Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID	5906
Gene name	RAP1A, member of RAS oncogene family
Gene symbol	RAP1A
Synonyms (NCBI Gene)	C21KGG-22KKREV-1KREV1RAP1SMGP21
Chromosome	1
Chromosome location	1p13.2
Summary	This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide ex

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006958	hsa-miR-337-3p	Luciferase reporter assayqRT-PCRWestern blot	22723956
MIRT051421	hsa-let-7e-5p	CLASH	23622248
MIRT554948	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT554947	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT554946	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT554945	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT554944	hsa-miR-6750-5p	PAR-CLIP	21572407
MIRT554943	hsa-miR-6822-5p	PAR-CLIP	21572407
MIRT554942	hsa-miR-5692b	PAR-CLIP	21572407
MIRT554941	hsa-miR-5692c	PAR-CLIP	21572407
MIRT554940	hsa-miR-6715a-3p	PAR-CLIP	21572407
MIRT554939	hsa-miR-412-3p	PAR-CLIP	21572407
MIRT554938	hsa-miR-6754-3p	PAR-CLIP	21572407
MIRT554937	hsa-miR-6837-3p	PAR-CLIP	21572407
MIRT554936	hsa-miR-4471	PAR-CLIP	21572407
MIRT554935	hsa-miR-8059	PAR-CLIP	21572407
MIRT554934	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT512898	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT512897	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT512896	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT512895	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT512894	hsa-miR-5000-5p	PAR-CLIP	23446348
MIRT512893	hsa-miR-4761-5p	PAR-CLIP	23446348
MIRT512892	hsa-miR-759	PAR-CLIP	23446348
MIRT512891	hsa-miR-4470	PAR-CLIP	23446348
MIRT448559	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT448557	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT448558	hsa-miR-512-3p	PAR-CLIP	22100165
MIRT448556	hsa-miR-135a-3p	PAR-CLIP	22100165
MIRT448555	hsa-miR-636	PAR-CLIP	22100165
MIRT448554	hsa-miR-4671-3p	PAR-CLIP	22100165
MIRT448553	hsa-miR-4473	PAR-CLIP	22100165
MIRT448552	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448551	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT554947	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT554948	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT735569	hsa-miR-590-3p	ELISAImmunohistochemistry (IHC)Luciferase reporter assayqRT-PCRWestern blotting	33332780
MIRT006958	hsa-miR-337-3p	Luciferase reporter assayWestern blottingqRT-PCR	33748908
MIRT554948	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT554947	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT554946	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT554945	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT554944	hsa-miR-6750-5p	PAR-CLIP	21572407
MIRT554943	hsa-miR-6822-5p	PAR-CLIP	21572407
MIRT554942	hsa-miR-5692b	PAR-CLIP	21572407
MIRT554941	hsa-miR-5692c	PAR-CLIP	21572407
MIRT554940	hsa-miR-6715a-3p	PAR-CLIP	21572407
MIRT554939	hsa-miR-412-3p	PAR-CLIP	21572407
MIRT554938	hsa-miR-6754-3p	PAR-CLIP	21572407
MIRT554937	hsa-miR-6837-3p	PAR-CLIP	21572407
MIRT554936	hsa-miR-4471	PAR-CLIP	21572407
MIRT554935	hsa-miR-8059	PAR-CLIP	21572407
