Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6204
Gene name	Ribosomal protein S10
Gene symbol	RPS10
Synonyms (NCBI Gene)	DBA9S10eS10
Chromosome	6
Chromosome location	6p21.31
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052450	hsa-let-7a-5p	CLASH	23622248
MIRT050485	hsa-miR-20a-5p	CLASH	23622248
MIRT049763	hsa-miR-92a-3p	CLASH	23622248
MIRT044184	hsa-miR-99b-5p	CLASH	23622248
MIRT041658	hsa-miR-484	CLASH	23622248
MIRT041658	hsa-miR-484	CLASH	23622248
MIRT041482	hsa-miR-193b-3p	CLASH	23622248
MIRT039432	hsa-miR-421	CLASH	23622248
MIRT038039	hsa-miR-423-5p	CLASH	23622248
MIRT036090	hsa-miR-1296-5p	CLASH	23622248
MIRT052799	hsa-miR-3176	CLASH	23622248
MIRT1317623	hsa-miR-129-5p	CLIP-seq
MIRT1317624	hsa-miR-186	CLIP-seq
MIRT1317625	hsa-miR-3183	CLIP-seq
MIRT1317626	hsa-miR-4272	CLIP-seq
MIRT1317627	hsa-miR-4687-3p	CLIP-seq
MIRT1317628	hsa-miR-4723-3p	CLIP-seq
MIRT1317629	hsa-miR-515-5p	CLIP-seq
MIRT1317630	hsa-miR-647	CLIP-seq
MIRT1317626	hsa-miR-4272	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	20159986, 28065601, 28132843, 30021884, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	20159986
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	NAS	7772601
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0016020	Component	Membrane	HDA	19946888
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0045202	Component	Synapse	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603632	10383	ENSG00000124614

P46783

Protein name

Small ribosomal subunit protein eS10 (40S ribosomal protein S10)

Protein function

Component of the 40S ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH , 6ZVJ , 6ZXD , 6ZXE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03501	S10_plectin	3 → 98	Plectin/S10 domain	Domain

Sequence

MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKE
QFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRG
EADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ

Sequence length

165

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Translation initiation complex formation
	Formation of a pool of free 40S subunits
	Formation of the ternary complex, and subsequently, the 43S complex
	Ribosomal scanning and start codon recognition
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diamond-Blackfan anemia	Pathogenic; Likely pathogenic	rs2113806114, rs2533030608, rs267607022, rs1581931439, rs1765648528	RCV001381292 RCV002428903 RCV001851701 RCV000809206 RCV001035752	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Diamond-Blackfan anemia 9	Pathogenic	rs2533030608, rs267607021, rs1581931541, rs267607022	RCV005252150 RCV000006562 RCV000006563 RCV000006564	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
RPS10-related disorder	Likely pathogenic	rs2533019856	RCV003400021	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANEMIA, DIAMOND-BLACKFAN	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	35819321	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	40465716	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (23)
Aase Smith syndrome 2	Aase-Smith syndrome	GENOMICS_ENGLAND_DG	22863883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acne	Acne	BEFREE	28218057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	30040709	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Diamond-Blackfan	Anemia	BEFREE	20116044, 21435509, 22510774		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Diamond-Blackfan	Anemia	GENOMICS_ENGLAND_DG	20116044, 22863883, 23718193, 28297620		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Macrocytic	Anemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	27089054		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blackfan-Diamond anemia	Blackfan-Diamond Anemia	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Diamond-Blackfan Anemia 9	Diamond-Blackfan anemia	CLINGEN_DG	20116044, 22510774, 22863883, 22939629, 25946618		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Diamond-Blackfan Anemia 9	Diamond-Blackfan anemia	GENOMICS_ENGLAND_DG	20116044, 22863883, 23718193		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Diamond-Blackfan Anemia 9	Diamond-Blackfan anemia	CTD_human_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Diamond-Blackfan Anemia 9	Diamond-Blackfan anemia	CLINVAR_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	30206415	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	16820872		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30389140		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	30040709	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26449484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcopenia	Sarcopenia	Pubtator	35241739	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	19034380		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RPS19	1	["Diamond-blackfan anemia"]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	8	["Disgenet (Diamond-blackfan anemia)","CTD (Diamond-blackfan anemia)","GWAS catalog (Diamond-blackfan anemia)","Orphanet (Diamond-blackfan anemia)","ClinGen (Diamond-blackfan anemia)","GenCC (Diamond-blackfan anemia)","ClinVar (Diamond-blackfan anemia)","HPO (Diamond-blackfan anemia)"]
RPS17	1	["Diamond-blackfan anemia"]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	7	["Disgenet (Diamond-blackfan anemia)","CTD (Diamond-blackfan anemia)","GWAS catalog (Diamond-blackfan anemia)","Orphanet (Diamond-blackfan anemia)","GenCC (Diamond-blackfan anemia)","ClinVar (Diamond-blackfan anemia)","HPO (Diamond-blackfan anemia)"]
RPS24	1	["Diamond-blackfan anemia"]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	7	["Disgenet (Diamond-blackfan anemia)","CTD (Diamond-blackfan anemia)","Orphanet (Diamond-blackfan anemia)","ClinGen (Diamond-blackfan anemia)","GenCC (Diamond-blackfan anemia)","ClinVar (Diamond-blackfan anemia)","HPO (Diamond-blackfan anemia)"]
RPS28	1	["Diamond-blackfan anemia"]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	6	["Disgenet (Diamond-blackfan anemia)","CTD (Diamond-blackfan anemia)","GWAS catalog (Diamond-blackfan anemia)","Orphanet (Diamond-blackfan anemia)","ClinVar (Diamond-blackfan anemia)","HPO (Diamond-blackfan anemia)"]
RPS29	1	["Diamond-blackfan anemia"]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	6	["Disgenet (Diamond-blackfan anemia)","CTD (Diamond-blackfan anemia)","GWAS catalog (Diamond-blackfan anemia)","Orphanet (Diamond-blackfan anemia)","ClinVar (Diamond-blackfan anemia)","HPO (Diamond-blackfan anemia)"]

RPS10 (ribosomal protein S10)

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