RNFT1 (ring finger protein, transmembrane 1)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 51136
• Gene name: Ring finger protein, transmembrane 1
• Gene symbol: RNFT1
• Synonyms (NCBI Gene): PTD016
• Chromosome: 17
• Chromosome location: 17q23.1

miRNA Show/Hide all (89)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022586	hsa-miR-124-3p	Microarray	18668037
MIRT024404	hsa-miR-215-5p	Microarray	19074876
MIRT026234	hsa-miR-192-5p	Microarray	19074876
MIRT501333	hsa-miR-4458	PAR-CLIP	24398324
MIRT501334	hsa-miR-4500	PAR-CLIP	24398324
MIRT501332	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT501331	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT501330	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT501329	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT501328	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT501327	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT501326	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT501325	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT501324	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT501323	hsa-miR-561-3p	PAR-CLIP	24398324
MIRT501321	hsa-miR-4517	PAR-CLIP	24398324
MIRT501322	hsa-miR-5583-3p	PAR-CLIP	24398324
MIRT501320	hsa-miR-6858-3p	PAR-CLIP	24398324
MIRT501319	hsa-miR-3927-3p	PAR-CLIP	24398324
MIRT501318	hsa-miR-6831-5p	PAR-CLIP	24398324
MIRT501317	hsa-miR-202-3p	PAR-CLIP	24398324
MIRT501316	hsa-miR-4451	PAR-CLIP	24398324
MIRT501315	hsa-miR-889-3p	PAR-CLIP	24398324
MIRT501333	hsa-miR-4458	PAR-CLIP	24398324
MIRT501334	hsa-miR-4500	PAR-CLIP	24398324
MIRT501332	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT501331	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT501330	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT501329	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT501328	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT501327	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT501326	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT501325	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT501324	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT501323	hsa-miR-561-3p	PAR-CLIP	24398324
MIRT501321	hsa-miR-4517	PAR-CLIP	24398324
MIRT501322	hsa-miR-5583-3p	PAR-CLIP	24398324
MIRT501320	hsa-miR-6858-3p	PAR-CLIP	24398324
MIRT501319	hsa-miR-3927-3p	PAR-CLIP	24398324
MIRT501318	hsa-miR-6831-5p	PAR-CLIP	24398324
MIRT501317	hsa-miR-202-3p	PAR-CLIP	24398324
MIRT501316	hsa-miR-4451	PAR-CLIP	24398324
MIRT501315	hsa-miR-889-3p	PAR-CLIP	24398324
MIRT1313879	hsa-miR-153	CLIP-seq
MIRT1313880	hsa-miR-181a	CLIP-seq
MIRT1313881	hsa-miR-181b	CLIP-seq
MIRT1313882	hsa-miR-181c	CLIP-seq
MIRT1313883	hsa-miR-181d	CLIP-seq
MIRT1313884	hsa-miR-199a-3p	CLIP-seq
MIRT1313885	hsa-miR-199b-3p	CLIP-seq
MIRT1313886	hsa-miR-219-2-3p	CLIP-seq
MIRT1313887	hsa-miR-2964a-3p	CLIP-seq
MIRT1313888	hsa-miR-3123	CLIP-seq
MIRT1313889	hsa-miR-3129-5p	CLIP-seq
MIRT1313890	hsa-miR-323-3p	CLIP-seq
MIRT1313891	hsa-miR-338-5p	CLIP-seq
MIRT1313892	hsa-miR-361-5p	CLIP-seq
MIRT1313893	hsa-miR-3671	CLIP-seq
MIRT1313894	hsa-miR-369-3p	CLIP-seq
MIRT1313895	hsa-miR-374c	CLIP-seq
MIRT1313896	hsa-miR-3919	CLIP-seq
MIRT1313897	hsa-miR-3924	CLIP-seq
MIRT1313898	hsa-miR-409-3p	CLIP-seq
MIRT1313899	hsa-miR-412	CLIP-seq
MIRT1313900	hsa-miR-4262	CLIP-seq
MIRT1313901	hsa-miR-448	CLIP-seq
MIRT1313902	hsa-miR-4528	CLIP-seq
MIRT1313903	hsa-miR-4666-3p	CLIP-seq
MIRT1313904	hsa-miR-4684-3p	CLIP-seq
MIRT1313905	hsa-miR-4793-5p	CLIP-seq
MIRT1313906	hsa-miR-4797-3p	CLIP-seq
MIRT1313907	hsa-miR-4797-5p	CLIP-seq
MIRT1313908	hsa-miR-532-5p	CLIP-seq
MIRT1313909	hsa-miR-655	CLIP-seq
MIRT1313910	hsa-miR-656	CLIP-seq
MIRT1313911	hsa-miR-936	CLIP-seq
MIRT1313880	hsa-miR-181a	CLIP-seq
MIRT1313881	hsa-miR-181b	CLIP-seq
MIRT1313882	hsa-miR-181c	CLIP-seq
MIRT1313883	hsa-miR-181d	CLIP-seq
MIRT1313900	hsa-miR-4262	CLIP-seq
MIRT2317938	hsa-miR-1293	CLIP-seq
MIRT2317939	hsa-miR-4483	CLIP-seq
MIRT2317940	hsa-miR-4728-3p	CLIP-seq
MIRT2317941	hsa-miR-548n	CLIP-seq
MIRT2317942	hsa-miR-548t	CLIP-seq
MIRT2613621	hsa-miR-2113	CLIP-seq
MIRT2613622	hsa-miR-4474-3p	CLIP-seq
MIRT2613623	hsa-miR-663b	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	27485036
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043130	Function	Ubiquitin binding	IDA	27485036
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	IDA	27485036
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	27485036
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:1904294	Process	Positive regulation of ERAD pathway	IBA
GO:1904294	Process	Positive regulation of ERAD pathway	IEA
GO:1904294	Process	Positive regulation of ERAD pathway	IMP	27485036

Other IDs

• MIM: 615172
• HGNC: 30206
• e!Ensembl: ENSG00000189050

Protein

• UniProt ID: Q5M7Z0
• Protein name: E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1)
• Protein function: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13920	zf-C3HC4_3	371 → 419		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at highest levels in testis, lower levels in heart, liver, lung, and kidney (PubMed:17074343). Not detected in brain, ovary, and uterus (PubMed:17074343). Down-regulated in testis from patients with maturation arrest (MA) or
• Sequence:

  MPLFLLSLPTPPSASGHERRQRPEAKTSGSEKKYLRAMQANRSQLHSPPGTGSSEDASTP
  QCVHTRLTGEGSCPHSGDVHIQINSIPKECAENASSRNIRSGVHSCAHGCVHSRLRGHSH
  SEARLTDDTAAESGDHGSSSFSEFRYLFKWLQKSLPYILILSVKLVMQHITGISLGIGLL
  TTFMYANKSIVNQVFLRERSSKIQCAWLLVFLAGSSVLLYYTFHSQSLYYSLIFLNPTLD
  HLSFWEVFWIVGITDFILKFFFMGLKCLILLVPSFIMPFKSKGYWYMLLEELCQYYRTFV
  PIPVWFRYLISYGEFGNVTRWSLGILLALLYLILKLLEFFGHLRTFRQVLRIFFTQPSYG
  VAASKRQCSDVDDICSICQAEFQKPILLICQHIFCEECMTLWFNREKTCPLCRTVISDHI
  NKWKDGATSSHLQIY

• Sequence length: 435

Related Genes

No strongly related genes found yet for RNFT1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RNFT1.