MIRT554934	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT512898	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT512897	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT512896	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT512895	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT512894	hsa-miR-5000-5p	PAR-CLIP	23446348
MIRT512893	hsa-miR-4761-5p	PAR-CLIP	23446348
MIRT512892	hsa-miR-759	PAR-CLIP	23446348
MIRT512891	hsa-miR-4470	PAR-CLIP	23446348
MIRT448559	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT448557	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT448558	hsa-miR-512-3p	PAR-CLIP	22100165
MIRT448556	hsa-miR-135a-3p	PAR-CLIP	22100165
MIRT448555	hsa-miR-636	PAR-CLIP	22100165
MIRT448554	hsa-miR-4671-3p	PAR-CLIP	22100165
MIRT448553	hsa-miR-4473	PAR-CLIP	22100165
MIRT448552	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448551	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT1289834	hsa-miR-1279	CLIP-seq
MIRT1289835	hsa-miR-1297	CLIP-seq
MIRT1289836	hsa-miR-19a	CLIP-seq
MIRT1289837	hsa-miR-19b	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT1289841	hsa-miR-25	CLIP-seq
MIRT1289842	hsa-miR-26a	CLIP-seq
MIRT1289843	hsa-miR-26b	CLIP-seq
MIRT1289844	hsa-miR-3156-5p	CLIP-seq
MIRT1289845	hsa-miR-32	CLIP-seq
MIRT1289846	hsa-miR-320a	CLIP-seq
MIRT1289847	hsa-miR-320b	CLIP-seq
MIRT1289848	hsa-miR-320c	CLIP-seq
MIRT1289849	hsa-miR-320d	CLIP-seq
MIRT1289850	hsa-miR-363	CLIP-seq
MIRT1289851	hsa-miR-3660	CLIP-seq
MIRT1289852	hsa-miR-367	CLIP-seq
MIRT1289853	hsa-miR-3925-3p	CLIP-seq
MIRT1289854	hsa-miR-4428	CLIP-seq
MIRT1289855	hsa-miR-4429	CLIP-seq
MIRT1289856	hsa-miR-4465	CLIP-seq
MIRT1289857	hsa-miR-4526	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT1289859	hsa-miR-4672	CLIP-seq
MIRT1289860	hsa-miR-4685-5p	CLIP-seq
MIRT1289861	hsa-miR-4789-5p	CLIP-seq
MIRT1289862	hsa-miR-5096	CLIP-seq
MIRT1289863	hsa-miR-515-5p	CLIP-seq
MIRT1289864	hsa-miR-518a-5p	CLIP-seq
MIRT1289865	hsa-miR-527	CLIP-seq
MIRT1289866	hsa-miR-539	CLIP-seq
MIRT1289867	hsa-miR-766	CLIP-seq
MIRT1289868	hsa-miR-92a	CLIP-seq
MIRT1289869	hsa-miR-92b	CLIP-seq
MIRT1289870	hsa-miR-1245b-3p	CLIP-seq
MIRT1289834	hsa-miR-1279	CLIP-seq
MIRT1289835	hsa-miR-1297	CLIP-seq
MIRT1289871	hsa-miR-1298	CLIP-seq
MIRT1289872	hsa-miR-1299	CLIP-seq
MIRT1289873	hsa-miR-149	CLIP-seq
MIRT1289836	hsa-miR-19a	CLIP-seq
MIRT1289837	hsa-miR-19b	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT1289874	hsa-miR-24	CLIP-seq
MIRT1289841	hsa-miR-25	CLIP-seq
MIRT1289842	hsa-miR-26a	CLIP-seq
MIRT1289843	hsa-miR-26b	CLIP-seq
MIRT1289875	hsa-miR-3064-5p	CLIP-seq
MIRT1289876	hsa-miR-3126-3p	CLIP-seq
MIRT1289877	hsa-miR-3145-3p	CLIP-seq
MIRT1289878	hsa-miR-3163	CLIP-seq
MIRT1289845	hsa-miR-32	CLIP-seq
MIRT1289879	hsa-miR-3613-3p	CLIP-seq
MIRT1289880	hsa-miR-3616-5p	CLIP-seq
MIRT1289850	hsa-miR-363	CLIP-seq
MIRT1289881	hsa-miR-3646	CLIP-seq
MIRT1289882	hsa-miR-3647-5p	CLIP-seq
MIRT1289883	hsa-miR-3662	CLIP-seq
MIRT1289852	hsa-miR-367	CLIP-seq
MIRT1289884	hsa-miR-3682-3p	CLIP-seq
MIRT1289885	hsa-miR-3685	CLIP-seq
MIRT1289886	hsa-miR-371b-5p	CLIP-seq
MIRT1289887	hsa-miR-384	CLIP-seq
