RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5910
• Gene name: Rap1 GTPase-GDP dissociation stimulator 1
• Gene symbol: RAP1GDS1
• Synonyms (NCBI Gene): GDS1, SmgGDS
• Chromosome: 4
• Chromosome location: 4q23
• Summary: The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

miRNA Show/Hide all (194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT662162	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT453732	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT453731	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT453730	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT453729	hsa-miR-5693	PAR-CLIP	23592263
MIRT453728	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT453726	hsa-miR-4797-3p	PAR-CLIP	23592263
MIRT453727	hsa-miR-4264	PAR-CLIP	23592263
MIRT453725	hsa-miR-6134	PAR-CLIP	23592263
MIRT453724	hsa-miR-3689d	PAR-CLIP	23592263
MIRT453722	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT453723	hsa-miR-4470	PAR-CLIP	23592263
MIRT453721	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT453720	hsa-miR-3153	PAR-CLIP	23592263
MIRT453719	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT453718	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT453717	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT453716	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT662162	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT453732	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT453731	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT453730	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT453729	hsa-miR-5693	PAR-CLIP	23592263
MIRT453728	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT453726	hsa-miR-4797-3p	PAR-CLIP	23592263
MIRT453727	hsa-miR-4264	PAR-CLIP	23592263
MIRT453725	hsa-miR-6134	PAR-CLIP	23592263
MIRT453724	hsa-miR-3689d	PAR-CLIP	23592263
MIRT453722	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT453723	hsa-miR-4470	PAR-CLIP	23592263
MIRT453721	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT453720	hsa-miR-3153	PAR-CLIP	23592263
MIRT453719	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT453718	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT453717	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT453716	hsa-miR-3688-5p	PAR-CLIP	23592263
MIRT1290137	hsa-miR-1225-5p	CLIP-seq
MIRT1290138	hsa-miR-3150a-3p	CLIP-seq
MIRT1290139	hsa-miR-3175	CLIP-seq
MIRT1290140	hsa-miR-3675-5p	CLIP-seq
MIRT1290141	hsa-miR-3714	CLIP-seq
MIRT1290142	hsa-miR-4434	CLIP-seq
MIRT1290143	hsa-miR-4516	CLIP-seq
MIRT1290144	hsa-miR-939	CLIP-seq
MIRT1290145	hsa-miR-302f	CLIP-seq
MIRT1290146	hsa-miR-4277	CLIP-seq
MIRT1290147	hsa-miR-4282	CLIP-seq
MIRT1290148	hsa-miR-1200	CLIP-seq
MIRT1290149	hsa-miR-1244	CLIP-seq
MIRT1290150	hsa-miR-199a-3p	CLIP-seq
MIRT1290151	hsa-miR-199b-3p	CLIP-seq
MIRT1290152	hsa-miR-28-5p	CLIP-seq
MIRT1290153	hsa-miR-3125	CLIP-seq
MIRT1290154	hsa-miR-3129-5p	CLIP-seq
MIRT1290155	hsa-miR-3139	CLIP-seq
MIRT1290156	hsa-miR-3529	CLIP-seq
MIRT1290157	hsa-miR-379	CLIP-seq
MIRT1290158	hsa-miR-3913-3p	CLIP-seq
MIRT1290159	hsa-miR-3916	CLIP-seq
