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Gene Gene information from NCBI Gene database.
Entrez ID 56254
Gene name Ring finger protein 20
Gene symbol RNF20
Synonyms (NCBI Gene)
BRE1BRE1AhBRE1
Chromosome 9
Chromosome location 9q31.1
Summary The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor su
miRNA miRNA information provided by mirtarbase database.
359 Show/Hide all (359)
miRTarBase ID miRNA Experiments Reference
MIRT024169 hsa-miR-221-3p Sequencing 20371350
MIRT036112 hsa-miR-1296-5p CLASH 23622248
MIRT543973 hsa-miR-483-5p PAR-CLIP 21572407
MIRT543971 hsa-miR-4781-3p PAR-CLIP 21572407
MIRT543972 hsa-miR-454-5p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39 Show/Hide all (39)
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IDA 16307923
GO:0000209 Process Protein polyubiquitination IDA 19037095
GO:0002039 Function P53 binding IDA 16337599
GO:0003682 Function Chromatin binding IEA
GO:0003713 Function Transcription coactivator activity IDA 16337599
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607699 10062 ENSG00000155827
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5VTR2
Protein name E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Protein function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histo
PDB 5TRB , 8GUI , 8GUJ , 8IEJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13920 zf-C3HC4_3 918 → 965 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the normal brain and also in malignant gliomas (at protein level). {ECO:0000269|PubMed:19037095}.
Sequence
MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAE
MLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDL
LTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVES
SRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQ
EKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVN
SKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQN
EKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQV
ELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLI
SSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDS
EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKES
EKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDK
VQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAM
AKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEE
KEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEA
AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPD
NVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKC
NAAFG
ANDFHRIYIG
Sequence length 975
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
E3 ubiquitin ligases ubiquitinate target proteins