RGS9BP (regulator of G protein signaling 9 binding protein)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 388531
• Gene name: Regulator of G protein signaling 9 binding protein
• Gene symbol: RGS9BP
• Synonyms (NCBI Gene): PERRS, PERRS2, R9AP, RGS9
• Chromosome: 19
• Chromosome location: 19q13.11
• Summary: The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. T

miRNA Show/Hide all (222)

miRTarBase ID	miRNA	Experiments	Reference
MIRT694266	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT694265	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT694264	hsa-miR-940	HITS-CLIP	23313552
MIRT694263	hsa-miR-3929	HITS-CLIP	23313552
MIRT694262	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694261	hsa-miR-4478	HITS-CLIP	23313552
MIRT694260	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694259	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT694258	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694257	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT694256	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT694255	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT694254	hsa-miR-1827	HITS-CLIP	23313552
MIRT694253	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694252	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694251	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT694250	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694249	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT694248	hsa-miR-1273e	HITS-CLIP	23313552
MIRT694247	hsa-miR-665	HITS-CLIP	23313552
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT666588	hsa-miR-4317	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT637538	hsa-miR-1267	HITS-CLIP	23824327
MIRT637537	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637527	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT637526	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637524	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT457977	hsa-miR-1288-5p	PAR-CLIP	23592263
MIRT457976	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT457974	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT457975	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT457973	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT457971	hsa-miR-4252	PAR-CLIP	23592263
MIRT457975	hsa-miR-1225-3p	PAR-CLIP	27292025
MIRT457973	hsa-miR-1233-3p	PAR-CLIP	27292025
MIRT457977	hsa-miR-1288-5p	PAR-CLIP	27292025
MIRT694254	hsa-miR-1827	PAR-CLIP	27292025
MIRT637536	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT694247	hsa-miR-665	PAR-CLIP	27292025
MIRT694266	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT694265	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT694264	hsa-miR-940	HITS-CLIP	23313552
MIRT694263	hsa-miR-3929	HITS-CLIP	23313552
MIRT694262	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694261	hsa-miR-4478	HITS-CLIP	23313552
MIRT694260	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694259	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT694258	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694257	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT694256	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT694255	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT694254	hsa-miR-1827	HITS-CLIP	23313552
MIRT694253	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694252	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694251	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT694250	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694249	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT694248	hsa-miR-1273e	HITS-CLIP	23313552
MIRT694247	hsa-miR-665	HITS-CLIP	23313552
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT666588	hsa-miR-4317	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT637538	hsa-miR-1267	HITS-CLIP	23824327
MIRT637537	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637527	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT637526	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637524	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT457977	hsa-miR-1288-5p	PAR-CLIP	23592263
