REEP4 (receptor accessory protein 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 80346
• Gene name: Receptor accessory protein 4
• Gene symbol: REEP4
• Synonyms (NCBI Gene): C8orf20, PP432, Yip2c
• Chromosome: 8
• Chromosome location: 8p21.3

miRNA Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032360	hsa-let-7b-5p	Proteomics	18668040
MIRT041356	hsa-miR-193b-3p	CLASH	23622248
MIRT041356	hsa-miR-193b-3p	CLASH	23622248
MIRT040173	hsa-miR-615-3p	CLASH	23622248
MIRT439789	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT439790	hsa-miR-543	HITS-CLIP	24374217
MIRT439788	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT726778	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT726777	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT439789	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT439790	hsa-miR-543	HITS-CLIP	24374217
MIRT439788	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT1299630	hsa-miR-103a	CLIP-seq
MIRT1299631	hsa-miR-107	CLIP-seq
MIRT1299632	hsa-miR-1197	CLIP-seq
MIRT1299633	hsa-miR-1205	CLIP-seq
MIRT1299634	hsa-miR-1207-3p	CLIP-seq
MIRT1299635	hsa-miR-1227	CLIP-seq
MIRT1299636	hsa-miR-1233	CLIP-seq
MIRT1299637	hsa-miR-1245b-5p	CLIP-seq
MIRT1299638	hsa-miR-1252	CLIP-seq
MIRT1299639	hsa-miR-129-3p	CLIP-seq
MIRT1299640	hsa-miR-1297	CLIP-seq
MIRT1299641	hsa-miR-1321	CLIP-seq
MIRT1299642	hsa-miR-1323	CLIP-seq
MIRT1299643	hsa-miR-138	CLIP-seq
MIRT1299644	hsa-miR-1470	CLIP-seq
MIRT1299645	hsa-miR-1909	CLIP-seq
MIRT1299646	hsa-miR-1972	CLIP-seq
MIRT1299647	hsa-miR-26a	CLIP-seq
MIRT1299648	hsa-miR-26b	CLIP-seq
MIRT1299649	hsa-miR-296-3p	CLIP-seq
MIRT1299650	hsa-miR-3127-5p	CLIP-seq
MIRT1299651	hsa-miR-3142	CLIP-seq
MIRT1299652	hsa-miR-3154	CLIP-seq
MIRT1299653	hsa-miR-3173-5p	CLIP-seq
MIRT1299654	hsa-miR-3179	CLIP-seq
MIRT1299655	hsa-miR-329	CLIP-seq
MIRT1299656	hsa-miR-362-3p	CLIP-seq
MIRT1299657	hsa-miR-3651	CLIP-seq
MIRT1299658	hsa-miR-3653	CLIP-seq
MIRT1299659	hsa-miR-3944-5p	CLIP-seq
MIRT1299660	hsa-miR-4254	CLIP-seq
MIRT1299661	hsa-miR-4270	CLIP-seq
MIRT1299662	hsa-miR-4308	CLIP-seq
MIRT1299663	hsa-miR-4436a	CLIP-seq
MIRT1299664	hsa-miR-4441	CLIP-seq
MIRT1299665	hsa-miR-4465	CLIP-seq
MIRT1299666	hsa-miR-4476	CLIP-seq
MIRT1299667	hsa-miR-4514	CLIP-seq
MIRT1299668	hsa-miR-4533	CLIP-seq
MIRT1299669	hsa-miR-455-5p	CLIP-seq
MIRT1299670	hsa-miR-4643	CLIP-seq
MIRT1299671	hsa-miR-4645-5p	CLIP-seq
MIRT1299672	hsa-miR-4650-5p	CLIP-seq
MIRT1299673	hsa-miR-4667-3p	CLIP-seq
MIRT1299674	hsa-miR-4673	CLIP-seq
MIRT1299675	hsa-miR-4687-5p	CLIP-seq
