RNF19B (ring finger protein 19B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 127544
• Gene name: Ring finger protein 19B
• Gene symbol: RNF19B
• Synonyms (NCBI Gene): IBRDC3, NKLAM
• Chromosome: 1
• Chromosome location: 1p35.1
• Summary: This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicin

miRNA Show/Hide all (297)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018297	hsa-miR-335-5p	Microarray	18185580
MIRT713894	hsa-miR-3155a	HITS-CLIP	19536157
MIRT713893	hsa-miR-3155b	HITS-CLIP	19536157
MIRT713892	hsa-miR-484	HITS-CLIP	19536157
MIRT713891	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT713890	hsa-miR-4772-3p	HITS-CLIP	19536157
MIRT654206	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT654205	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT654204	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT713889	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT713888	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT654202	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT700125	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT700124	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT700123	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT700122	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT700121	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT700120	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT700119	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT700118	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT700117	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT700116	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT700115	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT700114	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT700113	hsa-miR-302e	HITS-CLIP	23313552
MIRT700112	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT700111	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT700110	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT700109	hsa-miR-520b	HITS-CLIP	23313552
MIRT700108	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT700107	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT700106	hsa-miR-520e	HITS-CLIP	23313552
MIRT700105	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT700104	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT700103	hsa-miR-520h	HITS-CLIP	23313552
MIRT676969	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT700102	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT700101	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT700100	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT700099	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT700098	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT700097	hsa-miR-3665	HITS-CLIP	23313552
MIRT700096	hsa-miR-657	HITS-CLIP	23313552
MIRT700095	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT700094	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT700093	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT700092	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT700091	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT700090	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT700089	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT700088	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT676971	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676970	hsa-miR-764	HITS-CLIP	23824327
MIRT676969	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676968	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676967	hsa-miR-640	HITS-CLIP	23824327
MIRT676966	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676965	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT654212	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654211	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654210	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT673300	hsa-miR-5693	HITS-CLIP	23824327
MIRT654209	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT654208	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT654207	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT673299	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT673298	hsa-miR-3135b	HITS-CLIP	23824327
MIRT654203	hsa-miR-1251-3p	HITS-CLIP	23824327
MIRT673297	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT673296	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT673295	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT673294	hsa-miR-3652	HITS-CLIP	23824327
MIRT673292	hsa-miR-4430	HITS-CLIP	23824327
MIRT673293	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT654201	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT654200	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT673291	hsa-miR-5698	HITS-CLIP	23824327
MIRT654223	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT654222	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654221	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654220	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT654219	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT654218	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654217	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT654216	hsa-miR-1976	HITS-CLIP	23824327
MIRT654215	hsa-miR-4444	HITS-CLIP	23824327
MIRT654214	hsa-miR-4279	HITS-CLIP	23824327
MIRT654213	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT622459	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622458	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT622457	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT622456	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT622455	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622453	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT622452	hsa-miR-5096	HITS-CLIP	23824327
MIRT622451	hsa-miR-1303	HITS-CLIP	23824327
MIRT654223	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT654222	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654221	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654220	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT654219	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT654218	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654217	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT654216	hsa-miR-1976	HITS-CLIP	23824327
MIRT654215	hsa-miR-4444	HITS-CLIP	23824327
MIRT654214	hsa-miR-4279	HITS-CLIP	23824327
MIRT654213	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT654212	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654211	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654210	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654209	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT654208	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT654207	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT654206	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT654205	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT654204	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT654203	hsa-miR-1251-3p	HITS-CLIP	23824327
MIRT654202	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT654201	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT654200	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT622459	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622458	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT622457	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT622456	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT622455	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622453	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT622452	hsa-miR-5096	HITS-CLIP	23824327
MIRT622451	hsa-miR-1303	HITS-CLIP	23824327
MIRT534662	hsa-miR-3923	PAR-CLIP	22012620
MIRT534661	hsa-miR-146a-3p	PAR-CLIP	22012620
MIRT534660	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT713894	hsa-miR-3155a	HITS-CLIP	19536157
MIRT713893	hsa-miR-3155b	HITS-CLIP	19536157
MIRT713892	hsa-miR-484	HITS-CLIP	19536157
MIRT713891	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT713890	hsa-miR-4772-3p	HITS-CLIP	19536157
MIRT654206	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT654205	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT654204	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT713889	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT713888	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT654202	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT700125	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT700124	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT700123	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT700122	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT700121	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT700120	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT700119	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT700118	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT700117	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT700116	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT700115	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT700114	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT700113	hsa-miR-302e	HITS-CLIP	23313552