MIRT1289853	hsa-miR-3925-3p	CLIP-seq
MIRT1289888	hsa-miR-3942-3p	CLIP-seq
MIRT1289889	hsa-miR-4277	CLIP-seq
MIRT1289890	hsa-miR-4284	CLIP-seq
MIRT1289891	hsa-miR-4328	CLIP-seq
MIRT1289892	hsa-miR-4423-3p	CLIP-seq
MIRT1289893	hsa-miR-4434	CLIP-seq
MIRT1289856	hsa-miR-4465	CLIP-seq
MIRT1289894	hsa-miR-4516	CLIP-seq
MIRT1289859	hsa-miR-4672	CLIP-seq
MIRT1289860	hsa-miR-4685-5p	CLIP-seq
MIRT1289895	hsa-miR-4709-5p	CLIP-seq
MIRT1289896	hsa-miR-4733-5p	CLIP-seq
MIRT1289897	hsa-miR-4768-3p	CLIP-seq
MIRT1289898	hsa-miR-4775	CLIP-seq
MIRT1289861	hsa-miR-4789-5p	CLIP-seq
MIRT1289899	hsa-miR-4794	CLIP-seq
MIRT1289900	hsa-miR-486-5p	CLIP-seq
MIRT1289862	hsa-miR-5096	CLIP-seq
MIRT1289901	hsa-miR-511	CLIP-seq
MIRT1289863	hsa-miR-515-5p	CLIP-seq
MIRT1289864	hsa-miR-518a-5p	CLIP-seq
MIRT1289865	hsa-miR-527	CLIP-seq
MIRT1289902	hsa-miR-558	CLIP-seq
MIRT1289903	hsa-miR-573	CLIP-seq
MIRT1289904	hsa-miR-587	CLIP-seq
MIRT1289867	hsa-miR-766	CLIP-seq
MIRT1289905	hsa-miR-875-3p	CLIP-seq
MIRT1289906	hsa-miR-888	CLIP-seq
MIRT1289868	hsa-miR-92a	CLIP-seq
MIRT1289869	hsa-miR-92b	CLIP-seq
MIRT1289907	hsa-miR-935	CLIP-seq
MIRT2086103	hsa-miR-1	CLIP-seq
MIRT1289871	hsa-miR-1298	CLIP-seq
MIRT1289872	hsa-miR-1299	CLIP-seq
MIRT1289873	hsa-miR-149	CLIP-seq
MIRT2086104	hsa-miR-206	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT1289874	hsa-miR-24	CLIP-seq
MIRT1289841	hsa-miR-25	CLIP-seq
MIRT2086105	hsa-miR-299-5p	CLIP-seq
MIRT1289875	hsa-miR-3064-5p	CLIP-seq
MIRT1289876	hsa-miR-3126-3p	CLIP-seq
MIRT1289844	hsa-miR-3156-5p	CLIP-seq
MIRT1289845	hsa-miR-32	CLIP-seq
MIRT1289850	hsa-miR-363	CLIP-seq
MIRT1289851	hsa-miR-3660	CLIP-seq
MIRT1289852	hsa-miR-367	CLIP-seq
MIRT2086106	hsa-miR-3673	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT1289889	hsa-miR-4277	CLIP-seq
MIRT1289890	hsa-miR-4284	CLIP-seq
MIRT1289891	hsa-miR-4328	CLIP-seq
MIRT1289892	hsa-miR-4423-3p	CLIP-seq
MIRT1289854	hsa-miR-4428	CLIP-seq
MIRT1289857	hsa-miR-4526	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT1289895	hsa-miR-4709-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT1289896	hsa-miR-4733-5p	CLIP-seq
MIRT1289899	hsa-miR-4794	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT1289900	hsa-miR-486-5p	CLIP-seq
MIRT1289862	hsa-miR-5096	CLIP-seq
MIRT1289901	hsa-miR-511	CLIP-seq
MIRT1289864	hsa-miR-518a-5p	CLIP-seq
MIRT1289865	hsa-miR-527	CLIP-seq
MIRT1289866	hsa-miR-539	CLIP-seq
MIRT1289902	hsa-miR-558	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT2086112	hsa-miR-613	CLIP-seq
MIRT2086113	hsa-miR-628-5p	CLIP-seq
MIRT2086114	hsa-miR-656	CLIP-seq
MIRT1289905	hsa-miR-875-3p	CLIP-seq
MIRT1289868	hsa-miR-92a	CLIP-seq
MIRT1289869	hsa-miR-92b	CLIP-seq
MIRT1289907	hsa-miR-935	CLIP-seq
MIRT2086103	hsa-miR-1	CLIP-seq
MIRT1289871	hsa-miR-1298	CLIP-seq
MIRT1289872	hsa-miR-1299	CLIP-seq
MIRT2086104	hsa-miR-206	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT2311356	hsa-miR-300	CLIP-seq
MIRT2311357	hsa-miR-3123	CLIP-seq
MIRT1289844	hsa-miR-3156-5p	CLIP-seq
MIRT1289878	hsa-miR-3163	CLIP-seq
MIRT2311358	hsa-miR-335	CLIP-seq
MIRT1289880	hsa-miR-3616-5p	CLIP-seq
