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Gene Gene information from NCBI Gene database.
Entrez ID 57786
Gene name RB associated KRAB zinc finger
Gene symbol RBAK
Synonyms (NCBI Gene)
ZNF769
Chromosome 7
Chromosome location 7p22.1
Summary This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein
miRNA miRNA information provided by mirtarbase database.
401 Show/Hide all (401)
miRTarBase ID miRNA Experiments Reference
MIRT020857 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT021316 hsa-miR-125a-5p Sequencing 20371350
MIRT043869 hsa-miR-378a-3p CLASH 23622248
MIRT040111 hsa-miR-615-3p CLASH 23622248
MIRT020857 hsa-miR-155-5p MicroarrayqRT-PCR 25128227
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus TAS 10702291
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608191 17680 ENSG00000146587
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NYW8
Protein name RB-associated KRAB zinc finger protein (RB-associated KRAB repressor) (hRBaK) (Zinc finger protein 769)
Protein function May repress E2F-dependent transcription. May promote AR-dependent transcription.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 373 → 395 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 651 → 673 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 289 → 311 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 623 → 645 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 401 → 423 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 567 → 589 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 429 → 451 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 317 → 339 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 345 → 367 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 457 → 479 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 595 → 617 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 261 → 283 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 679 → 701 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 539 → 561 Zinc finger, C2H2 type Domain
PF01352 KRAB 7 → 48 KRAB box Family
Tissue specificity TISSUE SPECIFICITY: Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta. {ECO:0000269|PubMed:10702291}.
Sequence
MNTLQGPVSFKDVAVDFTQEEWQQLDPDEKITYRDVMLENYSHLVSVGYDTTKPNVIIKL
EQGEEPWIMGGEFPCQHSPEAWRVDDLIERIQENEDKHSRQAACINSKTLTEEKENTFSQ
IYMETSLVPSSIIAHNCVSCGKNLESISQLISSDGSYARTKPDECNECGKTYHGEKMCEF
NQNGDTYSHNEENILQKISILEKPFEYNECMEALDNEAVFIAHKRAYIGEKPYEWNDSGP
DFIQMSNFNAYQRSQMEMKPFECSECGKSFCKKSKFIIHQRAHTGEKPYECNVCGKSFSQ
KGTLTVHRRSH
LEEKPYKCNECGKTFCQKLHLTQHLRTHSGEKPYECSECGKTFCQKTHL
TLHQRNH
SGERPYPCNECGKSFSRKSALSDHQRTHTGEKLYKCNECGKSYYRKSTLITHQ
RTH
TGEKPYQCSECGKFFSRVSYLTIHYRSHLEEKPYECNECGKTFNLNSAFIRHRKVHT
EEKSHECSECGKFSQLYLTDHHTAHLEEKPYECNECGKTFLVNSAFDGHQPLPKGEKSYE
CNVCGKLFNELSYYTEHYRSH
SEEKPYGCSECGKTFSHNSSLFRHQRVHTGEKPYECYEC
GKFFSQKSYLTIHHRIH
SGEKPYECSKCGKVFSRMSNLTVHYRSHSGEKPYECNECGKVF
SQKSYLTVHYRTH
SGEKPYECNECGKKFHHRSAFNSHQRIHRRGNMNVLDVENL
Sequence length 714
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Prostate cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations