SEC31B (SEC31 homolog B, COPII component)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25956
• Gene name: SEC31 homolog B, COPII component
• Gene symbol: SEC31B
• Synonyms (NCBI Gene): SEC31B-1, SEC31L2
• Chromosome: 10
• Chromosome location: 10q24.31
• Summary: This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq

miRNA Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT722376	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT722375	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT722374	hsa-miR-4714-3p	HITS-CLIP	19536157
MIRT722373	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT722372	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT722371	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT722370	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT722369	hsa-miR-5096	HITS-CLIP	19536157
MIRT722376	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT722375	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT722374	hsa-miR-4714-3p	HITS-CLIP	19536157
MIRT722373	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT722372	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT722371	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT722370	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT722369	hsa-miR-5096	HITS-CLIP	19536157
MIRT1333289	hsa-miR-1207-5p	CLIP-seq
MIRT1333290	hsa-miR-137	CLIP-seq
MIRT1333291	hsa-miR-1827	CLIP-seq
MIRT1333292	hsa-miR-25	CLIP-seq
MIRT1333293	hsa-miR-3120-3p	CLIP-seq
MIRT1333294	hsa-miR-3123	CLIP-seq
MIRT1333295	hsa-miR-32	CLIP-seq
MIRT1333296	hsa-miR-363	CLIP-seq
MIRT1333297	hsa-miR-367	CLIP-seq
MIRT1333298	hsa-miR-3691-3p	CLIP-seq
MIRT1333299	hsa-miR-4257	CLIP-seq
MIRT1333300	hsa-miR-4668-5p	CLIP-seq
MIRT1333301	hsa-miR-4763-3p	CLIP-seq
MIRT1333302	hsa-miR-503	CLIP-seq
MIRT1333303	hsa-miR-548ag	CLIP-seq
MIRT1333304	hsa-miR-548ai	CLIP-seq
MIRT1333305	hsa-miR-548m	CLIP-seq
MIRT1333306	hsa-miR-646	CLIP-seq
MIRT1333307	hsa-miR-7	CLIP-seq
MIRT1333308	hsa-miR-767-5p	CLIP-seq
MIRT1333309	hsa-miR-92a	CLIP-seq
MIRT1333310	hsa-miR-92b	CLIP-seq
MIRT1333311	hsa-miR-940	CLIP-seq
MIRT2098554	hsa-miR-1184	CLIP-seq
MIRT2098555	hsa-miR-1205	CLIP-seq
MIRT2098556	hsa-miR-1321	CLIP-seq
MIRT2098557	hsa-miR-1909	CLIP-seq
MIRT2098558	hsa-miR-3158-5p	CLIP-seq
MIRT2098559	hsa-miR-3182	CLIP-seq
MIRT2098560	hsa-miR-4270	CLIP-seq
MIRT2098561	hsa-miR-4441	CLIP-seq
MIRT2098562	hsa-miR-4739	CLIP-seq
MIRT2098563	hsa-miR-4756-5p	CLIP-seq
MIRT2098564	hsa-miR-544	CLIP-seq
MIRT2098565	hsa-miR-765	CLIP-seq
MIRT2394169	hsa-miR-922	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005198	Function	Structural molecule activity	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IEA
GO:0007029	Process	Endoplasmic reticulum organization	IBA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030120	Component	Vesicle coat	IDA	22792322
GO:0030120	Component	Vesicle coat	IEA
GO:0030127	Component	COPII vesicle coat	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0070971	Component	Endoplasmic reticulum exit site	IBA
GO:0090110	Process	COPII-coated vesicle cargo loading	IBA

Other IDs

• MIM: 610258
• HGNC: 23197
• e!Ensembl: ENSG00000075826

Protein

• UniProt ID: Q9NQW1
• Protein name: Protein transport protein Sec31B (SEC31-like protein 2) (SEC31-related protein B) (SEC31B-1)
• Protein function: As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.
• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein leve
• Sequence:

  MKLKELERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHR
  GVLSALSRFHKLVWGSFGSGLLESSGVIVGGGDNGMLILYNVTHILSSGKEPVIAQKQKH
  TGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQPPEDIKALSWNRQA
  QHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDIATQLVLCSEDDRLPV
  IQLWDLRFASSPLKVLESHSRGILSVSWSQADAELLLTSAKDSQILCRNLGSSEVVYKLP
  TQSSWCFDVQWCPRDPSVFSAASFNGWISLYSVMGRSWEVQHMRQADKISSSFSKGQPLP
  PLQVPEQVAQAPLIPPLKKPPKWIRRPTGVSFAFGGKLVTFGLPSTPAHLVPQPCPRLVF
  ISQVTTESEFLMRSAELQEALGSGNLLNYCQNKSQQALLQSEKMLWQFLKVTLEQDSRMK
  FLKLLGYSKDELQKKVATWLKSDVGLGESPQPKGNDLNSDRQQAFCSQASKHTTKEASAS
  SAFFDELVPQNMTPWEIPITKDIDGLLSQALLLGELGPAVELCLKEERFADAIILAQAGG
  TDLLKQTQERYLAKKKTKISSLLACVVQKNWKDVVCTCSLKNWREALALLLTYSGTEKFP
  ELCDMLGTRMEQEGSRALTSEARLCYVCSGSVERLVECWAKCHQALSPMALQDLMEKVMV
  LNRSLEQLRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQLRDRL
  FHAQGSAVLGQQSPPFPFPRIVVGATLHSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSS
  PAMPLAPSHPSPYQGPRTQNISDYRAPGPQAIQPLPLSPGVRPASSQPQLLGGQRVQVPN
  PVGFPGTWPLPGSPLPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPAS
  FPVPYLPGDPGAPCSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPETFMPPAPIT
  APVMSLTPELQGILPSQPPVSSVSHAPPGVPGELSLQLQHLPPEKMERKELPPEHQSLKS
  SFEALLQRCSLSATDLKTKRKLEEAAQRLEYLYEKLCEGTLSPHVVAGLHEVARCVDAGS
  FEQGLAVHAQVAGCSSFSEVSSFMPILKAVLIIAHKLLV

• Sequence length: 1179

Pathways

KEGG Pathway:

Protein processing in endoplasmic reticulum

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for SEC31B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SEC31B.