RNH1 (ribonuclease/angiogenin inhibitor 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6050
• Gene name: Ribonuclease/angiogenin inhibitor 1
• Gene symbol: RNH1
• Synonyms (NCBI Gene): IIAE12, RAI, RNH
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition

miRNA Show/Hide all (122)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049793	hsa-miR-92a-3p	CLASH	23622248
MIRT045994	hsa-miR-125b-5p	CLASH	23622248
MIRT726720	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726719	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726718	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726717	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT1313974	hsa-miR-106a	CLIP-seq
MIRT1313975	hsa-miR-106b	CLIP-seq
MIRT1313976	hsa-miR-142-5p	CLIP-seq
MIRT1313977	hsa-miR-17	CLIP-seq
MIRT1313978	hsa-miR-193a-3p	CLIP-seq
MIRT1313979	hsa-miR-193b	CLIP-seq
MIRT1313980	hsa-miR-20a	CLIP-seq
MIRT1313981	hsa-miR-20b	CLIP-seq
MIRT1313982	hsa-miR-302a	CLIP-seq
MIRT1313983	hsa-miR-302b	CLIP-seq
MIRT1313984	hsa-miR-302c	CLIP-seq
MIRT1313985	hsa-miR-302d	CLIP-seq
MIRT1313986	hsa-miR-302e	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1313988	hsa-miR-340	CLIP-seq
MIRT1313989	hsa-miR-3609	CLIP-seq
MIRT1313990	hsa-miR-372	CLIP-seq
MIRT1313991	hsa-miR-373	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1313993	hsa-miR-4480	CLIP-seq
MIRT1313994	hsa-miR-4722-3p	CLIP-seq
MIRT1313995	hsa-miR-4796-3p	CLIP-seq
MIRT1313996	hsa-miR-519d	CLIP-seq
MIRT1313997	hsa-miR-520a-3p	CLIP-seq
MIRT1313998	hsa-miR-520b	CLIP-seq
MIRT1313999	hsa-miR-520c-3p	CLIP-seq
MIRT1314000	hsa-miR-520d-3p	CLIP-seq
MIRT1314001	hsa-miR-520e	CLIP-seq
MIRT1314002	hsa-miR-520f	CLIP-seq
MIRT1314003	hsa-miR-548ah	CLIP-seq
MIRT1314004	hsa-miR-892b	CLIP-seq
MIRT1314005	hsa-miR-93	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314007	hsa-miR-15a	CLIP-seq
MIRT1314008	hsa-miR-15b	CLIP-seq
MIRT1314009	hsa-miR-16	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314011	hsa-miR-1915	CLIP-seq
MIRT1314012	hsa-miR-195	CLIP-seq
MIRT1314013	hsa-miR-214	CLIP-seq
MIRT1314014	hsa-miR-296-3p	CLIP-seq
MIRT1314015	hsa-miR-3152-5p	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1314017	hsa-miR-3619-5p	CLIP-seq
MIRT1314018	hsa-miR-424	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314019	hsa-miR-4423-5p	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT1314023	hsa-miR-497	CLIP-seq
MIRT1314024	hsa-miR-761	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314007	hsa-miR-15a	CLIP-seq
MIRT1314008	hsa-miR-15b	CLIP-seq
MIRT1314009	hsa-miR-16	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314012	hsa-miR-195	CLIP-seq
MIRT1314013	hsa-miR-214	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1314017	hsa-miR-3619-5p	CLIP-seq
MIRT1314018	hsa-miR-424	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT1314023	hsa-miR-497	CLIP-seq
MIRT1314024	hsa-miR-761	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314007	hsa-miR-15a	CLIP-seq
MIRT1314008	hsa-miR-15b	CLIP-seq
MIRT1314009	hsa-miR-16	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314012	hsa-miR-195	CLIP-seq
MIRT1314013	hsa-miR-214	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1314017	hsa-miR-3619-5p	CLIP-seq
MIRT1314018	hsa-miR-424	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT1314023	hsa-miR-497	CLIP-seq
MIRT1314024	hsa-miR-761	CLIP-seq
MIRT2613697	hsa-miR-1207-5p	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT2613698	hsa-miR-138	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1314011	hsa-miR-1915	CLIP-seq
MIRT1314014	hsa-miR-296-3p	CLIP-seq
MIRT2613699	hsa-miR-296-5p	CLIP-seq
MIRT1314015	hsa-miR-3152-5p	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314019	hsa-miR-4423-5p	CLIP-seq
MIRT2613700	hsa-miR-4456	CLIP-seq
MIRT2613701	hsa-miR-4492	CLIP-seq
MIRT2613702	hsa-miR-4498	CLIP-seq
MIRT2613703	hsa-miR-4736	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT2613704	hsa-miR-4763-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq
MIRT2613705	hsa-miR-541	CLIP-seq
MIRT2613706	hsa-miR-654-5p	CLIP-seq
MIRT2613707	hsa-miR-762	CLIP-seq
MIRT1314006	hsa-miR-1236	CLIP-seq
MIRT1314010	hsa-miR-1909	CLIP-seq
MIRT1313987	hsa-miR-3200-5p	CLIP-seq
MIRT1314016	hsa-miR-3201	CLIP-seq
MIRT1313992	hsa-miR-4303	CLIP-seq
MIRT1314020	hsa-miR-4753-3p	CLIP-seq
MIRT1314021	hsa-miR-4768-5p	CLIP-seq
MIRT1314022	hsa-miR-4791	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IDA	38718836
GO:0005515	Function	Protein binding	IPI	2742853, 3064806, 3470787, 10413501, 17350650, 25416956, 28514442, 29892012, 29997244, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	23843625
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	23843625
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0006402	Process	MRNA catabolic process	NAS	2081593
GO:0008428	Function	Ribonuclease inhibitor activity	IBA
GO:0008428	Function	Ribonuclease inhibitor activity	IDA	3219362, 3243277, 3470787, 9050852, 12578357, 23843625
GO:0016477	Process	Cell migration	IBA
GO:0030027	Component	Lamellipodium	IBA
GO:0032055	Process	Negative regulation of translation in response to stress	IDA	38718836
GO:0032311	Component	Angiogenin-PRI complex	IBA
GO:0032311	Component	Angiogenin-PRI complex	IPI	3470787
GO:0034315	Process	Regulation of Arp2/3 complex-mediated actin nucleation	IBA
GO:0036416	Process	TRNA stabilization	IDA	23843625
GO:0045765	Process	Regulation of angiogenesis	IBA
GO:0045765	Process	Regulation of angiogenesis	IDA	3470787
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145

Other IDs

• MIM: 173320
• HGNC: 10074
• e!Ensembl: ENSG00000023191

Protein

• UniProt ID: P13489
• Protein name: Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI)
• Protein function: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inh
• PDB: 1A4Y , 1Z7X , 2BEX , 2Q4G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13516	LRR_6	396 → 419	Leucine Rich repeat	Repeat
  PF13516	LRR_6	111 → 134	Leucine Rich repeat	Repeat
  PF18779	LRR_RI_capping	1 → 35	Capping Ribonuclease inhibitor Leucine Rich Repeat	Repeat

• Sequence:

  MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
  SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
  DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
  DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
  ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
  LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
  SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS

• Sequence length: 461

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Encephalitis, acute, infection-induced, susceptibility to, 12	Uncertain significance; risk factor	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RNH1-related disorder	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for RNH1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RNH1.