MIRT700112	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT700111	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT700110	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT700109	hsa-miR-520b	HITS-CLIP	23313552
MIRT700108	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT700107	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT700106	hsa-miR-520e	HITS-CLIP	23313552
MIRT700105	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT700104	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT700103	hsa-miR-520h	HITS-CLIP	23313552
MIRT676969	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT700102	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT700101	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT700100	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT700099	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT700098	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT700097	hsa-miR-3665	HITS-CLIP	23313552
MIRT700096	hsa-miR-657	HITS-CLIP	23313552
MIRT700095	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT700094	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT700093	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT700092	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT700091	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT700090	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT700089	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT700088	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT676971	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676970	hsa-miR-764	HITS-CLIP	23824327
MIRT676969	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676968	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676967	hsa-miR-640	HITS-CLIP	23824327
MIRT676966	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676965	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT654212	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654211	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654210	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT673300	hsa-miR-5693	HITS-CLIP	23824327
MIRT654209	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT654208	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT654207	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT673299	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT673298	hsa-miR-3135b	HITS-CLIP	23824327
MIRT654203	hsa-miR-1251-3p	HITS-CLIP	23824327
MIRT673297	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT673296	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT673295	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT673294	hsa-miR-3652	HITS-CLIP	23824327
MIRT673292	hsa-miR-4430	HITS-CLIP	23824327
MIRT673293	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT654201	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT654200	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT673291	hsa-miR-5698	HITS-CLIP	23824327
MIRT654223	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT654222	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654221	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654220	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT654219	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT654218	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654217	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT654216	hsa-miR-1976	HITS-CLIP	23824327
MIRT654215	hsa-miR-4444	HITS-CLIP	23824327
MIRT654214	hsa-miR-4279	HITS-CLIP	23824327
MIRT654213	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT622459	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622458	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT622457	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT622456	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT622455	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622453	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT622452	hsa-miR-5096	HITS-CLIP	23824327
MIRT622451	hsa-miR-1303	HITS-CLIP	23824327
MIRT654223	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT654222	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654221	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654220	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT654219	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT654218	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654217	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT654216	hsa-miR-1976	HITS-CLIP	23824327
MIRT654215	hsa-miR-4444	HITS-CLIP	23824327
MIRT654214	hsa-miR-4279	HITS-CLIP	23824327
MIRT654213	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT654212	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT654211	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT654210	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT654209	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT654208	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT654207	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT654206	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT654205	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT654204	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT654203	hsa-miR-1251-3p	HITS-CLIP	23824327
MIRT654202	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT654201	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT654200	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT622459	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622458	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT622457	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT622456	hsa-miR-3152-3p	HITS-CLIP	23824327
MIRT622455	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT622454	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT622453	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT622452	hsa-miR-5096	HITS-CLIP	23824327
MIRT622451	hsa-miR-1303	HITS-CLIP	23824327
MIRT534662	hsa-miR-3923	PAR-CLIP	22012620
MIRT534661	hsa-miR-146a-3p	PAR-CLIP	22012620
MIRT534660	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT2458432	hsa-miR-1285	CLIP-seq
MIRT2458433	hsa-miR-3187-5p	CLIP-seq
MIRT2458434	hsa-miR-4292	CLIP-seq
MIRT2458435	hsa-miR-4308	CLIP-seq
MIRT2458436	hsa-miR-4330	CLIP-seq
MIRT2458437	hsa-miR-4446-5p	CLIP-seq
MIRT2458438	hsa-miR-4755-5p	CLIP-seq
MIRT2458439	hsa-miR-612	CLIP-seq
MIRT2458440	hsa-miR-670	CLIP-seq
MIRT2613110	hsa-miR-1228	CLIP-seq
MIRT2613111	hsa-miR-1246	CLIP-seq
MIRT2613112	hsa-miR-329	CLIP-seq
MIRT2613113	hsa-miR-362-3p	CLIP-seq
MIRT2613114	hsa-miR-4328	CLIP-seq
MIRT2613115	hsa-miR-4769-3p	CLIP-seq
MIRT2613116	hsa-miR-490-5p	CLIP-seq
MIRT2613117	hsa-miR-548a-3p	CLIP-seq
MIRT2613118	hsa-miR-548e	CLIP-seq
MIRT2613119	hsa-miR-548f	CLIP-seq
MIRT2613120	hsa-miR-642b	CLIP-seq
MIRT2613110	hsa-miR-1228	CLIP-seq
MIRT2613111	hsa-miR-1246	CLIP-seq
MIRT2613112	hsa-miR-329	CLIP-seq
MIRT2613113	hsa-miR-362-3p	CLIP-seq
MIRT2613114	hsa-miR-4328	CLIP-seq
MIRT2613115	hsa-miR-4769-3p	CLIP-seq
MIRT2613116	hsa-miR-490-5p	CLIP-seq
MIRT2613120	hsa-miR-642b	CLIP-seq

Gene ontology (GO) Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IBA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	16709802, 28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	27485036
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IBA
GO:0042267	Process	Natural killer cell mediated cytotoxicity	IEA
GO:0043130	Function	Ubiquitin binding	IDA	27485036
GO:0044194	Component	Cytolytic granule	IBA
GO:0044194	Component	Cytolytic granule	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	IDA	27485036
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	27485036
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 610872
• HGNC: 26886
• e!Ensembl: ENSG00000116514

Protein

• UniProt ID: Q6ZMZ0
• Protein name: E3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)
• Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01485	IBR	186 → 251	IBR domain, a half RING-finger domain	Domain
  PF01485	IBR	273 → 333	IBR domain, a half RING-finger domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells (PubMed:10438909). Present in natural killer cells (at protein level) (PubMed:10912506). Ubiquitously expressed with high expression in testis
• Sequence:

  MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
  AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
  LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
  DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
  CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
  SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
  ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
  VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
  IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
  VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
  QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
  ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
  TVLKPEGGEARV

• Sequence length: 732

Pathways

Reactome Pathway:

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for RNF19B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RNF19B.