MIRT1289882	hsa-miR-3647-5p	CLIP-seq
MIRT1289851	hsa-miR-3660	CLIP-seq
MIRT2086106	hsa-miR-3673	CLIP-seq
MIRT2311359	hsa-miR-381	CLIP-seq
MIRT1289888	hsa-miR-3942-3p	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT1289889	hsa-miR-4277	CLIP-seq
MIRT1289892	hsa-miR-4423-3p	CLIP-seq
MIRT1289893	hsa-miR-4434	CLIP-seq
MIRT1289894	hsa-miR-4516	CLIP-seq
MIRT1289857	hsa-miR-4526	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2311360	hsa-miR-4666-3p	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT1289895	hsa-miR-4709-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT1289897	hsa-miR-4768-3p	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT1289866	hsa-miR-539	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT1289903	hsa-miR-573	CLIP-seq
MIRT2086112	hsa-miR-613	CLIP-seq
MIRT1289905	hsa-miR-875-3p	CLIP-seq
MIRT1289907	hsa-miR-935	CLIP-seq
MIRT1289878	hsa-miR-3163	CLIP-seq
MIRT2607680	hsa-miR-1304	CLIP-seq
MIRT2607681	hsa-miR-142-5p	CLIP-seq
MIRT2086105	hsa-miR-299-5p	CLIP-seq
MIRT2607682	hsa-miR-3184	CLIP-seq
MIRT2607683	hsa-miR-340	CLIP-seq
MIRT1289879	hsa-miR-3613-3p	CLIP-seq
MIRT1289886	hsa-miR-371b-5p	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT2607684	hsa-miR-423-5p	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2607685	hsa-miR-4686	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT2607686	hsa-miR-520f	CLIP-seq
MIRT2607687	hsa-miR-548a-5p	CLIP-seq
MIRT2607688	hsa-miR-548ab	CLIP-seq
MIRT2607689	hsa-miR-548ak	CLIP-seq
MIRT2607690	hsa-miR-548b-5p	CLIP-seq
MIRT2607691	hsa-miR-548c-5p	CLIP-seq
MIRT2607692	hsa-miR-548d-5p	CLIP-seq
MIRT2607693	hsa-miR-548h	CLIP-seq
MIRT2607694	hsa-miR-548i	CLIP-seq
MIRT2607695	hsa-miR-548j	CLIP-seq
MIRT2607696	hsa-miR-548k	CLIP-seq
MIRT2607697	hsa-miR-548l	CLIP-seq
MIRT2607698	hsa-miR-548w	CLIP-seq
MIRT2607699	hsa-miR-548y	CLIP-seq
MIRT2607700	hsa-miR-559	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT2086114	hsa-miR-656	CLIP-seq
MIRT1289906	hsa-miR-888	CLIP-seq
MIRT2607680	hsa-miR-1304	CLIP-seq
MIRT2607681	hsa-miR-142-5p	CLIP-seq
MIRT2086105	hsa-miR-299-5p	CLIP-seq
MIRT2607682	hsa-miR-3184	CLIP-seq
MIRT2607683	hsa-miR-340	CLIP-seq
MIRT1289879	hsa-miR-3613-3p	CLIP-seq
MIRT1289886	hsa-miR-371b-5p	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT2607684	hsa-miR-423-5p	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2607685	hsa-miR-4686	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT2607687	hsa-miR-548a-5p	CLIP-seq
MIRT2607688	hsa-miR-548ab	CLIP-seq
MIRT2607689	hsa-miR-548ak	CLIP-seq
MIRT2607690	hsa-miR-548b-5p	CLIP-seq
MIRT2607691	hsa-miR-548c-5p	CLIP-seq
MIRT2607692	hsa-miR-548d-5p	CLIP-seq
MIRT2607693	hsa-miR-548h	CLIP-seq
MIRT2607694	hsa-miR-548i	CLIP-seq
MIRT2607695	hsa-miR-548j	CLIP-seq
MIRT2607696	hsa-miR-548k	CLIP-seq
MIRT2607697	hsa-miR-548l	CLIP-seq
MIRT2607698	hsa-miR-548w	CLIP-seq
MIRT2607699	hsa-miR-548y	CLIP-seq
MIRT2607700	hsa-miR-559	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT2086114	hsa-miR-656	CLIP-seq
MIRT1289906	hsa-miR-888	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
TWIST1	Repression	19051271
TWIST2	Repression	19051271

