SAMTOR (S-adenosylmethionine sensor upstream of mTORC1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 154743
• Gene name: S-adenosylmethionine sensor upstream of mTORC1
• Gene symbol: SAMTOR
• Synonyms (NCBI Gene): BMT2, C7orf60
• Chromosome: 7
• Chromosome location: 7q31.1

miRNA Show/Hide all (43)

miRTarBase ID	miRNA	Experiments	Reference
MIRT507917	hsa-miR-3133	PAR-CLIP	21572407
MIRT021184	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT102329	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT507915	hsa-miR-4661-3p	PAR-CLIP	21572407
MIRT507916	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT507914	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT507917	hsa-miR-3133	PAR-CLIP	21572407
MIRT021184	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT538781	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT538780	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT538779	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT102329	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT507915	hsa-miR-4661-3p	PAR-CLIP	21572407
MIRT507916	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT507914	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT507917	hsa-miR-3133	PAR-CLIP	22012620
MIRT021184	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT538781	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT538780	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT538779	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT102329	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT507915	hsa-miR-4661-3p	PAR-CLIP	22012620
MIRT507916	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT507914	hsa-miR-651-5p	PAR-CLIP	22012620
MIRT507917	hsa-miR-3133	PAR-CLIP	23446348
MIRT021184	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT102329	hsa-miR-32-3p	PAR-CLIP	23446348
MIRT507915	hsa-miR-4661-3p	PAR-CLIP	23446348
MIRT507916	hsa-miR-143-5p	PAR-CLIP	23446348
MIRT507914	hsa-miR-651-5p	PAR-CLIP	23446348
MIRT441034	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT441033	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT441034	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT728074	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT728073	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT728072	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT728071	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT441033	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT728070	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT728069	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT728068	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT728067	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT728065	hsa-miR-30e-5p	HITS-CLIP	22473208

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IDA	8706699, 34314702
GO:0005829	Component	Cytosol	TAS
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031503	Process	Protein-containing complex localization	IDA	28199306
GO:0031669	Process	Cellular response to nutrient levels	IDA	29236692, 29750193, 31601708, 31601764
GO:0032259	Process	Methylation	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IDA	28199306, 35338845
GO:0034198	Process	Cellular response to amino acid starvation	IDA	29123071
GO:0038202	Process	TORC1 signaling	IDA	12087098, 29750193, 38006878
GO:0044877	Function	Protein-containing complex binding	IDA	29123071
GO:0045947	Process	Negative regulation of translational initiation	IDA	22578813
GO:0045948	Process	Positive regulation of translational initiation	IDA	1922062, 29750193
GO:0061431	Process	Cellular response to methionine	IDA	38006878
GO:0061431	Process	Cellular response to methionine	IDA	29123071, 35776786
GO:0061462	Process	Protein localization to lysosome	IDA	28199306, 31601708
GO:1903432	Process	Regulation of TORC1 signaling	IDA	29123071, 35776786
GO:1904047	Function	S-adenosyl-L-methionine binding	IDA	29123071, 35776786
GO:1904262	Process	Negative regulation of TORC1 signaling	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IDA	28199306, 30651352, 35338845
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	29236692, 31601708, 31601764
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	29123071

Other IDs

• MIM: 617855
• HGNC: 26475
• e!Ensembl: ENSG00000164603

Protein

• UniProt ID: Q1RMZ1
• Protein name: S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-)
• Protein function: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine suff
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11968	Bmt2	129 → 334	25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2	Family

• Sequence:

  MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKI
  WREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDE
  KRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELLQASGKIRLLDVGSCFNPFLK
  FEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHV
  VVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESL
  GFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVR
  SDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS

• Sequence length: 405

Pathways

Reactome Pathway:

Amino acids regulate mTORC1

Related Genes

No strongly related genes found yet for SAMTOR.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SAMTOR.