SCML1 (Scm polycomb group protein like 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6322
• Gene name: Scm polycomb group protein like 1
• Gene symbol: SCML1
• Synonyms (NCBI Gene): -
• Chromosome: X
• Chromosome location: Xp22.13

miRNA Show/Hide all (257)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030379	hsa-miR-24-3p	Microarray	19748357
MIRT1329404	hsa-miR-1224-5p	CLIP-seq
MIRT1329405	hsa-miR-1225-5p	CLIP-seq
MIRT1329406	hsa-miR-1269	CLIP-seq
MIRT1329407	hsa-miR-1269b	CLIP-seq
MIRT1329408	hsa-miR-1297	CLIP-seq
MIRT1329409	hsa-miR-1324	CLIP-seq
MIRT1329410	hsa-miR-200b	CLIP-seq
MIRT1329411	hsa-miR-200c	CLIP-seq
MIRT1329412	hsa-miR-217	CLIP-seq
MIRT1329413	hsa-miR-24	CLIP-seq
MIRT1329414	hsa-miR-26a	CLIP-seq
MIRT1329415	hsa-miR-26b	CLIP-seq
MIRT1329416	hsa-miR-30a	CLIP-seq
MIRT1329417	hsa-miR-30b	CLIP-seq
MIRT1329418	hsa-miR-30c	CLIP-seq
MIRT1329419	hsa-miR-30d	CLIP-seq
MIRT1329420	hsa-miR-30e	CLIP-seq
MIRT1329421	hsa-miR-3120-3p	CLIP-seq
MIRT1329422	hsa-miR-3145-5p	CLIP-seq
MIRT1329423	hsa-miR-3159	CLIP-seq
MIRT1329424	hsa-miR-3163	CLIP-seq
MIRT1329425	hsa-miR-3169	CLIP-seq
MIRT1329426	hsa-miR-3622a-3p	CLIP-seq
MIRT1329427	hsa-miR-3622b-3p	CLIP-seq
MIRT1329428	hsa-miR-369-3p	CLIP-seq
MIRT1329429	hsa-miR-3973	CLIP-seq
MIRT1329430	hsa-miR-4274	CLIP-seq
MIRT1329431	hsa-miR-4280	CLIP-seq
MIRT1329432	hsa-miR-4284	CLIP-seq
MIRT1329433	hsa-miR-429	CLIP-seq
MIRT1329434	hsa-miR-4418	CLIP-seq
MIRT1329435	hsa-miR-4427	CLIP-seq
MIRT1329436	hsa-miR-4465	CLIP-seq
MIRT1329437	hsa-miR-4503	CLIP-seq
MIRT1329438	hsa-miR-4519	CLIP-seq
MIRT1329439	hsa-miR-4529-3p	CLIP-seq
MIRT1329440	hsa-miR-4680-3p	CLIP-seq
MIRT1329441	hsa-miR-4690-5p	CLIP-seq
MIRT1329442	hsa-miR-4694-3p	CLIP-seq
MIRT1329443	hsa-miR-4751	CLIP-seq
MIRT1329444	hsa-miR-4772-3p	CLIP-seq
MIRT1329445	hsa-miR-505	CLIP-seq
MIRT1329446	hsa-miR-508-5p	CLIP-seq
MIRT1329447	hsa-miR-509-3-5p	CLIP-seq
MIRT1329448	hsa-miR-509-5p	CLIP-seq
MIRT1329449	hsa-miR-520g	CLIP-seq
MIRT1329450	hsa-miR-520h	CLIP-seq
MIRT1329451	hsa-miR-522	CLIP-seq
MIRT1329452	hsa-miR-544b	CLIP-seq
MIRT1329453	hsa-miR-576-5p	CLIP-seq
MIRT1329454	hsa-miR-577	CLIP-seq
MIRT1329455	hsa-miR-875-5p	CLIP-seq
MIRT1329405	hsa-miR-1225-5p	CLIP-seq
MIRT1329409	hsa-miR-1324	CLIP-seq
MIRT1329456	hsa-miR-135a	CLIP-seq
MIRT1329457	hsa-miR-135b	CLIP-seq
MIRT1329412	hsa-miR-217	CLIP-seq
MIRT1329413	hsa-miR-24	CLIP-seq
MIRT1329416	hsa-miR-30a	CLIP-seq
MIRT1329417	hsa-miR-30b	CLIP-seq
MIRT1329418	hsa-miR-30c	CLIP-seq
MIRT1329419	hsa-miR-30d	CLIP-seq
MIRT1329420	hsa-miR-30e	CLIP-seq
MIRT1329458	hsa-miR-3115	CLIP-seq
MIRT1329422	hsa-miR-3145-5p	CLIP-seq
MIRT1329423	hsa-miR-3159	CLIP-seq
MIRT1329424	hsa-miR-3163	CLIP-seq
MIRT1329459	hsa-miR-3168	CLIP-seq
MIRT1329460	hsa-miR-338-5p	CLIP-seq
MIRT1329461	hsa-miR-3688-5p	CLIP-seq
MIRT1329428	hsa-miR-369-3p	CLIP-seq
MIRT1329462	hsa-miR-374a	CLIP-seq
MIRT1329463	hsa-miR-374b	CLIP-seq
MIRT1329464	hsa-miR-3943	CLIP-seq
MIRT1329429	hsa-miR-3973	CLIP-seq
MIRT1329431	hsa-miR-4280	CLIP-seq
MIRT1329432	hsa-miR-4284	CLIP-seq
MIRT1329465	hsa-miR-4311	CLIP-seq
MIRT1329434	hsa-miR-4418	CLIP-seq
MIRT1329435	hsa-miR-4427	CLIP-seq