Show/Hide all (82)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	10777492
GO:0003925	Function	G protein activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	7791872, 8756332, 10608844, 11022048, 11359771, 12845325, 15569673, 16698549, 17916086
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11359771, 23209302
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005769	Component	Early endosome	ISS
GO:0005770	Component	Late endosome	IEA
GO:0005770	Component	Late endosome	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0009743	Process	Response to carbohydrate	IEA
GO:0010008	Component	Endosome membrane	TAS
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0016020	Component	Membrane	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019003	Function	GDP binding	IBA
GO:0030054	Component	Cell junction	IEA
GO:0030054	Component	Cell junction	ISS
GO:0031267	Function	Small GTPase binding	IEA
GO:0032045	Component	Guanyl-nucleotide exchange factor complex	IEA
GO:0032486	Process	Rap protein signal transduction	IBA
GO:0032486	Process	Rap protein signal transduction	IEA
GO:0032486	Process	Rap protein signal transduction	IMP	21840392
GO:0032966	Process	Negative regulation of collagen biosynthetic process	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0038180	Process	Nerve growth factor signaling pathway	IEA
GO:0038180	Process	Nerve growth factor signaling pathway	ISS
GO:0043005	Component	Neuron projection	IEA
GO:0043547	Process	Positive regulation of GTPase activity	ISS
GO:0044877	Function	Protein-containing complex binding	IDA	23209302
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045860	Process	Positive regulation of protein kinase activity	ISS
GO:0046326	Process	Positive regulation of D-glucose import	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	11359771
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050766	Process	Positive regulation of phagocytosis	IEA
GO:0060369	Process	Positive regulation of Fc receptor mediated stimulatory signaling pathway	IEA
GO:0061028	Process	Establishment of endothelial barrier	IEA
GO:0061028	Process	Establishment of endothelial barrier	IMP	21840392
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070161	Component	Anchoring junction	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0071320	Process	Cellular response to cAMP	IBA
GO:0071320	Process	Cellular response to cAMP	IDA	21840392
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0072659	Process	Protein localization to plasma membrane	IDA	17916086
GO:0097225	Component	Sperm midpiece	IEA
GO:0097225	Component	Sperm midpiece	ISS
GO:0097327	Process	Response to antineoplastic agent	IEA
GO:0097421	Process	Liver regeneration	IEA
GO:0098696	Process	Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	12202034
GO:0098696	Process	Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	12202034
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	12202034
GO:0098978	Component	Glutamatergic synapse	IMP	12202034
GO:1901888	Process	Regulation of cell junction assembly	IMP	21840392
GO:1904322	Process	Cellular response to forskolin	IEA
GO:1990090	Process	Cellular response to nerve growth factor stimulus	IEA
GO:1990090	Process	Cellular response to nerve growth factor stimulus	ISS
GO:2000301	Process	Negative regulation of synaptic vesicle exocytosis	IBA
GO:2000301	Process	Negative regulation of synaptic vesicle exocytosis	IEA
GO:2001214	Process	Positive regulation of vasculogenesis	IEA
GO:2001214	Process	Positive regulation of vasculogenesis	ISS

