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGU
  GCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMD
  SCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVS
  QSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPD
  SAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNR
  TAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRF
  GLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKP
  RVIEVLPRGATAAVLAPDSSNASSEPSS

• Sequence length: 448

Pathways

KEGG Pathway	Reactome Pathway
Selenocompound metabolism	Selenocysteine synthesis
Metabolic pathways

Related Genes

SEPSECS 2 shared pathwaysSelenocompound metabolism, Selenocysteine synthesis Related via 2 shared pathways including Selenocompound metabolism, Selenocysteine synthesis.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SEPSECS	0	[]	2	["Selenocompound metabolism","Selenocysteine synthesis"]	0	[]

Diseases Linked via Similar Genes

Arthrogryposis multiplex congenita Linked via 1 of 1 related geneSEPSECS Cerebellar ataxia Linked via 1 of 1 related geneSEPSECS Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay Linked via 1 of 1 related geneSEPSECS Congenital brain malformation Linked via 1 of 1 related geneSEPSECS Congenital hypoplasia of part of brain Linked via 1 of 1 related geneSEPSECS

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Arthrogryposis multiplex congenita	1	["SEPSECS"]
Cerebellar ataxia	1	["SEPSECS"]
Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	1	["SEPSECS"]
Congenital brain malformation	1	["SEPSECS"]
Congenital hypoplasia of part of brain	1	["SEPSECS"]