MIRT457976	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT457974	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT457975	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT457973	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT457971	hsa-miR-4252	PAR-CLIP	23592263
MIRT1304572	hsa-miR-1207-5p	CLIP-seq
MIRT1304573	hsa-miR-1233	CLIP-seq
MIRT1304574	hsa-miR-1243	CLIP-seq
MIRT1304575	hsa-miR-1273d	CLIP-seq
MIRT1304576	hsa-miR-1276	CLIP-seq
MIRT1304577	hsa-miR-129-3p	CLIP-seq
MIRT1304578	hsa-miR-181a	CLIP-seq
MIRT1304579	hsa-miR-181b	CLIP-seq
MIRT1304580	hsa-miR-181c	CLIP-seq
MIRT1304581	hsa-miR-181d	CLIP-seq
MIRT1304582	hsa-miR-1909	CLIP-seq
MIRT1304583	hsa-miR-1972	CLIP-seq
MIRT1304584	hsa-miR-1976	CLIP-seq
MIRT1304585	hsa-miR-2277-5p	CLIP-seq
MIRT1304586	hsa-miR-302a	CLIP-seq
MIRT1304587	hsa-miR-302b	CLIP-seq
MIRT1304588	hsa-miR-302c	CLIP-seq
MIRT1304589	hsa-miR-302d	CLIP-seq
MIRT1304590	hsa-miR-302e	CLIP-seq
MIRT1304591	hsa-miR-3130-5p	CLIP-seq
MIRT1304592	hsa-miR-3150a-3p	CLIP-seq
MIRT1304593	hsa-miR-3158-5p	CLIP-seq
MIRT1304594	hsa-miR-3159	CLIP-seq
MIRT1304595	hsa-miR-3166	CLIP-seq
MIRT1304596	hsa-miR-3175	CLIP-seq
MIRT1304597	hsa-miR-3180	CLIP-seq
MIRT1304598	hsa-miR-3180-3p	CLIP-seq
MIRT1304599	hsa-miR-3184	CLIP-seq
MIRT1304600	hsa-miR-3196	CLIP-seq
MIRT1304601	hsa-miR-320a	CLIP-seq
MIRT1304602	hsa-miR-320b	CLIP-seq
MIRT1304603	hsa-miR-320c	CLIP-seq
MIRT1304604	hsa-miR-320d	CLIP-seq
MIRT1304605	hsa-miR-3691-3p	CLIP-seq
MIRT1304606	hsa-miR-372	CLIP-seq
MIRT1304607	hsa-miR-373	CLIP-seq
MIRT1304608	hsa-miR-423-5p	CLIP-seq
MIRT1304609	hsa-miR-4262	CLIP-seq
MIRT1304610	hsa-miR-4311	CLIP-seq
MIRT1304611	hsa-miR-4321	CLIP-seq
MIRT1304612	hsa-miR-4429	CLIP-seq
MIRT1304613	hsa-miR-4482	CLIP-seq
MIRT1304614	hsa-miR-4488	CLIP-seq
MIRT1304615	hsa-miR-4505	CLIP-seq
MIRT1304616	hsa-miR-4509	CLIP-seq
MIRT1304617	hsa-miR-4651	CLIP-seq
MIRT1304618	hsa-miR-4667-5p	CLIP-seq
MIRT1304619	hsa-miR-4697-5p	CLIP-seq
MIRT1304620	hsa-miR-4700-5p	CLIP-seq
MIRT1304621	hsa-miR-4731-5p	CLIP-seq
MIRT1304622	hsa-miR-4736	CLIP-seq
MIRT1304623	hsa-miR-4742-5p	CLIP-seq
MIRT1304624	hsa-miR-4744	CLIP-seq
MIRT1304625	hsa-miR-4763-3p	CLIP-seq
MIRT1304626	hsa-miR-4771	CLIP-seq
MIRT1304627	hsa-miR-4787-5p	CLIP-seq
MIRT1304628	hsa-miR-519a	CLIP-seq
MIRT1304629	hsa-miR-519b-3p	CLIP-seq
MIRT1304630	hsa-miR-519c-3p	CLIP-seq
MIRT1304631	hsa-miR-520a-3p	CLIP-seq
MIRT1304632	hsa-miR-520b	CLIP-seq
MIRT1304633	hsa-miR-520c-3p	CLIP-seq
MIRT1304634	hsa-miR-520d-3p	CLIP-seq
MIRT1304635	hsa-miR-520e	CLIP-seq
MIRT1304636	hsa-miR-583	CLIP-seq
MIRT1304637	hsa-miR-595	CLIP-seq
MIRT1304638	hsa-miR-602	CLIP-seq
MIRT1304639	hsa-miR-608	CLIP-seq
MIRT1304640	hsa-miR-648	CLIP-seq
MIRT1304641	hsa-miR-660	CLIP-seq
MIRT1304642	hsa-miR-718	CLIP-seq
MIRT1304643	hsa-miR-885-3p	CLIP-seq
MIRT1304644	hsa-miR-933	CLIP-seq
MIRT1304645	hsa-miR-939	CLIP-seq
MIRT1304576	hsa-miR-1276	CLIP-seq
MIRT2090238	hsa-miR-22	CLIP-seq
MIRT2090239	hsa-miR-3194-5p	CLIP-seq
MIRT2090240	hsa-miR-4290	CLIP-seq
MIRT2090241	hsa-miR-4300	CLIP-seq
MIRT1304610	hsa-miR-4311	CLIP-seq
MIRT2090242	hsa-miR-4687-5p	CLIP-seq
MIRT1304624	hsa-miR-4744	CLIP-seq
MIRT2090243	hsa-miR-558	CLIP-seq
MIRT1304636	hsa-miR-583	CLIP-seq
MIRT2090244	hsa-miR-920	CLIP-seq
MIRT2315019	hsa-miR-4271	CLIP-seq
MIRT2315020	hsa-miR-4447	CLIP-seq
MIRT2315021	hsa-miR-4472	CLIP-seq
MIRT2315022	hsa-miR-4725-3p	CLIP-seq
MIRT2315023	hsa-miR-4796-3p	CLIP-seq
MIRT2315024	hsa-miR-548t	CLIP-seq
MIRT2315025	hsa-miR-625	CLIP-seq
MIRT2315026	hsa-miR-7	CLIP-seq
MIRT2611337	hsa-miR-3613-3p	CLIP-seq
MIRT2611338	hsa-miR-371-5p	CLIP-seq
MIRT2611339	hsa-miR-371b-5p	CLIP-seq
MIRT2611340	hsa-miR-4421	CLIP-seq
MIRT2315024	hsa-miR-548t	CLIP-seq
MIRT2611337	hsa-miR-3613-3p	CLIP-seq
MIRT2611338	hsa-miR-371-5p	CLIP-seq
MIRT2611339	hsa-miR-371b-5p	CLIP-seq
MIRT2611340	hsa-miR-4421	CLIP-seq
MIRT2315023	hsa-miR-4796-3p	CLIP-seq
MIRT2315024	hsa-miR-548t	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007601	Process	Visual perception	IEA
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0050908	Process	Detection of light stimulus involved in visual perception	IBA
GO:0050908	Process	Detection of light stimulus involved in visual perception	IEA
GO:0120200	Component	Rod photoreceptor outer segment	IEA