MIM	HGNC	e!Ensembl
179520	9855	ENSG00000116473

P62834

Protein name

Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)

Protein function

Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role

PDB

1C1Y , 1GUA , 3KUC , 4KVG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	5 → 167	Ras family	Domain

Sequence

MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG
TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL
EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS
CLLL

Sequence length

184

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOYAMOYA DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOPOROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RAP1A-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (184)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Abnormal dermatoglyphic pattern	Abnormal dermatoglyphic pattern	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Megakaryocytic Leukemias	Megakaryocytic Leukemia	BEFREE	1549353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	22211192		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	8890957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	28786706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Age related macular degeneration	Age-related macular degeneration	BEFREE	31673119		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	35011725, 37999404	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Alzheimer disease, familial, type 3	Alzheimer disease	BEFREE	30257685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic coarctation	Aortic Coarctation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	17009234	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	12469204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	BEFREE	15064832		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	20436929		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood Coagulation Disorders	BEFREE	29925524		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Platelet Disorders	Platelet disorder	Pubtator	23243278, 27235135	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21429211, 23209302, 23405264, 31151140		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23405264, 33267867, 35197309, 37561760	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Byzanthine arch palate	High palate	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cap Myopathy	Cap myopathy	Pubtator	19470770	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	19470770, 23219753, 24316969, 25856570	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	28196746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24020493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	30144784	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	1485916, 22723956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	27812180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	25856570, 34446056	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carotid Artery Diseases	Carotid artery disease	Pubtator	29595698	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral cortical atrophy	Cerebral cortical atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	31154815		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	30883336		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical Intraepithelial Neoplasia	Cervical Intraepithelial Neoplasia	BEFREE	25856570		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	30883336		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	34211100	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chordoma	Chordoma	Pubtator	24452533, 32011476	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic granulomatous disease	Granulomatous Disease	BEFREE	1315174		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	29970392		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	33942972	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	26634692		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	26096612, 31836706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	1345809, 30064475		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	1345809		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30064475, 33779485	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conductive hearing loss	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of penis	Congenital Hypoplasia Of Penis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital ocular coloboma (disorder)	Congenital ocular coloboma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Restenosis	Coronary restenosis	Pubtator	38432855	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	20061197, 30500874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	30500874	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	16754837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	22970290	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	34028657	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	32705173, 37935955	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Cardiomyopathies	Diabetic cardiomyopathy	BEFREE	28853973		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	32869917	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	31399961		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	22859270		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	22859270		★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial Alzheimer Disease (FAD)	Alzheimer disease	BEFREE	16181736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial multiple trichoepitheliomata	Multiple Trichoepithelioma	BEFREE	28196746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	30307978		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	2514150		★★★★★ ★☆☆☆☆ Found in Text Mining only
Follicular thyroid carcinoma	Follicular Thyroid Carcinoma	BEFREE	29882482		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	Pubtator	35585182	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	24790104		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	32102991	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	24790104		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	25682201, 34894053	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	35114361	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hamartoma Syndrome, Multiple	Hamartoma	BEFREE	30500874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	29545335	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	34028657, 7654184	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Septal Defects	Heart Septal Defects	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Valve Diseases	Heart valve disease	Pubtator	35535387	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	15310461		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	28786706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydronephrosis	Hydronephrosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	25807985		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypodontia	Hypodontia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	23804711	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	20061197		★★★★★ ★☆☆☆☆ Found in Text Mining only
