RGL2 (ral guanine nucleotide dissociation stimulator like 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5863
• Gene name: Ral guanine nucleotide dissociation stimulator like 2
• Gene symbol: RGL2
• Synonyms (NCBI Gene): HKE1.5, KE1.5, RAB2L
• Chromosome: 6
• Chromosome location: 6p21.32

miRNA Show/Hide all (129)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018288	hsa-miR-335-5p	Microarray	18185580
MIRT492431	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT492431	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT492430	hsa-miR-196a-5p	PAR-CLIP	23592263
MIRT492429	hsa-miR-196b-5p	PAR-CLIP	23592263
MIRT492428	hsa-miR-4255	PAR-CLIP	23592263
MIRT492427	hsa-miR-200a-5p	PAR-CLIP	23592263
MIRT492426	hsa-miR-200b-5p	PAR-CLIP	23592263
MIRT492425	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT492424	hsa-miR-299-5p	PAR-CLIP	23592263
MIRT492423	hsa-miR-2052	PAR-CLIP	23592263
MIRT492422	hsa-miR-19a-5p	PAR-CLIP	23592263
MIRT492421	hsa-miR-19b-1-5p	PAR-CLIP	23592263
MIRT492420	hsa-miR-19b-2-5p	PAR-CLIP	23592263
MIRT492419	hsa-miR-4795-3p	PAR-CLIP	23592263
MIRT492418	hsa-miR-29b-2-5p	PAR-CLIP	23592263
MIRT492417	hsa-miR-659-3p	PAR-CLIP	23592263
MIRT469360	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT469359	hsa-miR-544b	PAR-CLIP	23592263
MIRT469358	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT469357	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT469356	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT469355	hsa-miR-6089	PAR-CLIP	23592263
MIRT469354	hsa-miR-874-5p	PAR-CLIP	23592263
MIRT469353	hsa-miR-409-5p	PAR-CLIP	23592263
MIRT469352	hsa-miR-203a-5p	PAR-CLIP	23592263
MIRT469351	hsa-miR-1273g-5p	PAR-CLIP	23592263
MIRT469350	hsa-miR-7848-3p	PAR-CLIP	23592263
MIRT492431	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT492431	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT492430	hsa-miR-196a-5p	PAR-CLIP	23592263
MIRT492429	hsa-miR-196b-5p	PAR-CLIP	23592263
MIRT492428	hsa-miR-4255	PAR-CLIP	23592263
MIRT492427	hsa-miR-200a-5p	PAR-CLIP	23592263
MIRT492426	hsa-miR-200b-5p	PAR-CLIP	23592263
MIRT492425	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT492424	hsa-miR-299-5p	PAR-CLIP	23592263
MIRT492423	hsa-miR-2052	PAR-CLIP	23592263
MIRT492422	hsa-miR-19a-5p	PAR-CLIP	23592263
MIRT492421	hsa-miR-19b-1-5p	PAR-CLIP	23592263
MIRT492420	hsa-miR-19b-2-5p	PAR-CLIP	23592263
MIRT492419	hsa-miR-4795-3p	PAR-CLIP	23592263
MIRT492418	hsa-miR-29b-2-5p	PAR-CLIP	23592263
MIRT492417	hsa-miR-659-3p	PAR-CLIP	23592263
MIRT469360	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT469359	hsa-miR-544b	PAR-CLIP	23592263
MIRT469358	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT469357	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT469356	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT469355	hsa-miR-6089	PAR-CLIP	23592263
MIRT469354	hsa-miR-874-5p	PAR-CLIP	23592263
MIRT469353	hsa-miR-409-5p	PAR-CLIP	23592263
MIRT469352	hsa-miR-203a-5p	PAR-CLIP	23592263
MIRT469351	hsa-miR-1273g-5p	PAR-CLIP	23592263
MIRT469350	hsa-miR-7848-3p	PAR-CLIP	23592263
MIRT1302917	hsa-miR-1284	CLIP-seq
MIRT1302918	hsa-miR-146b-3p	CLIP-seq
MIRT1302919	hsa-miR-149	CLIP-seq
MIRT1302920	hsa-miR-1913	CLIP-seq
MIRT1302921	hsa-miR-204	CLIP-seq
MIRT1302922	hsa-miR-211	CLIP-seq
MIRT1302923	hsa-miR-24	CLIP-seq
MIRT1302924	hsa-miR-3173-5p	CLIP-seq
MIRT1302925	hsa-miR-3202	CLIP-seq
MIRT1302926	hsa-miR-324-3p	CLIP-seq
MIRT1302927	hsa-miR-3652	CLIP-seq
MIRT1302928	hsa-miR-4283	CLIP-seq
MIRT1302929	hsa-miR-4287	CLIP-seq
MIRT1302930	hsa-miR-4292	CLIP-seq
MIRT1302931	hsa-miR-4427	CLIP-seq
MIRT1302932	hsa-miR-4430	CLIP-seq
MIRT1302933	hsa-miR-4437	CLIP-seq
MIRT1302934	hsa-miR-4489	CLIP-seq
MIRT1302935	hsa-miR-4505	CLIP-seq
MIRT1302936	hsa-miR-4533	CLIP-seq
MIRT1302937	hsa-miR-4680-3p	CLIP-seq
MIRT1302938	hsa-miR-4685-3p	CLIP-seq
MIRT1302939	hsa-miR-4747-5p	CLIP-seq
MIRT1302940	hsa-miR-4762-3p	CLIP-seq
MIRT1302941	hsa-miR-4789-5p	CLIP-seq
MIRT1302942	hsa-miR-4793-3p	CLIP-seq
MIRT1302943	hsa-miR-490-5p	CLIP-seq
MIRT1302944	hsa-miR-874	CLIP-seq
