RANBP3 (RAN binding protein 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8498
• Gene name: RAN binding protein 3
• Gene symbol: RANBP3
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have be

miRNA Show/Hide all (91)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004172	hsa-miR-192-5p	Microarray	16822819
MIRT037884	hsa-miR-455-3p	CLASH	23622248
MIRT439825	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439825	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1289587	hsa-miR-15a	CLIP-seq
MIRT1289588	hsa-miR-15b	CLIP-seq
MIRT1289589	hsa-miR-16	CLIP-seq
MIRT1289590	hsa-miR-195	CLIP-seq
MIRT1289591	hsa-miR-2110	CLIP-seq
MIRT1289592	hsa-miR-3165	CLIP-seq
MIRT1289593	hsa-miR-3202	CLIP-seq
MIRT1289594	hsa-miR-330-3p	CLIP-seq
MIRT1289595	hsa-miR-3650	CLIP-seq
MIRT1289596	hsa-miR-3656	CLIP-seq
MIRT1289597	hsa-miR-3926	CLIP-seq
MIRT1289598	hsa-miR-424	CLIP-seq
MIRT1289599	hsa-miR-4271	CLIP-seq
MIRT1289600	hsa-miR-4505	CLIP-seq
MIRT1289601	hsa-miR-4667-5p	CLIP-seq
MIRT1289602	hsa-miR-4700-5p	CLIP-seq
MIRT1289603	hsa-miR-4725-3p	CLIP-seq
MIRT1289604	hsa-miR-4731-5p	CLIP-seq
MIRT1289605	hsa-miR-4747-5p	CLIP-seq
MIRT1289606	hsa-miR-483-5p	CLIP-seq
MIRT1289607	hsa-miR-497	CLIP-seq
MIRT1289608	hsa-miR-548s	CLIP-seq
MIRT1289609	hsa-miR-1908	CLIP-seq
MIRT1289591	hsa-miR-2110	CLIP-seq
MIRT1289593	hsa-miR-3202	CLIP-seq
MIRT1289610	hsa-miR-320e	CLIP-seq
MIRT1289597	hsa-miR-3926	CLIP-seq
MIRT1289611	hsa-miR-3943	CLIP-seq
MIRT1289599	hsa-miR-4271	CLIP-seq
MIRT1289612	hsa-miR-4486	CLIP-seq
MIRT1289613	hsa-miR-4488	CLIP-seq
MIRT1289614	hsa-miR-4492	CLIP-seq
MIRT1289615	hsa-miR-4498	CLIP-seq
MIRT1289600	hsa-miR-4505	CLIP-seq
MIRT1289616	hsa-miR-4640-5p	CLIP-seq
MIRT1289601	hsa-miR-4667-5p	CLIP-seq
MIRT1289617	hsa-miR-4685-5p	CLIP-seq
MIRT1289618	hsa-miR-4697-5p	CLIP-seq
MIRT1289602	hsa-miR-4700-5p	CLIP-seq
MIRT1289603	hsa-miR-4725-3p	CLIP-seq
MIRT1289619	hsa-miR-4726-5p	CLIP-seq
MIRT1289604	hsa-miR-4731-5p	CLIP-seq
MIRT1289605	hsa-miR-4747-5p	CLIP-seq
MIRT1289608	hsa-miR-548s	CLIP-seq
MIRT1289620	hsa-miR-637	CLIP-seq
MIRT1289621	hsa-miR-663	CLIP-seq
MIRT1289622	hsa-miR-762	CLIP-seq
MIRT2086028	hsa-miR-4639-3p	CLIP-seq
MIRT2311262	hsa-miR-1207-5p	CLIP-seq
MIRT2311263	hsa-miR-1269	CLIP-seq
MIRT2311264	hsa-miR-1269b	CLIP-seq
MIRT2311265	hsa-miR-1288	CLIP-seq
MIRT2311266	hsa-miR-1343	CLIP-seq
MIRT2311267	hsa-miR-214	CLIP-seq
MIRT1289593	hsa-miR-3202	CLIP-seq
MIRT2311268	hsa-miR-3619-5p	CLIP-seq
MIRT2311269	hsa-miR-3682-3p	CLIP-seq
MIRT2311270	hsa-miR-378	CLIP-seq
MIRT2311271	hsa-miR-378b	CLIP-seq
MIRT2311272	hsa-miR-378c	CLIP-seq
MIRT2311273	hsa-miR-378d	CLIP-seq
MIRT2311274	hsa-miR-378e	CLIP-seq
MIRT2311275	hsa-miR-378f	CLIP-seq
MIRT2311276	hsa-miR-378h	CLIP-seq
MIRT2311277	hsa-miR-378i	CLIP-seq
MIRT1289597	hsa-miR-3926	CLIP-seq
MIRT2311278	hsa-miR-422a	CLIP-seq
MIRT1289613	hsa-miR-4488	CLIP-seq
MIRT2311279	hsa-miR-4502	CLIP-seq
MIRT2311280	hsa-miR-4515	CLIP-seq
MIRT1289618	hsa-miR-4697-5p	CLIP-seq
MIRT2311281	hsa-miR-4740-5p	CLIP-seq
MIRT1289605	hsa-miR-4747-5p	CLIP-seq
MIRT2311282	hsa-miR-4758-3p	CLIP-seq
MIRT2311283	hsa-miR-4763-3p	CLIP-seq
MIRT2311284	hsa-miR-486-3p	CLIP-seq
MIRT2311285	hsa-miR-548q	CLIP-seq
MIRT1289608	hsa-miR-548s	CLIP-seq
MIRT2311286	hsa-miR-550a	CLIP-seq
MIRT1289620	hsa-miR-637	CLIP-seq
MIRT2311287	hsa-miR-761	CLIP-seq
MIRT2607615	hsa-miR-1324	CLIP-seq
MIRT2607616	hsa-miR-296-5p	CLIP-seq
MIRT2607617	hsa-miR-3918	CLIP-seq
MIRT2607615	hsa-miR-1324	CLIP-seq
MIRT2607616	hsa-miR-296-5p	CLIP-seq
MIRT2607617	hsa-miR-3918	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	9637251, 11932251, 21960005, 37219487
GO:0005634	Component	Nucleus	IDA	9637251, 10567565, 18280241
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	10567565, 18280241
GO:0005737	Component	Cytoplasm	IEA
GO:0006611	Process	Protein export from nucleus	IBA
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IPI	9637251
GO:0070412	Function	R-SMAD binding	IPI	19289081

Other IDs

• MIM: 603327
• HGNC: 9850
• e!Ensembl: ENSG00000031823

Protein

• UniProt ID: Q9H6Z4
• Protein name: Ran-binding protein 3 (RanBP3)
• Protein function: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear
• PDB: 2CRF , 2Y8F , 2Y8G , 5XZX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00638	Ran_BP1	390 → 505	RanBP1 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with high levels in testis and heart. {ECO:0000269|PubMed:9637251}.
• Sequence:

  MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGE
  HALEPPAPAGASASTPPPPAPEAQLPPFPRELAGRSAGGSSPEGGEDSDREDGNYCPPVK
  RERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAP
  QPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNES
  SNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFL
  QYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQ
  EATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWVE
  RGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDT
  EDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSD
  DDDVLAPSGATAAGAGDEGDGQTTGST

• Sequence length: 567

Pathways

KEGG Pathway:

Human T-cell leukemia virus 1 infection

Related Genes

No strongly related genes found yet for RANBP3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to RANBP3.