RFPL3 (ret finger protein like 3)

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Gene Gene information from NCBI Gene database.
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Entrez ID 10738
Gene name Ret finger protein like 3
Gene symbol RFPL3
Synonyms (NCBI Gene)
RNF120
Chromosome 22
Chromosome location 22q12.3
miRNA miRNA information provided by mirtarbase database.
1
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miRTarBase ID miRNA Experiments Reference
MIRT1301949 hsa-miR-4777-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0008270 Function Zinc ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
605970 9980 ENSG00000128276
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75679
Protein name Ret finger protein-like 3
Protein function (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00622 SPRY 179 → 296 SPRY domain Family
PF11002 RDM 83 → 124 RFPL defining motif (RDM) Domain
PF13765 PRY 127 → 175 SPRY-associated domain Family
PF15227 zf-C3HC4_4 40 → 81 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed during neurogenesis in differentiating human embryonic stem cells and in the developing human neocortex. {ECO:0000269|PubMed:18656177}.
Sequence
Sequence length 317
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Malignant tumor of urinary bladder Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Lung Neoplasms Lung neoplasms Pubtator 26318425 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Non-Small Cell Lung Carcinoma Lung carcinoma BEFREE 29749533
★★★★★
★☆☆☆☆
Found in Text Mining only

No strongly related genes found yet for RFPL3.

No additional diseases found yet through genes similar to RFPL3.