RBMX2 (RNA binding motif protein X-linked 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51634
• Gene name: RNA binding motif protein X-linked 2
• Gene symbol: RBMX2
• Synonyms (NCBI Gene): CGI-79, Snu17
• Chromosome: X
• Chromosome location: Xq26.1

miRNA Show/Hide all (59)

miRTarBase ID	miRNA	Experiments	Reference
MIRT2088313	hsa-miR-1200	CLIP-seq
MIRT2088314	hsa-miR-204	CLIP-seq
MIRT2088315	hsa-miR-211	CLIP-seq
MIRT2088316	hsa-miR-3074-5p	CLIP-seq
MIRT2088317	hsa-miR-3115	CLIP-seq
MIRT2088318	hsa-miR-3124-3p	CLIP-seq
MIRT2088319	hsa-miR-3140-5p	CLIP-seq
MIRT2088320	hsa-miR-3647-3p	CLIP-seq
MIRT2088321	hsa-miR-4446-5p	CLIP-seq
MIRT2088322	hsa-miR-4755-5p	CLIP-seq
MIRT2088323	hsa-miR-615-5p	CLIP-seq
MIRT2088324	hsa-miR-623	CLIP-seq
MIRT2088313	hsa-miR-1200	CLIP-seq
MIRT2609513	hsa-miR-186	CLIP-seq
MIRT2088314	hsa-miR-204	CLIP-seq
MIRT2088315	hsa-miR-211	CLIP-seq
MIRT2088316	hsa-miR-3074-5p	CLIP-seq
MIRT2088317	hsa-miR-3115	CLIP-seq
MIRT2609514	hsa-miR-3121-3p	CLIP-seq
MIRT2088318	hsa-miR-3124-3p	CLIP-seq
MIRT2088319	hsa-miR-3140-5p	CLIP-seq
MIRT2609515	hsa-miR-325	CLIP-seq
MIRT2609516	hsa-miR-335	CLIP-seq
MIRT2088320	hsa-miR-3647-3p	CLIP-seq
MIRT2088321	hsa-miR-4446-5p	CLIP-seq
MIRT2088322	hsa-miR-4755-5p	CLIP-seq
MIRT2609517	hsa-miR-4777-5p	CLIP-seq
MIRT2609518	hsa-miR-4799-5p	CLIP-seq
MIRT2609519	hsa-miR-518d-5p	CLIP-seq
MIRT2609520	hsa-miR-519b-5p	CLIP-seq
MIRT2609521	hsa-miR-519c-5p	CLIP-seq
MIRT2609522	hsa-miR-520c-5p	CLIP-seq
MIRT2609523	hsa-miR-526a	CLIP-seq
MIRT2088323	hsa-miR-615-5p	CLIP-seq
MIRT2088324	hsa-miR-623	CLIP-seq
MIRT2609524	hsa-miR-628-3p	CLIP-seq
MIRT2088313	hsa-miR-1200	CLIP-seq
MIRT2609513	hsa-miR-186	CLIP-seq
MIRT2088314	hsa-miR-204	CLIP-seq
MIRT2088315	hsa-miR-211	CLIP-seq
MIRT2088316	hsa-miR-3074-5p	CLIP-seq
MIRT2609514	hsa-miR-3121-3p	CLIP-seq
MIRT2088318	hsa-miR-3124-3p	CLIP-seq
MIRT2088319	hsa-miR-3140-5p	CLIP-seq
MIRT2609515	hsa-miR-325	CLIP-seq
MIRT2088320	hsa-miR-3647-3p	CLIP-seq
MIRT2088321	hsa-miR-4446-5p	CLIP-seq
MIRT2689502	hsa-miR-4522	CLIP-seq
MIRT2088322	hsa-miR-4755-5p	CLIP-seq
MIRT2609517	hsa-miR-4777-5p	CLIP-seq
MIRT2609518	hsa-miR-4799-5p	CLIP-seq
MIRT2609519	hsa-miR-518d-5p	CLIP-seq
MIRT2609520	hsa-miR-519b-5p	CLIP-seq
MIRT2609521	hsa-miR-519c-5p	CLIP-seq
MIRT2609522	hsa-miR-520c-5p	CLIP-seq
MIRT2609523	hsa-miR-526a	CLIP-seq
MIRT2088323	hsa-miR-615-5p	CLIP-seq
MIRT2088324	hsa-miR-623	CLIP-seq
MIRT2609524	hsa-miR-628-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	29360106
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	31744343
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	22365833, 32296183, 33961781, 39251607
GO:0005634	Component	Nucleus	IDA	29360106
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	31744343
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	NAS	31744343
GO:0005686	Component	U2 snRNP	IBA
GO:0005686	Component	U2 snRNP	NAS	31744343
GO:0005730	Component	Nucleolus	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0031965	Component	Nuclear membrane	IDA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	29360106
GO:0071011	Component	Precatalytic spliceosome	IBA
GO:1903241	Process	U2-type prespliceosome assembly	NAS	31744343

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9Y388
• Protein name: RNA-binding motif protein, X-linked 2
• Protein function: Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, EC
• PDB: 5Z56 , 5Z57 , 5Z58 , 6FF4 , 6FF7 , 7ABH , 7ABI , 7DVQ , 8I0P , 8I0R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	38 → 108	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MNPLTKVKLINELNEREVQLGVADKVSWHSEYKDSAWIFLGGLPYELTEGDIICVFSQYG
  EIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYRAPKD
  SEEIDDVTRQLQEKGCGARTPSPSLSESSEDEKPTKKHKKDKKEKKKKKKEKEKADREVQ
  AEQPSSSSPRRKTVKEKDDTGPKKHSSKNSERAQKSEPREGQKLPKSRTAYSGGAEDLER
  ELKKEKPKHEHKSSSRREAREEKTRIRDRGRSSDAHSSWYNGRSEGRSYRSRSRSRDKSH
  RHKRARRSRERESSNPSDRWRH

• Sequence length: 322

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Abnormality of neuronal migration	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bipolar Disorder	Bipolar disorder	Pubtator	34914762	Associate	★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	17012841		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for RBMX2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RBMX2.