ROMO1 (reactive oxygen species modulator 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 140823
• Gene name: Reactive oxygen species modulator 1
• Gene symbol: ROMO1
• Synonyms (NCBI Gene): C20orf52, MTGM, MTGMP, bA353C18.2
• Chromosome: 20
• Chromosome location: 20q11.22
• Summary: The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial me

miRNA Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT637197	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT637196	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT637195	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT637194	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT637193	hsa-miR-3666	HITS-CLIP	23824327
MIRT637192	hsa-miR-4295	HITS-CLIP	23824327
MIRT637191	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT637190	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637189	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637188	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637187	hsa-miR-3652	HITS-CLIP	23824327
MIRT637186	hsa-miR-4430	HITS-CLIP	23824327
MIRT637185	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT637197	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT637196	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT637195	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT637194	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT637193	hsa-miR-3666	HITS-CLIP	23824327
MIRT637192	hsa-miR-4295	HITS-CLIP	23824327
MIRT637191	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT637190	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637189	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637188	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637187	hsa-miR-3652	HITS-CLIP	23824327
MIRT637186	hsa-miR-4430	HITS-CLIP	23824327
MIRT637185	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT637197	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT637196	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT637195	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT637194	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT637193	hsa-miR-3666	HITS-CLIP	23824327
MIRT637192	hsa-miR-4295	HITS-CLIP	23824327
MIRT637191	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT637190	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637189	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637188	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637187	hsa-miR-3652	HITS-CLIP	23824327
MIRT637186	hsa-miR-4430	HITS-CLIP	23824327
MIRT637185	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT637185	hsa-miR-106a-3p	PAR-CLIP	27292025
MIRT637197	hsa-miR-130a-3p	PAR-CLIP	27292025
MIRT637196	hsa-miR-130b-3p	PAR-CLIP	27292025
MIRT637195	hsa-miR-301a-3p	PAR-CLIP	27292025
MIRT637194	hsa-miR-301b-3p	PAR-CLIP	27292025
MIRT637193	hsa-miR-3666	PAR-CLIP	27292025
MIRT637192	hsa-miR-4295	PAR-CLIP	27292025
MIRT637191	hsa-miR-454-3p	PAR-CLIP	27292025
MIRT637197	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT637196	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT637195	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT637194	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT637193	hsa-miR-3666	HITS-CLIP	23824327
MIRT637192	hsa-miR-4295	HITS-CLIP	23824327
MIRT637191	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT637190	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637189	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637188	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637187	hsa-miR-3652	HITS-CLIP	23824327
MIRT637186	hsa-miR-4430	HITS-CLIP	23824327
MIRT637185	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT637197	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT637196	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT637195	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT637194	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT637193	hsa-miR-3666	HITS-CLIP	23824327
MIRT637192	hsa-miR-4295	HITS-CLIP	23824327
MIRT637191	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT637190	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637189	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637188	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637187	hsa-miR-3652	HITS-CLIP	23824327
MIRT637186	hsa-miR-4430	HITS-CLIP	23824327
MIRT637185	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT637197	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT637196	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT637195	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT637194	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT637193	hsa-miR-3666	HITS-CLIP	23824327
MIRT637192	hsa-miR-4295	HITS-CLIP	23824327
MIRT637191	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT637190	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637189	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637188	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637187	hsa-miR-3652	HITS-CLIP	23824327
MIRT637186	hsa-miR-4430	HITS-CLIP	23824327
MIRT637185	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT1315108	hsa-miR-1587	CLIP-seq
MIRT1315109	hsa-miR-182	CLIP-seq
MIRT1315110	hsa-miR-3202	CLIP-seq
MIRT1315111	hsa-miR-4259	CLIP-seq
MIRT1315112	hsa-miR-4475	CLIP-seq
MIRT1315113	hsa-miR-4492	CLIP-seq
MIRT1315114	hsa-miR-4498	CLIP-seq
MIRT1315115	hsa-miR-4505	CLIP-seq
MIRT1315116	hsa-miR-4656	CLIP-seq
MIRT1315117	hsa-miR-4675	CLIP-seq
MIRT1315118	hsa-miR-4703-3p	CLIP-seq
MIRT1315119	hsa-miR-4715-5p	CLIP-seq
MIRT1315120	hsa-miR-4741	CLIP-seq
MIRT1315121	hsa-miR-4747-5p	CLIP-seq
MIRT1315122	hsa-miR-4802-3p	CLIP-seq
MIRT1315123	hsa-miR-762	CLIP-seq
MIRT1315108	hsa-miR-1587	CLIP-seq
MIRT1315109	hsa-miR-182	CLIP-seq
MIRT1315110	hsa-miR-3202	CLIP-seq
MIRT1315111	hsa-miR-4259	CLIP-seq
MIRT1315112	hsa-miR-4475	CLIP-seq
MIRT1315113	hsa-miR-4492	CLIP-seq
MIRT1315114	hsa-miR-4498	CLIP-seq
MIRT1315115	hsa-miR-4505	CLIP-seq
MIRT1315116	hsa-miR-4656	CLIP-seq
MIRT1315117	hsa-miR-4675	CLIP-seq
MIRT1315118	hsa-miR-4703-3p	CLIP-seq
MIRT1315119	hsa-miR-4715-5p	CLIP-seq
MIRT1315120	hsa-miR-4741	CLIP-seq
MIRT1315121	hsa-miR-4747-5p	CLIP-seq
MIRT1315122	hsa-miR-4802-3p	CLIP-seq
MIRT1315123	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	16842742
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	29545371
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	10339406
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IBA
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IDA	30598479
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	NAS	10339406
GO:0006886	Process	Intracellular protein transport	NAS	10339406
GO:0008324	Function	Monoatomic cation transmembrane transporter activity	IDA	29545371
GO:0016020	Component	Membrane	IEA
GO:0030150	Process	Protein import into mitochondrial matrix	IBA
GO:0031640	Process	Killing of cells of another organism	IDA	22083756
GO:0031640	Process	Killing of cells of another organism	IMP	22083756
GO:0034614	Process	Cellular response to reactive oxygen species	IMP	18836179
GO:0042742	Process	Defense response to bacterium	IDA	22083756
GO:0042742	Process	Defense response to bacterium	IEA
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	IBA
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	IMP	30598479
GO:0050829	Process	Defense response to Gram-negative bacterium	IDA	22083756
GO:0050829	Process	Defense response to Gram-negative bacterium	IMP	22083756
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	22083756
GO:0051838	Process	Cytolysis by host of symbiont cells	IDA	22083756
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IMP	22083756
GO:0090399	Process	Replicative senescence	IMP	18836179
GO:0098655	Process	Monoatomic cation transmembrane transport	IDA	29545371
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	IDA	16842742

Other IDs

• MIM: 618894
• HGNC: 16185
• e!Ensembl: ENSG00000125995

Protein

• UniProt ID: P60602
• Protein name: Reactive oxygen species modulator 1 (ROS modulator 1) (Epididymis tissue protein Li 175) (Glyrichin) (Mitochondrial targeting GxxxG motif protein) (MTGM) (Protein MGR2 homolog)
• Protein function: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10247	Romo1	14 → 79	Reactive mitochondrial oxygen species modulator 1	Family

• Tissue specificity: TISSUE SPECIFICITY: Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors. {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}.
• Sequence:

  MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTM
  MQSGGTFGTFMAIGMGIRC

• Sequence length: 79

Related Genes

No strongly related genes found yet for ROMO1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ROMO1.