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Gene Gene information from NCBI Gene database.
Entrez ID 117584
Gene name Ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Gene symbol RFFL
Synonyms (NCBI Gene)
CARP-2CARP2FRINGRIFIFYLINRNF189RNF34L
Chromosome 17
Chromosome location 17q12
miRNA miRNA information provided by mirtarbase database.
629 Show/Hide all (629)
miRTarBase ID miRNA Experiments Reference
MIRT002905 hsa-miR-124-3p Microarray 18668037
MIRT025938 hsa-miR-7-5p Microarray 19073608
MIRT049627 hsa-miR-92a-3p Luciferase reporter assay 23622248
MIRT052109 hsa-let-7b-5p CLASH 23622248
MIRT049627 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49 Show/Hide all (49)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 18450452
GO:0002020 Function Protease binding IPI 15069192
GO:0002039 Function P53 binding IEA
GO:0002039 Function P53 binding IPI 17121812, 18382127
GO:0005515 Function Protein binding IPI 22609986, 32814053
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609735 24821 ENSG00000092871
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WZ73
Protein name E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger pro
Protein function E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degrad
PDB 1Y02
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13920 zf-C3HC4_3 312 → 357 Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:15069192}.
Sequence
MWATCCNWFCLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLEPSCKSCGAHFANTARK
QTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELMKMKVKDLRDYLSLHDIST
EMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFLTQPHSSMVPPTSPNLPSS
SAQATSVPPAQVQENQQANGHVSQDQEEPVYLESVARVPAEDETQSIDSEDSFVPGRRAS
LSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHLVSGAE
DQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHV
FRS
Sequence length 363
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Regulation of TP53 Degradation