MIRT1329466	hsa-miR-4494	CLIP-seq
MIRT1329437	hsa-miR-4503	CLIP-seq
MIRT1329467	hsa-miR-4652-3p	CLIP-seq
MIRT1329440	hsa-miR-4680-3p	CLIP-seq
MIRT1329441	hsa-miR-4690-5p	CLIP-seq
MIRT1329444	hsa-miR-4772-3p	CLIP-seq
MIRT1329468	hsa-miR-4780	CLIP-seq
MIRT1329469	hsa-miR-4793-5p	CLIP-seq
MIRT1329470	hsa-miR-488	CLIP-seq
MIRT1329471	hsa-miR-499a-5p	CLIP-seq
MIRT1329446	hsa-miR-508-5p	CLIP-seq
MIRT1329447	hsa-miR-509-3-5p	CLIP-seq
MIRT1329448	hsa-miR-509-5p	CLIP-seq
MIRT1329472	hsa-miR-520d-5p	CLIP-seq
MIRT1329449	hsa-miR-520g	CLIP-seq
MIRT1329450	hsa-miR-520h	CLIP-seq
MIRT1329473	hsa-miR-524-5p	CLIP-seq
MIRT1329474	hsa-miR-548a-5p	CLIP-seq
MIRT1329475	hsa-miR-548ab	CLIP-seq
MIRT1329476	hsa-miR-548ak	CLIP-seq
MIRT1329477	hsa-miR-548b-5p	CLIP-seq
MIRT1329478	hsa-miR-548c-5p	CLIP-seq
MIRT1329479	hsa-miR-548d-5p	CLIP-seq
MIRT1329480	hsa-miR-548h	CLIP-seq
MIRT1329481	hsa-miR-548i	CLIP-seq
MIRT1329482	hsa-miR-548j	CLIP-seq
MIRT1329483	hsa-miR-548n	CLIP-seq
MIRT1329484	hsa-miR-548t	CLIP-seq
MIRT1329485	hsa-miR-548w	CLIP-seq
MIRT1329486	hsa-miR-548y	CLIP-seq
MIRT1329487	hsa-miR-559	CLIP-seq
MIRT1329454	hsa-miR-577	CLIP-seq
MIRT1329488	hsa-miR-578	CLIP-seq
MIRT1329489	hsa-miR-623	CLIP-seq
MIRT2097701	hsa-miR-1236	CLIP-seq
MIRT1329408	hsa-miR-1297	CLIP-seq
MIRT2097702	hsa-miR-139-5p	CLIP-seq
MIRT2097703	hsa-miR-153	CLIP-seq
MIRT2097704	hsa-miR-2355-3p	CLIP-seq
MIRT1329414	hsa-miR-26a	CLIP-seq
MIRT1329415	hsa-miR-26b	CLIP-seq
MIRT1329421	hsa-miR-3120-3p	CLIP-seq
MIRT1329424	hsa-miR-3163	CLIP-seq
MIRT2097705	hsa-miR-3182	CLIP-seq
MIRT1329460	hsa-miR-338-5p	CLIP-seq
MIRT2097706	hsa-miR-339-5p	CLIP-seq
MIRT2097707	hsa-miR-3655	CLIP-seq
MIRT2097708	hsa-miR-3688-3p	CLIP-seq
MIRT1329428	hsa-miR-369-3p	CLIP-seq
MIRT2097709	hsa-miR-382	CLIP-seq
MIRT2097710	hsa-miR-3909	CLIP-seq
MIRT2097711	hsa-miR-3915	CLIP-seq
MIRT2097712	hsa-miR-3928	CLIP-seq
MIRT2097713	hsa-miR-4261	CLIP-seq
MIRT2097714	hsa-miR-4303	CLIP-seq
MIRT2097715	hsa-miR-4445	CLIP-seq
MIRT1329436	hsa-miR-4465	CLIP-seq
MIRT2097716	hsa-miR-448	CLIP-seq
MIRT2097717	hsa-miR-4649-3p	CLIP-seq
MIRT2097718	hsa-miR-4705	CLIP-seq
MIRT2097719	hsa-miR-4753-3p	CLIP-seq
MIRT1329470	hsa-miR-488	CLIP-seq
MIRT1329445	hsa-miR-505	CLIP-seq
MIRT1329474	hsa-miR-548a-5p	CLIP-seq
MIRT1329475	hsa-miR-548ab	CLIP-seq
MIRT1329476	hsa-miR-548ak	CLIP-seq
MIRT1329477	hsa-miR-548b-5p	CLIP-seq
MIRT1329478	hsa-miR-548c-5p	CLIP-seq
MIRT1329479	hsa-miR-548d-5p	CLIP-seq
MIRT1329480	hsa-miR-548h	CLIP-seq
MIRT1329481	hsa-miR-548i	CLIP-seq
MIRT1329482	hsa-miR-548j	CLIP-seq
MIRT1329483	hsa-miR-548n	CLIP-seq
MIRT1329485	hsa-miR-548w	CLIP-seq
MIRT1329486	hsa-miR-548y	CLIP-seq
MIRT1329487	hsa-miR-559	CLIP-seq
MIRT1329488	hsa-miR-578	CLIP-seq
MIRT2097720	hsa-miR-670	CLIP-seq
MIRT2097721	hsa-miR-676	CLIP-seq
MIRT2097703	hsa-miR-153	CLIP-seq
MIRT1329421	hsa-miR-3120-3p	CLIP-seq
MIRT2321969	hsa-miR-323-3p	CLIP-seq
MIRT2321970	hsa-miR-545	CLIP-seq
MIRT1329488	hsa-miR-578	CLIP-seq
MIRT1329456	hsa-miR-135a	CLIP-seq
MIRT1329457	hsa-miR-135b	CLIP-seq
MIRT2618440	hsa-miR-103b	CLIP-seq
MIRT2618441	hsa-miR-127-5p	CLIP-seq
MIRT2097703	hsa-miR-153	CLIP-seq
MIRT2618442	hsa-miR-29a	CLIP-seq
