RNF167 (ring finger protein 167)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26001
• Gene name: Ring finger protein 167
• Gene symbol: RNF167
• Synonyms (NCBI Gene): 5730408C10Rik, LP2254, RING105
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

miRNA Show/Hide all (66)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047365	hsa-miR-34a-5p	CLASH	23622248
MIRT045239	hsa-miR-186-5p	CLASH	23622248
MIRT041982	hsa-miR-484	CLASH	23622248
MIRT037242	hsa-miR-877-5p	CLASH	23622248
MIRT251362	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT251363	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT1310977	hsa-miR-1226	CLIP-seq
MIRT1310978	hsa-miR-188-5p	CLIP-seq
MIRT1310979	hsa-miR-19a	CLIP-seq
MIRT1310980	hsa-miR-19b	CLIP-seq
MIRT1310981	hsa-miR-297	CLIP-seq
MIRT1310982	hsa-miR-4257	CLIP-seq
MIRT1310983	hsa-miR-4463	CLIP-seq
MIRT1310984	hsa-miR-4733-3p	CLIP-seq
MIRT1310985	hsa-miR-567	CLIP-seq
MIRT1310986	hsa-miR-7	CLIP-seq
MIRT2316955	hsa-miR-1	CLIP-seq
MIRT1310977	hsa-miR-1226	CLIP-seq
MIRT1310979	hsa-miR-19a	CLIP-seq
MIRT1310980	hsa-miR-19b	CLIP-seq
MIRT2316956	hsa-miR-206	CLIP-seq
MIRT2316957	hsa-miR-2114	CLIP-seq
MIRT1310981	hsa-miR-297	CLIP-seq
MIRT2316958	hsa-miR-3130-5p	CLIP-seq
MIRT2316959	hsa-miR-3189-5p	CLIP-seq
MIRT2316960	hsa-miR-3667-5p	CLIP-seq
MIRT2316961	hsa-miR-3673	CLIP-seq
MIRT1310982	hsa-miR-4257	CLIP-seq
MIRT2316962	hsa-miR-4267	CLIP-seq
MIRT2316963	hsa-miR-4327	CLIP-seq
MIRT2316964	hsa-miR-4482	CLIP-seq
MIRT1310984	hsa-miR-4733-3p	CLIP-seq
MIRT2316965	hsa-miR-4758-3p	CLIP-seq
MIRT1310985	hsa-miR-567	CLIP-seq
MIRT2316966	hsa-miR-613	CLIP-seq
MIRT2316967	hsa-miR-642a	CLIP-seq
MIRT2316957	hsa-miR-2114	CLIP-seq
MIRT2316958	hsa-miR-3130-5p	CLIP-seq
MIRT2316959	hsa-miR-3189-5p	CLIP-seq
MIRT2612842	hsa-miR-371b-5p	CLIP-seq
MIRT2316962	hsa-miR-4267	CLIP-seq
MIRT2316963	hsa-miR-4327	CLIP-seq
MIRT2612843	hsa-miR-4434	CLIP-seq
MIRT2612844	hsa-miR-4453	CLIP-seq
MIRT2612845	hsa-miR-4475	CLIP-seq
MIRT2316964	hsa-miR-4482	CLIP-seq
MIRT2612846	hsa-miR-450b-3p	CLIP-seq
MIRT2612847	hsa-miR-4516	CLIP-seq
MIRT2612848	hsa-miR-4538	CLIP-seq
MIRT2612849	hsa-miR-4749-3p	CLIP-seq
MIRT2316965	hsa-miR-4758-3p	CLIP-seq
MIRT2612850	hsa-miR-555	CLIP-seq
MIRT2316967	hsa-miR-642a	CLIP-seq
MIRT2612851	hsa-miR-769-3p	CLIP-seq
MIRT2316957	hsa-miR-2114	CLIP-seq
MIRT2316958	hsa-miR-3130-5p	CLIP-seq
MIRT2316959	hsa-miR-3189-5p	CLIP-seq
MIRT2612842	hsa-miR-371b-5p	CLIP-seq
MIRT2316962	hsa-miR-4267	CLIP-seq
MIRT2316963	hsa-miR-4327	CLIP-seq
MIRT2612845	hsa-miR-4475	CLIP-seq
MIRT2316964	hsa-miR-4482	CLIP-seq
MIRT2612849	hsa-miR-4749-3p	CLIP-seq
MIRT2316965	hsa-miR-4758-3p	CLIP-seq
MIRT2612850	hsa-miR-555	CLIP-seq
MIRT2316967	hsa-miR-642a	CLIP-seq

Gene ontology (GO) Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IDA	16314844
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	16314844, 33594058, 35114100
GO:0005515	Function	Protein binding	IPI	16314844, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	16314844
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IDA	27808481, 32409562, 35114100
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	27808481, 35114100
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IDA	24387786
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IDA	32409562
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	27808481, 33594058
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031090	Component	Organelle membrane	IEA
GO:0031669	Process	Cellular response to nutrient levels	IDA	36528027
GO:0032418	Process	Lysosome localization	IDA	32409562
GO:0032418	Process	Lysosome localization	IDA	16537643
GO:0032418	Process	Lysosome localization	IDA	27808481
GO:0034198	Process	Cellular response to amino acid starvation	IDA	26972053, 33594058
GO:0035519	Process	Protein K29-linked ubiquitination	IDA	33594058
GO:0036020	Component	Endolysosome membrane	IDA	23129617
GO:0045786	Process	Negative regulation of cell cycle	IBA
GO:0045786	Process	Negative regulation of cell cycle	IMP	16314844
GO:0046872	Function	Metal ion binding	IEA
GO:0051640	Process	Organelle localization	IMP	24387786
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IDA	23129617
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	23129617, 23353890, 27808481, 33594058, 35114100
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	35114100
GO:0085020	Process	Protein K6-linked ubiquitination	IDA	36528027
GO:1902532	Process	Negative regulation of intracellular signal transduction	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IDA	26972053, 33594058
GO:1904262	Process	Negative regulation of TORC1 signaling	IDA	35114100
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	36528027
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	33594058
GO:1990253	Process	Cellular response to leucine starvation	IDA	35114100

Other IDs

• MIM: 610431
• HGNC: 24544
• e!Ensembl: ENSG00000108523

Protein

• UniProt ID: Q9H6Y7
• Protein name: E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167)
• Protein function: E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:33594058, PubMed:35114100). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitina
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02225	PA	54 → 148	PA domain	Family
  PF13639	zf-RING_2	228 → 272	Ring finger domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed (PubMed:23129617). Strongly expressed in the kidney, pancreas, testis and liver (at protein level) (PubMed:16314844, PubMed:23129617). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617}.
• Sequence:

  MHPAAFPLPVVVAAVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVE
  AHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELL
  NMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNTFPLGYYLIPFTGI
  VGLLVLAMGAVMIARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDQYDVCAICLDEYEDG
  DKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPR
  DHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV

• Sequence length: 350

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Renal carnitine transport defect	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Neoplasms	Neoplasms	BEFREE	16314844		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for RNF167.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RNF167.