Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	6257
Gene name	Retinoid X receptor beta
Gene symbol	RXRB
Synonyms (NCBI Gene)	DAUDI6H-2RIIBPNR2B2RCoR-1RXR-betaRXRbeta
Chromosome	6
Chromosome location	6p21.32
Summary	This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptor

276

Show/Hide all (276)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004176	hsa-miR-197-3p	Microarray	16822819
MIRT004235	hsa-miR-346	Microarray	16822819
MIRT016771	hsa-miR-335-5p	Microarray	18185580
MIRT028819	hsa-miR-26b-5p	Microarray	19088304
MIRT051998	hsa-let-7b-5p	CLASH	23622248
MIRT049481	hsa-miR-92a-3p	CLASH	23622248
MIRT042213	hsa-miR-484	CLASH	23622248
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT488003	hsa-miR-320e	PAR-CLIP	23592263
MIRT488002	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT488001	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT488000	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487999	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT487998	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT487997	hsa-miR-3960	PAR-CLIP	23592263
MIRT487996	hsa-miR-8072	PAR-CLIP	23592263
MIRT487995	hsa-miR-6077	PAR-CLIP	23592263
MIRT487994	hsa-miR-4467	PAR-CLIP	23592263
MIRT487993	hsa-miR-3180	PAR-CLIP	23592263
MIRT487992	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT487990	hsa-miR-3196	PAR-CLIP	23592263
MIRT487991	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT487989	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT487988	hsa-miR-4488	PAR-CLIP	23592263
MIRT487987	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT487986	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT487985	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT487984	hsa-miR-4278	PAR-CLIP	23592263
MIRT455426	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT455425	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT455424	hsa-miR-4418	PAR-CLIP	23592263
MIRT455423	hsa-miR-509-3-5p	PAR-CLIP	23592263
MIRT455422	hsa-miR-509-5p	PAR-CLIP	23592263
MIRT455421	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT455420	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT455419	hsa-miR-5002-3p	PAR-CLIP	23592263
MIRT455418	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT455417	hsa-miR-298	PAR-CLIP	23592263
MIRT455416	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455414	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455415	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT455413	hsa-miR-573	PAR-CLIP	23592263
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT628659	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT610405	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT610404	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT610403	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT610402	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT004176	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610401	hsa-miR-6083	HITS-CLIP	23824327
MIRT488003	hsa-miR-320e	PAR-CLIP	23592263
MIRT488002	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT488001	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT488000	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT487999	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT487998	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT487997	hsa-miR-3960	PAR-CLIP	23592263
MIRT487996	hsa-miR-8072	PAR-CLIP	23592263
MIRT487995	hsa-miR-6077	PAR-CLIP	23592263
MIRT487994	hsa-miR-4467	PAR-CLIP	23592263
MIRT487993	hsa-miR-3180	PAR-CLIP	23592263
MIRT487992	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT487990	hsa-miR-3196	PAR-CLIP	23592263
MIRT487991	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT487989	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT487988	hsa-miR-4488	PAR-CLIP	23592263
MIRT487987	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT487986	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT487985	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT487984	hsa-miR-4278	PAR-CLIP	23592263
MIRT455426	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT455425	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT455424	hsa-miR-4418	PAR-CLIP	23592263
MIRT455423	hsa-miR-509-3-5p	PAR-CLIP	23592263