Other IDs

• MIM: 607814
• HGNC: 30304
• e!Ensembl: ENSG00000186326

Protein

• UniProt ID: Q6ZS82
• Protein name: Regulator of G-protein signaling 9-binding protein (RGS9-anchoring protein)
• Protein function: Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to
• Sequence:

  MAREECKALLDGLNKTTACYHHLVLTVGGSADSQNLRQELQKTRQKAQELAVSTCARLTA
  VLRDRGLAADERAEFERLWVAFSGCLDLLEADMRRALELGAAFPLHAPRRPLVRTGVAGA
  SSGVAARALSTRSLRLEAEGDFDVADLRELEREVLQVGEMIDNMEMKVNVPRWTVQARQA
  AGAELLSTVSAGPSSVVSLQERGGGCDPRKALAAILFGAVLLAAVALAVCVAKLS

• Sequence length: 235

Pathways

Reactome Pathway:

Inactivation, recovery and regulation of the phototransduction cascade

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Bradyopsia	Pathogenic	rs758583548, rs1968005848	RCV000002965 RCV001283837	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Prolonged electroretinal response suppression 2	Pathogenic	rs1968006085	RCV003990409	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Retinal dystrophy	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA 1	—	CTD	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RGS9BP-related disorder	Likely benign; Uncertain significance; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (15)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Abnormal involuntary movement	Abnormal Involuntary Movement	BEFREE	15728856		★☆☆☆☆ Found in Text Mining only
Bradyopsia	Bradyopsia	Orphanet			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cone Dystrophy	Cone dystrophy	Pubtator	26957898	Associate	★☆☆☆☆ Found in Text Mining only
Disorder of eye	Disorder Of Eye	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Dyskinesia, Drug-Induced	Dyskinesia	CTD_human_DG	18160641, 24663062		★☆☆☆☆ Found in Text Mining only
Dyskinetic syndrome	Dyskinetic Syndrome	BEFREE	15728856, 18548510		★☆☆☆☆ Found in Text Mining only
Dystonia Disorders	Dystonia	BEFREE	30552094		★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	GWASCAT_DG	30067105		★☆☆☆☆ Found in Text Mining only
Leber Congenital Amaurosis	Leber Congenital Amaurosis	CLINVAR_DG	30718709		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24317514		★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	17318883		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	15728856		★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	15728856, 17318883		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	16786561, 17318883, 18548510		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	CTD_human_DG	17318883		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for RGS9BP.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RGS9BP.