MIRT1290160	hsa-miR-3924	CLIP-seq
MIRT1290161	hsa-miR-4324	CLIP-seq
MIRT1290162	hsa-miR-4451	CLIP-seq
MIRT1290163	hsa-miR-4476	CLIP-seq
MIRT1290164	hsa-miR-4496	CLIP-seq
MIRT1290165	hsa-miR-4533	CLIP-seq
MIRT1290166	hsa-miR-4633-3p	CLIP-seq
MIRT1290167	hsa-miR-4650-3p	CLIP-seq
MIRT1290168	hsa-miR-4765	CLIP-seq
MIRT1290169	hsa-miR-489	CLIP-seq
MIRT1290170	hsa-miR-494	CLIP-seq
MIRT1290171	hsa-miR-544b	CLIP-seq
MIRT1290172	hsa-miR-548u	CLIP-seq
MIRT1290173	hsa-miR-582-3p	CLIP-seq
MIRT1290174	hsa-miR-708	CLIP-seq
MIRT1290175	hsa-miR-936	CLIP-seq
MIRT2086258	hsa-miR-193a-5p	CLIP-seq
MIRT2086259	hsa-miR-34a	CLIP-seq
MIRT2086260	hsa-miR-34c-5p	CLIP-seq
MIRT2086261	hsa-miR-449a	CLIP-seq
MIRT2086262	hsa-miR-449b	CLIP-seq
MIRT2086263	hsa-miR-942	CLIP-seq
MIRT2311396	hsa-miR-514	CLIP-seq
MIRT2311397	hsa-miR-514b-3p	CLIP-seq
MIRT2086259	hsa-miR-34a	CLIP-seq
MIRT2086260	hsa-miR-34c-5p	CLIP-seq
MIRT2086261	hsa-miR-449a	CLIP-seq
MIRT2086262	hsa-miR-449b	CLIP-seq
MIRT2311398	hsa-miR-4517	CLIP-seq
MIRT2311399	hsa-miR-4704-5p	CLIP-seq
MIRT2311400	hsa-miR-4709-3p	CLIP-seq
MIRT2311401	hsa-miR-4717-3p	CLIP-seq
MIRT2311402	hsa-miR-889	CLIP-seq
MIRT1290137	hsa-miR-1225-5p	CLIP-seq
MIRT2607730	hsa-miR-1237	CLIP-seq
MIRT2607731	hsa-miR-1248	CLIP-seq
MIRT2607732	hsa-miR-129-3p	CLIP-seq
MIRT2607733	hsa-miR-1295	CLIP-seq
MIRT2607734	hsa-miR-1303	CLIP-seq
MIRT2607735	hsa-miR-1321	CLIP-seq
MIRT2607736	hsa-miR-136	CLIP-seq
MIRT2607737	hsa-miR-140-5p	CLIP-seq
MIRT2607738	hsa-miR-1910	CLIP-seq
MIRT1290150	hsa-miR-199a-3p	CLIP-seq
MIRT1290151	hsa-miR-199b-3p	CLIP-seq
MIRT2607739	hsa-miR-204	CLIP-seq
MIRT2607740	hsa-miR-2052	CLIP-seq
MIRT2607741	hsa-miR-211	CLIP-seq
MIRT1290154	hsa-miR-3129-5p	CLIP-seq
MIRT1290138	hsa-miR-3150a-3p	CLIP-seq
MIRT1290139	hsa-miR-3175	CLIP-seq
MIRT2607742	hsa-miR-3545-5p	CLIP-seq
MIRT2607743	hsa-miR-3605-3p	CLIP-seq
MIRT2607744	hsa-miR-3665	CLIP-seq
MIRT1290140	hsa-miR-3675-5p	CLIP-seq
MIRT1290141	hsa-miR-3714	CLIP-seq
MIRT1290158	hsa-miR-3913-3p	CLIP-seq
MIRT2607745	hsa-miR-4270	CLIP-seq
MIRT2607746	hsa-miR-431	CLIP-seq
MIRT2607747	hsa-miR-432	CLIP-seq
MIRT1290142	hsa-miR-4434	CLIP-seq
MIRT2607748	hsa-miR-4441	CLIP-seq
MIRT2607749	hsa-miR-4460	CLIP-seq
MIRT1290164	hsa-miR-4496	CLIP-seq
MIRT1290143	hsa-miR-4516	CLIP-seq
MIRT2607750	hsa-miR-4520a-3p	CLIP-seq
MIRT2607751	hsa-miR-4520b-3p	CLIP-seq
MIRT2607752	hsa-miR-4529-3p	CLIP-seq
MIRT2607753	hsa-miR-4704-3p	CLIP-seq
MIRT2607754	hsa-miR-4717-5p	CLIP-seq
MIRT2607755	hsa-miR-4736	CLIP-seq
MIRT2607756	hsa-miR-4739	CLIP-seq
MIRT2607757	hsa-miR-4755-5p	CLIP-seq
MIRT2607758	hsa-miR-4756-5p	CLIP-seq
MIRT2607759	hsa-miR-4760-5p	CLIP-seq
MIRT2607760	hsa-miR-4775	CLIP-seq
MIRT2607761	hsa-miR-4777-3p	CLIP-seq
MIRT1290169	hsa-miR-489	CLIP-seq
MIRT2607762	hsa-miR-513a-5p	CLIP-seq
MIRT1290172	hsa-miR-548u	CLIP-seq
MIRT2607763	hsa-miR-578	CLIP-seq
MIRT2607764	hsa-miR-623	CLIP-seq
MIRT2607765	hsa-miR-885-3p	CLIP-seq
MIRT2607766	hsa-miR-885-5p	CLIP-seq
MIRT1290175	hsa-miR-936	CLIP-seq
MIRT1290144	hsa-miR-939	CLIP-seq
MIRT2607767	hsa-miR-940	CLIP-seq
MIRT1290137	hsa-miR-1225-5p	CLIP-seq
MIRT2607730	hsa-miR-1237	CLIP-seq
