RGL4 (ral guanine nucleotide dissociation stimulator like 4)

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Gene Gene information from NCBI Gene database.
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Entrez ID 266747
Gene name Ral guanine nucleotide dissociation stimulator like 4
Gene symbol RGL4
Synonyms (NCBI Gene)
Rgr
Chromosome 22
Chromosome location 22q11.23
Summary This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate sever
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT1302945 hsa-miR-1185 CLIP-seq
MIRT1302946 hsa-miR-1301 CLIP-seq
MIRT1302947 hsa-miR-31 CLIP-seq
MIRT1302948 hsa-miR-3605-5p CLIP-seq
MIRT1302949 hsa-miR-3679-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005085 Function Guanyl-nucleotide exchange factor activity IBA
GO:0005085 Function Guanyl-nucleotide exchange factor activity IEA
GO:0005886 Component Plasma membrane IBA
GO:0007264 Process Small GTPase-mediated signal transduction IEA
GO:0007265 Process Ras protein signal transduction IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
612214 31911 ENSG00000159496
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IZJ4
Protein name Ral-GDS-related protein (hRGR) (Ral guanine nucleotide dissociation stimulator-like 4) (RalGDS-like 4)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00617 RasGEF 222 → 421 RasGEF domain Family
Sequence 
MRKLLTNLPAAAVLSAQVYSAVLQGLWEENVCGTPGRTRVCTALLYGQVCPFQDSTDGLR
TITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGLGLEDHQEIVLGQLVLPEPNE
AKPDDPAPRPGQHALTMPALEPAPPLLADLGPALEPESPAALGPPGYLHSAPGPAPAPGE
GPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVL
HECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWI
KVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLL
IKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSK
EVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEPENP
Sequence length 473
Interactions View interactions

No strongly related genes found yet for RGL4.

No additional diseases found yet through genes similar to RGL4.