insulinoma	Insulinoma	BEFREE	1573790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kabuki make-up syndrome	Kabuki Syndrome	BEFREE	26280580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kabuki make-up syndrome	Kabuki Syndrome	ORPHANET_DG	26280580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	22120639		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukocyte adhesion deficiency type 1	Leukocyte adhesion deficiency	BEFREE	14551137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukocyte adhesion deficiency type 1	Leukocyte adhesion deficiency	Pubtator	14551137	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukocyte Adhesion Deficiency Type III	Leukocyte adhesion deficiency	Pubtator	14551137, 17576779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukocyte-Adhesion Deficiency Syndrome	Leukocyte adhesion deficiency	BEFREE	14551137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukocyte-Adhesion Deficiency Syndrome	Leukocyte adhesion deficiency	LHGDN	14551137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	23685049, 29764501, 30307978		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	24020493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure Acute	Liver failure	Pubtator	31521462	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	22723956, 28232663	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Macrotia	Macrotia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	21873678, 34341398	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	23241957		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21429211, 23209302, 23405264, 31151140		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	22859270		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	30307978		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	1485916, 22723956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	12628187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	23716716		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	21454517, 25636908, 27624889, 31746380		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21698158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12628187, 16171553, 23565202, 25856570, 28196746, 28456710, 28853973, 29621614, 29725465, 30064475, 30680073, 31545475		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	30883336		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	26096612, 31836706		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	23405264		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	16912161, 19147557, 21454517, 31401046		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	16754837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	28853973		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	BEFREE	28851815		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mevalonate Kinase Deficiency	Mevalonate kinase deficiency	Pubtator	31474985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcornea	Microcornea	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Microdontia (disorder)	Microdontia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	23219753	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	24239198, 30016091		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	17873362		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	33795012	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	LHGDN	16118622		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	28039940		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocarditis	Myocarditis	BEFREE	24920725		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	31414345		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10880549, 12469204, 12892713, 1345809, 17020976, 18037957, 19147557, 20028760, 23405264, 23565202, 24790104, 26527515, 28196746, 29764501, 8084835, 8890957 View all (1 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	1573790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrosis, congenital	Nephrosis, Congenital	BEFREE	31171376		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	20190816, 28456710		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30257685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	22723956, 28518145, 31293647, 31465829, 31805277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	23405264, 30144784		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	23791522, 23791526, 23809762, 30307978		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	HPO_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ocular Hypertension	Ocular hypertension	Pubtator	35585182	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	GWASDB_DG	20548944		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteoporosis	Osteoporosis	GWASCAT_DG	20548944		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteoporosis	Osteoporosis	BEFREE	30413613		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteosarcoma	Osteosarcoma	BEFREE	15949576		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	21622131	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	31865146	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	23716716		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	17210721, 18948674, 22304389		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precocious Puberty	Precocious puberty	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	21056083		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	21454517, 25636908, 27624889, 31746380		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19470770, 31746380	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	Pubtator	37935955	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal fibrosis	Renal fibrosis	BEFREE	29216750, 31399961		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	17009234		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	33762319	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	28917843, 29320740		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Scoliosis, unspecified	Scoliosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	13679863, 16436672, 25856570		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	13679863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	22859270, 23906251, 31545475		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	20028760, 23219753	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	20028760, 23349315		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	30307978		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	21698158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	21698158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Subarachnoid Hemorrhage	Subarachnoid hemorrhage	BEFREE	29922213		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombocythemia Essential	Essential thrombocythemia	Pubtator	23243278	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombocythemia, Essential	Thrombocythemia	BEFREE	23243278		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	19066305, 22696507	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid cancer, follicular	Thyroid cancer	BEFREE	29882482		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	22696507		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	35264562	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tuberous Sclerosis	Tuberous Sclerosis	BEFREE	12469204, 7608212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tuberous Sclerosis	Tuberous sclerosis complex	Pubtator	7608212	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	20061197		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Dysplasia	Uterine disease	Pubtator	25856570	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	30883336	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
von Willebrand Disease	von Willebrand disorder	BEFREE	29925524		★★★★★ ★☆☆☆☆ Found in Text Mining only

RAP1A (RAP1A, member of RAS oncogene family)