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Gene Gene information from NCBI Gene database.
Entrez ID 1903
Gene name Sphingosine-1-phosphate receptor 3
Gene symbol S1PR3
Synonyms (NCBI Gene)
C9orf108C9orf47EDG-3EDG3LPB3S1P3bA791O21.3
Chromosome 9
Chromosome location 9q22.1
Summary This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular e
miRNA miRNA information provided by mirtarbase database.
933 Show/Hide all (933)
miRTarBase ID miRNA Experiments Reference
MIRT676953 hsa-miR-125a-3p HITS-CLIP 23824327
MIRT676952 hsa-miR-764 HITS-CLIP 23824327
MIRT676951 hsa-miR-3934-5p HITS-CLIP 23824327
MIRT676950 hsa-miR-186-3p HITS-CLIP 23824327
MIRT676949 hsa-miR-150-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28 Show/Hide all (28)
GO ID Ontology Definition Evidence Reference
GO:0003376 Process Sphingosine-1-phosphate receptor signaling pathway IEA
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity TAS 10555146
GO:0005178 Function Integrin binding IPI 24851274
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601965 3167 ENSG00000213694
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99500
Protein name Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3)
Protein function Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating
PDB 7C4S , 7EW2 , 7EW3 , 7EW4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 56 → 298 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
Sequence
Sequence length 378
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Sphingolipid signaling pathway G alpha (i) signalling events
Neuroactive ligand-receptor interaction Lysosphingolipid and LPA receptors
  Extra-nuclear estrogen signaling