MIRT1299676	hsa-miR-4690-3p	CLIP-seq
MIRT1299677	hsa-miR-4692	CLIP-seq
MIRT1299678	hsa-miR-4726-3p	CLIP-seq
MIRT1299679	hsa-miR-4728-5p	CLIP-seq
MIRT1299680	hsa-miR-4739	CLIP-seq
MIRT1299681	hsa-miR-4755-3p	CLIP-seq
MIRT1299682	hsa-miR-4756-5p	CLIP-seq
MIRT1299683	hsa-miR-486-3p	CLIP-seq
MIRT1299684	hsa-miR-488	CLIP-seq
MIRT1299685	hsa-miR-548o	CLIP-seq
MIRT1299686	hsa-miR-548q	CLIP-seq
MIRT1299687	hsa-miR-576-3p	CLIP-seq
MIRT1299688	hsa-miR-579	CLIP-seq
MIRT1299689	hsa-miR-642b	CLIP-seq
MIRT1299690	hsa-miR-659	CLIP-seq
MIRT1299691	hsa-miR-922	CLIP-seq
MIRT1299692	hsa-miR-940	CLIP-seq
MIRT1299638	hsa-miR-1252	CLIP-seq
MIRT1299632	hsa-miR-1197	CLIP-seq
MIRT1299633	hsa-miR-1205	CLIP-seq
MIRT1299634	hsa-miR-1207-3p	CLIP-seq
MIRT1299636	hsa-miR-1233	CLIP-seq
MIRT1299638	hsa-miR-1252	CLIP-seq
MIRT1299639	hsa-miR-129-3p	CLIP-seq
MIRT1299640	hsa-miR-1297	CLIP-seq
MIRT1299643	hsa-miR-138	CLIP-seq
MIRT1299644	hsa-miR-1470	CLIP-seq
MIRT1299645	hsa-miR-1909	CLIP-seq
MIRT2089130	hsa-miR-214	CLIP-seq
MIRT1299647	hsa-miR-26a	CLIP-seq
MIRT1299648	hsa-miR-26b	CLIP-seq
MIRT2089131	hsa-miR-3151	CLIP-seq
MIRT1299652	hsa-miR-3154	CLIP-seq
MIRT1299653	hsa-miR-3173-5p	CLIP-seq
MIRT1299654	hsa-miR-3179	CLIP-seq
MIRT1299655	hsa-miR-329	CLIP-seq
MIRT2089132	hsa-miR-3619-5p	CLIP-seq
MIRT1299656	hsa-miR-362-3p	CLIP-seq
MIRT1299657	hsa-miR-3651	CLIP-seq
MIRT1299658	hsa-miR-3653	CLIP-seq
MIRT1299660	hsa-miR-4254	CLIP-seq
MIRT2089133	hsa-miR-4291	CLIP-seq
MIRT1299662	hsa-miR-4308	CLIP-seq
MIRT2089134	hsa-miR-4433	CLIP-seq
MIRT1299663	hsa-miR-4436a	CLIP-seq
MIRT2089135	hsa-miR-4459	CLIP-seq
MIRT1299665	hsa-miR-4465	CLIP-seq
MIRT1299666	hsa-miR-4476	CLIP-seq
MIRT1299667	hsa-miR-4514	CLIP-seq
MIRT1299668	hsa-miR-4533	CLIP-seq
MIRT1299669	hsa-miR-455-5p	CLIP-seq
MIRT1299670	hsa-miR-4643	CLIP-seq
MIRT1299671	hsa-miR-4645-5p	CLIP-seq
MIRT1299673	hsa-miR-4667-3p	CLIP-seq
MIRT1299674	hsa-miR-4673	CLIP-seq
MIRT1299675	hsa-miR-4687-5p	CLIP-seq
MIRT1299677	hsa-miR-4692	CLIP-seq
MIRT2089136	hsa-miR-4722-5p	CLIP-seq
MIRT1299678	hsa-miR-4726-3p	CLIP-seq
MIRT2089137	hsa-miR-4768-3p	CLIP-seq
MIRT2089138	hsa-miR-4779	CLIP-seq
MIRT1299684	hsa-miR-488	CLIP-seq
MIRT1299686	hsa-miR-548q	CLIP-seq
MIRT1299689	hsa-miR-642b	CLIP-seq
MIRT2089139	hsa-miR-761	CLIP-seq
MIRT2089140	hsa-miR-9	CLIP-seq
MIRT1299691	hsa-miR-922	CLIP-seq
MIRT1299692	hsa-miR-940	CLIP-seq
MIRT1299632	hsa-miR-1197	CLIP-seq
MIRT1299635	hsa-miR-1227	CLIP-seq
MIRT1299638	hsa-miR-1252	CLIP-seq
MIRT1299640	hsa-miR-1297	CLIP-seq
MIRT1299642	hsa-miR-1323	CLIP-seq