MIRT2607731	hsa-miR-1248	CLIP-seq
MIRT2607732	hsa-miR-129-3p	CLIP-seq
MIRT2607733	hsa-miR-1295	CLIP-seq
MIRT2607735	hsa-miR-1321	CLIP-seq
MIRT2607736	hsa-miR-136	CLIP-seq
MIRT2607737	hsa-miR-140-5p	CLIP-seq
MIRT2607738	hsa-miR-1910	CLIP-seq
MIRT1290150	hsa-miR-199a-3p	CLIP-seq
MIRT1290151	hsa-miR-199b-3p	CLIP-seq
MIRT2607739	hsa-miR-204	CLIP-seq
MIRT2607740	hsa-miR-2052	CLIP-seq
MIRT2607741	hsa-miR-211	CLIP-seq
MIRT1290154	hsa-miR-3129-5p	CLIP-seq
MIRT1290138	hsa-miR-3150a-3p	CLIP-seq
MIRT1290139	hsa-miR-3175	CLIP-seq
MIRT2607742	hsa-miR-3545-5p	CLIP-seq
MIRT2607743	hsa-miR-3605-3p	CLIP-seq
MIRT2607744	hsa-miR-3665	CLIP-seq
MIRT1290140	hsa-miR-3675-5p	CLIP-seq
MIRT1290141	hsa-miR-3714	CLIP-seq
MIRT1290158	hsa-miR-3913-3p	CLIP-seq
MIRT2607745	hsa-miR-4270	CLIP-seq
MIRT2607746	hsa-miR-431	CLIP-seq
MIRT2607747	hsa-miR-432	CLIP-seq
MIRT1290142	hsa-miR-4434	CLIP-seq
MIRT2607748	hsa-miR-4441	CLIP-seq
MIRT2607749	hsa-miR-4460	CLIP-seq
MIRT1290143	hsa-miR-4516	CLIP-seq
MIRT2607750	hsa-miR-4520a-3p	CLIP-seq
MIRT2607751	hsa-miR-4520b-3p	CLIP-seq
MIRT2607752	hsa-miR-4529-3p	CLIP-seq
MIRT2607753	hsa-miR-4704-3p	CLIP-seq
MIRT2607754	hsa-miR-4717-5p	CLIP-seq
MIRT2607755	hsa-miR-4736	CLIP-seq
MIRT2607756	hsa-miR-4739	CLIP-seq
MIRT2607757	hsa-miR-4755-5p	CLIP-seq
MIRT2607758	hsa-miR-4756-5p	CLIP-seq
MIRT2607760	hsa-miR-4775	CLIP-seq
MIRT2607761	hsa-miR-4777-3p	CLIP-seq
MIRT2607762	hsa-miR-513a-5p	CLIP-seq
MIRT2607763	hsa-miR-578	CLIP-seq
MIRT2607764	hsa-miR-623	CLIP-seq
MIRT2607765	hsa-miR-885-3p	CLIP-seq
MIRT2607766	hsa-miR-885-5p	CLIP-seq
MIRT1290144	hsa-miR-939	CLIP-seq
MIRT2607767	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003300	Process	Cardiac muscle hypertrophy	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	21242305, 28630045, 30190425
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	20936779, 24415755, 25416956, 27716788, 28630045, 30190425, 31406347, 31980649, 32296183, 32353859, 32814053, 32838362, 33060197, 33961781, 34159380, 35271311, 36217030
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	12551911
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	24349085
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	24349085
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	24349085
GO:0005829	Component	Cytosol	IEA
GO:0010821	Process	Regulation of mitochondrion organization	IMP	27716788
GO:0014829	Process	Vascular associated smooth muscle contraction	IEA
GO:0030695	Function	GTPase regulator activity	IEA
GO:0031034	Process	Myosin filament assembly	IEA
GO:0032471	Process	Negative regulation of endoplasmic reticulum calcium ion concentration	IMP	24349085
GO:0034504	Process	Protein localization to nucleus	IMP	12551911
GO:0051561	Process	Positive regulation of mitochondrial calcium ion concentration	IMP	24349085
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070376	Process	Regulation of ERK5 cascade	IEA
GO:0080120	Process	CAAX-box protein maturation	IMP	20709748
GO:0086098	Process	Angiotensin-activated signaling pathway involved in heart process	IEA
GO:1904464	Process	Regulation of matrix metallopeptidase secretion	IEA