MIRT1302917	hsa-miR-1284	CLIP-seq
MIRT1302919	hsa-miR-149	CLIP-seq
MIRT1302920	hsa-miR-1913	CLIP-seq
MIRT1302921	hsa-miR-204	CLIP-seq
MIRT1302922	hsa-miR-211	CLIP-seq
MIRT2089925	hsa-miR-3120-5p	CLIP-seq
MIRT2089926	hsa-miR-3180-5p	CLIP-seq
MIRT1302925	hsa-miR-3202	CLIP-seq
MIRT1302926	hsa-miR-324-3p	CLIP-seq
MIRT2089927	hsa-miR-338-3p	CLIP-seq
MIRT1302927	hsa-miR-3652	CLIP-seq
MIRT1302929	hsa-miR-4287	CLIP-seq
MIRT1302931	hsa-miR-4427	CLIP-seq
MIRT1302932	hsa-miR-4430	CLIP-seq
MIRT1302935	hsa-miR-4505	CLIP-seq
MIRT2089928	hsa-miR-4530	CLIP-seq
MIRT1302936	hsa-miR-4533	CLIP-seq
MIRT2089929	hsa-miR-4652-3p	CLIP-seq
MIRT2089930	hsa-miR-4659a-5p	CLIP-seq
MIRT2089931	hsa-miR-4659b-5p	CLIP-seq
MIRT1302937	hsa-miR-4680-3p	CLIP-seq
MIRT1302938	hsa-miR-4685-3p	CLIP-seq
MIRT1302939	hsa-miR-4747-5p	CLIP-seq
MIRT1302940	hsa-miR-4762-3p	CLIP-seq
MIRT2089932	hsa-miR-4776-3p	CLIP-seq
MIRT1302941	hsa-miR-4789-5p	CLIP-seq
MIRT1302942	hsa-miR-4793-3p	CLIP-seq
MIRT1302943	hsa-miR-490-5p	CLIP-seq
MIRT2314761	hsa-miR-128	CLIP-seq
MIRT1302917	hsa-miR-1284	CLIP-seq
MIRT2314762	hsa-miR-27a	CLIP-seq
MIRT2314763	hsa-miR-27b	CLIP-seq
MIRT2089926	hsa-miR-3180-5p	CLIP-seq
MIRT2314764	hsa-miR-3182	CLIP-seq
MIRT1302925	hsa-miR-3202	CLIP-seq
MIRT2089927	hsa-miR-338-3p	CLIP-seq
MIRT2314765	hsa-miR-3591-5p	CLIP-seq
MIRT2314766	hsa-miR-3607-3p	CLIP-seq
MIRT2314767	hsa-miR-3686	CLIP-seq
MIRT2089928	hsa-miR-4530	CLIP-seq
MIRT1302936	hsa-miR-4533	CLIP-seq
MIRT1302939	hsa-miR-4747-5p	CLIP-seq
MIRT1302941	hsa-miR-4789-5p	CLIP-seq
MIRT1302942	hsa-miR-4793-3p	CLIP-seq
MIRT1302943	hsa-miR-490-5p	CLIP-seq
MIRT2314768	hsa-miR-617	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	NAS	8976381
GO:0005515	Function	Protein binding	IPI	20936779, 25416956, 32296183, 34591612, 34591642
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	NAS	8976381
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	IEA
GO:0032485	Process	Regulation of Ral protein signal transduction	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA

Other IDs

• MIM: 602306
• HGNC: 9769
• e!Ensembl: ENSG00000237441

Protein

• UniProt ID: O15211
• Protein name: Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)
• Protein function: Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
• PDB: 8AU4 , 8B69
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00617	RasGEF	246 → 461	RasGEF domain	Family
  PF00618	RasGEF_N	91 → 188	RasGEF N-terminal motif	Domain
  PF00788	RA	648 → 735	Ras association (RalGDS/AF-6) domain	Domain

• Sequence:

  MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDE
  EEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAF
  LATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKG
  QLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPADPTDVL
  VFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGA
  VVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQS
  SPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPR
  SGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGY
  NLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSV
  GVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPSH
  LSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGE
  DGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYA
  MDGASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF

• Sequence length: 777

Pathways

KEGG Pathway:

Ras signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Lung cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	20801877		★☆☆☆☆ Found in Text Mining only
Calcinosis	Calcinosis	Pubtator	21160498	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	20801877	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36941538	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	20801877		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34793589	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	20801877		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	20801877	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for RGL2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RGL2.