MIRT1299645	hsa-miR-1909	CLIP-seq
MIRT1299647	hsa-miR-26a	CLIP-seq
MIRT1299648	hsa-miR-26b	CLIP-seq
MIRT1299652	hsa-miR-3154	CLIP-seq
MIRT1299654	hsa-miR-3179	CLIP-seq
MIRT1299655	hsa-miR-329	CLIP-seq
MIRT1299656	hsa-miR-362-3p	CLIP-seq
MIRT1299658	hsa-miR-3653	CLIP-seq
MIRT1299663	hsa-miR-4436a	CLIP-seq
MIRT1299665	hsa-miR-4465	CLIP-seq
MIRT1299666	hsa-miR-4476	CLIP-seq
MIRT1299668	hsa-miR-4533	CLIP-seq
MIRT1299669	hsa-miR-455-5p	CLIP-seq
MIRT1299670	hsa-miR-4643	CLIP-seq
MIRT1299678	hsa-miR-4726-3p	CLIP-seq
MIRT1299681	hsa-miR-4755-3p	CLIP-seq
MIRT1299683	hsa-miR-486-3p	CLIP-seq
MIRT1299685	hsa-miR-548o	CLIP-seq
MIRT1299688	hsa-miR-579	CLIP-seq
MIRT1299689	hsa-miR-642b	CLIP-seq
MIRT1299690	hsa-miR-659	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15778465, 32296183, 33961781, 36931259
GO:0005783	Component	Endoplasmic reticulum	IDA	23911198
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005881	Component	Cytoplasmic microtubule	IBA
GO:0006998	Process	Nuclear envelope organization	IMP	23911198
GO:0007084	Process	Mitotic nuclear membrane reassembly	IMP	23911198
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	ISS
GO:0016020	Component	Membrane	IEA
GO:0051301	Process	Cell division	IEA
GO:0071782	Component	Endoplasmic reticulum tubular network	IBA
GO:0071786	Process	Endoplasmic reticulum tubular network organization	IBA

Other IDs

• MIM: 609349
• HGNC: 26176
• e!Ensembl: ENSG00000168476

Protein

• UniProt ID: Q9H6H4
• Protein name: Receptor expression-enhancing protein 4
• Protein function: Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03134	TB2_DP1_HVA22	19 → 95	TB2/DP1, HVA22 family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in circumvallate papillae and testis. {ECO:0000269|PubMed:16720576}.
• Sequence:

  MVSWMICRLVVLVFGMLCPAYASYKAVKTKNIREYVRWMMYWIVFALFMAAEIVTDIFIS
  WFPFYYEIKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDAYIVQAKERSYETVLS
  FGKRGLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSISDAPAPAYHDPLYLEDQVSHR
  RPPIGYRAGGLQDSDTEDECWSDTEAVPRAPARPREKPLIRSQSLRVVKRKPPVREGTSR
  SLKVRTRKKTVPSDVDS

• Sequence length: 257

Pathways

Reactome Pathway:

Olfactory Signaling Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Blepharospasm	Blepharospasm	BEFREE	30956059		★☆☆☆☆ Found in Text Mining only
Blepharospasm	Blepharospasm	Pubtator	30956059	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	38552216	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for REEP4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to REEP4.