Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6124
Gene name	Ribosomal protein L4
Gene symbol	RPL4
Synonyms (NCBI Gene)	L4uL4
Chromosome	15
Chromosome location	15q22.31
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

91 Show/Hide all (91)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031387	hsa-miR-16-5p	Proteomics	18668040
MIRT052435	hsa-let-7a-5p	CLASH	23622248
MIRT045063	hsa-miR-186-5p	CLASH	23622248
MIRT042914	hsa-miR-324-3p	CLASH	23622248
MIRT042484	hsa-miR-423-3p	CLASH	23622248
MIRT042484	hsa-miR-423-3p	CLASH	23622248
MIRT039546	hsa-miR-652-3p	CLASH	23622248
MIRT039230	hsa-miR-454-3p	CLASH	23622248
MIRT038237	hsa-miR-330-5p	CLASH	23622248
MIRT037542	hsa-miR-744-5p	CLASH	23622248
MIRT036248	hsa-miR-1237-3p	CLASH	23622248
MIRT035943	hsa-miR-1180-3p	CLASH	23622248
MIRT052730	hsa-miR-1260b	CLASH	23622248
MIRT518014	hsa-miR-562	PAR-CLIP	21572407
MIRT518013	hsa-miR-4438	PAR-CLIP	21572407
MIRT518012	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT518011	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT518010	hsa-miR-5697	PAR-CLIP	21572407
MIRT518009	hsa-miR-3691-3p	PAR-CLIP	21572407
MIRT551472	hsa-miR-5695	PAR-CLIP	21572407
MIRT518008	hsa-miR-7155-5p	PAR-CLIP	21572407
MIRT518007	hsa-miR-767-5p	PAR-CLIP	21572407
MIRT518005	hsa-miR-4731-5p	PAR-CLIP	21572407
MIRT518006	hsa-miR-193b-5p	PAR-CLIP	21572407
MIRT518003	hsa-miR-5095	PAR-CLIP	21572407
MIRT518004	hsa-miR-7151-3p	PAR-CLIP	21572407
MIRT518002	hsa-miR-3170	PAR-CLIP	21572407
MIRT518001	hsa-miR-6855-5p	PAR-CLIP	21572407
MIRT518014	hsa-miR-562	PAR-CLIP	23446348
MIRT518013	hsa-miR-4438	PAR-CLIP	23446348
MIRT518012	hsa-miR-501-3p	PAR-CLIP	23446348
MIRT518011	hsa-miR-502-3p	PAR-CLIP	23446348
MIRT518010	hsa-miR-5697	PAR-CLIP	23446348
MIRT518009	hsa-miR-3691-3p	PAR-CLIP	23446348
MIRT518008	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT518007	hsa-miR-767-5p	PAR-CLIP	23446348
MIRT518005	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT518006	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT518003	hsa-miR-5095	PAR-CLIP	23446348
MIRT518004	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT518002	hsa-miR-3170	PAR-CLIP	23446348
MIRT518001	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT518014	hsa-miR-562	PAR-CLIP	21572407
MIRT518013	hsa-miR-4438	PAR-CLIP	21572407
MIRT518012	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT518011	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT518010	hsa-miR-5697	PAR-CLIP	21572407
MIRT518009	hsa-miR-3691-3p	PAR-CLIP	21572407
MIRT551472	hsa-miR-5695	PAR-CLIP	21572407
MIRT518008	hsa-miR-7155-5p	PAR-CLIP	21572407
MIRT518007	hsa-miR-767-5p	PAR-CLIP	21572407
MIRT518005	hsa-miR-4731-5p	PAR-CLIP	21572407
MIRT518006	hsa-miR-193b-5p	PAR-CLIP	21572407
MIRT518003	hsa-miR-5095	PAR-CLIP	21572407
MIRT518004	hsa-miR-7151-3p	PAR-CLIP	21572407
MIRT518002	hsa-miR-3170	PAR-CLIP	21572407
MIRT518001	hsa-miR-6855-5p	PAR-CLIP	21572407
MIRT518014	hsa-miR-562	PAR-CLIP	23446348
MIRT518013	hsa-miR-4438	PAR-CLIP	23446348
MIRT518012	hsa-miR-501-3p	PAR-CLIP	23446348
MIRT518011	hsa-miR-502-3p	PAR-CLIP	23446348
MIRT518010	hsa-miR-5697	PAR-CLIP	23446348
MIRT518009	hsa-miR-3691-3p	PAR-CLIP	23446348
MIRT518008	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT518007	hsa-miR-767-5p	PAR-CLIP	23446348
MIRT518005	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT518006	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT518003	hsa-miR-5095	PAR-CLIP	23446348
MIRT518004	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT518002	hsa-miR-3170	PAR-CLIP	23446348
MIRT518001	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT1316984	hsa-miR-1229	CLIP-seq
MIRT1316985	hsa-miR-192	CLIP-seq
MIRT1316986	hsa-miR-215	CLIP-seq
MIRT1316987	hsa-miR-3658	CLIP-seq
MIRT1316988	hsa-miR-3662	CLIP-seq
MIRT1316989	hsa-miR-3688-3p	CLIP-seq
MIRT1316990	hsa-miR-4272	CLIP-seq
MIRT1316991	hsa-miR-4698	CLIP-seq
MIRT1316992	hsa-miR-568	CLIP-seq
MIRT1316988	hsa-miR-3662	CLIP-seq
MIRT1316989	hsa-miR-3688-3p	CLIP-seq
MIRT1316991	hsa-miR-4698	CLIP-seq
MIRT1316988	hsa-miR-3662	CLIP-seq
MIRT1316990	hsa-miR-4272	CLIP-seq
MIRT1316991	hsa-miR-4698	CLIP-seq
MIRT1316992	hsa-miR-568	CLIP-seq
MIRT1316988	hsa-miR-3662	CLIP-seq
MIRT1316990	hsa-miR-4272	CLIP-seq
MIRT1316991	hsa-miR-4698	CLIP-seq
MIRT1316992	hsa-miR-568	CLIP-seq