MIRT2618443	hsa-miR-29b	CLIP-seq
MIRT2618444	hsa-miR-29c	CLIP-seq
MIRT2618445	hsa-miR-3119	CLIP-seq
MIRT1329421	hsa-miR-3120-3p	CLIP-seq
MIRT2618446	hsa-miR-3121-3p	CLIP-seq
MIRT2618447	hsa-miR-3143	CLIP-seq
MIRT2618448	hsa-miR-3160-5p	CLIP-seq
MIRT1329424	hsa-miR-3163	CLIP-seq
MIRT2321969	hsa-miR-323-3p	CLIP-seq
MIRT2618449	hsa-miR-337-3p	CLIP-seq
MIRT1329460	hsa-miR-338-5p	CLIP-seq
MIRT2618450	hsa-miR-33a	CLIP-seq
MIRT2618451	hsa-miR-33b	CLIP-seq
MIRT1329428	hsa-miR-369-3p	CLIP-seq
MIRT1329462	hsa-miR-374a	CLIP-seq
MIRT1329463	hsa-miR-374b	CLIP-seq
MIRT1329464	hsa-miR-3943	CLIP-seq
MIRT2618452	hsa-miR-4263	CLIP-seq
MIRT2618453	hsa-miR-4328	CLIP-seq
MIRT1329435	hsa-miR-4427	CLIP-seq
MIRT2618454	hsa-miR-4474-5p	CLIP-seq
MIRT2097716	hsa-miR-448	CLIP-seq
MIRT1329466	hsa-miR-4494	CLIP-seq
MIRT2618455	hsa-miR-4509	CLIP-seq
MIRT2618456	hsa-miR-4645-3p	CLIP-seq
MIRT1329440	hsa-miR-4680-3p	CLIP-seq
MIRT2618457	hsa-miR-4744	CLIP-seq
MIRT2618458	hsa-miR-4799-5p	CLIP-seq
MIRT1329471	hsa-miR-499a-5p	CLIP-seq
MIRT1329472	hsa-miR-520d-5p	CLIP-seq
MIRT1329473	hsa-miR-524-5p	CLIP-seq
MIRT2618459	hsa-miR-543	CLIP-seq
MIRT2321970	hsa-miR-545	CLIP-seq
MIRT2618460	hsa-miR-548a-3p	CLIP-seq
MIRT1329474	hsa-miR-548a-5p	CLIP-seq
MIRT1329475	hsa-miR-548ab	CLIP-seq
MIRT1329476	hsa-miR-548ak	CLIP-seq
MIRT1329477	hsa-miR-548b-5p	CLIP-seq
MIRT1329478	hsa-miR-548c-5p	CLIP-seq
MIRT1329479	hsa-miR-548d-5p	CLIP-seq
MIRT2618461	hsa-miR-548e	CLIP-seq
MIRT2618462	hsa-miR-548f	CLIP-seq
MIRT2618463	hsa-miR-548g	CLIP-seq
MIRT1329480	hsa-miR-548h	CLIP-seq
MIRT1329481	hsa-miR-548i	CLIP-seq
MIRT1329482	hsa-miR-548j	CLIP-seq
MIRT2618464	hsa-miR-548k	CLIP-seq
MIRT2618465	hsa-miR-548l	CLIP-seq
MIRT2618466	hsa-miR-548m	CLIP-seq
MIRT1329483	hsa-miR-548n	CLIP-seq
MIRT1329485	hsa-miR-548w	CLIP-seq
MIRT1329486	hsa-miR-548y	CLIP-seq
MIRT1329487	hsa-miR-559	CLIP-seq
MIRT1329453	hsa-miR-576-5p	CLIP-seq
MIRT1329488	hsa-miR-578	CLIP-seq
MIRT2618467	hsa-miR-633	CLIP-seq
MIRT2618468	hsa-miR-889	CLIP-seq
MIRT2618440	hsa-miR-103b	CLIP-seq
MIRT2618441	hsa-miR-127-5p	CLIP-seq
MIRT2618442	hsa-miR-29a	CLIP-seq
MIRT2618443	hsa-miR-29b	CLIP-seq
MIRT2618444	hsa-miR-29c	CLIP-seq
MIRT1329421	hsa-miR-3120-3p	CLIP-seq
MIRT2618446	hsa-miR-3121-3p	CLIP-seq
MIRT2618447	hsa-miR-3143	CLIP-seq
MIRT2321969	hsa-miR-323-3p	CLIP-seq
MIRT2618450	hsa-miR-33a	CLIP-seq
MIRT2618451	hsa-miR-33b	CLIP-seq
MIRT2618455	hsa-miR-4509	CLIP-seq
MIRT2618457	hsa-miR-4744	CLIP-seq
MIRT2618459	hsa-miR-543	CLIP-seq
MIRT2321970	hsa-miR-545	CLIP-seq
MIRT1329474	hsa-miR-548a-5p	CLIP-seq
MIRT1329475	hsa-miR-548ab	CLIP-seq
MIRT1329476	hsa-miR-548ak	CLIP-seq
MIRT1329477	hsa-miR-548b-5p	CLIP-seq
MIRT1329478	hsa-miR-548c-5p	CLIP-seq
MIRT1329479	hsa-miR-548d-5p	CLIP-seq
MIRT1329480	hsa-miR-548h	CLIP-seq
MIRT1329481	hsa-miR-548i	CLIP-seq
MIRT1329482	hsa-miR-548j	CLIP-seq
MIRT2618464	hsa-miR-548k	CLIP-seq
MIRT2618465	hsa-miR-548l	CLIP-seq
MIRT1329485	hsa-miR-548w	CLIP-seq
MIRT1329486	hsa-miR-548y	CLIP-seq
MIRT1329487	hsa-miR-559	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0042393	Function	Histone binding	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA

Other IDs

• MIM: 300227
• HGNC: 10580
• e!Ensembl: ENSG00000047634

Protein

• UniProt ID: Q9UN30
• Protein name: Sex comb on midleg-like protein 1
• Protein function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00536	SAM_1	256 → 322	SAM domain (Sterile alpha motif)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Expressed in fetal and adult tissues. {ECO:0000269|PubMed:9570953}.
• Sequence:

  MMSNSSSEIDVIKTRIPTYDEDDNTILYAYETKPEFVNKEPNIVSDASCNTEEQLKTVDD
  VLIHCQVIYDALQNLDKKIDVIRRKVSKIQRFHARSLWTNHKRYGYKKHSYRLVKKLKLQ
  KMKKNEVYETFSYPESYSPTLPVSRRENNSPSNLPRPSFCMEEYQRAELEEDPILSRTPS
  PVHPSDFSEHNCQPYYASDGATYGSSSGLCLGNPRADSIHNTYSTDHASAAPPSVTRSPV
  ENDGYIEEGSITKHPSTWSVEAVVLFLKQTDPLALCPLVDLFRSHEIDGKALLLLTSDVL
  LKHLGVKLGTAVKLCYYIDRLKQGKCFEN

• Sequence length: 329

Pathways

KEGG Pathway:

Polycomb repressive complex

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Gastric cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Azoospermia	Azoospermia	Pubtator	31916079	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	30693177		★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	31916079	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30693177		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for SCML1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SCML1.