Other IDs

• MIM: 179502
• HGNC: 9859
• e!Ensembl: ENSG00000138698

Protein

• UniProt ID: P52306
• Protein name: Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
• Protein function: Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (PubMed:11948427, PubMed:1549351, PubMed:20709748, PubMe
• PDB: 5XGC , 5ZHX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00514	Arm	346 → 390	Armadillo/beta-catenin-like repeat	Repeat
  PF00514	Arm	78 → 118	Armadillo/beta-catenin-like repeat	Repeat
  PF00514	Arm	169 → 211	Armadillo/beta-catenin-like repeat	Repeat
  PF00514	Arm	479 → 519	Armadillo/beta-catenin-like repeat	Repeat

• Sequence:

  MDNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTP
  QSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDS
  HEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMG
  VIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDK
  REMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLL
  LGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVE
  KLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF
  KLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK
  DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR
  LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE
  QRLTVES

• Sequence length: 607

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Alfadhel syndrome	Pathogenic	rs2110217457, rs2529805271	RCV003448987 RCV003449002	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
RAP1GDS1-related disorder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (21)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	10929031		★☆☆☆☆ Found in Text Mining only
Aphasia	Aphasia	Pubtator	32431071	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	24197117, 24552806		★☆☆☆☆ Found in Text Mining only
Congenital Abnormalities	Congenital abnormalities	Pubtator	32431071	Associate	★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	28866990		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	32431071	Associate	★☆☆☆☆ Found in Text Mining only
Language Development Disorders	Language development disorders	Pubtator	32431071	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	16419055, 26004809		★☆☆☆☆ Found in Text Mining only
Lymphoid leukemia	Lymphoid leukemia	BEFREE	10477737		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	24197117, 24552806		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	18973191		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10477737, 17951244, 18973191, 20709748, 24197117, 24552806, 28806394		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	24197117		★☆☆☆☆ Found in Text Mining only
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	18973191		★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	29528693		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17951244, 18973191, 24197117		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	17951244, 24552806		★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	10477737, 11325654, 12810632, 16467868, 26004809		★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	28866990		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	18973191		★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasias	Prostatic Neoplasms	BEFREE	18973191		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for RAP1GDS1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RAP1GDS1.