MIRT455422	hsa-miR-509-5p	PAR-CLIP	23592263
MIRT455421	hsa-miR-3158-5p	PAR-CLIP	23592263
MIRT455420	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT455419	hsa-miR-5002-3p	PAR-CLIP	23592263
MIRT455418	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT455417	hsa-miR-298	PAR-CLIP	23592263
MIRT455416	hsa-miR-3689d	PAR-CLIP	23592263
MIRT455414	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT455415	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT455413	hsa-miR-573	PAR-CLIP	23592263
MIRT1323443	hsa-miR-1225-3p	CLIP-seq
MIRT1323444	hsa-miR-1253	CLIP-seq
MIRT1323445	hsa-miR-1291	CLIP-seq
MIRT1323446	hsa-miR-146b-3p	CLIP-seq
MIRT1323447	hsa-miR-1825	CLIP-seq
MIRT1323448	hsa-miR-188-5p	CLIP-seq
MIRT1323449	hsa-miR-1910	CLIP-seq
MIRT1323450	hsa-miR-1913	CLIP-seq
MIRT1323451	hsa-miR-199a-5p	CLIP-seq
MIRT1323452	hsa-miR-199b-5p	CLIP-seq
MIRT1323453	hsa-miR-2116	CLIP-seq
MIRT1323454	hsa-miR-3151	CLIP-seq
MIRT1323455	hsa-miR-3153	CLIP-seq
MIRT1323456	hsa-miR-3173-5p	CLIP-seq
MIRT1323457	hsa-miR-324-3p	CLIP-seq
MIRT1323458	hsa-miR-339-5p	CLIP-seq
MIRT1323459	hsa-miR-3682-5p	CLIP-seq
MIRT1323460	hsa-miR-3909	CLIP-seq
MIRT1323461	hsa-miR-3919	CLIP-seq
MIRT1323462	hsa-miR-3922-5p	CLIP-seq
MIRT1323463	hsa-miR-3924	CLIP-seq
MIRT1323464	hsa-miR-3925-3p	CLIP-seq
MIRT1323465	hsa-miR-4268	CLIP-seq
MIRT1323466	hsa-miR-4302	CLIP-seq
MIRT1323467	hsa-miR-432	CLIP-seq
MIRT1323468	hsa-miR-4323	CLIP-seq
MIRT1323469	hsa-miR-4443	CLIP-seq
MIRT1323470	hsa-miR-4447	CLIP-seq
MIRT1323471	hsa-miR-4448	CLIP-seq
MIRT1323472	hsa-miR-4472	CLIP-seq
MIRT1323473	hsa-miR-450b-3p	CLIP-seq
MIRT1323474	hsa-miR-4671-5p	CLIP-seq
MIRT1323475	hsa-miR-4677-5p	CLIP-seq
MIRT1323476	hsa-miR-4691-5p	CLIP-seq
MIRT1323477	hsa-miR-4712-3p	CLIP-seq
MIRT1323478	hsa-miR-4717-5p	CLIP-seq
MIRT1323479	hsa-miR-4727-5p	CLIP-seq
MIRT1323480	hsa-miR-4753-5p	CLIP-seq
MIRT1323481	hsa-miR-4756-3p	CLIP-seq
MIRT1323482	hsa-miR-4764-5p	CLIP-seq
MIRT1323483	hsa-miR-4775	CLIP-seq
MIRT1323484	hsa-miR-4780	CLIP-seq
MIRT1323485	hsa-miR-486-5p	CLIP-seq
MIRT1323486	hsa-miR-488	CLIP-seq
MIRT1323487	hsa-miR-491-5p	CLIP-seq
MIRT1323488	hsa-miR-513a-5p	CLIP-seq
MIRT1323489	hsa-miR-623	CLIP-seq
MIRT1323490	hsa-miR-629	CLIP-seq
MIRT1323491	hsa-miR-659	CLIP-seq
MIRT1323492	hsa-miR-769-3p	CLIP-seq
MIRT1323493	hsa-miR-874	CLIP-seq
MIRT2096030	hsa-miR-101	CLIP-seq
MIRT2096031	hsa-miR-144	CLIP-seq
MIRT2096032	hsa-miR-2276	CLIP-seq
MIRT1323459	hsa-miR-3682-5p	CLIP-seq
MIRT2096033	hsa-miR-4747-5p	CLIP-seq
MIRT2096034	hsa-miR-627	CLIP-seq
MIRT2096035	hsa-miR-924	CLIP-seq
MIRT2096030	hsa-miR-101	CLIP-seq
MIRT2320319	hsa-miR-1226	CLIP-seq
MIRT2320320	hsa-miR-1256	CLIP-seq
MIRT2096031	hsa-miR-144	CLIP-seq
MIRT1323450	hsa-miR-1913	CLIP-seq
MIRT2320321	hsa-miR-1915	CLIP-seq
MIRT2320322	hsa-miR-197	CLIP-seq
MIRT2320323	hsa-miR-3127-5p	CLIP-seq
MIRT2320324	hsa-miR-3135b	CLIP-seq
MIRT2320325	hsa-miR-3150b-3p	CLIP-seq
MIRT1323455	hsa-miR-3153	CLIP-seq
MIRT1323457	hsa-miR-324-3p	CLIP-seq
MIRT2320326	hsa-miR-3652	CLIP-seq
MIRT1323459	hsa-miR-3682-5p	CLIP-seq
MIRT2320327	hsa-miR-3689a-3p	CLIP-seq
MIRT2320328	hsa-miR-3689c	CLIP-seq
MIRT2320329	hsa-miR-3918	CLIP-seq
MIRT2320330	hsa-miR-412	CLIP-seq
MIRT2320331	hsa-miR-4313	CLIP-seq
MIRT2320332	hsa-miR-4430	CLIP-seq
MIRT2320333	hsa-miR-4446-3p	CLIP-seq
MIRT2320334	hsa-miR-4453	CLIP-seq
MIRT2320335	hsa-miR-4476	CLIP-seq
MIRT2320336	hsa-miR-4492	CLIP-seq
MIRT2320337	hsa-miR-4493	CLIP-seq
MIRT2320338	hsa-miR-4498	CLIP-seq
MIRT2320339	hsa-miR-4538	CLIP-seq
MIRT2320340	hsa-miR-455-5p	CLIP-seq
MIRT2320341	hsa-miR-4646-5p	CLIP-seq
MIRT2320342	hsa-miR-4668-5p	CLIP-seq
MIRT2320343	hsa-miR-4685-5p	CLIP-seq
MIRT2320344	hsa-miR-4714-3p	CLIP-seq
MIRT2320345	hsa-miR-4720-5p	CLIP-seq
MIRT2320346	hsa-miR-4728-5p	CLIP-seq
MIRT2320347	hsa-miR-4763-5p	CLIP-seq
MIRT2320348	hsa-miR-4784	CLIP-seq
MIRT2320349	hsa-miR-4799-3p	CLIP-seq
MIRT2320350	hsa-miR-490-3p	CLIP-seq
MIRT2320351	hsa-miR-548k	CLIP-seq
MIRT2320352	hsa-miR-762	CLIP-seq
MIRT2320353	hsa-miR-765	CLIP-seq
MIRT1323450	hsa-miR-1913	CLIP-seq
MIRT2320321	hsa-miR-1915	CLIP-seq
MIRT1323457	hsa-miR-324-3p	CLIP-seq
MIRT2320343	hsa-miR-4685-5p	CLIP-seq
MIRT2320322	hsa-miR-197	CLIP-seq
MIRT2320330	hsa-miR-412	CLIP-seq

Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	12767074
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12767074
GO:0001701	Process	In utero embryonic development	IEA
GO:0001893	Process	Maternal placenta development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003707	Function	Nuclear steroid receptor activity	IEA
GO:0004879	Function	Nuclear receptor activity	IBA
GO:0004879	Function	Nuclear receptor activity	IDA	1662118, 7990953
GO:0005515	Function	Protein binding	IPI	16189514, 20195357, 20211142, 21988832, 25303530, 25416956, 25609649, 26871637, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	7990953
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007399	Process	Nervous system development	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009755	Process	Hormone-mediated signaling pathway	ISS
GO:0009755	Process	Hormone-mediated signaling pathway	NAS	27011007
GO:0030154	Process	Cell differentiation	IBA
GO:0030501	Process	Positive regulation of bone mineralization	NAS	27184385
GO:0030518	Process	Nuclear receptor-mediated steroid hormone signaling pathway	IEA
GO:0031490	Function	Chromatin DNA binding	IEA
GO:0042789	Process	MRNA transcription by RNA polymerase II	ISS
GO:0042789	Process	MRNA transcription by RNA polymerase II	NAS	27011007
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044323	Function	Retinoic acid-responsive element binding	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	1662118
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12767074
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	NAS	27011007
GO:0046872	Function	Metal ion binding	IEA
GO:0048384	Process	Retinoic acid receptor signaling pathway	IBA
GO:0055012	Process	Ventricular cardiac muscle cell differentiation	IEA
GO:0060038	Process	Cardiac muscle cell proliferation	IEA
GO:0070564	Process	Positive regulation of vitamin D receptor signaling pathway	ISS
GO:0071300	Process	Cellular response to retinoic acid	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IPI	25416956, 27011007
GO:0090575	Component	RNA polymerase II transcription regulator complex	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
180246	10478	ENSG00000204231

P28702

Protein name

Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)

Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR

PDB

1H9U , 1UHL , 5HJP , 5I4V , 5KYA , 5KYJ , 7A78

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00105	zf-C4	203 → 272	Zinc finger, C4 type (two domains)	Domain
PF00104	Hormone_recep	331 → 513	Ligand-binding domain of nuclear hormone receptor	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in aortic endothelial cells (at protein level) (PubMed:28167758). Expressed in monocytes (PubMed:26463675). Expressed in a variety of tumor cell lines. {ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|Pu

Sequence

MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA

Sequence length

533

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RXRB-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (47)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthropathy	Arthropathy	BEFREE	30779748		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bile Duct Neoplasms	Bile duct neoplasms	Pubtator	18375961	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	12767074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	22322885		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	8384307	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	12514092	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Embryonal	Embryonal carcinoma	Pubtator	1736309	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	11092983	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	17389020		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	29098164	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Follicular adenoma	Adenoma	BEFREE	23639973		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallstones	Gallstones	Pubtator	18375961	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Granulomatosis with polyangiitis	Granulomatosis With Polyangiitis	BEFREE	16526951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Granulomatosis with Polyangiitis	Granulomatosis with polyangiitis	Pubtator	16526951, 19811264	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	29928977	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	24322297		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	11839661		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	19961602	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	21148756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	21148756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	12767074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	22322885		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	24322297		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29515775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	22322885		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	22322885		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	22322885		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	9228081	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	24322297	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	11591367	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	12767074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	19217805	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	16012182	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	29169171	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pauci-immune Glomerulonephritis associated with Granulomatosis with Polyangiitis	Granulomatosis with polyangiitis	BEFREE	16526951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Kidney Autosomal Recessive	Polycystic kidney disease	Pubtator	11092983	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	12514092		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	12514092	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Sarcoidosis	Pubtator	16526951	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	11840500, 27992436		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Systemic Scleroderma	Scleroderma	BEFREE	28506627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	23639973		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Diseases	Thyroid Diseases	BEFREE	19155317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vasculitis	Vasculitis	BEFREE	19811264		★★★★★ ★☆☆☆☆ Found in Text Mining only

RXRB (retinoid X receptor beta)