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Gene Gene information from NCBI Gene database.
Entrez ID 8153
Gene name Rho family GTPase 2
Gene symbol RND2
Synonyms (NCBI Gene)
ARHNRHO7RhoN
Chromosome 17
Chromosome location 17q21.31
Summary This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neu
miRNA miRNA information provided by mirtarbase database.
324 Show/Hide all (324)
miRTarBase ID miRNA Experiments Reference
MIRT050163 hsa-miR-26a-5p CLASH 23622248
MIRT050163 hsa-miR-26a-5p CLASH 23622248
MIRT038658 hsa-miR-15b-3p CLASH 23622248
MIRT642734 hsa-miR-6840-3p HITS-CLIP 23824327
MIRT642733 hsa-miR-1915-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21 Show/Hide all (21)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0002080 Component Acrosomal membrane IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 8938427
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601555 18315 ENSG00000108830
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P52198
Protein name Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2)
Protein function May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 9 → 182 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis.
Sequence
Sequence length 227
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
EBV-positive nodal T- and NK-cell lymphoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Corneal Dystrophy Fleck Corneal dystrophy Pubtator 29461643 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Intracranial Hypertension Intracranial hypertension Pubtator 18613964 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Sepsis Sepsis Pubtator 36450776 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only