SARAF (store-operated calcium entry associated regulatory factor)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 51669
• Gene name: Store-operated calcium entry associated regulatory factor
• Gene symbol: SARAF
• Synonyms (NCBI Gene): FOAP-7, HSPC035, TMEM66, XTP3
• Chromosome: 8
• Chromosome location: 8p12

miRNA Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT698197	hsa-miR-4311	HITS-CLIP	23313552
MIRT698196	hsa-miR-1276	HITS-CLIP	23313552
MIRT698195	hsa-miR-583	HITS-CLIP	23313552
MIRT698194	hsa-miR-5003-3p	HITS-CLIP	23313552
MIRT698193	hsa-miR-196a-5p	HITS-CLIP	23313552
MIRT698192	hsa-miR-196b-5p	HITS-CLIP	23313552
MIRT698191	hsa-miR-1278	HITS-CLIP	23313552
MIRT698190	hsa-miR-4744	HITS-CLIP	23313552
MIRT698189	hsa-miR-4509	HITS-CLIP	23313552
MIRT698188	hsa-miR-4799-5p	HITS-CLIP	23313552
MIRT698187	hsa-miR-2053	HITS-CLIP	23313552
MIRT698185	hsa-miR-4263	HITS-CLIP	23313552
MIRT698186	hsa-miR-576-5p	HITS-CLIP	23313552
MIRT698184	hsa-miR-3613-5p	HITS-CLIP	23313552
MIRT440622	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440621	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT439425	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT440622	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440621	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT439425	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT740780	hsa-miR-4311	HITS-CLIP	23313552
MIRT740781	hsa-miR-1276	HITS-CLIP	23313552
MIRT740782	hsa-miR-583	HITS-CLIP	23313552
MIRT740783	hsa-miR-5003-3p	HITS-CLIP	23313552
MIRT740784	hsa-miR-196a-5p	HITS-CLIP	23313552
MIRT740785	hsa-miR-196b-5p	HITS-CLIP	23313552
MIRT740786	hsa-miR-1278	HITS-CLIP	23313552
MIRT740787	hsa-miR-4744	HITS-CLIP	23313552
MIRT740788	hsa-miR-4509	HITS-CLIP	23313552
MIRT740789	hsa-miR-4799-5p	HITS-CLIP	23313552
MIRT740790	hsa-miR-2053	HITS-CLIP	23313552
MIRT740791	hsa-miR-4263	HITS-CLIP	23313552
MIRT740792	hsa-miR-576-5p	HITS-CLIP	23313552
MIRT740793	hsa-miR-3613-5p	HITS-CLIP	23313552

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22464749, 28514442, 30481768, 33961781
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	22464749
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0140268	Component	Endoplasmic reticulum-plasma membrane contact site	IDA	22464749
GO:2001256	Process	Regulation of store-operated calcium entry	IBA
GO:2001256	Process	Regulation of store-operated calcium entry	IDA	22464749
GO:2001256	Process	Regulation of store-operated calcium entry	IEA

Other IDs

• MIM: 614768
• HGNC: 28789
• e!Ensembl: ENSG00000133872

Protein

• UniProt ID: Q96BY9
• Protein name: Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (HBV X-transactivated gene 3 protein) (HBV XAg-transactivated protein 3) (Protein FOAP-7) (Transmembrane protein 66)
• Protein function: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or
• PDB: 6O2U , 6O2V , 6O2W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06682	SARAF	18 → 339	SOCE-associated regulatory factor of calcium homoeostasis	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in macrophages. {ECO:0000269|Ref.2}.
• Sequence:

  MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDP
  IPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESS
  EDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIV
  VLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGH
  GATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYP
  GTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR

• Sequence length: 339

Related Genes

No strongly related genes found yet for SARAF.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SARAF.