RRP1 (ribosomal RNA processing 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8568
• Gene name: Ribosomal RNA processing 1
• Gene symbol: RRP1
• Synonyms (NCBI Gene): D21S2056E, NNP-1, NOP52, RRP1A
• Chromosome: 21
• Chromosome location: 21q22.3
• Summary: The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. [

miRNA Show/Hide all (47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045681	hsa-miR-149-5p	CLASH	23622248
MIRT042587	hsa-miR-423-3p	CLASH	23622248
MIRT040667	hsa-miR-92b-3p	CLASH	23622248
MIRT040457	hsa-miR-615-3p	CLASH	23622248
MIRT1320202	hsa-miR-145	CLIP-seq
MIRT1320203	hsa-miR-192	CLIP-seq
MIRT1320204	hsa-miR-2110	CLIP-seq
MIRT1320205	hsa-miR-215	CLIP-seq
MIRT1320206	hsa-miR-2467-5p	CLIP-seq
MIRT1320207	hsa-miR-3153	CLIP-seq
MIRT1320208	hsa-miR-326	CLIP-seq
MIRT1320209	hsa-miR-330-5p	CLIP-seq
MIRT1320210	hsa-miR-3937	CLIP-seq
MIRT1320211	hsa-miR-3974	CLIP-seq
MIRT1320212	hsa-miR-4271	CLIP-seq
MIRT1320213	hsa-miR-4667-5p	CLIP-seq
MIRT1320214	hsa-miR-4691-3p	CLIP-seq
MIRT1320215	hsa-miR-4700-5p	CLIP-seq
MIRT1320216	hsa-miR-4725-3p	CLIP-seq
MIRT1320217	hsa-miR-622	CLIP-seq
MIRT1320218	hsa-miR-637	CLIP-seq
MIRT1320219	hsa-miR-658	CLIP-seq
MIRT1320220	hsa-miR-760	CLIP-seq
MIRT1920881	hsa-miR-3136-3p	CLIP-seq
MIRT1320211	hsa-miR-3974	CLIP-seq
MIRT1320214	hsa-miR-4691-3p	CLIP-seq
MIRT1920881	hsa-miR-3136-3p	CLIP-seq
MIRT1320211	hsa-miR-3974	CLIP-seq
MIRT1320214	hsa-miR-4691-3p	CLIP-seq
MIRT2319442	hsa-miR-1909	CLIP-seq
MIRT2319443	hsa-miR-214	CLIP-seq
MIRT2319444	hsa-miR-3619-5p	CLIP-seq
MIRT2319445	hsa-miR-761	CLIP-seq
MIRT2615209	hsa-miR-1470	CLIP-seq
MIRT2615210	hsa-miR-1538	CLIP-seq
MIRT2615211	hsa-miR-3189-3p	CLIP-seq
MIRT2615212	hsa-miR-328	CLIP-seq
MIRT2615213	hsa-miR-4469	CLIP-seq
MIRT2615214	hsa-miR-4667-3p	CLIP-seq
MIRT2615215	hsa-miR-4745-3p	CLIP-seq
MIRT2615209	hsa-miR-1470	CLIP-seq
MIRT2615210	hsa-miR-1538	CLIP-seq
MIRT2615211	hsa-miR-3189-3p	CLIP-seq
MIRT2615212	hsa-miR-328	CLIP-seq
MIRT2615213	hsa-miR-4469	CLIP-seq
MIRT2615214	hsa-miR-4667-3p	CLIP-seq
MIRT2615215	hsa-miR-4745-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	20926688, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9192856
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	HDA	16780588
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0030688	Component	Preribosome, small subunit precursor	IEA

Other IDs

• MIM: 610653
• HGNC: 18785
• e!Ensembl: ENSG00000160214

Protein

• UniProt ID: P56182
• Protein name: Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein)
• Protein function: Plays a critical role in the generation of 28S rRNA.
• PDB: 8FKP , 8FKR , 8FKT , 8FKV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05997	Nop52	11 → 219	Nucleolar protein,Nop52	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed in fetal and adult tissues. {ECO:0000269|PubMed:9192856}.
• Sequence:

  MVSRVQLPPEIQLAQRLAGNEQVTRDRAVRKLRKYIVARTQRAAGGFTHDELLKVWKGLF
  YCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMNREWTGIDRLRLDKFYM
  LMRMVLNESLKVLKMQGWEERQIEELLELLMTEILHPSSQAPNGVKSHFIEIFLEELTKV
  GAEELTADQNLKFIDPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQD
  EEVASDSDESSEGGERGDALSQKRSEKPPAGSICRAEPEAGEEQAGDDRDSGGPVLQFDY
  EAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEIPEKACRRLLEGRRQKK
  TKKQKRLLRLQQERGKGEKEPPSPGMERKRSRRRGVGADPEARAEAGEQPGTAERALLRD
  QPRGRGQRGARQRRRTPRPLTSARAKAANVQEPEKKKKRRE

• Sequence length: 461

Pathways

Reactome Pathway:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Breast ductal adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for RRP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RRP1.