39 Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	TAS	8268230
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8268230
GO:0005515	Function	Protein binding	IPI	14743216, 22720776, 23275563, 24454821, 24965446, 25866880, 28514442, 30021884, 31980649, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	22720776
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005791	Component	Rough endoplasmic reticulum	IDA	24454821
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8268230
GO:0016020	Component	Membrane	HDA	19946888
GO:0016604	Component	Nuclear body	IDA
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	8268230
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
180479	10353	ENSG00000174444

P36578

Protein name

Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4)

Protein function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

PDB

4UG0 , 4V6X , 5A8L , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00573	Ribosomal_L4	22 → 263	Ribosomal protein L4/L1 family	Family
PF14374	Ribos_L4_asso_C	275 → 349	60S ribosomal protein L4 C-terminal domain	Domain

Sequence

MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTT
EEKKPAA

Sequence length

427

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Exstrophy-epispadias complex	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OMPHALOCELE EXSTROPHY IMPERFORATE ANUS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEPSIS	—	CTD, Disgenet CTD, Disgenet	27978524	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (10)
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	32358373	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholecystolithiasis	Cholecystolithiasis	BEFREE	16454670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholelithiasis	Cholelithiasis	BEFREE	16454670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Infertility Male	Male infertility	Pubtator	36369953	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31545291		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhinitis Allergic	Rhinitis	Pubtator	23472126	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	27978524		★★★★★ ★☆☆☆☆ Found in Text Mining only
Shwachman syndrome	Shwachman Syndrome	BEFREE	19602484		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	32358373	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RPL9	1	["Sepsis"]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	2	["CTD (Sepsis)","Disgenet (Sepsis)"]
RPL35	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]
RPL10L	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]
RPL22L1	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]
RPL13A	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]

RPL4 (ribosomal protein L4)

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