RPL6 (ribosomal protein L6)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6128
• Gene name: Ribosomal protein L6
• Gene symbol: RPL6
• Synonyms (NCBI Gene): L6, SHUJUN-2, TAXREB107, TXREB1, eL6
• Chromosome: 12
• Chromosome location: 12q24.13
• Summary: This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcr

miRNA Show/Hide all (20)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030194	hsa-miR-26b-5p	Microarray	19088304
MIRT032025	hsa-miR-16-5p	Proteomics	18668040
MIRT1316993	hsa-miR-208a	CLIP-seq
MIRT1316994	hsa-miR-208b	CLIP-seq
MIRT1316995	hsa-miR-2116	CLIP-seq
MIRT1316996	hsa-miR-3617	CLIP-seq
MIRT1316997	hsa-miR-499-5p	CLIP-seq
MIRT1316998	hsa-miR-641	CLIP-seq
MIRT1316993	hsa-miR-208a	CLIP-seq
MIRT1316994	hsa-miR-208b	CLIP-seq
MIRT1316995	hsa-miR-2116	CLIP-seq
MIRT1316996	hsa-miR-3617	CLIP-seq
MIRT1316997	hsa-miR-499-5p	CLIP-seq
MIRT1316998	hsa-miR-641	CLIP-seq
MIRT1316993	hsa-miR-208a	CLIP-seq
MIRT1316994	hsa-miR-208b	CLIP-seq
MIRT1316995	hsa-miR-2116	CLIP-seq
MIRT1316996	hsa-miR-3617	CLIP-seq
MIRT1316997	hsa-miR-499-5p	CLIP-seq
MIRT1316998	hsa-miR-641	CLIP-seq

Gene ontology (GO) Show/Hide all (42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003677	Function	DNA binding	TAS	8457378
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	TAS	8479925
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8479925
GO:0005515	Function	Protein binding	IPI	14743216, 31980649
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005791	Component	Rough endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	8457378
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8479925
GO:0014069	Component	Postsynaptic density	IEA
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	8479925
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA	15121898
GO:0045202	Component	Synapse	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 603703
• HGNC: 10362
• e!Ensembl: ENSG00000089009

Protein

• UniProt ID: Q02878
• Protein name: Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107)
• Protein function: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962
• PDB: 4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01159	Ribosomal_L6e	181 → 288	Ribosomal protein L6e	Family
  PF03868	Ribosomal_L6e_N	36 → 95	Ribosomal protein L6, N-terminal domain	Domain

• Sequence:

  MAGEKVEKPDTKEKKPEAKKVDAGGKVKKGNLKAKKPKKGKPHCSRNPVLVRGIGRYSRS
  AMYSRKAMYKRKYSAAKSKVEKKKKEKVLATVTKPVGGDKNGGTRVVKLRKMPRYYPTED
  VPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRVVFLKQLASGLLLVTGPLV
  LNRVPLRRTHQKFVIATSTKIDISNVKIPKHLTDAYFKKKKLRKPRHQEGEIFDTEKEKY
  EITEQRKIDQKAVDSQILPKIKAIPQLQGYLRSVFALTNGIYPHKLVF

• Sequence length: 288

Pathways

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (7)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	39998322	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	CTD	12376462	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEOPARD SYNDROME 1	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NOONAN SYNDROME 1	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	CTD, Disgenet CTD, Disgenet	18353766	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	38763176	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	33667223	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (21)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	35766008, 38176923	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anaplastic carcinoma	Anaplastic Carcinoma	CTD_human_DG	12376462		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	37919065	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	CTD_human_DG	12376462		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma, Spindle-Cell	Carcinoma	CTD_human_DG	12376462		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Darier Disease	Darier disease	Pubtator	9529352	Associate	★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	31487418		★☆☆☆☆ Found in Text Mining only
Hemoglobinuria Paroxysmal	Hemoglobinuria paroxysmal	Pubtator	11823033	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	31487418		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	22043320, 31565098		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	23077530	Associate	★☆☆☆☆ Found in Text Mining only
Noonan Syndrome	Noonan Syndrome	BEFREE	11043511		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	CTD_human_DG	18353766		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Paroxysmal nocturnal hemoglobinuria	Paroxysmal nocturnal hemoglobinuria	BEFREE	11823033		★☆☆☆☆ Found in Text Mining only
Penile Neoplasms	Penile neoplasm	Pubtator	23341933	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	22043320, 31565098		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	12678981		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	15846068, 22043320	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31565098	Inhibit	★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	CTD_human_DG	12376462		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MKRN2 2 shared diseasesLeopard syndrome, Noonan syndrome 2 shared evidence sourcesDisgenet (Leopard syndrome), Disgenet (Noonan syndrome) Related via 2 shared diseases including Leopard syndrome, Noonan syndrome — evidence mostly Disgenet. RPL23A 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2 shared evidence sourcesDisgenet (Parkinson disease), CTD (Parkinson disease) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19 — evidence mostly Disgenet. RPL14 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2 shared evidence sourcesDisgenet (Parkinson disease), CTD (Parkinson disease) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19 — evidence mostly Disgenet. RPS8 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2 shared evidence sourcesDisgenet (Parkinson disease), CTD (Parkinson disease) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19 — evidence mostly Disgenet. RPL3 1 shared diseaseCarcinoma 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1 shared evidence sourceCTD (Carcinoma) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19 — evidence mostly CTD.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MKRN2	2	["Leopard syndrome","Noonan syndrome"]	0	[]	2	["Disgenet (Leopard syndrome)","Disgenet (Noonan syndrome)"]
RPL23A	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	2	["Disgenet (Parkinson disease)","CTD (Parkinson disease)"]
RPL14	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	2	["Disgenet (Parkinson disease)","CTD (Parkinson disease)"]
RPS8	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	2	["Disgenet (Parkinson disease)","CTD (Parkinson disease)"]
RPL3	1	["Carcinoma"]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	1	["CTD (Carcinoma)"]

Diseases Linked via Similar Genes

Breast neoplasms Linked via 2 of 5 related genesRPL23A, RPS8 Systemic lupus erythematosus Linked via 2 of 5 related genesRPL14, RPL3 Gout Linked via 1 of 5 related genesMKRN2 Renal cell carcinoma Linked via 1 of 5 related genesRPL14 Ankylosing spondylitis Linked via 1 of 5 related genesRPL3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Breast neoplasms	2	["RPL23A","RPS8"]
Systemic lupus erythematosus	2	["RPL14","RPL3"]
Gout	1	["MKRN2"]
Renal cell carcinoma	1	["RPL14"]
Ankylosing spondylitis	1	["RPL3"]